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Home> Encyclopedia >Cardiovascular Agents>Herbal Extract>Pharmaceutical Intermediates
Astragaloside IV structure
Astragaloside IV structure

Astragaloside IV

Iupac Name:(2R,3R,4S,5S,6R)-2-[[(1S,3R,6S,8R,9S,11S,12S,14S,15R,16R)-14-hydroxy-15-[(2R,5S)-5-(2-hydroxypropan-2-yl)-2-methyloxolan-2-yl]-7,7,12,16-tetramethyl-6-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxy-9-pentacyclo[,3.03,8.012,16]octadecanyl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol
CAS No.: 84687-43-4
Molecular Weight:784.981
Modify Date.: 2023-02-11 20:26
Introduction: vasodilator, antihypertensive, antiaging Astragaloside IVSupplier View more+
1. Names and Identifiers
1.1 Name
Astragaloside IV
1.2 Synonyms

(3Β,6α,9Β,16Β,20R,24S)-16,25-Dihydroxy-3-(Β-D-xylopyranosyloxy)-20,24-epoxy-9,19-cyclolanostan-6-yl Β-D-glucopyranoside (5ξ,6β,8ξ,9ξ,16α,20R,24S)-16,25-Dihydroxy-3-(β-D-xylopyranosyloxy)-20,24-epoxy-9,19-cyclolanostan-6-yl β-D-glucopyranoside 16,25-Dihydroxy-3-(pentopyranosyloxy)-20,24-epoxy-9,19-cyclolanostan-6-yl hexopyranoside 20,24-epoxy-16,25-dihydroxy-3-(β-D- 2-Hydroxy-1-(5-(1-hydroxy-1-methylethyl)-2-methyltetrahydro-2-furanyl)-3a,6,6,12a-tetramethyl-7-(pentopyranosyloxy)tetradecahydro-1H-cyclopenta[a]cyclopropa[e]phenanthren-5-yl hexopyranoside ASTRAGALOSIDE AstragalosideIV/CH83947 AstragalosideIV/CH90651 Astragalus extract Astragalus Polysaccharides Astrasieversianin XIV beta-D-Glucopyranoside, (3beta,6alpha,16beta,20R,24S)-20,24-epoxy-16,25-dihydroxy-3-(beta-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl cyclosieversioside F cyclosiversioside F Hexopyranoside, 20,24-epoxy-16,25-dihydroxy-3-(pentopyranosyloxy)-9,19-cyclolanostan-6-yl MFCD07368617 xylopyranosyloxy)-9,19-cyclolanostan-6-yl β-D-Glucopyranoside, (3β,6α,16β,20R,24S)- β-D-Glucopyranoside, (3β,6α,16β,20R,24S)-20,24-epoxy-16,25-dihydroxy-3-(β-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl Β-D-Glucopyranoside, (3Β,6α,9Β,16Β,20R,24S)-20,24-epoxy-16,25-dihydroxy-3-(Β-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl β-D-Glucopyranoside, (5ξ,6β,8ξ,9ξ,16α,20R,24S)-20,24-epoxy-16,25-dihydroxy-3-(β-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl

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1.3 CAS No.
1.4 CID
1.6 Molecular Formula
C41H68O14 (isomer)
1.7 Inchi
1.8 InChIkey
1.9 Canonical Smiles
1.10 Isomers Smiles
2. Properties
2.1 Density
2.1 Melting point
2.1 Boiling point
895.7 °C at 760 mmHg
2.1 Refractive index
2.1 Flash Point
895.7 °C at 760 mmHg
2.1 Precise Quality
2.1 PSA
2.1 logP
2.1 Appearance
hydroscopic brown or yellow powder
2.2 Color/Form
2.3 pKa
2.4 Water Solubility
Transport Information: OTH
Hazard Symbols:UN NO.
2.5 StorageTemp
3. Use and Manufacturing
3.1 Usage
vasodilator, antihypertensive, antiaging Astragaloside IVSupplier
4. Safety and Handling
4.1 Risk Statements
4.1 Safety Statements
NONH for all modes of transport
4.1 WGK Germany
4.1 Safety
Safety Statements:22-24/25
22:Do not breathe dust
24/25:Avoid contact with skin and eyes
4.2 Specification

The Astragaloside IV, with its cas register number 84687-43-4, has other names as 9,19-cyclolanostane-beta-d-glucopyranoside; astragaloside; astragalosideiv/ch83947; astragalosideiv/ch90651; astrasieversianin xiv; astragaloside iv; 20,24-epoxy-16,25-dihydroxy-3-(β-d-; xylopyranosyloxy)-9,19-cyclolanostan-6-yl.

The characteristics of this chemical are as below: (1)ACD/LogP: 1.96; (2)# of Rule of 5 Violations: 3; (3)ACD/LogD (pH 5.5): 1.96; (4)ACD/LogD (pH 7.4): 1.96; (5)#H bond acceptors: 14; (6)#H bond donors: 9; (7)#Freely Rotating Bonds: 16; (8)Polar Surface Area: 228.22; (9)Index of Refraction: 1.62; (10)Molar Refractivity: 197.78 cm3; (11)Molar Volume: 562.5 cm3; (12)Polarizability: 78.4× 10-24 cm3; (13)Surface Tension: 70.9 dyne/cm; (14)Density: 1.39 g/cm3; (15)Flash Point: 495.5 °C; (16)Enthalpy of Vaporization: 147.85 kJ/mol; (17)Boiling Point: 895.7 °C at 760 mmHg.

This is a kind of brownish yellow powder. And it is the quality control components in the herbal medicine Astragalus Membranaceus, and it has the function of improving immunity of the organism, clear the free radical, protect the cardiocytes, strengthen the myocardium, deduce the myocardial ischemia, resist the cardiac failure, and so on.

When using this chemical, you should be very cautious. Do not breathe dust and try to avoid contacting with skin and eyes. As to its product categories, there are various, including sugars, carbohydrates & glucosides; the group of astralosides; a; alphabetic; AR to AZ.

Additionally, you could convert the following data information to obtain the molecular structure:

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2.Hazard identification

2.1 Classification of the substance or mixture

no data available

2.2 GHS label elements, including precautionary statements

Pictogram(s) no data available
Signal word

no data available

Hazard statement(s)

no data available

Precautionary statement(s)

no data available


no data available


no data available


no data available

2.3 Other hazards which do not result in classification

no data available

6. Other Information
6.0 Mesh Entry Terms
3beta,6alpha,16beta,20R,24S; astragaloside IV of astragaloside A
6.1 Outline
Astragaloside IV is a cycloartane-type triterpene glycosides, it is one of the main active ingredients of traditional Chinese medicine Astragalus membranaceus, whose content is the main criteria for evaluation of the quality merits of Astragalus membranaceus. Astragaloside IV has effects in anti-tumor, anti-inflammatory, antioxidant, hypoglycemic, myocardial protection, anti-viral myocarditis, protecting brain tissue and anti-hepatitis B virus etc., and it has a wide range of pharmacological effects and very bright application.
6.2 Astragalus Extract
Astragalus extracts are the extraction of raw material products of dry roots of Astralgus membranceus (Fisch) Bge Var. Mongholicus (Bye).
[Crude Medicine Resources] There are about 1600 species under genus Astragalus in the world, and more than 200 species in China, among which about seven species used as medicines. Astragalus membranacus mainly distributes in Heilongjiang, Liaoning, Inner Mongolia, Hebei, Shandong, Shanxi, Shaanxi, Ningxia, Gansu, Qinghai, Xinjiang, Sichuan and Yunnan in China, and it also has distribution in Mongolia, North Korea and Russia. Radix Astragali mainly distributes in the Great Khingan, Nenjiang, Aihun, Sunwu, Morin Dawa banner in Inner Mongolia. Ninggu Astragali mainly distributes in Ning'an of Heilongjiang Province, Dongning, Linkou, Muling, Hailin. Zhenggu Astragali mainly distributes in Hebei, Zhangjiakou areas. Astragalus mongolicus mainly distributes in Jilin, Hebei, Shanxi and Inner Mongolia of China, and it also has distribution in Mongolia and Russia. The wild resources of Astragalus have been rare in China, with Astragalus membranacus and Astragalus mongolicus falling into the third-ranking national protection category. At present most Astragalus for medicinal use are cultivars, which are mainly produced in Hunyuan, Fanshi, Ying county, Dai county, Guangling of Shanxi, Guyang, Wuchuan, Zhuozi of Inner Mongolia, Heilongjiang and Jilin provinces.
[Main Components]Astragaloside IV, flavonoids, polysaccharides, amino acids, organic acids, trace elements, riboflavin, folic acid, vitamin P, sitosterol, lupeol, n-hexadecyl alcohol etc.
Astragalus membranaceus
Figure 1. Astragalus membranaceus
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6.3 Uses
vasodilator, antihypertensive, antiaging
7. Computational chemical data
  • Molecular Weight: 784.981g/mol
  • Molecular Formula: C41H68O14
  • Compound Is Canonicalized: True
  • XLogP3-AA: 1.3
  • Exact Mass: 784.46090684
  • Monoisotopic Mass: 784.46090684
  • Complexity: 1460
  • Rotatable Bond Count: 7
  • Hydrogen Bond Donor Count: 9
  • Hydrogen Bond Acceptor Count: 14
  • Topological Polar Surface Area: 228
  • Heavy Atom Count: 55
  • Defined Atom Stereocenter Count: 21
  • Undefined Atom Stereocenter Count: 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Isotope Atom Count: 0
  • Covalently-Bonded Unit Count: 1
8. Question & Answer
9. Recommended Suppliers
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10. Realated Product Infomation