3D Mol Similar

1-Phenylpiperazine

: Iupac Name：1-phenylpiperazine; CAS No.: 92-54-6; Molecular Weight：162.236; Modify Date.: 2022-11-29 05:43; Introduction:
clear colorless to yellow liquid
View more+

Request For Quotation

1. Names and Identifiers

: 1.1 Name; 1-Phenylpiperazine; 1.2 Synonyms; 1-Fenylpiperazin 1-fenylpiperazine 1-PHENYLPIPERAINE 1-phenyl-piperazine 4-Phenylpiperazine 4-Ph-piperazine AKOS BBS-00003581 EINECS 202-165-6 LABOTEST-BB LTBB000705 Levodropropizine EP Impurity B Levodropropizine ImpurityⅡ:l-phenylpiperazine MFCD00005957 N-PHENYLPIPERAZINE phenyl piperazine Phenylpiperazine Piperazine, 1-phenyl- TIMTEC-BB SBB003943; View all

1.3 CAS No.: 92-54-6

1.4 CID: 7096

1.5 EINECS(EC#): 202-165-6

1.6 Molecular Formula: C10H14N2 (isomer)

1.7 Inchi: InChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2

1.8 InChIkey: YZTJYBJCZXZGCT-UHFFFAOYSA-N

1.9 Canonical Smiles: C1CN(CCN1)C2=CC=CC=C2

1.10 Isomers Smiles: C1CN(CCN1)C2=CC=CC=C2

2. Properties

2.1 Density: 1.062

2.1 Melting point: 18.8℃

2.1 Boiling point: 286℃

2.1 Refractive index: 1.5865-1.5885

2.1 Flash Point: 140℃

2.1 Precise Quality: 162.11600

2.1 PSA: 15.27000

2.1 logP: 1.49000

2.1 Solubility: Insoluble

2.2 Appearance: Clear colorless to yellow Liquid

2.3 Storage: Ambient temperatures.

2.4 Chemical Properties: clear colorless to yellow liquid

2.5 Color/Form: Clear colorless to yellow

2.6 pKa: pK1:8.71(+1) (25°C,μ=0.1)

2.7 Water Solubility: Insoluble

2.8 Stability: Stable under normal temperatures and pressures.

2.9 StorageTemp: 2-8°C

3. Use and Manufacturing

3.1 GHS Classification: Signal: Danger
GHS Hazard Statements
Aggregated GHS information provided by 45 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

H301 (95.56%): Toxic if swallowed [Danger Acute toxicity, oral]
H310 (42.22%): Fatal in contact with skin [Danger Acute toxicity, dermal]
H311 (55.56%): Toxic in contact with skin [Danger Acute toxicity, dermal]
H314 (97.78%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

Precautionary Statement Codes
P260, P262, P264, P270, P280, P301+P310, P301+P330+P331, P302+P350, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P361, P363, P405, and P501; View all

4. Safety and Handling

4.1 Symbol: GHS05, GHS06

4.1 Hazard Codes: T

4.1 Signal Word: Danger

4.1 Risk Statements: R22;R24;R34

4.1 Safety Statements: S26;S28;S36/37/39;S45

4.1 Packing Group: II

4.1 Hazard Class: 6.1

4.1 Hazard Declaration: H301 + H311-H314

4.1 RIDADR: UN 2922

4.1 Safety Profile: Poison by ingestion and skin contact. A skin and severe eye irritant. Mutation data reported. Combustible when exposed to heat or flame. It supports combustion and decomposes to yield toxic fumes of NOx. To fight fire, use water, foam, dry chemical. See also PIPERAZINE 1-Phenylpiperazine Preparation Products And Raw materials Preparation Products

4.2 Caution Statement: Missing Phrase - N15.00950417-P260-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338

4.2 WGK Germany: 3

4.2 RTECS: TM2625000

5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 3

Acute toxicity - Dermal, Category 3

Skin corrosion, Category 1B

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H311 Toxic in contact with skin H314 Causes severe skin burns and eye damage
Precautionary statement(s)
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection. P260 Do not breathe dust/fume/gas/mist/vapours/spray.
Response	P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/\u2026 P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P312 Call a POISON CENTER/doctor/\u2026if you feel unwell. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower]. P363 Wash contaminated clothing before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P310 Immediately call a POISON CENTER/doctor/\u2026 P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

View all

6. NMR Spectrum

13C NMR : in CDCl3

1H NMR : 400 MHz in CDCl3

IR : liquid film

Raman : 4880 A,200 M,liquid

Mass

Mass spectrum (electron ionization)

UV/Visible spectrum

7. Synthesis Route

92-54-6Total: 24 Synthesis Route

110-85-0 85 Suppliers

92-54-6 240 Suppliers

Literatures:
Tetrahedron Letters, , vol. 37, # 47 p. 8487 - 8488
Yield: null

142-04-1 47 Suppliers

92-54-6 240 Suppliers

Literatures:
Yakugaku Zasshi, , vol. 74, p. 1049 Chem.Abstr., , p. 11666 Journal of the American Chemical Society, , vol. 56, p. 2199 Yakugaku Zasshi, , vol. 73, p. 1110,1111,1113 Chem.Abstr., , p. 12121
Yield: null

108-86-1 200 Suppliers

92-54-6 240 Suppliers

Literatures:
WO2011/28947 A2, ; WO 2011/028947 A1
Yield: null

View all

8. Precursor and Product

precursor:

10024-89-2

111-42-2

142-04-1

74497-02-2

334-22-5

49858-38-0

821-48-7

77278-63-8

4004-95-9

1692-78-0

591-50-4

77697-11-1

4004-96-0

110-85-0

43204-63-3

108-90-7

14426-21-2

108-86-1

21057-43-2

View all

product :

3074-43-9

96530-59-5

29609-33-4

2208-51-7

17419-71-5

3965-85-3

84344-43-4

66307-58-2

84344-44-5

61015-46-1

67455-41-8

84344-47-8

40224-22-4

20529-19-5

6323-13-3

6323-12-2

78702-84-8

72566-27-9

68944-97-8

85868-45-7

6323-08-6

14258-45-8

6306-91-8

36245-26-8

81816-82-2

View all

9. Other Information

9.0 Mesh: Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. (See all compounds classified as Adrenergic alpha-Antagonists.)|A loosely defined grouping of drugs that have effects on psychological function. Here the psychotropic agents include the antidepressive agents, hallucinogens, and tranquilizing agents (including the antipsychotics and anti-anxiety agents). (See all compounds classified as Psychotropic Drugs.)

9.1 Mesh Entry Terms: 1-phenylpiperazine

9.2 Manufacturing Info: Piperazine, 1-phenyl-: INACTIVE

9.3 BRN: 132157

9.4 Chemical Properties: clear colorless to yellow liquid

9.5 Safety Profile: Poison by ingestion and skin contact. A skin and severe eye irritant. Mutation data reported. Combustible when exposed to heat or flame. It supports combustion and decomposes to yield toxic fumes of NOx. To fight fire, use water, foam, dry chemical. See also PIPERAZINE

10. Computational chemical data

Molecular Weight: 162.236g/mol
Molecular Formula: C₁₀H₁₄N₂
Compound Is Canonicalized: True
XLogP3-AA: null
Exact Mass: 162.115698455
Monoisotopic Mass: 162.115698455
Complexity: 124
Rotatable Bond Count: 1
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 2
Topological Polar Surface Area: 15.3
Heavy Atom Count: 12
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Isotope Atom Count: 0
Covalently-Bonded Unit Count: 1
CACTVS Substructure Key Fingerprint: AAADccBzAAAAAAAAAAAAAAAAAAAAAAAAAAA8QAAAAAAAAAABAAAAHAAQAAAACAjBEAQwwIPAAACAACRCQACCAAAhAgAIiIAIZIgIYCLAkZGUIAhgkADIyAcQAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA==

11. Question & Answer

How to Prepare 1-Phenylpiperazine Efficiently and Economically? May 21 2023
1-Phenylpiperazine is an important compound in medicinal chemistry and serves as a key intermediate for the antitussive drug levopropylhexedrine. Preparation Methods There are two industrial preparati..
What should we consider when purchasing 1-Phenylpiperazine? Apr 07 2023
1-Phenylpiperazine is a raw material widely used in pharmaceutical production, commonly used in the treatment of hypertension, heart failure, and various cardiovascular diseases. When purchasing 1-Ph..

12. Recommended Suppliers

Global229SuppliersView all >>

Hebei Saisier Technology Co., LTD Diamond member

1YR

Products:Our company specializes in the research and development of fine chemicals, food additives and pharmaceutical raw materials
Tel:86-17656389-633
Email:vicky@hbsaisier.cn

1-phenyl-piperazine 92-54-6

Purity:99%Packing: 200kg/bag FOB
Price: 4 RMB/g
Time: 2023/09/21

Inquire

Henan Bao Enluo International Trade Co. Ltd Diamond member

1YR

Products:Pharmaceutical intermediates
Tel:173-31933971-17331933971
Email:deasea125996@gmail.com

1-Phenylpiperazine CAS NO.92-54-6

Purity:99%Packing: 200kg/bag FOB
Price: 1 USD/kg
Time: 2023/09/21

Inquire

Hubei Shanglin Trading Co. Diamond member

1YR

Products:Top quality and high purity with safe transportation and low price pmk powder ;pmk oil ;bmk powder ;bmk oil
Tel:+8617720-212189-+8617720212189
Email:mia@whslchemical.com

Factory wholesale High purity 99.9% CAS：92-54-6 LABOTEST-BB LTBB000705

Purity:99%Packing: 200kg/bag FOB
Price: 100 USD/g
Time: 2023/09/21

Inquire

Xiamen wonderful Biotechnology Co., Ltd. Diamond member

1YR

Products:Top quality and high purity with safe transportation and low price
Tel:+86153-59898336-15359898336
Email:aya@xmwonderfulbio.com

CAS 92-54-6 1-Phenylpiperazine Factory wholesale

Purity:99%Packing: 200kg/bag FOB
Price: 10 USD/g
Time: 2023/09/21

Inquire

Hebei Bester Biotechnology Co., Ltd. Diamond member

1YR

Products:pmk powder ;pmk oil ;bmk powder ;bmk oil ;Protonitazene hcl ; Bromazolam ; Metonitazene; 2-Bromo-4'-methylpropiophenone ;
Tel:+8613073-165382-+8613102867802
Email:luly@chbbest.com

1-Phenylpiperazine cas92-54-6

Purity:99%Packing: 200kg/bag FOB
Price: 10 USD/kg
Time: 2023/09/20

Inquire

13. Realated Product Infomation

5271-26-1 2-Phenylpiperazine

63921-23-3 1-PHENYLPIPERAZINE

2210-93-7 1-PHENYLPIPERAZINE HYDROCHLORIDE

4004-95-9 1-Phenylpiperazine dihydrochloride

872139-22-5 2-PHENYLPIPERAZINE DIHYDROCHLORIDE

5271-27-2 1-Methyl-3-phenylpiperazine

5368-28-5 3-Phenylpiperazin-2-one

Recently Updated : 1009119-62-3 2446484-57-5 2446481-80-5 1118567-46-6 1447940-07-9 2947584-56-5 32259-88-4 1372158-13-8 2813950-07-9 849481-53-4