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Current Position: Home > Dictionary EN > N > 98-92-0

98-92-0

Chemical Name Nicotinamide
CAS Registry Number 98-92-0
PubChemID 936
Molecular Weight 122.127
PSA 55.98000
LogP 0.88080
EINECS 202-713-4
Molecular Formula C6H6N2O
Aliases
 
98-92-0 Properties
Density 1.204
Boiling Point 264 to 268° F (NTP, 1992)
Flash Point 182°C
Melting Point 128-131℃
Appearance White to off white powder
Refractive Index 1.466 (20 C)
Solubility Incompatible with strong oxidizing agents
Color/Form white
Other physical and chemical properties PHYSICAL DESCRIPTION: White powder. (NTP, 1992)
Stability Stable. Incompatible with strong oxidizing agents.
HS Code 29362990
Storage temp 0-6°C
Spectral properties MAX ABSORPTION (ALCOHOL): 255 NM (LOG E= 3.4); 262.5 NM (LOG E= 3.4); INDEX OF REFRACTION: 1.466; SADTLER REFERENCE NUMBER: 860 (IR, PRISM); 8106 (IR, GRATING)
Index of refraction: 1.466
IR: 5080 (Coblentz Society Spectral Collection)
UV: 261 (Sadtler Research Laboratories Spectral Collection)
1H NMR: 453 (Varian Associates NMR Spectra Catalogue)
13C NMR: 259 (Johnson and Jankowski, Carbon-13 NMR for Organic Chemists, John Wiley & Sons, New York)
MASS: 2279 (NIST/EPA/MSDC Mass Spectral database, 1990 version)
Raman: 518 (Sadtler Research Laboratories spectral collection)
Intense mass spectral peaks: 78 m/z, 106 m/z, 122 m/z
 
98-92-0 Safety Infomation
Safety Statements S26;S36
Risk Statements R36/37/38
Hazard Note H315; H319; H335
Safety

Hazard Codes: Xi
Risk Statements: 36/37/38:?Irritating to eyes, respiratory system and skin?
Safety Statements: 26-36-37/39
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice?
36:?Wear suitable protective clothing
37/39: Wear suitable gloves and eye/face protection.
Nicotinamide rarely causes side effects, and is considered generally safe as a food additive, and as a component in cosmetics and medication.
?

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mammal (species unspecified) LD50 unreported 2500mg/kg (2500mg/kg) ? Pharmaceutical Chemistry Journal Vol. 20, Pg. 29, 1986.
mouse LD50 intraperitoneal 2050mg/kg (2050mg/kg) ? Radiation Research. Vol. 109, Pg. 479, 1987.
mouse LD50 oral 2500mg/kg (2500mg/kg) ? Drugs in Japan Vol. 6, Pg. 545, 1982.
mouse LD50 subcutaneous 2gm/kg (2000mg/kg) ? Quarterly Journal of Pharmacy & Pharmacology. Vol. 19, Pg. 48, 1946.
rat LD50 oral 3500mg/kg (3500mg/kg) ? "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1390, 1986.
rat LD50 subcutaneous 1680mg/kg (1680mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Proceedings of the Society for Experimental Biology and Medicine. Vol. 62, Pg. 19, 1946.

Cleanup Methods Evacuate persons not wearing protective equipment from area of spill or leak until clean up is complete. Remove all ignition sources. Use HEPA vacuum or wet method to reduce dust during cleanup. Do not dry sweep. Collect powdered material in the most convenient and safe manner and deposit in sealed containers. Ventilate after clean up is complete. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material of contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your Department of Environmental Protection or regional office of the federal EPA for specific recommendations. If employees are expected to clean up spills, they must be trained and equipped. OSHA 1910.120 may be applicable.
Transport 25kgs
Fire Fighting Procedures This chemical is a noncombustible solid. Use dry chemical, carbon dioxide, water spray, or alcohol foam extinguishers. Poisonous gases are produced in fire. If material of contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increase in volume and pitch, tank discolors, or shows any signs of deforming), withdraw immediately to a secure position. If employees are expected to fight fires, they must be trained and equipped in OSHA 1910.156.
Formulations/Preparations Oral: Tablets: 50 mg; 100 mg; 500 mg. (available by nonproprietary name).
Nicotinamide is sold in three grades: pharmaceutical (USP, NF, Ph. Eur.(European Pharmacopeia)), food (USP/FCC), and feed-technical.
Exposure Standards and Regulations Niacinamide used as a nutrient and/or dietary supplement in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.
Specification

?Nicotinamide , with CAS number of 98-92-0, can be called Niamide ; Niacinamide/Nicotinamide ; Austrovit PP ; beta.-Pyridinecarboxamide ; Nikotinsaeureamid ; Amid kyseliny nikotinove ; Nicotinamidum ; Pyridine-3-carboxylic acid amide ; Nikotinsaeureamid ; Nicotinamide(Vitamin B3) ; a-Alanine,N-[(2R)-2,4-dihydroxy-3,3- dimethyl-1-oxobutyl]- ; 3-Pyridinecarboxamide ; Nicotinamida ; Niacinamide ; 3-Pyridinecarboxylic acid amide ; Nicotine acid amide . Nicotinamide, also known as niacinamide and Nicotinic acid amide, is the amide of Nicotinic acid (vitamin B3). It is a water-soluble vitamin and is part of the vitamin B group.Nicotinic acid(also known as niacin)can be converte to niacinamide in vivo.?It is a?white to off white powder.

Octanol/Water Partition Coefficient log Kow = -0.37
Disposal Methods SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.
 
 
 
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