3D Mol Similar

Felodipine

: Iupac Name：5-O-ethyl 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; CAS No.: 72509-76-3; Molecular Weight：384.26; Modify Date.: 2022-11-08 02:44; Introduction: Felodipine is a vasodilatory calcium antagonist with a high degree of vascular selectivity.It is currently indicated for use only in hypertension, either as monotherapy or inconjunction with diuretics or beta blockers. View more+

Request For Quotation

1. Names and Identifiers

: 1.1 Name; Felodipine; 1.2 Synonyms; (±)-Felodipine (RS)-Felodipine ,ethylmethylester 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, 3-ethyl 5-methyl ester 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, ethyl methyl ester 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid Ethyl Methyl Ester 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-3-pyridinecarboxylic acid ethyl ester Agon CGH-869 Delmuno dl-Felodipine Ethyl Methyl 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate ethylmethyl4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedica Feloday Flodil H 154/82 Hydac Munobal P|endil Plendil Prevex Spendil Splendil; View all

1.3 CAS No.: 72509-76-3

1.4 CID: 3333

1.5 Molecular Formula: C18H19Cl2NO4 (isomer)

1.6 Inchi: InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3

1.7 InChIkey: RZTAMFZIAATZDJ-UHFFFAOYSA-N

1.8 Canonical Smiles: CCOC(=O)C1=C(NC(=C(C1C2=C(C(=CC=C2)Cl)Cl)C(=O)OC)C)C

1.9 Isomers Smiles: CCOC(=O)C1=C(NC(=C(C1C2=C(C(=CC=C2)Cl)Cl)C(=O)OC)C)C

2. Properties

2.1 Density: 1.277

2.1 Melting point: 142-145℃

2.1 Boiling point: 471.5°C at 760 mmHg

2.1 Refractive index: 1.549

2.1 Flash Point: 239°C

2.1 PSA: 64.63000

2.1 logP: 4.29310

2.1 Solubility: DMSO: 28?mg/mL

2.2 Appearance: White to Light yellow powder to crystal

2.3 Storage: Keep Cold.

2.4 Chemical Properties: White or Light Yellow Crystalline Powder

2.5 Color/Form: Yellow powder

2.6 pKa: 2.73±0.70(Predicted)

2.7 Water Solubility: insoluble

2.8 StorageTemp: Store at +4°C

3. Use and Manufacturing

3.1 Definition: ChEBI: The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth mscle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris.

3.2 General Description: Felodipine, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethylmethyl ester (Plendil), is a second-generation dihydropyridinechannel blocker of the nifedipine type. It is more selectivefor vascular smooth muscle than for myocardial tissueand serves as an effective vasodilator.

3.3 Usage: vasodilator, Ca channel blocker

4. Safety and Handling

4.1 Hazard Codes: Xn;

4.1 Risk Statements: R22

4.1 Safety Statements: S36

4.1 WGK Germany: 3

4.1 RTECS: US7968700

5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 4

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed
Precautionary statement(s)
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product.
Response	P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/\u2026if you feel unwell. P330 Rinse mouth.
Storage	none
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

View all

6. NMR Spectrum

Mass spectrum (electron ionization)

7. Synthesis Route

72509-76-3Total: 9 Synthesis Route

626-34-6 98 Suppliers

72509-76-3 258 Suppliers

Literatures:
Tetrahedron, , vol. 67, # 52 p. 10222 - 10228
Yield: null

94739-24-9

72509-76-3 258 Suppliers

Literatures:
Organic Preparations and Procedures International, , vol. 28, # 1 p. 91 - 95
Yield: null

175688-78-5 4 Suppliers

72509-76-3 258 Suppliers

Literatures:
Organic Preparations and Procedures International, , vol. 28, # 1 p. 91 - 95
Yield: null

View all

8. Precursor and Product

precursor:

1352187-23-5

1215080-81-1

68064-69-7

124-41-4

1215080-80-0

626-34-6

175688-78-5

21731-17-9

68064-64-2

94739-24-9

81777-30-2

product :

105618-03-9

96382-71-7

119945-59-4

9. Other Information

9.0 Usage: Felodipine is used as a dihydropyridine calcium channel blocker. It displays high vascular selectivity; lowers arterial blood pressure without altering cardiac contractility. Antihypertensive.

10. Computational chemical data

Molecular Weight: 384.26g/mol
Molecular Formula: C₁₈H₁₉Cl₂NO₄
Compound Is Canonicalized: True
XLogP3-AA: null
Exact Mass: 383.0691135
Monoisotopic Mass: 383.0691135
Complexity: 614
Rotatable Bond Count: 6
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 5
Topological Polar Surface Area: 64.6
Heavy Atom Count: 25
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 1
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Isotope Atom Count: 0
Covalently-Bonded Unit Count: 1
CACTVS Substructure Key Fingerprint: AAADceB6OAAGAAAAAAAAAAAAAAAAAAAAAAAwQAAAAAAAAAABAAAAHgIQAAAADQqhmCIyCILABACIAiTSSAACAAAgBQAIikEAAsgIJDKBMxCCMAAkkACIqUeI7uiOgAAAIAABAAQAAABAAAIACAAAAAAAAA==

11. Question & Answer

Can Felodipine be used to treat hypertension? May 23 2022
Hypertension is a common chronic disease that requires proper treatment after onset. Additionally, it is important to pay attention to the patient's emotional changes in daily life, as both high and l..
Why is Felodipine considered a high-quality long-acting antihypertensive drug? Dec 01 2021
Felodipine is a well-known medication among hypertensive patients. So, what makes it a high-quality long-acting antihypertensive drug? In this article, we will explore the efficacy and side effects of..
What symptoms does Felodipine treat? Jul 25 2021
The relationship between medication and consumer's life is very close. Many patients rely on medication to ensure their own health. Some patients can also prevent the spread of virus cells in the body..
What are the uses, dosage, side effects, contraindications, and precautions of Felodipine? May 22 2021
Felodipine is a dihydropyridine calcium channel blocker. Indications 1. Hypertension 2. Stable angina Dosage and Administration Oral administration, the dosage should be individualized. The medication..

12. Recommended Suppliers

Global285SuppliersView all >>

Hebei Chengcai Biotechnology Co., LTD Diamond member

1YR

Products:We are engaged in the development, marketing and sales of apis, intermediates, natural products (extracts), fine chemicals, food additives, agricultural chemicals and other products.
Tel:0086-0319-19131200228
Email:17610795226@chengcaibio.com

Felodipine CAS 72509-76-3 for API