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Home> Encyclopedia >Auxiliaries and Other Medicinal Chemical...>Immune Function Agents>Pharmaceutical Intermediates
Erythromycin thiocyanate structure
Erythromycin thiocyanate structure

Erythromycin thiocyanate

Iupac Name:(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione;thiocyanic acid
CAS No.: 7704-67-8
Molecular Weight:793.023
Modify Date.: 2022-11-29 03:53
Introduction: Antibiotic medicines, For the treatment Infections caused by penicillin-resistant staphylococcus and streptococcus etc. View more+
1. Names and Identifiers
1.1 Name
Erythromycin thiocyanate
1.2 Synonyms

ERTHROMYCIN THIOCYANATE ErythroMicyn thiocyanate erythromycin A thiocyanate erythromycin thiocyanante ErythroMycin Thiocyanate CGMP ERYTHROMYCIN THIOCYANATE CP2000 ERYTHROMYCIN THIOCYANATE NOT LESS THAN 750 U OF ERYFHROMYCIN PER MG erythromycin thiocynante ERYTHROMYCIN THIOCYNATE Erythromycin, thiocyanate (salt)

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1.3 CAS No.
1.4 CID
1.6 Molecular Formula
C38H68N2O13S (isomer)
1.7 Inchi
1.8 InChIkey
1.9 Canonical Smiles
1.10 Isomers Smiles
2. Properties
2.1 Melting point
2.1 Boiling point
818.4 °C at 760 mmHg
2.1 Flash Point
448.8 °C
2.1 Precise Quality
2.1 PSA
2.1 logP
2.1 Chemical Properties
White or almost white powder.
3. Use and Manufacturing
3.1 GHS Classification
Signal: Warning
GHS Hazard Statements
Aggregated GHS information provided by 45 companies from 3 notifications to the ECHA C&L Inventory.

Reported as not meeting GHS hazard criteria by 1 of 45 companies. For more detailed information, please visit ECHA C&L website

Of the 2 notification(s) provided by 44 of 45 companies with hazard statement code(s):

H319 (97.73%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

Precautionary Statement Codes
P264, P280, P305+P351+P338, P33, and P313
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3.2 Usage
Antibiotic medicines, For the treatment Infections caused by penicillin-resistant staphylococcus and streptococcus etc.
4. Safety and Handling
4.1 Hazard Declaration
4.1 Caution Statement
P264, P280, P305+P351+P338, P33, P313
4.1 Specification

?Erythromycin thiocyanate , its cas register number is 7704-67-8. It also can be called Erythromycin, thiocyanate (salt) .


2.Hazard identification

2.1 Classification of the substance or mixture

Skin sensitization, Category 1

Respiratory sensitization, Category 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

2.2 GHS label elements, including precautionary statements

Signal word


Hazard statement(s)

H317 May cause an allergic skin reaction

H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled

H411 Toxic to aquatic life with long lasting effects

Precautionary statement(s)

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P272 Contaminated work clothing should not be allowed out of the workplace.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P284 [In case of inadequate ventilation] wear respiratory protection.

P273 Avoid release to the environment.


P302+P352 IF ON SKIN: Wash with plenty of water/...

P333+P313 If skin irritation or rash occurs: Get medical advice/attention.

P321 Specific treatment (see ... on this label).

P362+P364 Take off contaminated clothing and wash it before reuse.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P342+P311 If experiencing respiratory symptoms: Call a POISON CENTER/doctor/...

P391 Collect spillage.




P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification


6. NMR Spectrum
7. Synthesis Route
8. Precursor and Product
9. Other Information
9.0 靶点

Bacterial; RNA-dependent protein synthesis

9.1 体外研究

Erythromycin inhibits growth of P. falciparum with IC 50 and IC 90 values of 58.2 μM and 104.0 μM, respectively.

9.2 Macrolide antibiotics
Thiocyanate thiocyanate is the thiocyanate of commonly used macrolide antibiotic erythromycin. It is a veterinary product for the treatment of gram-positive bacteria and mycoplasma infections, and has been widely used as an "animal growth promoters" in a foreign country. In China together with tylosin, tetracycline and oxytetracycline, they are the largest exported veterinary antibiotics products. In addition the product is used as an important intermediate in the synthesis of mainstream macrolide antibiotics product, for example erythromycin, roxithromycin, azithromycin and clarithromycin. China began the production of erythromycin thiocyanate in 1980s-1990s, but the yield was less than 100 tons. By 2007 it became the largest exported macrolide antibiotic with production capacity more than 10,000 tons. The antibacterial spectrum of erythromycin thiocyanate is similar to that of benzylpenicillin. It has strong effect to staphylococcus aureus, streptococcus and pneumoniae bacteria in gram-positive bacteria, and also has some effect to pasteurella and brucella in gram-negative bacteria. In addition to that, the product is effective to mycoplasma, rickettsia, leptospira, actinomycetes and ardia, but non-effective to echerichia coli, salmonella spp and other intestinal negative bacteria. It is mainly used for serious infections caused by drug-resistant Staphylococcus aureus and hemolytic streptococcus, such as pneumonia, septicemia, endometritis and mastitis etc. Besides it also has good effect on mycoplasma-caused chronic respiratory disease in poultry and swine mycoplasma pneumonia. Moreover it is also used for nocardiosis treatment of dogs and cats, for prevention of white head and mouth disease of black, grass, bighead carp and other fish species, bacterial gill disease of grass and black carp, white fish disease of silver, bighead carp and other fish, and streptococcus disease of tilapia.
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9.3 Uses
Antibiotic medicines, For the treatment Infections caused by penicillin-resistant staphylococcus and streptococcus etc.
9.4 Chemical Properties
White or almost white powder.
9.5 Uses
Food additive; drug (veterinary).
9.6 Use Classification
Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
10. Computational chemical data
  • Molecular Weight: 793.023g/mol
  • Molecular Formula: C38H68N2O13S
  • Compound Is Canonicalized: True
  • XLogP3-AA: null
  • Exact Mass: 792.44421140
  • Monoisotopic Mass: 792.44421140
  • Complexity: 1210
  • Rotatable Bond Count: 7
  • Hydrogen Bond Donor Count: 6
  • Hydrogen Bond Acceptor Count: 16
  • Topological Polar Surface Area: 219
  • Heavy Atom Count: 54
  • Defined Atom Stereocenter Count: 18
  • Undefined Atom Stereocenter Count: 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Isotope Atom Count: 0
  • Covalently-Bonded Unit Count: 2
11. Question & Answer
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13. Realated Product Infomation