8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT

Iupac Name：(4aR,6R,7R,7aS)-6-(6-amino-8-bromopurin-9-yl)-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol

CAS No.: 76939-46-3

Molecular Weight：407.09

Modify Date.: 2022-11-22 20:03

Introduction:

8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt), a cyclic AMP analog, is an activator of cyclic AMP-dependent protein kinase (PKA)[1].

A long-acting derivative of cyclic AMP. It is an activator of cyclic AMP-dependent protein kinase, but resistant to degradation by cyclic AMP phosphodiesterase.

View more+

Request For Quotation

1. Names and Identifiers

: 1.1 Name; 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT; 1.2 Synonyms; 4H-Furo[3,2-d]-1,3,2-dioxaphosphorin-7-ol, 6-(6-amino-8-bromo-9H-purin-9-yl)tetrahydro-2-hydroxy-, 2-oxide, sodium salt, (4aR,6R,7R,7aS)- (1:1) 8-BR-CAMP NA 8-BR-CAMP SODIUM SALT 8-BROM-ADENOSIN-3',5'-CYCLOPHOSPHAT 8-Bromoadenosine 3',5'-phosphoric acid sodium salt 8-BROMOADENOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT 8-bromoadenosine 3:5-cyclic*monophosphate sodiu 8-BROMOADENOSINE 3':5'-CYCLICMONOPHOSPHA TE SODIUM 8-BROMOADENOSINE-3',5'-CYCLOPHOSPHATE SODIUM SALT 8-bromoadenosine-3’,5’-cyclicmonophosphate(8-br-camp),sodiumsalt 8-BROMO-CAMP, NA 8-BROMO-CAMP, SODIUM SALT 8-BROMO-CAMP,NA 8-BROMO-CAMP,SODIUM SALT ADENOSINE 3',5'-CYCLIC MONOPHOSPHATE, 8-BROMO-, SODIUM SALT CAMP, 8-BR, NA CAMP,8-BR,NA MFCD00005844 Sodium (4aR,6R,7R,7aS)-6-(6-amino-8-bromo-9H-purin-9-yl)-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-oxide; View all

1.3 CAS No.: 76939-46-3

1.4 CID: 71434121

1.5 Molecular Formula: C10H10BrN5O6P- (isomer)

1.6 Inchi: InChI=1S/C10H11BrN5O6P/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14)/p-1/t3-,5-,6-,9-/m1/s1

1.7 InChIkey: DVKQVRZMKBDMDH-UUOKFMHZSA-M

1.8 Canonical Smiles: C1C2C(C(C(O2)N3C4=NC=NC(=C4N=C3Br)N)O)OP(=O)(O1)[O-]

1.9 Isomers Smiles: C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C4=NC=NC(=C4N=C3Br)N)O)OP(=O)(O1)[O-]

2. Properties

2.1 Precise Quality: 405.95521

2.1 PSA: 167.48000

2.1 logP: 0.96450

2.1 Solubility: H2O: 100?mg/mL

2.2 Appearance: off-white powder

2.3 Chemical Properties: Off-white powder

2.4 Color/Form: off-white

2.5 Water Solubility: H2O: 100?mg/mL

2.6 StorageTemp: -20°C

3. Safety and Handling

3.1 Risk Statements: 22-24/25

3.1 Safety Statements: 22-24/25

3.1 RIDADR: NONH for all modes of transport

3.1 WGK Germany: 3

4. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

no data available

2.2 GHS label elements, including precautionary statements

Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Precautionary statement(s)
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

2.3 Other hazards which do not result in classification

no data available

View all

5. Other Information

5.0 Mesh Entry Terms: 8 Br Cyclic AMP

5.1 BRN: 7739743

5.2 Target: Value

5.3 PKA (): 0.05 μM(Ka)

5.4 Chemical Properties: Off-white powder

5.5 Uses

8-Bromoadenosine 3′,5′-cyclic monophosphate sodium salt has been used:

to study its effect on fas and caspase-3 mRNA expression and on P4 production in bovine mid luteal cell culture
used to treat choriocarcinoma BeWo cell line and study its effect on cell viability, apoptosis and morphological changes in the nuclei
in superfusion medium for head kidneys stimulation

6. Computational chemical data

Molecular Weight: 407.09g/mol
Molecular Formula: C₁₀H₁₀BrN₅O₆P-
Compound Is Canonicalized: True
XLogP3-AA: -1.6
Exact Mass: 405.95521
Monoisotopic Mass: 405.95521
Complexity: 524
Rotatable Bond Count: 1
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 10
Topological Polar Surface Area: 158
Heavy Atom Count: 23
Defined Atom Stereocenter Count: 4
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Isotope Atom Count: 0
Covalently-Bonded Unit Count: 1
CACTVS Substructure Key Fingerprint: AAADccBzuAIAEAAAAAAAAAAAAAAAAWJAAAAsSAAAAAAAAFgB+AAAHgBQCCAAGBzhlwYF8L9MFxCgQQZhZICAgC0REKABUCAoVBCDWAJAyEAeRAgPAALTACDwMAIAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA==

7. Recommended Suppliers

Global26SuppliersView all >>

Hubei Jiutian Bio-medical Technology Co., Ltd Diamond member

4YRS

Products:electronic chemicals; pharmaceutical intermediates;pesticide intermediates;ultraviolet absorbent; food additives
Tel:86-173-54350817
Email:Ryan@jiutian-bio.com

Adenosine, 8-bromo-,cyclic 3',5'-(hydrogen phosphate), monosodium salt (9CI)

Purity:99%Packing: 200kg/bag FOB
Price:
Time: 2023/02/03

Inquire

Alfa Chemistry Diamond member

1YR

Products:Nanomaterials, Catalysts, Active Pharmaceutical Ingredients, Protection Reagents, Boronic Compounds, Fluorophores, Dyes, reagents, Insect Pheromone, Ionic Liquids, Lipids, Material &, Chemicals
Tel:1-516-7346573
Email:support@alfa-chemistry.com

Adenosine 3?,5?-cyclic Monophosphate, 8-Bromo-, Sodium Salt - CAS 76939-46-3