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(11B,16A)-9-FLUORO-11,17,21-TRIHYDROXY-16-METHYL-PREGNA-1,4-DIENE-3,20-DIONE (11b,16a)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione (11BETA,16ALPHA)-9-FLUORO-11,17,21-TRIHYDROXY-16-METHYLPREGNA-1,4-DIENE-3,20-DIONE (11Β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylp (11Β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione (8S,9R,10S,11S,13S,14S,16R,17R)-9-Fluor-11,17-dihydroxy-17-(hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-on (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one (8S,9R,10S,11S,13S,14S,16R,17R)-9-Fluoro-17-glycoloyl-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one 1,4-PREGNADIEN-9ALPHA-FLUORO-16ALPHA-METHYL-11BETA, 17ALPHA, 21-TRIOL 3,20-DIONE 16a-Methyl-9a-fluoro-1,4-pregnadiene-11b,17a,21-triol-3,20-dione 16a-Methyl-9a-fluoro-D1-hydrocortisone 16a-Methyl-9a-fluoroprednisolone 16α-Methyl-9α-fluoroprednisolone 1-Dehydro-16a-methyl-9a-fluorohydrocortisone 1-Dehydro-16α-methyl-9α-fluorohydrocortisone 9a-Fluoro-16a-methylprednisolone 9-Fluoro-11-Β,17,21-trihydroxy-16-α-methylpregna-1,4-diene-3,20-dione 9α-Fluoro-16α-methylprednisolone Adexone Aphthasolone Auxiron CALONAT Corson Decacort Dexa Dexa-Mamallet DEXAMETHASON DEXAMETHASONE BASE DEXAMETHASONUM Dexamonozon Dexone Dezone DXM Dxms EINECS 200-003-9 Hl-dex MFCD00064136 mk125 pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11b,16a)- Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11Β,16α)- Pregna-1,4-diene-3,20-dione, 9-fluoro-11Β,17,21-trihydroxy-16α-methyl-
Hazard Codes:?Xi,Xn
Risk Statements: 43-40-36/37/38-20/21/22
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.?
R36/37/38:Irritating to eyes, respiratory system and skin.?
R40:Limited evidence of a carcinogenic effect.?
R43:May cause sensitization by skin contact.
Safety Statements: 36/37-45-36-26-22
S22:Do not breathe dust.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.?
S36/37:Wear suitable protective clothing and gloves.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
?Dexamethasone , its cas register number is 50-02-2. It also can be called 9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregn-1,4-diene-3,20-dione .?It is a potent synthetic member of the glucocorticoid class of steroid hormones, and acts as an anti-inflammatory and immunosuppressant. It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Then you have the ingesting of the product: Wash mouth out with water, and get medical aid immediately.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 410mg/kg (410mg/kg) | ? | Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 281, 1970. |
mouse | LD50 | subcutaneous | 4400mg/kg (4400mg/kg) | ? | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 2117, 1979. |
rabbit | LD50 | subcutaneous | 7200ug/kg (7.2mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" |
Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 687, 1984. |
rat | LD50 | intraperitoneal | 54mg/kg (54mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 687, 1984. |
rat | LD50 | oral | > 3gm/kg (3000mg/kg) | ? | Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 687, 1984. |
rat | LD50 | subcutaneous | 14mg/kg (14mg/kg) | ? | Toxicology and Applied Pharmacology. Vol. 8, Pg. 250, 1966. |
women | TDLo | multiple routes | 4759ug/kg/18D (4.759mg/kg) | KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED | Intensive Care Medicine. Vol. 21, Pg. 238, 1995. ? |
Reproductive toxicity, Category 1B
Pictogram(s) | ![]() |
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Signal word | Danger |
Hazard statement(s) | H360 May damage fertility or the unborn child |
Precautionary statement(s) | |
Prevention | P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P280 Wear protective gloves/protective clothing/eye protection/face protection. |
Response | P308+P313 IF exposed or concerned: Get medical advice/ attention. |
Storage | P405 Store locked up. |
Disposal | P501 Dispose of contents/container to ... |
none
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