DL-Serine
- Iupac Name：2-amino-3-hydroxypropanoic acid
- CAS No.: 302-84-1
- Molecular Weight：105.09258
- Modify Date.: 2022-11-29 09:49
- Introduction: 1. It can be used for biochemical research, the preparation of tissue culture media, and as amino acids health food in the field of medicine. 2. It can be used as nutritional supplements.3. It can be used as biochemical reagents.4. It can be used as pharmaceutical intermediates, or APIs.
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1. Names and Identifiers
- 1.1 Name
- DL-Serine
- 1.2 Synonyms
(±)-Serine (2R)-2-azaniumyl-3-hydroxy-propanoate (2S)-2-azaniumyl-3-hydroxy-propanoate 2-Azaniumyl-3-hydroxypropanoate DL-2-Amino-3-Hydroxypropionic Acid DL-Ser H-DL-Ser-OH NSC 9960 Serin Serine DL-form Serine, DL-
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- 1.3 CAS No.
- 302-84-1
- 1.4 CID
- 617
- 1.5 EINECS(EC#)
- 206-130-6
- 1.6 Molecular Formula
- C3H7NO3 (isomer)
- 1.7 Inchi
- InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)
- 1.8 InChIkey
- MTCFGRXMJLQNBG-UHFFFAOYSA-N
- 1.9 Canonical Smiles
- C(C(C(=O)O)N)O
- 1.10 Isomers Smiles
- C(C(C(=O)O)N)O
2. Properties
- 2.1 Density
- 1.53
- 2.1 Melting point
- 240℃ (dec.)
- 2.1 Boiling point
- 394.8 °C at 760 mmHg
- 2.1 Refractive index
- 1.519
- 2.1 Flash Point
- 394.8 °C at 760 mmHg
- 2.1 Precise Quality
- 105.04300
- 2.1 PSA
- 83.55000
- 2.1 logP
- -0.90910
- 2.1 Solubility
- H2O: soluble
- 2.2 Appearance
- White Crystalline Powder
- 2.3 Storage
- Ambient temperatures.
- 2.4 Color/Form
- HEXAGONAL PLATES OR PRISMS
COLORLESS CRYSTALS
- 2.5 Odor
- Odorless
- 2.6 pKa
- 2.19(at 25℃)
- 2.7 Water Solubility
- H2O: 50.23 g/L (25 oC)
- 2.8 Spectral Properties
- SPECIFIC OPTICAL ROTATION: -6.83 DEG @ 20 DEG C/D (1.5 G IN 15 G AQ SOLN); +14.45 DEG @ 25 DEG C/D (C= 0.5 G IN 5.6 NORMAL HCL)
IR: 1593 (Sadtler Research Laboratories IR Grating Collection)
NMR: 9189 (Sadtler Research Laboratories Spectral Collection)
MASS: 4017 (National Bureau of Standards EPA-NIH Mass Spectra Data Base, NSRDS-NBS-63)
- 2.9 StorageTemp
- Store at RT.
3. Use and Manufacturing
- 3.1 Definition
- ChEBI: An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
- 3.2 Methods of Manufacturing
- In the presence of excess copper carbonate, formaldehyde and glycine are used as raw materials to reflux, and the product is obtained by filtration, acidification, column chromatography and crystallization after cooling.
- 3.3 Usage
- 1. It can be used for biochemical research, the preparation of tissue culture media, and as amino acids health food in the field of medicine. 2. It can be used as nutritional supplements.3. It can be used as biochemical reagents.4. It can be used as pharmaceutical intermediates, or APIs.
4. Safety and Handling
- 4.1 Hazard Codes
- Xi
- 4.1 Risk Statements
- R36/37/38
- 4.1 Safety Statements
- S24/25
- 4.1 Exposure Standards and Regulations
- Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended; 21 U.S.C. 321-392).
- 4.2 Octanol/Water Partition Coefficient
- LogP = -3.07
- 4.3 DisposalMethods
- SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
- 4.4 RIDADR
- 25kgs
- 4.4 Safety Profile
- When heated to decomposition emits toxic fumes of NOx. DL-Serine Preparation Products And Raw materials Preparation Products
- 4.5 Formulations/Preparations
- Flavor, food and pharmaceutical grades; USP and FCC grades
- 4.6 WGK Germany
- 3
- 4.6 RTECS
- VT8100000
5. MSDS
2.Hazard identification
2.1 Classification of the substance or mixture
Not classified.
2.2 GHS label elements, including precautionary statements
| Pictogram(s) | No symbol. |
| Signal word | No signal word. |
| Hazard statement(s) | none |
| Precautionary statement(s) | |
| Prevention | none |
| Response | none |
| Storage | none |
| Disposal | none |
2.3 Other hazards which do not result in classification
none
7. Synthesis Route
302-84-1Total: 25 Synthesis Route
9. Other Information
- 9.0 Storage Conditions
- In the presence of excess copper carbonate, formaldehyde and glycine are used as raw materials to reflux, and the product is obtained by filtration, acidification, column chromatography and crystallization after cooling.
- 9.1 Mesh Entry Terms
- poly-L-serine
- 9.2 Manufacturing Info
- Serine: ACTIVE
- 9.3 Use Classification
- Food additives -> Flavoring Agents|Fatty Acyls [FA] -> Fatty Acids and Conjugates [FA01] -> Amino fatty acids [FA0110]
- 9.4 Usage
- DL-Serine is used in the synthesis of novel tryptoline derivatives as IDO (indoleamine 2,3-Deoxygenase) inhibitors, for potential use in Alzheimer?s treatment.
10. Computational chemical data
- Molecular Weight: 105.09258g/mol
- Molecular Formula: C3H7NO3
- Compound Is Canonicalized: True
- XLogP3-AA: null
- Exact Mass: 105.042593085
- Monoisotopic Mass: 105.042593085
- Complexity: 72.6
- Rotatable Bond Count: 2
- Hydrogen Bond Donor Count: 3
- Hydrogen Bond Acceptor Count: 4
- Topological Polar Surface Area: 83.6
- Heavy Atom Count: 7
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count: 1
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Isotope Atom Count: 0
- Covalently-Bonded Unit Count: 1
- CACTVS Substructure Key Fingerprint: AAADcYBCMAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAHgAQCAAACCjhgAYACABAAgAIAACQCAAAAAAAAAAAAIGAAAACEAQAAAAAQAABMAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA==
11. Question & Answer
-
DL-Serine, also known as DL-Serine, is a white crystalline solid at room temperature and pressure. It belongs to the class of amino acid derivatives and is also known as β-hydroxyalanine. Its chemica..
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DL-Serine
- Purity:99%Packing: 200kg/bag FOB
- Price: 1 USD/kilogram
- Time: 2023/06/27
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