3D Mol Similar

2,2'-Bipyridine

Iupac Name：2-pyridin-2-ylpyridine

CAS No.: 366-18-7

Molecular Weight：156.18392

Modify Date.: 2022-11-29 10:26

Introduction:

White crystalline powder

DryPowder; PelletsLargeCrystals|WHITE CRYSTALS.

2,2'-bipyridine is a bipyridine in which the two pyridine moieties are linked by a bond between positions C-2 and C-2'. It has a role as a ferroptosis inhibitor and a chelator.|A reagent used for the determination of iron.

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1. Names and Identifiers

1.1 Name: 2,2'-Bipyridine
1.2 Synonyms: [2,2]Bipyridinyl 2-(2-pyridyl)pyridine 2,2&lsquo-Dipyridyl 2,2&rsquo-bipyridine 2,2&rsquo-Bipyridyl 2,2`-Bipyridyl 2,2″ bipyridine 2,2″-bipyridine 2,2″-bipyridinyl 2,2″-bipyridyl 2,2'-Bipyridin 2,2-BIPYRIDINE 2,2'-BIPYRIDINE (2,2'-Bipyridyl) 2,2'-BIPYRIDINE-3,3'-DIOL 2,2'-Bipyridyl 2,2-Bispyridine 2,2'-dipyridine 2,2'-Dipyridyl 2,2-Dipyridyl 2,2'-Dipyridyl p.a. 2,6'-Bipyridine 2'-Bipyridine 2-pyridin-2-ylpyridine bipy bipyridine bipyridyl bpy dipyridyl Dipyridyl, 2,2' EINECS 206-674-4 MFCD00006212 α,α'-bipyridine α,α'-Bipyridyl α,α'-dipyridine α,α'-dipyridyl α,α'-Dipyridyl, 2,2'-Dipyridyl

1.3 CAS No.: 366-18-7

1.4 CID: 1474

1.5 EINECS(EC#): 206-674-4

1.6 Molecular Formula: C10H8N2 (isomer)

1.7 Inchi: InChI=1S/C10H8N2/c1-3-7-11-9(5-1)10-6-2-4-8-12-10/h1-8H

1.8 InChkey: ROFVEXUMMXZLPA-UHFFFAOYSA-N

1.9 Canonical Smiles: C1=CC=NC(=C1)C2=CC=CC=N2

1.10 Isomers Smiles: C1=CC=NC(=C1)C2=CC=CC=N2

2. Properties

2.1 Density: 272

2.1 Melting point: 70-73℃

2.1 Boiling point: 273℃

2.1 Refractive index: 1.58

2.1 Flash Point: 121 °C

2.1 Precise Quality: 156.06900

2.1 PSA: 25.78000

2.1 logP: 2.14360

2.1 Solubility: 5.5g/l

2.2 Λmax: 280(EtOH)nm

2.3 Appearance: White to almost white Crystalline Powder

2.4 Storage: Ambient temperatures.

2.5 Chemical Properties: White crystalline powder

2.6 Color/Form: White crystals|Crystals from dilute alcohol|PRISMS FROM PETROLEUM ETHER

2.7 Decomposition: When heated to decomposition it emits toxic fumes of /nitrogen oxides/.

2.8 Odor: Characteristic odour

2.9 PH: 7.5 (5g/l, H2O, 25℃)

2.10 pKa: pK1:-0.52(+2);pK2:4.352(+1) (20°C)

2.11 Water Solubility: H2O: 5.5 g/L 22 oC

2.12 Spectral Properties: MAX ABSORPTION (METHANOL): 235 NM (LOG E= 4.01); 280 NM (LOG E= 3.85)
IR: 8616 (Sadtler Research Laboratories IR Grating Collection)
UV: 3468 (Sadtler Research Laboratories Spectral Collection)
NMR: 3247 (Sadtler Research Laboratories Spectral Collection)
MASS: 78049 (NIST/EPA/MSDC Mass Spectral Database 1990 Version); 113 (Aldermaston, Eight Peak Index of Mass Spectra, UK)

2.13 Stability: Stable. Incompatible with strong oxidizing agents, most common metals. May be light sensitive.

2.14 StorageTemp: room temp

3. Use and Manufacturing

3.1 Definition: ChEBI: A bipyridine in which the two pyridine moieties are linked by a bond between positions C-2 and C-2'.

3.2 Methods of Manufacturing: Derived from pyridine and ferric chloride.?Mix 70g of anhydrous pyridine with 13g of anhydrous ferric chloride, heat at 300°C in a sealed tube for about 35h.?After cooling, the reaction solidified into red-black crystals, opened the sealed tube, and washed out the red-black solution of the solid with a small amount of hot water.?Extract with ether to remove oily impurities.?After neutralization with sodium bicarbonate, excess pyridine was removed with steam heating.?The mixture was then made strongly alkaline and 2, 2'-bipyridine was distilled off with steam.?The distillate was acidified, evaporated and concentrated, then added sodium hydroxide, extracted with ether, and the ether was removed to obtain a crude product.?The crude product is recrystallized with B and the activated carbon is decolorized to obtain the pure product.?In addition, the product can also be prepared by the reaction of α-picoline [109-06-8] with potassium permanganate and purification treatment.

3.3 Purification Methods: 2,2'-Bipyridyl crystallises from hexane, or EtOH, or (after charcoal treatment of a CHCl3 solution) from pet ether. Also, it precipitates from a concentrated solution in EtOH by addition of H2O. Dry it in a vacuum over P2O5. It can be further purified by chromatography on Al2O3 or by sublimation. UV (EtOH): at 280nm (log 4.13). max [Airoldi et al. J Chem Soc, Dalton Trans 1913 1986, Beilstein 23 H 199, 23/8 V 16.] 2,2'-Bipyridine Preparation Products And Raw materials Raw materials

3.4 Usage: A high-affinity chelator of iron

4. Safety and Handling

4.1 Symbol: GHS06

4.1 Hazard Codes: T

4.1 Signal Word: Danger

4.1 Risk Statements: R25

4.1 Safety Statements: S36/37;S45

4.1 Packing Group: III

4.1 Octanol/Water Partition Coefficient: log Kow= 1.50

4.2 Other Preventative Measures: SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

4.3 Hazard Class: 6.1

4.3 Hazard Declaration: H301 + H311

4.3 DisposalMethods: SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

4.4 RIDADR: UN 1663/2811

4.4 Safety Profile: Poison by ingestion,subcutaneous, and intraperitoneal routes. Experimentalteratogenic data. Questionable carcinogen withexperimental tumorigenic data. Mutation data reported.When heated to decomposition it emits toxic fumes ofNOx.

4.5 Caution Statement: P280-P301 + P310-P312

4.5 Formulations/Preparations: GRADE: REAGENT.

4.6 WGK Germany: 3

4.6 RTECS: DW1750000

4.6 Protective Equipment and Clothing: Pyridine and its derivatives cause local irritation on contact with the skin, mucous membranes and cornea. /Pyridine and its derivatives/

4.7 Skin, Eye, and Respiratory Irritations: Pyridine and its derivatives cause local irritation on contact with the skin, mucous membranes and cornea. /Pyridine and its derivatives/

4.8 Safety: Hazard Codes:?T?Xi?
Risk Statements: 25-36/37/38-20/21-23/24/25
R25 : Toxic if swallowed.?
R36/37/38: Irritating to eyes, respiratory system and skin.?
R20/21: Harmful by inhalation and in contact with skin.?
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed.
Safety Statements: 36/37-45-36/37/39-26
S36/37: Wear suitable protective clothing and gloves.?
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: DW1750000
F: 8
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 29333999

4.9 Specification: 2,2'-Bipyridine (CAS NO.366-18-7) is a white crystalline powder.?Product Categories about it are?Pyridine ; Pyridines derivates ; Analytical Chemistry ; Bipyridyls, etc. (Chelating Reagents) ; Chelating Reagents ; Aromatics ; Metalloprotease inhibitorProtease Inhibitors ; Metalloproteinase InhibitorsEnzyme Inhibitors ; Broad Spectrum Inhibitors of Proteolytic Enzyme Classes ; Enzyme Inhibitors by Enzyme ; L to ; Protease Inhibitors ; C9 to C46Derivatization Reagents TLC ; TLC Reagents, D-FDerivatization Reagents TLC ; Heterocyclic Building Blocks ; Pyridines ; Vitamins ; Metal IonsTitration ; TLC Reagents, A-CSpectroscopy ; Derivatization Reagents TLC ; Indicators ; Redox IndicatorsDerivatization Reagents TLC ; TLC Visualization Reagents (alphabetic sort) ; TLC Visualization Reagents (by application) ; UV/Vis Reagents ; UV/Visible (UV/VIS) Spectroscopy ; A-BAlphabetic ; Alpha sort ; B ; BI - BZ ; Pesticides&Metabolites.

4.10 Toxicity: Oral-rat LD50: 100 mg/kg; Abdominal cavity-mouse LD50:200 mg/kg

5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Not classified.

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H312 Harmful in contact with skin
Precautionary statement(s)
Prevention	none
Response	none
Storage	none
Disposal	none

2.3 Other hazards which do not result in classification

none

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6. NMR Spectrum

ESR : COPPER(II) COMPLEX POWDER, Q-BAND

ESR : COPPER(II) COMPLEX POWDER, X-BAND

ESR : COPPER(II) COMPLEX, IN METHANOL, 77K

ESR : CR(0) COMPLEXC ANION RADICAL, IN THF, RT

ESR : RH(0) COMPLEX, IN CH3CN 77K, G=2

ESR : RH(0) COMPLEX, IN CH3CN 77K, G=4

ESR : TUNGSTEN(V)-OXO COMPLEX IN DMF

13C NMR : in CDCl3

1H NMR : parameter in CCl4

7. Synthesis Route

366-18-7Total: 195 Synthesis Route

75-74-1 15 Suppliers

366-18-7 335 Suppliers

56100-19-7 14 Suppliers

Literatures:
Journal of the American Chemical Society, , vol. 104, # 5 p. 1319 - 1330
Yield: null

109-09-1 215 Suppliers

366-18-7 335 Suppliers

Literatures:
Dhital, Raghu Nath; Kamonsatikul, Choavarit; Somsook, Ekasith; Sakurai, Hidehiro Catalysis Science and Technology, 2013 , vol. 3, # 11 p. 3030 - 3035
Yield: ~98%

109-04-6 380 Suppliers

366-18-7 335 Suppliers

Literatures:
Qi, Chenze; Sun, Xudong; Lu, Cuiyun; Yang, Jinzhi; Du, Yijun; Wu, Huajiang; Zhang, Xian-Man Journal of Organometallic Chemistry, 2009 , vol. 694, # 18 p. 2912 - 2916
Yield: ~96%

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8. Precursor and Product

precursor:

100-70-9

594-19-4

504-29-0

531-67-9

121-45-9

75-74-1

626-05-1

591-51-5

110-86-1

109-04-6

109-09-1

694-59-7

372-48-5

View all

product :

1762-41-0

87855-81-0

18511-72-3

1148-79-4

4411-80-7

531-67-9

61633-06-5

78797-04-3

4411-83-0

61633-07-6

78797-03-2

2764-72-9

7275-43-6

4392-85-2

15862-19-8

4479-74-7

14244-75-8

18511-69-8

33421-43-1

61633-03-2

2767-24-0

4032-26-2

32190-42-4

53344-72-2

6153-92-0

View all

9. Other Information

9.0 Merck: 14,3347

9.1 BRN: 113089

9.2 职业标准: TWA STEL

9.3 Chemical Properties: White crystalline powder

9.4 Uses: A high-affinity chelator of iron

9.5 Uses: As a reagent for the determination of iron.

9.6 Definition: ChEBI: A bipyridine in which the two pyridine moieties are linked by a bond between positions C-2 and C-2'.

9.7 Synthesis Reference(s): Journal of the American Chemical Society, 100, p. 5567, 1978 DOI: 10.1021/ja00485a053
Synthesis, p. 564, 1986 DOI: 10.1055/s-1986-31705

9.8 General Description: 2,2′-Bipyridyl, is a symmetrical bipyridine commonly used as a neutral ligand for complexation with metal ions. The molecule is planar with trans-conformation and crystallizes in the monoclinic crystal system.

9.9 Storage Conditions: Derived from pyridine and ferric chloride.?Mix 70g of anhydrous pyridine with 13g of anhydrous ferric chloride, heat at 300°C in a sealed tube for about 35h.?After cooling, the reaction solidified into red-black crystals, opened the sealed tube, and washed out the red-black solution of the solid with a small amount of hot water.?Extract with ether to remove oily impurities.?After neutralization with sodium bicarbonate, excess pyridine was removed with steam heating.?The mixture was then made strongly alkaline and 2, 2'-bipyridine was distilled off with steam.?The distillate was acidified, evaporated and concentrated, then added sodium hydroxide, extracted with ether, and the ether was removed to obtain a crude product.?The crude product is recrystallized with B and the activated carbon is decolorized to obtain the pure product.?In addition, the product can also be prepared by the reaction of α-picoline [109-06-8] with potassium permanganate and purification treatment.

9.10 Dissociation Constants: pKa = 4.33 (conjugate acid)

9.11 Physical Dangers: Dust explosion possible if in powder or granular form, mixed with air.

9.12 Storage features: Treasury is ventilated, low temperature and dry; stored separately from food materials

9.13 Disposal Methods: SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

9.14 Fire Hazards: Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Finely dispersed particles form explosive mixtures in air.

9.15 Personal Protective Equipment: Depending on the extent of possible contact, workers should be provided with personal protective equipment. A charcoal gas mask canister respirator has been found to be effective against a 2% pyridine concentration at 30 l/min for 1 hr. Rubber and plastic gloves should not be relied upon to prevent skin contact because pyridine and many of its derivatives penetrate these materials ... . /Pyridine, homologs, and derivatives/

9.16 Preventive Measures: SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

9.17 Spillage Disposal: Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

9.18 Safe Storage: Separated from strong oxidants.

9.19 Inhalation Risk: A nuisance-causing concentration of airborne particles can be reached quickly when dispersed.

9.20 Effects Of Short Term Exposure: The substance is irritating to the eyes, skin and respiratory tract.

9.21 Fire Prevention: NO open flames. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust.

9.22 Exposure Prevention: PREVENT DISPERSION OF DUST!

9.23 Inhalation Prevention: Use ventilation (not if powder).

9.24 Skin Prevention: Protective gloves.

9.25 Eye Pprevention: Wear safety spectacles.

9.26 Interactions: 2,2'-BIPYRIDINE AT CONCENTRATIONS OF 1.0-5.0 MILLIMOLE GREATLY INCREASED THE COVALENT BINDING OF (14)C-LABELED CARBON TETRACHLORIDE TO RAT LIVER MICROSOMES.|BIOTRANSFORMATION OF M-FLUOROTYROSINE BY TYROSINE METABOLIC PATHWAY OF THE LIVER PLAYED AN IMPORTANT ROLE IN THE ELICITATION OF CONVULSIONS IN MICE BY M-FLUOROTYROSINE. SIMULTANEOUS ADMINISTRATION OF M-FLUOROTYROSINE & ALPHA,ALPHA-DIPYRIDYL PREVENTED THE APPEARANCE OF M-FLUOROTYROSINE INDUCED SEIZURES.

9.27 Pollution Sources: 2,2'-Bipyridine's use in the production of the herbicide, diquat(1), may result in its direct release to the environment or in its release to the environment through various waste streams(SRC).

9.28 Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 160(SRC), determined from a log Kow of 1.5(2) and a regression-derived equation(3), indicates that 2,2'-bipyridine is expected to have moderate mobility in soil(SRC). Volatilization of 2,2'-bipyridine from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 5.4X10-10 atm-cu m/mole(4). 2,2'-Bipyridine is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 1.3X10-5 mm Hg(SRC), derived from a water solubility, 5.9X10+3 mg/l(5), and its estimated Henry's Law constant(4).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 160(SRC), determined from a log Kow of 1.5(2) and a regression-derived equation(3), indicates that 2,2'-bipyridine is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 5.4X10-10 atm-cu m/mole(4). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). 2,2'-Bipyridine was shown to undergo slow oxidation with photochemically generated hydroxyl radicals in aqueous solution (half-life of about 129 days)(7).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2,2'-bipyridine, which has an estimated vapor pressure of 1.3X10-5 mm Hg at 25 °C(SRC), derived from a water solubility, 5.9X10+3 mg/l(2), and an estimated Henry's Law constant, 5.3X10-10 atm-cu m/mole(3), will exist in both the vapor and particulate phases in the ambient atmosphere(SRC). Vapor-phase 2,2'-bipyridine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 12.5 days(SRC), calculated from its rate constant of 1.3X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(4). Particulate-phase 2,2'-bipyridine may be removed from the air by wet and dry deposition(SRC).

9.29 Usage: 2,2'-bipyridine acts as a bidentate chelating ligand which form complexes with transition metal ions and shows antifungal, antibacterial and antiviral activity. It is used for the colorimetric determination of iron as well as oxidation reduction indicators to confirm the presence of ferrous ion in soils. It forms complexes with ruthenium and platinum, exhibit intense luminescence, which may have practical applications. Copper(I) bipyridine complexes involved in the oxidation of alcohols under aerobic conditions.

9.30 Usage: Reagent for iron determinations.2,2'-bipyridine acts as a bidentate chelating ligand which form complexes with transition metal ions and shows antifungal, antibacterial and antiviral activity. It is used for the colorimetric determination of iron as well as oxidation reduction indicators to confirm the presence of ferrous ion in soils. It forms complexes with ruthenium and platinum, exhibit intense luminescence, which may have practical applications. Copper(I) bipyridine complexes involved in the oxidation of alcohols under aerobic conditions.

9.31 Abiotic Degradation: The rate constant for the vapor-phase reaction of 2,2'-bipyridine with photochemically-produced hydroxyl radicals has been estimated as 1.3X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 12 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). The rate constant for the reaction of 2,2'-bipyridine with photochemically-produced hydroxyl radicals in water has been measured to be 6.2X10+9 M-1 sec-1 at 21 °C and a pH of 9.3(2), which corresponds to an aqueous half-life of about 129 days at a hydroxyl radical concn of 1X10-17 M(3). 2,2'-Bipyridine is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(4). Data are not available to assess this compound's potential for direct photolysis.

9.32 Bioconcentration: According to a classification scheme(1), an estimated BCF of 3(SRC), from its water solubility(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC).

9.33 Mobility: 39.81 L/kg|The Koc of 2,2'-bipyridine is estimated as 160(SRC), using a log Kow of 1.5(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 2,2'-bipyridine is expected to have moderate mobility in soil(SRC).

9.34 Volatilization: The Henry's Law constant for 2,2'-bipyridine is estimated as 5.4X10-10 atm-cu m/mole(1). This Henry's Law constant indicates that 2,2'-bipyridine is expected to be essentially nonvolatile from water surfaces(2). 2,2'-Bipyridine is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 1.3X10-5 mm Hg(SRC), derived from its water solubility, 5.9X10+3 mg/l(3), and an estimated Henry's Law constant(1).

9.35 Human Exposure: NIOSH (NOES Survey 1981-1983) has statistically estimated that 3,684 workers (886 of these are female) are potentially exposed to 2,2'-bipyridine in the US(1). Occupational exposure to 2,2'-bipyridine may occur by dermal contact with this compound at workplaces where 2,2'-bipyridine is produced or used(SRC).

9.36 Mesh: Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant and Hackh's Chemical Dictionary, 5th ed, p301, p499) (See all compounds classified as Indicators and Reagents.)|Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS. (See all compounds classified as Chelating Agents.)

9.37 Absorption: PYRIDINE & ITS ALKYL DERIVATIVES ARE ABSORBED FROM GI TRACT, INTRAPERITONEAL CAVITY & LUNGS. PERITONEAL ABSORPTION IS APPARENTLY ONLY SLIGHTLY MORE RAPID & COMPLETE THAN GI ABSORPTION ... IN GENERAL THE BASES ARE RAPIDLY ABSORBED THROUGH INTACT SKIN. /ALKYL DERIVATIVES OF PYRIDINE/

9.38 Metabolism: 2,2'-BIPYRIDINE INHIBITED AROMATIC HYDROXYLATION IN MICROSOMES DERIVED FROM 3-METHYLCHOLANTHRENE TREATED RATS & ENHANCED THIS PROCESS IN MICROSOMES FROM PHENOBARBITAL SODIUM TREATED RATS. 2,2'-BIPYRIDINE PRODUCED A TYPE I BINDING SPECTRUM WITH AEROBIC MICROSOMAL FRACTIONS FROM PHENOBARBITAL SODIUM TREATED RATS & A TYPE II BINDING SPECTRUM WITH MICROSOMES FROM 3-METHYLCHOLANTHRENE TREATED RATS.

9.39 First Aid

Fresh air, rest.

Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

9.40 Antidote: /SRP:/ Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Aromatic hydrocarbons and related compounds/|/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Aromatic hydrocarbons and related compounds/

9.41 Mesh Entry Terms: 2,2 Bipyridine

9.42 Symptoms

Cough. Sore throat.

Redness. Pain.

9.43 Production: 25,000 - 100,000 lb

9.44 Formulations: GRADE: REAGENT.

9.45 Manufacturing Info: Paint and coating manufacturing|2,2'-Bipyridine: ACTIVE

10. Computational chemical data

Molecular Weight: 156.18392g/mol
Molecular Formula: C₁₀H₈N₂
Compound Is Canonicalized: True
XLogP3-AA: null
Exact Mass: 156.068748264
Monoisotopic Mass: 156.068748264
Complexity: 120
Rotatable Bond Count: 1
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 2
Topological Polar Surface Area: 25.8
Heavy Atom Count: 12
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Isotope Atom Count: 0
Covalently-Bonded Unit Count: 1
CACTVS Substructure Key Fingerprint: AAADccBzAAAAAAAAAAAAAAAAAAAAAAAAAAAsWAAAAAAAAAAB4AAAHAAAAAAACAjBFgQ8gJIIEACgATRnRACCgCAxAiAI2CA4ZJgIYOLAkZGUIAhggADIyAcQgIAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA==

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High Quality CAS 366-18-7 2,2'-Bipyridine

Purity:99%Packing: 200kg/bag FOB
Price: 10 USD/g
Time: 2023/06/05

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Hebei Yingong New Material Technology Co.,Ltd. Diamond member

-120YR

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High Quality CAS 366-18-7 2,2'-bipyridine

Purity:99%Packing: 200kg/bag FOB
Price: 58 USD/kg
Time: 2023/06/05

Inquire

12. Realated Product Infomation

553-26-4 4,4'-Bipyridine

581-50-0 2,3'-Bipyridine

18820-87-6 2,2'-BIPYRIDINE HYDROCHLORIDE

18511-71-2 4,4'-DIBROMO-2,2'-BIPYRIDINE

142646-58-0 4,4'-Dinonyl-2,2'-bipyridine

17217-57-1 4,4'-DIMETHOXY-2,2'-BIPYRIDINE

15862-19-8 5-BROMO-2,2'-BIPYRIDINE

Recently Updated : 1934623-32-1 1934672-39-5 1934679-01-2 1934712-49-8 2375720-18-4 1934751-71-9 1527851-69-9 1934806-29-7 1934872-29-3 1934885-52-5