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Home> Encyclopedia >Food Additives>Pharmaceutical Intermediates>Organic Intermediate
5-(2-Hydroxyethyl)-4-methylthiazole structure
5-(2-Hydroxyethyl)-4-methylthiazole structure


Iupac Name:2-(4-methyl-1,3-thiazol-5-yl)ethanol
CAS No.: 137-00-8
Molecular Weight:143.20676
Modify Date.: 2022-10-25 19:22
Introduction: 4-Methy 1-5-thiazoleethanol has the characteristic disagreeableodor of thiazole compounds. It is somewhat pleasant and nut-likeon extreme dilution. It may be prepared by reduction of ethyl-4-methylthiazole-5-acetate using LiAlH4; by condensation of thioformamidewith bromoacetopropanol or with y,y-dichloro-y,ydiacetodipropylether. View more+
1. Names and Identifiers
1.1 Name
1.2 Synonyms

2-(4-Methyl-1,3-thiazol-5-yl)ethanol 2-(4-Methylthiazole-5-yl)ethanol 4-Methyl-5-(Β-hydroxyethyl)thiazole 4-Methyl-5-beta-hydroxyxyethylthiazole 4-Methyl-5-hydroethylthiazole 4-Methyl-5-thiazole 4-methyl-5-thiazoleethano 4-Methyl-5-Thiazoleethanol 4-Methyl-5-thiazolylethanol 4-Methylthiazol-5ylethanol 4-methylthiazole-5-thiazoleethanol 5-(2-hydroxyethyl)-4-methyl-1,3-thiazole 5-(Β-Hydroxyethyl)-4-methylthiazole 5-Thiazoleethanol, 4-methyl- EINECS 205-272-6 FEMA 3204 FEMA NUMBER 3204 Hemineurine METHYLHYDROXYETHYLTHIAZOLE MFCD00005339 MHT Sulfurol sulfurol,4-methyl-5-hydroxyethyl-thiazole SULPHUROL ENHANCER T5N CSJ D2Q E1 thiaminethiazole

1.3 CAS No.
1.4 CID
1.6 Molecular Formula
C6H9NOS (isomer)
1.7 Inchi
1.8 InChkey
1.9 Canonical Smiles
1.10 Isomers Smiles
2. Properties
2.1 Density
2.1 Melting point
< 25 °C
2.1 Boiling point
135℃ (7 torr)
2.1 Refractive index
2.1 Flash Point
109.7 °C
2.1 Precise Quality
2.1 PSA
2.1 logP
2.1 Solubility
alcohol: soluble(lit.)
2.2 Appearance
Colorless to light yellow liquid
2.3 Storage
Ambient temperatures.
2.4 Chemical Properties
It appears as colorless to pale yellow viscous oily liquid. The color will turn dark after being subject to long-term storage. It emit unpleasant thiophene compound odor with high dilution generating nut aroma. The boiling point is 103 ° C (133 Pa), or 135 ° C (933 Pa). It is easily soluble in water, soluble in ethanol, ether, benzene and chloroform.
2.5 Color/Form
deep yellow
2.6 Odor
meaty, roasted odor
2.7 pKa
2.8 Water Solubility
2.9 Stability
Stable under normal temperatures and pressures.
2.10 StorageTemp
3. Use and Manufacturing
3.1 Definition
ChEBI: A 1,3-thiazole that is thiazole substituted by a methyl group at position 4 and a 2-hydroxyethyl group at position 5.
4. Safety and Handling
4.1 Symbol
4.1 Hazard Codes
4.1 Signal Word
4.1 Risk Statements
4.1 Safety Statements
4.1 Hazard Declaration
H315; H319; H335
UN3334 9
4.1 Caution Statement
P261-P305 + P351 + P338
4.1 WGK Germany
4.1 Safety

Hazard Codes: ? Xi
The Risk Statements:
36/37/38:? Irritating to eyes, respiratory system and skin?
The Safety Statements:
26:? In case of contact with eyes, rinse immediately with plenty of water and seek medical advice?
36:? Wear suitable protective clothing?
7/9:? Keep container tightly closed and in a well-ventilated place?
24/25:? Avoid contact with skin and eyes?
WGK Germany: 3
Hazard Note:? Irritant/Stench

4.2 Sensitive
4.3 Specification

?4-Methyl-5-thiazoleethanol , its cas register number is 137-00-8. It also can be called Sulfurol ; 4-Methyl-5-(2'-hydroxyethyl)-thiazole ; 5-(2-Hydroxyethyl)-4-methylthiazole ; 4-Methyl-5-beta-hydroxyethyl thiazole ; and 4-Methyl-5-hydroxyethylthiazole . It is hazardous, so the first aid measures and others should be known. Such as: When on the skin:?Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Or in the eyes:?Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. While, it's inhaled: Remove from exposure and move to fresh air immediately. Then you have the ingesting of the product:?Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
In addition,? 4-Methyl-5-thiazoleethanol (CAS NO.137-00-8)? could be stable under normal temperatures and pressures. It is not compatible with strong oxidizing agents, and you must not take it with incompatible materials. And also prevent it to broken down into hazardous decomposition products:?Nitrogen oxides, carbon monoxide, oxides of sulfur, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

4.4 Toxicity

?4-Methyl-5-thiazoleethanol (CAS NO.137-00-8) hasn't been listed as a carcinogen by NTP, IARC, ACGIH, or CA Prop 65.


2.Hazard identification

2.1 Classification of the substance or mixture

Not classified.

2.2 GHS label elements, including precautionary statements

Pictogram(s) No symbol.
Signal word

No signal word.

Hazard statement(s)


Precautionary statement(s)








2.3 Other hazards which do not result in classification


9. Other Information
9.0 Merck
9.1 BRN
9.2 毒性
9.3 Content analysis
It was determined by gas chromatography (GT-10-4) using a nonpolar column method.
9.4 Usage limit FEMA
soft drinks, cold drinks, candy, baked goods, jelly, pudding, jelly sugar, seasonings, meat products, meat soup, milk and dairy products as well as cereal product: 55.0mg/kg.
9.5 Chemical properties
It appears as colorless to pale yellow viscous oily liquid. The color will turn dark after being subject to long-term storage. It emit unpleasant thiophene compound odor with high dilution generating nut aroma. The boiling point is 103 ° C (133 Pa), or 135 ° C (933 Pa). It is easily soluble in water, soluble in ethanol, ether, benzene and chloroform.
9.6 Application
  • Used as temporarily allowable food spices;
  • For nuts, dairy products, meat products, etc., as pharmaceutical intermediates;
  • Used for the deployment of chocolate, milk and nuts
9.7 Preparation
It is obtained from the reduction of 4-methyl thiazole 5-ethyl acetate reduction with lithium aluminum hydride.
9.8 Description
4-Methy 1-5-thiazoleethanol has the characteristic disagreeable odor of thiazole compounds. It is somewhat pleasant and nut-like on extreme dilution. It may be prepared by reduction of ethyl- 4-methylthiazole-5-acetate using LiAlH4; by condensation of thioformamide with bromoacetopropanol or with y,y-dichloro-y,ydiacetodipropyl ether.
9.9 Chemical Properties
4-Methyl-5-thiazoleethanol has a disagreeable odor typical of thiazole compounds; somewhat pleasant, reminiscent of beef and nut-like, on extreme dilution
9.10 Chemical Properties
Colorless to light yellow liqui
9.11 Occurrence
Reported found in grilled and roasted beef, cognac, brandy, Finnish whiskey, cocoa, peanuts, beans and malt.
9.12 Uses
4-Methyl-5-thiazoleethanol has been used in the synthesis of novel thiazolium halogenide ionic liquids.
10. Computational chemical data
  • Molecular Weight: 143.20676g/mol
  • Molecular Formula: C6H9NOS
  • Compound Is Canonicalized: True
  • XLogP3-AA: null
  • Exact Mass: 143.04048508
  • Monoisotopic Mass: 143.04048508
  • Complexity: 89.1
  • Rotatable Bond Count: 2
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 3
  • Topological Polar Surface Area: 61.4
  • Heavy Atom Count: 9
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count: 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Isotope Atom Count: 0
  • Covalently-Bonded Unit Count: 1
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12. Realated Product Infomation