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General procedure: To a solution of H-Phe-OH (100 mg, 60.5 mmol) in 50 percent MeCN (6.1 mL)were added Fmoc-OPhth (233 mg, 60.5 mmol) and K2CO3 (167 mg, 121 mmol) and stirred at room temperature. After 2 h of stirring saturated sodium bicarbonate solution and H2O were added and the resulting solution was washed with diethyl ether. The aqueous phase is acidified to pH 1 with 1M HCl and extracted with diethyl ether. The organic phase was washed with 1 M HCl, H2O, brine, dried over MgSO4. The filtrate was evaporatedevaporated under reduced pressure to give yellow solid as crude product.EXAMPLE 22
View more+(2R)-2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-4-methylpentanoate (2S)-2-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)-4-methylpentanoic acid (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-methylpentanoic acid (2S)-2-[[[(9H-Fluoren-9-yl)methoxy]carbonyl]amino]-4-methylpentanoic acid 217: PN: US20070042401 PAGE: 29 claimed protein 908: PN: WO2006135786 PAGE: 58 claimed protein D-Leucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, ion(1-) F-L-LEU Fmoc-leucine FMOC-LEU-OH FMOC-L-LEU FMOC-L-LEU-OH L-Leucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]- L-Leucine-1-13C-N-FMOC N-(9-Fluorenylmethoxycarbonyl)leucine N-(9-Fluorenylmethoxycarbonyl)-L-leucine N-(Fluorenylmethoxycarbonyl)leucine N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-leucine N-FMOC-leucine N-Fmoc-L-leucine NPC 15199 NSC 334290
Not classified.
Pictogram(s) | No symbol. |
---|---|
Signal word | No signal word. |
Hazard statement(s) | none |
Precautionary statement(s) | |
Prevention | none |
Response | none |
Storage | none |
Disposal | none |
none
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Literatures:
Oppolzer, Wolfgang; Lienard, Philippe Helvetica Chimica Acta, 1992 , vol. 75, # 8 p. 2572 - 2582 ![]() Yield: ~93% |