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Home> Encyclopedia >Vitamins, Amino Acids and Coenzymes>Pharmaceutical Intermediates>Organic Intermediate
DL-Serine structure
DL-Serine structure

DL-Serine

Iupac Name:2-amino-3-hydroxypropanoic acid
CAS No.: 302-84-1
Molecular Weight:105.09258
Modify Date.: 2022-11-29 09:49
Introduction: 1. It can be used for biochemical research, the preparation of tissue culture media, and as amino acids health food in the field of medicine. 2. It can be used as nutritional supplements.3. It can be used as biochemical reagents.4. It can be used as pharmaceutical intermediates, or APIs. View more+
1. Names and Identifiers
1.1 Name
DL-Serine
1.2 Synonyms

(±)-Serine (2R)-2-azaniumyl-3-hydroxy-propanoate (2S)-2-azaniumyl-3-hydroxy-propanoate 2-Azaniumyl-3-hydroxypropanoate DL-2-Amino-3-Hydroxypropionic Acid DL-Ser H-DL-Ser-OH NSC 9960 Serin Serine DL-form Serine, DL-

View all
1.3 CAS No.
302-84-1
1.4 CID
617
1.5 EINECS(EC#)
206-130-6
1.6 Molecular Formula
C3H7NO3 (isomer)
1.7 Inchi
InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)
1.8 InChIkey
MTCFGRXMJLQNBG-UHFFFAOYSA-N
1.9 Canonical Smiles
C(C(C(=O)O)N)O
1.10 Isomers Smiles
C(C(C(=O)O)N)O
2. Properties
2.1 Density
1.53
2.1 Melting point
240℃ (dec.)
2.1 Boiling point
394.8 °C at 760 mmHg
2.1 Refractive index
1.519
2.1 Flash Point
394.8 °C at 760 mmHg
2.1 Precise Quality
105.04300
2.1 PSA
83.55000
2.1 logP
-0.90910
2.1 Solubility
H2O: soluble
2.2 Appearance
White Crystalline Powder
2.3 Storage
Ambient temperatures.
2.4 Color/Form
HEXAGONAL PLATES OR PRISMS
COLORLESS CRYSTALS
2.5 Odor
Odorless
2.6 pKa
2.19(at 25℃)
2.7 Water Solubility
H2O: 50.23 g/L (25 oC)
2.8 Spectral Properties
SPECIFIC OPTICAL ROTATION: -6.83 DEG @ 20 DEG C/D (1.5 G IN 15 G AQ SOLN); +14.45 DEG @ 25 DEG C/D (C= 0.5 G IN 5.6 NORMAL HCL)
IR: 1593 (Sadtler Research Laboratories IR Grating Collection)
NMR: 9189 (Sadtler Research Laboratories Spectral Collection)
MASS: 4017 (National Bureau of Standards EPA-NIH Mass Spectra Data Base, NSRDS-NBS-63)
2.9 StorageTemp
Store at RT.
3. Use and Manufacturing
3.1 Definition
ChEBI: An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
3.2 Methods of Manufacturing
In the presence of excess copper carbonate, formaldehyde and glycine are used as raw materials to reflux, and the product is obtained by filtration, acidification, column chromatography and crystallization after cooling.
3.3 Usage
1. It can be used for biochemical research, the preparation of tissue culture media, and as amino acids health food in the field of medicine. 2. It can be used as nutritional supplements.3. It can be used as biochemical reagents.4. It can be used as pharmaceutical intermediates, or APIs.
4. Safety and Handling
4.1 Hazard Codes
Xi
4.1 Risk Statements
R36/37/38
4.1 Safety Statements
S24/25
4.1 Exposure Standards and Regulations
Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended; 21 U.S.C. 321-392).
4.2 Octanol/Water Partition Coefficient
LogP = -3.07
4.3 DisposalMethods
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
4.4 RIDADR
25kgs
4.4 Safety Profile
When heated to decomposition emits toxic fumes of NOx. DL-Serine Preparation Products And Raw materials Preparation Products
4.5 Formulations/Preparations
Flavor, food and pharmaceutical grades; USP and FCC grades
4.6 WGK Germany
3
4.6 RTECS
VT8100000
5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Not classified.

2.2 GHS label elements, including precautionary statements

Pictogram(s) No symbol.
Signal word

No signal word.

Hazard statement(s)

none

Precautionary statement(s)
Prevention

none

Response

none

Storage

none

Disposal

none

2.3 Other hazards which do not result in classification

none

6. NMR Spectrum
9. Other Information
9.0 Storage Conditions
In the presence of excess copper carbonate, formaldehyde and glycine are used as raw materials to reflux, and the product is obtained by filtration, acidification, column chromatography and crystallization after cooling.
9.1 Mesh Entry Terms
poly-L-serine
9.2 Manufacturing Info
Serine: ACTIVE
9.3 Use Classification
Food additives -> Flavoring Agents|Fatty Acyls [FA] -> Fatty Acids and Conjugates [FA01] -> Amino fatty acids [FA0110]
9.4 Usage
DL-Serine is used in the synthesis of novel tryptoline derivatives as IDO (indoleamine 2,3-Deoxygenase) inhibitors, for potential use in Alzheimer?s treatment.
10. Computational chemical data
  • Molecular Weight: 105.09258g/mol
  • Molecular Formula: C3H7NO3
  • Compound Is Canonicalized: True
  • XLogP3-AA: null
  • Exact Mass: 105.042593085
  • Monoisotopic Mass: 105.042593085
  • Complexity: 72.6
  • Rotatable Bond Count: 2
  • Hydrogen Bond Donor Count: 3
  • Hydrogen Bond Acceptor Count: 4
  • Topological Polar Surface Area: 83.6
  • Heavy Atom Count: 7
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count: 1
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Isotope Atom Count: 0
  • Covalently-Bonded Unit Count: 1
  • CACTVS Substructure Key Fingerprint: AAADcYBCMAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAHgAQCAAACCjhgAYACABAAgAIAACQCAAAAAAAAAAAAIGAAAACEAQAAAAAQAABMAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA==
11. Question & Answer
  • DL-Serine, also known as DL-Serine, is a white crystalline solid at room temperature and pressure. It belongs to the class of amino acid derivatives and is also known as β-hydroxyalanine. Its chemica..
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