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Betamethasone 21-phosphate disodium structure
Betamethasone 21-phosphate disodium structure

Betamethasone 21-phosphate disodium

Iupac Name:disodium;[2-[(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] phosphate
CAS No.: 151-73-5
Molecular Weight:516.41
Modify Date.: 2022-11-07 22:13
Introduction: White or almost white powder, very hygroscopic.ChEBI: An organic sodium salt that is the disodium salt of betamethasone phosphate. View more+
1. Names and Identifiers
1.1 Name
Betamethasone 21-phosphate disodium
1.2 Synonyms

(11b,16b)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 21-(Disodium Phosphate) 1,4-PREGNADIEN-9-ALPHA-FLUORO-16-BETA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-PHOSPHATE, DISODIUM SALT 9a-fluoro-16b-methylprednisolone-21-(disodium phosphate) Bentelan Betamethasone 21-(Dihydrogen Phosphate) Disodium Salt Betamethasone 21-disodium phosphate BETAMETHASONE 21-PHOSPHATE DISODIUM SALT Betamethasone Sodium Phosphate BETAMETHASONESODIUMPHOSPHATE,USP Betnelan Celestan Disodium (11Β,16Β)-9-fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl phosphate disodium 2-[(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl phosphate Disodium betamethasone 21-phosphate Disodium Βmethasone 21-phosphate Durabetason EINECS 205-797-0 MFCD00200361 Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, sodium salt, (11Β,16Β)- (1:2) Pregna-1,4-Diene-3,20-Dione,9-Fluoro-11,17-Dihydroxy-16-Methyl-21-(Phosphonooxy)-,DisodiumSalt,(11Beta,16Beta)- UNII-7BK02SCL3W

1.3 CAS No.
1.4 CID
1.6 Molecular Formula
C22H28FNa2O8P (isomer)
1.7 Inchi
1.8 InChkey
1.9 Canonical Smiles
1.10 Isomers Smiles
2. Properties
2.1 Boiling point
669.6 oC at 760 mmHg
2.1 Flash Point
2.1 Precise Quality
2.1 PSA
2.1 logP
2.1 Appearance
white powder
2.2 Chemical Properties
White or almost white powder, very hygroscopic.
2.3 PH
7.5~9.0(5g/l, 25℃)
2.4 Water Solubility
Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
2.5 StorageTemp
room temp
3. Use and Manufacturing
3.1 Definition
ChEBI: An organic sodium salt that is the disodium salt of betamethasone phosphate.
3.2 GHS Classification
Signal: Danger
GHS Hazard Statements
Aggregated GHS information provided by 39 companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

H302 (82.05%): Harmful if swallowed [Warning Acute toxicity, oral]
H317 (17.95%): May cause an allergic skin reaction [Warning Sensitization, Skin]
H330 (17.95%): Fatal if inhaled [Danger Acute toxicity, inhalation]
H360 (23.08%): May damage fertility or the unborn child [Danger Reproductive toxicity]
H361 (10.26%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
H373 (28.21%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

Precautionary Statement Codes
P201, P202, P260, P261, P264, P270, P271, P272, P280, P281, P284, P301+P312, P302+P352, P304+P340, P308+P313, P310, P314, P320, P321, P330, P333+P313, P363, P403+P233, P405, and P501
3.3 Usage
An anti-inflammatory agent
4. Safety and Handling
4.1 Symbol
4.1 Hazard Codes
4.1 Signal Word
4.1 Risk Statements
4.1 Safety Statements
4.1 Hazard Declaration
NONH for all modes of transport
4.1 Safety Profile
Moderately toxic by ingestion andother routes. An experimental teratogen. Otherexperimental reproductive effects. When heated todecomposition it emits toxic fumes of F??, POx and Na2O. Betamethasone 21-phosphate disodiumSupplier
4.2 Caution Statement
P301 + P312 + P330
4.2 WGK Germany
4.2 Safety

The safety information of Betamethasone disodium phosphate (CAS NO.151-73-5) is as follows:
Hazard Codes: Xn
Risk Statements: 22
22: Harmful if swallowed
Safety Statements: 36
36: Wear suitable protective clothing
WGK Germany: 3
RTECS: TU4056500
Moderately toxic by ingestion and other routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of F, POx and Na2O.

4.3 Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1166mg/kg (1166mg/kg)   Shikoku Igaku Zasshi. Shikoku Medical Journal. Vol. 29, Pg. 153, 1973.
mouse LD50 intravenous 1304mg/kg (1304mg/kg)   Drugs in Japan Vol. -, Pg. 1075, 1990.
mouse LD50 oral 1607mg/kg (1607mg/kg)   Shikoku Igaku Zasshi. Shikoku Medical Journal. Vol. 29, Pg. 153, 1973.
mouse LD50 subcutaneous 1363mg/kg (1363mg/kg)   Shikoku Igaku Zasshi. Shikoku Medical Journal. Vol. 29, Pg. 153, 1973.
rat LD50 intramuscular 1291mg/kg (1291mg/kg)   Drugs in Japan Vol. -, Pg. 1075, 1990.
rat LD50 intraperitoneal 1179mg/kg (1179mg/kg)   Drugs in Japan Vol. -, Pg. 1075, 1990.
rat LD50 intravenous 1276mg/kg (1276mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 2117, 1979.
rat LD50 oral 1877mg/kg (1877mg/kg)   Drugs in Japan Vol. -, Pg. 1075, 1990.
rat LD50 subcutaneous 1265mg/kg (1265mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

Oyo Yakuri. Pharmacometrics. Vol. 52, Pg. 105, 1996.


2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 4

2.2 GHS label elements, including precautionary statements

Signal word


Hazard statement(s)

H302 Harmful if swallowed

Precautionary statement(s)

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.


P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/\u2026if you feel unwell.

P330 Rinse mouth.




P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification


7. Other Information
7.0 Merck
7.1 Indications and Usage
Betamethasone Sodium Phosphate, also called Bentelan, Betnesol, betamethasone phosphate, and celestone phosphate, is an adrenal cortex hormone, an isomer of dexamethasone with the same effects as prednisolone and dexamethasone.
It is mainly used against inflammation and allergies. Its effects are the same as those of dexamethasone, and its anti-inflammatory effects are stronger than dexamethasone, prednisone, and cortisone, with fewer side effects. It is used to treat active rheumatism, rheumatoid arthritis, lupus erythematosus, severe bronchial asthma, severe dermatitis, acute leukemia, allergic dermatitis, eczema, neurodermatitis, seborrheic dermatitis, pruritis, and comprehensively treat some infections.
7.2 Mechanisms of Action
Betamethasone sodium phosphate has pharmacological effects in treating inflammation, rheumatism, allergies, and immunosuppressive conditions. Its anti-inflammatory effects are stronger than those of dexamethasone, triamcinolone, and hydrocortisone. It can reduce and prevent tissue response to inflammation, partly eliminating non-infectious inflammation caused by fever, redness, and swelling, thereby reducing the presence of swelling. The anti-inflammatory effects of 0.3 mg of betamethasone sodium phosphate are comparable to those of 0.75 mg of dexamethasone, 5 mg of prednisone, or 25 mg of cortisone. Its sodium retention effects are more than a hundred times those of cortisone. In case of primary adrenal hypofunction, together with corticosteroids, it can be used to replace treatment or prevention, or inhibit of cellular immune response, delay allergic reaction, and reduce the extension of the primary immune response, suitable for low renin and low aldosterone syndrome and orthodontic hypotension caused by autonomic neuropathy.
7.3 Contraindications
Not for use by those with a history of serious mental illness, active duodenum, gastric ulcers, recent gastrointestinal anastomosis, serious osteoporosis, pronounced diabetes, or serious high blood pressure, viruses which cannot be treated by antibiotics, bacterial of fungal infection, thrombophlebitis, or infectious skin diseases such as impetigo, tinea corporis, or tinea cruris.
7.4 Category
7.5 Toxicity level
7.6 Acute toxicity
Oral administration - mice LD50: >4500 mg/kg
7.7 Flammability
Flammable; produces toxic fluoride fumes
7.8 Storage and transport
Store in a cool, ventilated, and dry place
7.9 Extinguishing agents
Dry powder, foam, sand, carbon dioxide, mist
7.10 Chemical Properties
White or almost white powder, very hygroscopic.
7.11 Uses
An anti-inflammatory agent
7.12 Uses
A Betamethasone
7.13 Uses
antiinflammatory, glucocorticoid
7.14 Uses
Nasal, Ophthalmic, Oral, Parenteral
7.15 Definition
ChEBI: An organic sodium salt that is the disodium salt of betamethasone phosphate.
7.16 Brand name
Celestone (Schering).
7.17 Biochem/physiol Actions
Betamethasone is used to treat neonatal respiratory distress syndrome, and psoriasis.
7.18 Safety Profile
Moderately toxic by ingestion andother routes. An experimental teratogen. Otherexperimental reproductive effects. When heated todecomposition it emits toxic fumes of F??, POx and Na2O.
8. Computational chemical data
  • Molecular Weight: 516.41g/mol
  • Molecular Formula: C22H28FNa2O8P
  • Compound Is Canonicalized: True
  • XLogP3-AA: null
  • Exact Mass: 516.13012157
  • Monoisotopic Mass: 516.13012157
  • Complexity: 962
  • Rotatable Bond Count: 3
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 9
  • Topological Polar Surface Area: 147
  • Heavy Atom Count: 34
  • Defined Atom Stereocenter Count: 8
  • Undefined Atom Stereocenter Count: 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Isotope Atom Count: 0
  • Covalently-Bonded Unit Count: 3
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10. Realated Product Infomation