Calcium phosphate
- Iupac Name：pentacalcium;hydroxide;triphosphate
- CAS No.: 7758-87-4
- Molecular Weight：310.18
- Modify Date.: 2022-11-10 22:43
- Introduction: Calcium Phosphate is the calcium salt of phosphoric acid with widely used applications. It occur abundantly in nature in several forms and are the principal minerals for the production of phosphate fertilizers and for a range of phosphorus compounds. For example, the tribasic variety (precipitated calcium phosphate), Ca3(PO4)2, is the principal inorganic constituent of bone ash. The acid salt Ca(H2PO4)2, produced by treating mineral phosphates with sulfuric acid, is employed as a plant food and stabilizer for plastics. It is a natural constituent of mammals, and it is a component of bone replacement transplants in much higher amounts with no toxicological problems.
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1. Names and Identifiers
- 1.1 Name
- Calcium phosphate
- 1.2 Synonyms
APATITE TTCP, MONOCLINIC calcigenolsimple calcium phosphate，tertiary calciumorthophosphate,tri-(tert) calciumphosphate(3:2) calciumphosphate(ca3(po4)2) MFCD03456105 tricalcium phosphate for technical grade
- 1.3 CAS No.
- 7758-87-4
- 1.4 CID
- 24456
- 1.5 EINECS(EC#)
- 215-145-7; 235-330-6
- 1.6 Molecular Formula
- Ca3O8P2 (isomer)
- 1.7 Inchi
- InChI=1S/3Ca.2H3O4P/c;;;2*1-5(2,3)4/h;;;2*(H3,1,2,3,4)/q3*+2;;/p-6
- 1.8 InChIkey
- QORWJWZARLRLPR-UHFFFAOYSA-H
- 1.9 Canonical Smiles
- [O-]P(=O)([O-])[O-].[O-]P(=O)([O-])[O-].[Ca+2].[Ca+2].[Ca+2]
- 1.10 Isomers Smiles
- [O-]P(=O)([O-])[O-].[O-]P(=O)([O-])[O-].[Ca+2].[Ca+2].[Ca+2]
2. Properties
- 2.1 Density
- 3.14
- 2.1 Melting point
- 1670°C
- 2.1 Boiling point
- 158 °C at 760 mmHg
- 2.1 Refractive index
- 1.63
- 2.1 Precise Quality
- 501.67600
- 2.1 PSA
- 311.24000
- 2.1 logP
- 0.98120
- 2.1 Solubility
- 0.1 g/L (25 oC)
- 2.2 Appearance
- white powder
- 2.3 Chemical Properties
- White or almost white powder.
- 2.4 Color/Form
- White
- 2.5 Odor
- Odorless
- 2.6 PH
- 6-8 (50g/l, H2O, 20°C) suspension
- 2.7 Water Solubility
- 0.1 g/L (25 oC)
- 2.8 Spectral Properties
- INDEX OF REFRACTION: 1.629, 1.626
- 2.9 Stability
- STABLE IN AIR /TRIBASIC CALCIUM PHOSPHATE, NATIONAL FORMULARY/
- 2.10 StorageTemp
- room temp
3. Use and Manufacturing
- 3.1 Usage
- Calcium Phosphate is a compound existing in several forms which include the monobasic, dibasic, and tribasic forms of calcium phos-phate. as calcium phosphate monobasic, also termed monocalcium phosphate, calcium biphosphate, and acid calcium phosphate, it is used as a leavening agent and acidulant. calcium phosphate diba-sic, also termed dicalcium phosphate dihydrate, is used as a dough conditioner and mineral supplement. calcium phosphate tribasic, also termed tricalcium phosphate and precipitated calcium phos-phate, is used as an anticaking agent, mineral supplement, and con-ditioning agent.
4. Safety and Handling
- 4.1 Hazard Codes
- Xi
- 4.1 Risk Statements
- 36/37/38
- 4.1 Safety Statements
- 26-36-24/25-22
- 4.1 Exposure Standards and Regulations
- Substances classified as stabilizers, when migrating from food-packaging material shall incl ... calcium phosphate.
Calcium phosphate (mono-, di-, and tribasic) used as a multiple purpose GRAS food substance in food for human consumption is generally recognized as safe when used in accordance with good manufacturing practice. /Calcium phosphate (mono-, di-, and tribasic)/
Calcium phosphate (mono-, di-, tribasic) used as a dietary supplement in food for human consumption is generally recognized as safe when used in accordance with good manufacturing practice. /Calcium phosphate (mono-, di-, and tribasic)/
Calcium phosphate (mono-, di-, and tribasic) used as a nutrient in food for human consumption is generally recognized as safe when used in accordance with good manufacturing practice. /Calcium phosphate (mono-, di-, and tribasic)/
Calcium phosphate (mono-, di-, and tribasic) used as a general purpose food additive in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice. /Calcium phosphate (mono-, di-, and tribasic)/
Calcium phosphate (mono-, di-, andtribasic) used as a nutrient and/or dietary supplement in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice. /Calcium phosphate (mono-, di-, and tribasic)/ - View all
- 4.2 DisposalMethods
- SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
- 4.3 RIDADR
- NONH for all modes of transport
- 4.3 Formulations/Preparations
- Grade: it is about 96% pure, usually containing an excess of calcium oxide.
Grades: granular; technical; chemically pure: a grade designation signifying a minimum of impurities, but not 100% purity; National Formulary; pure precipitated; Food Chemicals Codex.
- 4.4 WGK Germany
- 3
- 4.4 Toxicity
- LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 2000 mg/kg
5. MSDS
2.Hazard identification
2.1 Classification of the substance or mixture
Not classified.
2.2 GHS label elements, including precautionary statements
| Pictogram(s) | No symbol. |
| Signal word | No signal word. |
| Hazard statement(s) | none |
| Precautionary statement(s) | |
| Prevention | none |
| Response | none |
| Storage | none |
| Disposal | none |
2.3 Other hazards which do not result in classification
none
6. Other Information
- 6.0 Merck
- 13,1699
- 6.1 Description
- Calcium Phosphate is the calcium salt of phosphoric acid with widely used applications. It occur abundantly in nature in several forms and are the principal minerals for the production of phosphate fertilizers and for a range of phosphorus compounds. For example, the tribasic variety (precipitated calcium phosphate), Ca3(PO4)2, is the principal inorganic constituent of bone ash. The acid salt Ca(H2PO4)2, produced by treating mineral phosphates with sulfuric acid, is employed as a plant food and stabilizer for plastics. It is a natural constituent of mammals, and it is a component of bone replacement transplants in much higher amounts with no toxicological problems.
Calcium phosphates are the largest group of artificial bone graft substitutes. This is mainly due to their close resemblance to the mineral components of bone. This Product can be used as a countermeasure for exposure to strontium and radium radionuclides. Upon oral uptake, calcium phosphate competes for and blocks the absorption of radium (Ra-226) and strontium (Sr-90) in the gastrointestinal (GI) tract. - View all
- 6.2 Chemical Properties
- White or almost white powder.
- 6.3 Chemical Properties
- Tricalcium phosphate is white solid, insoluble in water; reactive with silicon oxide and carbon at electric furnace temperature yielding phosphorus vapor; reactive with H2SO4 to form, according to the proportions used, phosphoric acid, or dicalcium hydrogen phosphate, CaHPO4, white solid, insoluble; or calcium dihydrogen phosphate, Ca(H2PO4)2·H2O, white solid, soluble. pKsp = 28.70.
- 6.4 Physical properties
- White amorphous powder; refractive index 1.63; density 3.14 g/cm3; melts at 1,670°C; insoluble in water; KSP 1.0x10-25; soluble in acids.
- 6.5 Occurrence
- Tribasic calcium phosphate occurs in nature as minerals, oxydapatite, whitlockite, voelicherite, apatite, phosphorite. It has many industrial applica tions. Some are similar to the monobasic and dibasic salts. It is used in fertil izers, dental products, ceramics and polishing powder. Some other important applications are in plastics as a stabilizer; as an anticaking agent; as a nutri ent supplement in cattle food; for clarifying sugar syrup; as a mordant in dye ing textiles; and as a buffer to control pH.
- 6.6 Uses
- Calcium Phosphate is a compound existing in several forms which include the monobasic, dibasic, and tribasic forms of calcium phos- phate. as calcium phosphate monobasic, also termed monocalcium phosphate, calcium biphosphate, and acid calcium phosphate, it is used as a leavening agent and acidulant. calcium phosphate diba- sic, also termed dicalcium phosphate dihydrate, is used as a dough conditioner and mineral supplement. calcium phosphate tribasic, also termed tricalcium phosphate and precipitated calcium phos- phate, is used as an anticaking agent, mineral supplement, and con- ditioning agent.
- 6.7 Uses
- Calcium Phosphate is an anticaking agent and calcium source that is a white powder that is almost insoluble in water. It is used as an anticaking agent in table salt and dry vinegar. It is used as a source of calcium and phosphorus in cereals and desserts. It functions as a bleaching agent in flour and in lard, and prevents undesirable coloring and improves stability for frying. It is also termed tribasic calcium phosphate, tricalcium orthophosphate, calcium phosphate tribasic, and precipitated calcium phosphate.
- 6.8 Uses
- manufacture of fertilizers, H3PO4 and P Compounds; manufacture of milk-glass, polishing and dental powders, porcelains, pottery; enameling; clarifying sugar syrups; in animal feeds; as noncaking agent; in the textile industry.
- 6.9 Preparation
- Tribasic calcium phosphate is obtained from naturally occurring minerals for fertilizer applications. The compound may be prepared in the laboratory by the reaction of sodium phosphate with calcium chloride with excess of ammonia. Also, it can be prepared by treatment of calcium hydroxide with phosphoric acid:
2H3PO4 + 3Ca(OH)2 → Ca3(PO4)2 + 6H2O
- 6.10 General Description
-
β-tri-Calcium phosphate belongs to the category of calcium-phosphate based ceramics, which has been involved in the preparation of a new biosynthetic material possessing morphogenetic activity that is used as a bone implant.
7. Computational chemical data
- Molecular Weight: 310.18g/mol
- Molecular Formula: Ca3O8P2
- Compound Is Canonicalized: True
- XLogP3-AA: null
- Exact Mass: 309.7946135
- Monoisotopic Mass: 309.7946135
- Complexity: 36.8
- Rotatable Bond Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 8
- Topological Polar Surface Area: 173
- Heavy Atom Count: 13
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count: 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Isotope Atom Count: 0
- Covalently-Bonded Unit Count: 5
- CACTVS Substructure Key Fingerprint: AAADcQAAPAMAAAgAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACAAAAAAAAAAAAAAABAAQAAAAIAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA==
8. Question & Answer
-
Calcium phosphate is widely used in various fields, not only for supplementing calcium during children's growth. Many calcium compounds are white substances, and if not used properly, problems may ari..
-
In recent years, food safety issues have been frequently reported, especially in some children's snacks, which have been found to contain formaldehyde or hormones, posing risks of illness and cancer. ..
-
When it comes to food additives, many people immediately think of preservatives, leavening agents, improvers, and so on. So, are food additives really dangerous? Should they be cancelled? Food additiv..
-
Calcium phosphate is a highly sought-after material in the field of biomedical engineering due to its excellent biocompatibility, bioactivity, and biodegradability. Specifically, β-Calcium phosphate ..
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