3D Mol Similar

Amlodipine Besylate

: Iupac Name：benzenesulfonic acid; 3-O-ethyl 5-O-methyl
2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,
4-dihydropyridine-3,5-dicarboxylate; CAS No.: 111470-99-6; Molecular Weight：567.05094; Modify Date.: 2022-11-07 21:43; Introduction: Amlodipine (generic name Amlodipine Besylate) is a class of calcium channel blockers. One of the amlodipine product on the market is Norvasc®.Amlodipine functionalizes by the dilation of blood vessels and the improvement of blood flow, which lead to lowered blood pressure. Thereby, it is used to treat high bold pressure (hypertension). Lowering high blood pressure also reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions, and kidney problems. Amlodipine is also used to prevent certain types of chest pains (angina), which may help to increase the ability to exercise and decrease the frequency of angina attacks. Amlodipine can be used to treat coronary artery disease (CAD) including chronic stable angina, vasospastic angina, and angiographically documented CAD. View more+

Request For Quotation

1. Names and Identifiers

: 1.1 Name; Amlodipine Besylate; 1.2 Synonyms; 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzenesulfonate 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, benzenesulfonate (1:1) 3-Ethyl 5-Methyl (±)-2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylate Monobenzenesulfonate 3-ethyl 5-Methyl 2-((2-aMinoethoxy)Methyl)-4-(2-chlorophenyl)-6-Methyl-1,4-dihydropyridine-3,5-dicarboxylate benzenesulfonate 3-Ethyl 5-Methyl 2-(2-Aminoethoxy)methyl-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate Benzenesulfonate 2-(2-Aminoethoxy)methyl-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic Acid 3-Ethyl 5-Methyl Ester Benzenesulfona 3-Ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylate benzenesulfonate 3-Ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylate benzenesulfonate (1:1) 3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate benzenesulfonate 3-Ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate benzenesulfonate (1:1) acide benzènesulfonique - 2-[(2-aminoéthoxy)méthyl]-4-(2-chlorophényl)-6-méthyl-1,4-dihydropyridine-3,5-dicarboxylate de 3-éthyle et de 5-méthyle (1:1) Amlodin Amlodipine Beaylate AMLODIPINE BENZENESULFONATE AMlodipine bes Amlodipine Besilate Amlodipine besilate (crystalline) benzenesulfonic acid,3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate Benzolsulfonsäure--3-ethyl-5-methyl-2-[(2-aminoethoxy)methyl]-4-(2-chlorphenyl)-6-methyl-1,4-dihydropyridin-3,5-dicarboxylat(1:1) MFCD00887594 Norvasc raw material amlodipine besylate UNII:864V2Q084H Vazkor; View all

1.3 CAS No.: 111470-99-6

1.4 CID: 60496

1.5 EINECS(EC#): 601-097-8

1.6 Molecular Formula: C26H31ClN2O8S (isomer)

1.7 Inchi: InChI=1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)

1.8 InChIkey: ZPBWCRDSRKPIDG-UHFFFAOYSA-N

1.9 Canonical Smiles: CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC=C(C=C1)S(=O)(=O)O

1.10 Isomers Smiles: CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC=C(C=C1)S(=O)(=O)O

2. Properties

2.1 Density: 1.227

2.1 Melting point: 199-201℃

2.1 Boiling point: 527.2 oC at 760 mmHg

2.1 Refractive index: 1.697 (Predicted)

2.1 Flash Point: 272.6 oC

2.1 Precise Quality: 566.14900

2.1 PSA: 162.63000

2.1 logP: 5.30950

2.1 Solubility: DMSO: 20?mg/mL

2.2 Appearance: White powder

2.3 Storage: Ambient temperatures.

2.4 Chemical Properties: White Crystalline Solid

2.5 Color/Form: Powder

2.6 pKa: 8.6

2.7 Water Solubility: DMSO: 20?mg/mL

2.8 StorageTemp: Store at RT

3. Use and Manufacturing

3.1 Definition: ChEBI: The benzenesulfonate salt of amlodipine.

3.2 Usage: A dihydropyridine calcium channel blocker. Used as an antianginal and antihypertensive

4. Safety and Handling

4.1 Symbol: GHS07

4.1 Hazard Codes: Xn

4.1 Signal Word: Warning

4.1 Risk Statements: R22

4.1 Safety Statements: S26;S36

4.1 Exposure Standards and Regulations: The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed prescription drug products, incl amlodipine besylate, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act.

4.2 Octanol/Water Partition Coefficient: log Kow = 3.00 [Austin RP et al; J Pharm Sci 84: 1180-83 (1995)] PubMed Abstract

4.3 Hazard Declaration: H302

4.3 RIDADR: NONH for all modes of transport

4.3 Caution Statement: P301 + P312 + P330

4.3 Formulations/Preparations: Norvasc /(Amlodipine besylate)/; available as 2.5, 5, 10 mg tablet /from table/
... Amlor; Antacal; Istin; Monopina ... .

4.4 WGK Germany: 3

4.4 RTECS: US7967700

4.4 Safety: Hazard Codes:Xn
Risk Statements: 22-36/37/38-20/21/22?
R22:Harmful if swallowed.?
R36/37/38:Irritating to eyes, respiratory system and skin.?
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-36?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS of Amlodipine besylate (CAS NO.111470-99-6): US7967700

4.5 Specification: ?Amlodipine besylate (CAS NO.111470-99-6), its Synonyms are -Ethyl 5-methyl (+-)-2-((2-aminoethoxy)methyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate, monobenzenesulfonate ; Amcard ; Amdepin ; Amdipin ; Amlodin ; Amlodipine benzenesulfonate ; Amlodipine besilate ; ,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (+-)-, monobenzenesulfonate ; 3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl-5-methyl ester, monobenzenesulfonate . It is white crystalline solid.

4.6 Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	oral	10mg/kg (10mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: NAUSEA OR VOMITING	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 36, Pg. 1169, 1994.
man	TDLo	oral	1429ug/kg (1.429mg/kg)	VASCULAR: SHOCK KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA	American Journal of Emergency Medicine. Vol. 16, Pg. 527, 1998.
mouse	LD50	intraperitoneal	31mg/kg (31mg/kg)	?	Drugs in Japan Vol. -, Pg. 71, 1995.
mouse	LD50	oral	37mg/kg (37mg/kg)	?	Drugs in Japan Vol. -, Pg. 71, 1995.
mouse	LD50	subcutaneous	36mg/kg (36mg/kg)	?	Drugs in Japan Vol. -, Pg. 71, 1995.
rat	LD50	intraperitoneal	42mg/kg (42mg/kg)	?	Drugs in Japan Vol. -, Pg. 71, 1995.
rat	LD50	oral	393mg/kg (393mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BLOOD: OTHER CHANGES	Oyo Yakuri. Pharmacometrics. Vol. 42, Pg. 177, 1991.
rat	LD50	subcutaneous	678mg/kg (678mg/kg)	?	Drugs in Japan Vol. -, Pg. 71, 1995.
women	TDLo	oral	1mg/kg (1mg/kg)	CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION	Annals of Pharmacotherpy. Vol. 31, Pg. 853, 1997.
women	TDLo	unreported	6mg/kg/60D-I (6mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION	Lancet. Vol. 341, Pg. 1102, 1993.

View all

5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 4

Skin irritation, Category 2

Eye irritation, Category 2

Acute toxicity - Inhalation, Category 4

Specific target organ toxicity \u2013 single exposure, Category 3

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H332 Harmful if inhaled H335 May cause respiratory irritation
Precautionary statement(s)
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/\u2026if you feel unwell. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P313 If skin irritation occurs: Get medical advice/attention. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313 If eye irritation persists: Get medical advice/attention. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P312 Call a POISON CENTER/doctor/\u2026if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

View all

6. NMR Spectrum

Predict 1H proton NMR

7. Synthesis Route

111470-99-6Total: 9 Synthesis Route

88150-42-9 318 Suppliers

98-11-3 159 Suppliers

111470-99-6 512 Suppliers

Literatures:
EOS ECZACIBASI OZGUN KIMYASAL URUNLER SANAYI VE TICARET A.S. Patent: WO2004/58711 A1, 2004 ; Location in patent: Page 16, 17 ;
Yield: ~87%

88150-62-3 104 Suppliers

98-11-3 159 Suppliers

111470-99-6 512 Suppliers

Literatures:
WO2011/117876 A1, ; Page/Page column 11-12 ;
Yield: null

156366-27-7

98-11-3 159 Suppliers

111470-99-6 512 Suppliers

Literatures:
WO2007/131759 A1, ; Page/Page column 8-10 ;
Yield: null

View all

8. Precursor and Product

precursor:

246852-10-8

88150-42-9

246852-13-1

98-11-3

246852-09-5

515-42-4

88150-62-3

246852-11-9

246852-08-4

product :

88150-42-9

9. Other Information

9.0 Merck: 14,491

9.1 Description: Amlodipine (generic name Amlodipine Besylate) is a class of calcium channel blockers. One of the amlodipine product on the market is Norvasc®.
Amlodipine functionalizes by the dilation of blood vessels and the improvement of blood flow, which lead to lowered blood pressure. Thereby, it is used to treat high bold pressure (hypertension). Lowering high blood pressure also reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions, and kidney problems. Amlodipine is also used to prevent certain types of chest pains (angina), which may help to increase the ability to exercise and decrease the frequency of angina attacks. Amlodipine can be used to treat coronary artery disease (CAD) including chronic stable angina, vasospastic angina, and angiographically documented CAD.

9.2 References: [1] http://www.webmd.com/drugs/2/drug-5891/amlodipine-oral/details
[2] https://www.drugs.com/amlodipine.html
[3] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b4b30c56-7403-4f69-9a8e-3d82a37e8bc5#section-1

9.3 Chemical Properties: White Crystalline Solid

9.4 Uses: A dihydropyridine calcium channel blocker. Used as an antianginal and antihypertensive

9.5 Uses: Angiotensin II inhibitor prodrug, antihypertensive

9.6 Uses: Amlodipine besylate is a L-type calcium channel blocker which may be used for the treatment of angina pectoris and hypertension. Amlodipine also inhibits growth of human epidermoid carcinoma A431 cells and has antireproductive effects in male rats.

9.7 Definition: ChEBI: The benzenesulfonate salt of amlodipine.

9.8 Brand name: Norvasc (Pfizer).

9.9 Biological Activity: L-type calcium channel blocker that displays antihypertensive properties. Inhibits Ca 2+ -induced contractions in depolarized rat aorta (IC 50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC 50 = 25 μ M).

9.10 Usage: Amlodipine besylate is used as a dihydropyridine calcium channel blocker. It is also used as an antianginal and antihypertensive. Amlodipine besylate also displays vasoprotective effects in cardiovascular disease and inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM). Amlodipine besylate has been shown to inhibit proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells.

10. Computational chemical data

Molecular Weight: 567.05094g/mol
Molecular Formula: C₂₆H₃₁ClN₂O₈S
Compound Is Canonicalized: True
XLogP3-AA: null
Exact Mass: 566.1489648
Monoisotopic Mass: 566.1489648
Complexity: 830
Rotatable Bond Count: 11
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 10
Topological Polar Surface Area: 163
Heavy Atom Count: 38
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 1
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Isotope Atom Count: 0
Covalently-Bonded Unit Count: 2
CACTVS Substructure Key Fingerprint: AAADceB7PABEAAAAAAAAAAAAAAAAAAAAAAAwYIAAAAAAAAABQAAAHgYQCAAADQrh2CYyCYLABIKIAiTSSHBCAEAgBQAIiJkAAsgKJDKBMxCDMAAkkACYqUeI7uiOgAAAAAABAAAAAAAAAAIAAAAAAAAAAA==

11. Question & Answer

What is the recommended dosage of Amlodipine Besylate? Sep 26 2022
Amlodipine Besylate is a medication used to treat hypertension and can be used alone or in combination with other drugs. It is also effective in treating angina, particularly spontaneous angina. Howev..
What are the adverse reactions during the intake of Amlodipine Besylate? Aug 09 2022
Amlodipine Besylate is a long-acting calcium channel blocker widely used in clinical medicine, primarily for treating cardiovascular diseases such as hypertension and symptoms of angina. Most patients..
Is Amlodipine Besylate the Ultimate Hypertension Medication? Feb 15 2022
Amlodipine Besylate is hailed as a remarkable medication for hypertension, with its excellent blood pressure-lowering effects and widespread recognition among patients. Clinical studies have summarize..
Can Children Take Amlodipine Besylate? Sep 17 2021
Amlodipine Besylate is a medication primarily used to treat hypertension. It is also effective for coronary artery disease and vasospastic angina. However, this medication has certain side effects, s..

12. Recommended Suppliers

Global497SuppliersView all >>

Wuhan Fortuna Chemical Co., Ltd. Diamond member

10YRS

Products:API,fine chemical&its intermediates,biological chemistry
Tel:0086-27-59207850
Email:info@fortunachem.com

Factory supply USP Amlodipine besylate Cas 111470-99-6 with favorable price

Purity:99%Packing: 200kg/bag FOB
Price: 95 USD/kilogram
Time: 2023/09/25

Inquire

Qiaoxi Shengyou Chemical Co., LTD Diamond member

1YR

Products:pharmaceutical intermediates Organic raw materialsAnimal and plant extracts1.4BDO, Eutylone,4MMC, JWH ,SGT Peptide, Steroids, Benzos,Dissociatives
Tel:86-311-18034511316
Email:saleroom@yeah.net

Amlodipine besylate cas 111470-99-6 Amlodipine benzenesulfonate

Purity:99%Packing: 200kg/bag FOB
Price: 11 USD/g
Time: 2023/09/25

Inquire

Hebei Chengcai Biotechnology Co., LTD Diamond member

1YR

Products:We are engaged in the development, marketing and sales of apis, intermediates, natural products (extracts), fine chemicals, food additives, agricultural chemicals and other products.
Tel:0086-0319-19131200228
Email:17610795226@chengcaibio.com

The queen of quality Amlodipine besylate CAS 111470-99-6