D(-)-Glutamic acid
- Iupac Name：(2R)-2-aminopentanedioic acid
- CAS No.: 6893-26-1
- Molecular Weight：147.12926
- Modify Date.: 2022-11-25 02:24
- Introduction: D-Glutamic Acid is the unnatural (R)-enantiomer of Glutamic Acid, a non-essential amino acid. Its salt form (glutamate) is an important neurotransmitter that plays a key role in long-term potentiation and is important for learning and memory. Glutamic Acid is also a key molecule in cellular metabolism.
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1. Names and Identifiers
- 1.1 Name
- D(-)-Glutamic acid
- 1.2 Synonyms
(-)-Glutamic acid (2R)-2-Aminopentanedioic acid (2R)-2-azaniumylpentanedioate (2R)-Glutamic acid (R)-(-)-Glutamic acid (R)-2-aminopentanedioic acid (R)-2-Amino-pentanedioic acid (R)-Glutamic acid 2-aminopentanedioic acid D-(-)-Glutamic acid D(-)-Glutamicacid D-2-Aminoglutaric acid D-2-Aminopentanedioic acid D-GLT d-Glu D-Glutamate D-Glutamic acid D-Glutaminsaeure EINECS 230-000-8 glutamic acid D-form Glutamic acid, D- H-D-Glu-OH H-DL-Glu-OH hydrogen D-glutamate MFCD00063112 NSC 77686 R-(-)-Glutamic acid Δ-Glutamic acid
- 1.3 CAS No.
- 6893-26-1
- 1.4 CID
- 23327
- 1.5 EINECS(EC#)
- 230-000-8
- 1.6 Molecular Formula
- C5H9NO4 (isomer)
- 1.7 Inchi
- InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
- 1.8 InChkey
- WHUUTDBJXJRKMK-GSVOUGTGSA-N
- 1.9 Canonical Smiles
- C(CC(=O)O)C(C(=O)O)N
- 1.10 Isomers Smiles
- C(CC(=O)O)[C@H](C(=O)O)N
2. Properties
- 2.1 Density
- 1.538 g/cu cm at 20 °C
- 2.1 Melting point
- 200-202℃
- 2.1 Boiling point
- 333.8°C at 760 mmHg
- 2.1 Refractive index
- 1.4210 (estimate)
- 2.1 Flash Point
- 155.7°C
- 2.1 Precise Quality
- 147.053162
- 2.1 PSA
- 100.62
- 2.1 logP
- -1.43
- 2.1 Solubility
- 7 g/L (20 ºC)
- 2.2 Appearance
- white crystals
- 2.3 Storage
- Ambient temperatures.
- 2.4 Chemical Properties
- White cryst. powder
- 2.5 Color/Form
- White to Yellow Solid
- 2.6 Odor
- Odorless
- 2.7 PH
- Between 3,0 and 3,5 (saturated solution)
- 2.8 pKa
- pK1:2.162(＋1);pK2:4.272(0);pK3:9.358(－1) (25°C)
- 2.9 Water Solubility
- H2O: 8.88 mg/mL at 25 °C
- 2.10 Stability
- Stable under recommended storage conditions. /L-Glutamic acid hydrochloride/
- 2.11 StorageTemp
- Store at RT.
3. Use and Manufacturing
- 3.1 Definition
- ChEBI: An optically active form of glutamic acid having D-configuration.
- 3.2 Usage
- D-Glutamic Acid is the unnatural (R)-enantiomer of Glutamic Acid, a non-essential amino acid. Its salt form (glutamate) is an important neurotransmitter that plays a key role in long-term potentiation and is important for learning and memory. Glutamic Acid is also a key molecule in cellular metabolism.
4. Safety and Handling
- 4.1 Hazard Codes
- Xi
- 4.1 Risk Statements
- 36/37/38
- 4.1 Safety Statements
- S24/25
- 4.1 Hazard Declaration
- H315
- 4.1 RIDADR
- NONH for all modes of transport
- 4.1 Caution Statement
- P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
- 4.1 WGK Germany
- 3
5. MSDS
2.Hazard identification
2.1 Classification of the substance or mixture
Not classified.
2.2 GHS label elements, including precautionary statements
| Pictogram(s) | No symbol. |
| Signal word | No signal word. |
| Hazard statement(s) | none |
| Precautionary statement(s) | |
| Prevention | none |
| Response | none |
| Storage | none |
| Disposal | none |
2.3 Other hazards which do not result in classification
none
7. Synthesis Route
6893-26-1Total: 53 Synthesis Route
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Literatures:
Oikawa, Tadao; Watanabe, Mayumi; Makiura, Hidemi; Kusakabe, Hitoshi; Yamade, Kazuhiro; Soda, Kenji
Bioscience, Biotechnology and Biochemistry, 1999 , vol. 63, # 12 p. 2168 - 2173
Yield: null
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9. Other Information
- 9.0 Usage
- D-Glutamic acid acts as a superior to alpha ketoglutarate. It helps in the growth of Lactobacillus arabinosus. It can inhibit the IgE binding to peanut allergens. It is widely used in pharmaceuticals and foods.
- 9.1 Mesh Entry Terms
- Aluminum L Glutamate
- 9.2 Manufacturing Info
- D-Glutamic acid: ACTIVE
10. Computational chemical data
- Molecular Weight: 147.12926g/mol
- Molecular Formula: C5H9NO4
- Compound Is Canonicalized: True
- XLogP3-AA: null
- Exact Mass: 147.05315777
- Monoisotopic Mass: 147.05315777
- Complexity: 145
- Rotatable Bond Count: 4
- Hydrogen Bond Donor Count: 3
- Hydrogen Bond Acceptor Count: 5
- Topological Polar Surface Area: 101
- Heavy Atom Count: 10
- Defined Atom Stereocenter Count: 1
- Undefined Atom Stereocenter Count: 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Isotope Atom Count: 0
- Covalently-Bonded Unit Count: 1
- CACTVS Substructure Key Fingerprint: AAADccBiOAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAHgAQCAAACCjBgAQACABAAgAIAACQCAAAAAAAAAAAAIGAAAACABIAgAAAQAAEEAAAAACsJgAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA==
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12. Realated Product Infomation
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