Guidechem | China Chemical Manufacturers,suppliers,B2B Marketplace
Encyclop..
  • Products
  • Encyclopedia
  • Buy offers
  • Suppliers
Home> Encyclopedia >Organic Intermediate>Pharmaceutical Intermediates>Custom Manufacturing
FMOC-S-trityl-L-cysteine structure
FMOC-S-trityl-L-cysteine structure

FMOC-S-trityl-L-cysteine

Iupac Name:(2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-tritylsulfanylpropanoic
acid
CAS No.: 103213-32-7
Molecular Weight:585.71134
Modify Date.: 2023-04-30 05:17
1. Names and Identifiers
1.1 Name
FMOC-S-trityl-L-cysteine
1.2 Synonyms

(2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-tritylsulfanylpropanoic acid (2R)-2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-3-(tritylsulfanyl)propanoic acid (2S,3aR,7aR)-1-[(2S)-2-{[(1R)-1-Carboxybutyl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid (non-preferred name) 2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(tritylthio)propanoic acid Cysteine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-S-(triphenylmethyl)- FMOC-CYS(TRT) FMOC-CYS(TRT)-OH FMOC-CYSTEINE(TRT)-OH FMOC-L-CYS(TRITYL) FMOC-L-CYS(TRT) FMOC-L-CYS(TRT)-OH FMOC-L-CYSTEINE (TRT) FMOC-L-CYSTEINE(TRITYL) MFCD00038538 N-(9-Fluorenyl methoxy carbonyl)-S-trityl-L-cysteine N-[(9H-Fluoren-9-ylMethoxy)carbonyl]-S-(triphenylMethyl)-L-cysteine N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-tritylcysteine Na-Fmoc-Ng-trityl-L-glutamine N-Fmoc-S-trityl-L-cysteine

View all
1.3 CAS No.
103213-32-7
1.4 CID
128239
1.5 EINECS(EC#)
600-408-4
1.6 Molecular Formula
C37H31NO4S (isomer)
1.7 Inchi
InChI=1S/C37H31NO4S/c39-35(40)34(38-36(41)42-24-33-31-22-12-10-20-29(31)30-21-11-13-23-32(30)33)25-43-37(26-14-4-1-5-15-26,27-16-6-2-7-17-27)28-18-8-3-9-19-28/h1-23,33-34H,24-25H2,(H,38,41)(H,39,40)/t34-/m0/s1
1.8 InChIkey
KLBPUVPNPAJWHZ-UMSFTDKQSA-N
1.9 Canonical Smiles
C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)SCC(C(=O)O)NC(=O)OCC4C5=CC=CC=C5C6=CC=CC=C46
1.10 Isomers Smiles
C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)SC[C@@H](C(=O)O)NC(=O)OCC4C5=CC=CC=C5C6=CC=CC=C46
2. Properties
2.1 Density
1.27
2.1 Melting point
172-177℃
2.1 Boiling point
763.4 °C at 760 mmHg
2.1 Refractive index
18 ° (C=1, THF)
2.1 Flash Point
415.5 °C
2.1 Precise Quality
585.19700
2.1 PSA
100.93000
2.1 logP
8.09450
2.1 Appearance
White to almost white Powder
2.2 Storage
Keep Cold.
2.3 Chemical Properties
white to light yellow crystal powde FMOC-S-trityl-L-cysteineSupplier
2.4 Color/Form
White to almost white
2.5 pKa
3.70±0.10(Predicted)
2.6 Water Solubility
Insoluble in water. soluble in most organic solvents.
2.7 StorageTemp
2-8°C
3. Safety and Handling
3.1 Hazard Codes
Xi
3.1 Risk Statements
R36/37/38
3.1 Safety Statements
S22;S24/25
3.1 Hazard Declaration
H302
3.1 RIDADR
NONH for all modes of transport
3.1 Caution Statement
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501
3.1 WGK Germany
3
3.1 Safety

Hazard Codes:?IrritantXi
Risk Statements: 36/37/38?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24/25-26?
S22:Do not breathe dust.?
S24/25:Avoid contact with skin and eyes.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
F: 9-21
Hazard Note: Irritant

3.2 Specification

?Fmoc-Cys(Trt)-OH , its cas register number is 103213-32-7. It also can be called?2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-3-(tritylthio)propanoic acid; Fmoc-Cys(Trt)-OH .
?Fmoc-Cys(Trt)-OH (CAS NO.103213-32-7) could be stable. It should avoid the condition like incompatible materials. It is not compatible with strong oxidizing agents, acids, acid chlorides, carbon dioxide, acid anhydrides. And also prevent it to broken down into hazardous decomposition products: carbon monoxide, oxides of nitrogen, oxides of sulfur, carbon dioxide. However, its hazardous polymerization will not occur.

3.3 Toxicity

?Fmoc-Cys(Trt)-OH (CAS NO.103213-32-7)?hasn't been listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65. And the toxicological properties have not been fully investigated.

4. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Not classified.

2.2 GHS label elements, including precautionary statements

Pictogram(s) No symbol.
Signal word

No signal word.

Hazard statement(s)

none

Precautionary statement(s)
Prevention

none

Response

none

Storage

none

Disposal

none

2.3 Other hazards which do not result in classification

none

6. Other Information
6.0 Usage
It is potentially useful for proteomics studies, and solid phase peptide synthesis techniques. Cysteine is versatile amino acid involved with many biological processes, including the formation of disulfide bonds - a critical component of protein structure. This compound could be useful as an unusual amino acid analog to aid in the deconvolution of protein structure and function.
6.1 Uses
Fmoc-Cys(Trt)-OH is an N-terminal protected cysteine derivative used in peptide synthesis. Some of the examples are:
  • Synthesis of mono- and bi-functionalized platinum(IV) complexes to target angiogenic tumor vasculature.
  • Synthesis of proteins through native chemical ligation of peptide hydrazides as thioester surrogates via solid-phase synthesis.
  • Synthesis of glycoconjugates by conjugating reducing sugars to cysteine residues of peptides.

6.2 Mesh Entry Terms
Fmoc-S-trityl-Cys
6.3 BRN
4221286
6.4 Chemical Properties
white to light yellow crystal powde
7. Computational chemical data
  • Molecular Weight: 585.71134g/mol
  • Molecular Formula: C37H31NO4S
  • Compound Is Canonicalized: True
  • XLogP3-AA: 8
  • Exact Mass: 585.19737964
  • Monoisotopic Mass: 585.19737964
  • Complexity: 841
  • Rotatable Bond Count: 11
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 5
  • Topological Polar Surface Area: 101
  • Heavy Atom Count: 43
  • Defined Atom Stereocenter Count: 1
  • Undefined Atom Stereocenter Count: 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Isotope Atom Count: 0
  • Covalently-Bonded Unit Count: 1
  • CACTVS Substructure Key Fingerprint: AAADceB+OABAAAAAAAAAAAAAAAAAAYAAAAAwYMGDAAAAAGABVAAAHgQQCAAADSjl2AawCILABgiIAiDSGAACAAAgABAIiIGIAIkKICKgETCIYAAk1gE4iAeAwPAOgAAAAAAQAAAAAAAAACAAAQAACAAAAA==
8. Question & Answer
9. Recommended Suppliers
Global229SuppliersView all >>
  • Products:Pharmaceutical intermediates
  • Tel:173-31933971-17331933971
  • Email:deasea125996@gmail.com
Best Pharmaceutical intermediate FMOC-S-trityl-L-cysteine CAS 103213-32-7
  • Purity:99%Packing: 200kg/bag FOB
  • Price: 40 USD/kg
  • Time: 2023/09/21
Inquire
  • Products:Pharmaceutical Intermediate , Apis , Food Additives , Herbal Extracts , Fine Chemicals , ...
  • Tel:00-86-13023277276
  • Email:hanna@xljxcl.com
Pharmaceutical intermediate FMOC-S-trityl-L-cysteine CAS 103213-32-7
  • Purity:99%Packing: 200kg/bag FOB
  • Price: 30 USD/kilogram
  • Time: 2023/09/21
Inquire
  • Products:Manufacture & Supply Biopharm Chemical, Specialty Chemical, PetroChemical.
  • Tel:86-592-8883942
  • Email:sale@amitychem.com
Factory Supply Fmoc-S-trityl-L-Cysteine
  • Purity:99%Packing: 200kg/bag FOB
  • Price: 0.1 USD/kilogram
  • Time: 2023/06/28
Inquire
  • Products:Chemical products
  • Tel:86-571-88938639
  • Email:sales-gc@dycnchem.com
Fmoc-L-Cys(Trt)-OH
  • Purity:99%Packing: 200kg/bag FOB
  • Price: 1 USD/kilogram
  • Time: 2023/09/20
Inquire
  • Products:Veterinary products,Nutrition products,Agrochemicals,Active pharmaceutical Ingredients,Custom systhesis,Contract manufacturing
  • Tel:86-571-85829052
  • Email:market@royalpharms.com
FMOC-S-trityl-L-cysteine
  • Purity:99%Packing: 200kg/bag FOB
  • Price: 100 USD/kilogram
  • Time: 2023/07/07
Inquire
10. Realated Product Infomation