Formestane
- Iupac Name：(8R,9S,10R,13S,14S)-4-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,
16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione
- CAS No.: 566-48-3
- Molecular Weight：302.40794
- Modify Date.: 2022-11-02 11:25
- Introduction: Formestane is a potent aromatase inhibitor launched in the UK as a second-lineendocrine treatment for breast cancer. As a synthetic derivative of androstanedione, thenatural substrate for the biosynthesis of estrogen by the enzyme aromatase, formastaneselectively inhibits aromatase and binds to its steroid receptor site to cause a rapid andsustained fall in circulating estrogen level and, therefore, inhibits tumor growth. In patientswith existing bulky primary tumors, formestane effectively reduces the size of the tumors.Formastane has apparent tolerability advantages and less side effects than other agents suchas aminoglutethimide.
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1. Names and Identifiers
- 1.1 Name
- Formestane
- 1.2 Synonyms
(8R,9S,10R,13S,14S)-4-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione 4-ANDROSTEN-4-OL-3,17-DIONE 4-HYDROXY-4-ANDROSTENE-3,17-DIONE 4-hydroxy-androst-4-ene-17-dione 4-HYDROXYANDROST-4-ENE-3,17-DIONE 4-HYDROXYANDROSTENEDIONE 4-hydroxy-delta(sub4)-androstenedione 4-OHA 4-OH-A Androst-4-ene-3,17-dione, 4-hydroxy- B,Aromatase inhibitor CGP-32349 Lentaron MFCD00057814
- 1.3 CAS No.
- 566-48-3
- 1.4 CID
- 11273
- 1.5 EINECS(EC#)
- 625-331-3
- 1.6 Molecular Formula
- C19H26O3 (isomer)
- 1.7 Inchi
- InChI=1S/C19H26O3/c1-18-10-8-15(20)17(22)14(18)4-3-11-12-5-6-16(21)19(12,2)9-7-13(11)18/h11-13,22H,3-10H2,1-2H3/t11-,12-,13-,18+,19-/m0/s1
- 1.8 InChkey
- OSVMTWJCGUFAOD-KZQROQTASA-N
- 1.9 Canonical Smiles
- CC12CCC(=O)C(=C1CCC3C2CCC4(C3CCC4=O)C)O
- 1.10 Isomers Smiles
- C[C@]12CCC(=O)C(=C1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CCC4=O)C)O
2. Properties
- 2.1 Density
- 1.19
- 2.1 Melting point
- 199-202°C
- 2.1 Boiling point
- 475.4°Cat760mmHg
- 2.1 Refractive index
- 1.545
- 2.1 Flash Point
- 255.4°C
- 2.1 Precise Quality
- 302.18800
- 2.1 PSA
- 54.37000
- 2.1 logP
- 3.97310
- 2.1 Appearance
- White powder.
- 2.2 Storage
- 2-8°C
- 2.3 Color/Form
- Powder
- 2.4 pKa
- 9.31±0.60(Predicted)
- 2.5 Water Solubility
- Insoluble
- 2.6 StorageTemp
- 2-8°C
3. Use and Manufacturing
- 3.1 Definition
- ChEBI: A 17-oxo steroid that is androst-4-ene-3,17-dione in which the hydrogen at position 4 is replaced by a hydroxy group. Formestane was the first selective, type I steroidal aromatase inhibitor, suppressing oestrogen production from anabolic steroids or prohomones. It was formerly used in the treatment of oestrogen-receptor positive breast cancer in post-meopausal women. As it has poor oral bioavailability, it had to be administered by (fortnightly) intramuscular injection. It fell out of use with the subsequet development of cheaper, orally active aromatase inhibitors. Formestane is listed by the World Anti-Doping Agency as a substance prohibited from use by athletes.
- 3.2 Usage
- aromatase inhibitors ,it is used for progressive breast cancer. male hormones, assimilating protein class.
4. Safety and Handling
- 4.1 Symbol
- GHS08
- 4.1 Hazard Codes
- T
- 4.1 Signal Word
- Danger
- 4.1 Risk Statements
- R60
- 4.1 Safety Statements
- S53;S36/37/39;S45
- 4.1 Hazard Declaration
- H360
- 4.1 RIDADR
- NONH for all modes of transport
- 4.1 Caution Statement
- P201-P308 + P313
- 4.1 WGK Germany
- 3
- 4.1 RTECS
- BV8152500
- 4.1 Safety
-
Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes: .gif)
T
Risk Statements: 60
60: May impair fertility
Safety Statements: 53-36/37/39-45
53: Avoid exposure - obtain special instruction before use
36/37/39: Wear suitable protective clothing, gloves and eye/face protection?
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
WGK Germany: 3
RTECS: BV8152500.
5. MSDS
2.Hazard identification
2.1 Classification of the substance or mixture
Reproductive toxicity, Category 1B
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |  |
| Signal word | Danger |
| Hazard statement(s) | H360 May damage fertility or the unborn child |
| Precautionary statement(s) | |
| Prevention | P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P280 Wear protective gloves/protective clothing/eye protection/face protection. |
| Response | P308+P313 IF exposed or concerned: Get medical advice/ attention. |
| Storage | P405 Store locked up. |
| Disposal | P501 Dispose of contents/container to ... |
2.3 Other hazards which do not result in classification
none
7. Synthesis Route
566-48-3Total: 25 Synthesis Route
9. Other Information
- 9.0 Anti-cancer drugs
- Formestane also known as lentaron,is an anti-cancer drug, it is primarily used for the treatment of postmenopausal women with advanced breast cancer, it is also effective in prostate cancer.
Formestane is a androstenedione derivative, and it belongs to an aromatase inhibitor with aminoglutethimide, it is a hormone antineoplastic agent. In physiological conditions, it may competitively inhibit the synthesis of the enzyme leading to estrogen biosynthesis decrease in tissues, then it plays its role in cancer. When the tumor tissue growth relies on the presence of estrogen, in order to inhibit tumor growth, the elimination of tumor estrogen-mediated growth stimulation is necessary. This product is more selective than aminoglutethimide while its activity is 100 to 1000 times of aminoglutethimide, and it does not inhibit the synthesis of adrenal hormones，without having to recharge cortisone, etc . The in vitro inhibition of aromatase enzyme of this product is 60 times stronger than aminoglutethimide.
While it is used alone, the drug can not significantly reduce the pre-menopausal estrogen levels in the blood of women,when it is combined with goserelin (gonadotropin-releasing hormone agonist)， its inhibitory effect of estrogen in premenopausal women is greater than goserelin used alone. Formestane has no cross-resistance with other aromatase inhibitors , it has no side effects of aminoglutethimide. After oral administration，it is rapidly absorbed by gastrointestinal, its peak plasma concentration time is 1 to 1.5 hours, but the peak concentration of individual is of great difference; after intramuscular injection，it can be accumulated at the injection site and be slowly absorbed. It performs Biphasic elimination process, the initial elimination half-life is 2 to 4 days, the terminal elimination half-life is 5 to 10 days. It is mainly metabolized in the liver after oral administration, in the form of glycosides acid metabolites excreted in the urine.
- 9.1 Chemical Properties
- Crystallized from aqueous methanol, m.p. 199~202 ℃; crystallized from ethyl acetate, m.p. 203.5~206 ℃. UV absorption maximum (99.5% ethanol): 278nm (ε11030). [α] D20 + 181 ° (C = 7.7, chloroform).
- 9.2 Uses
- aromatase inhibitors ,it is used for progressive breast cancer.
male hormones, assimilating protein class.
- 9.3 production method
- Androst-4-ene-3,17-dione (Ⅰ) (1.432g, 5mmo1) is dissolved in 50ml tert-butanol ,add 38mg (0.15mmo1) osmium tetroxide in 2ml t-butanol solution at room temperature, and then 5ml 35% hydrogen peroxide is added, followed by stirring at room temperature for 3 days. After dilution of 100ml brine, and extract with dichloromethane (2 × 100m1). The extract is washed with 100ml brine, , 50ml 10% sodium bisulfite solution, 50ml 10% sodium carbonate solution and 100ml brine, dry over anhydrous sodium sulfate, and concentrate. The residue (1.824g) of the compound (Ⅱ), is dissolved in methanol (10ml),add potassium hydroxide (393mg, 7mmo1) in 3ml methanol . Plus Albert, stirring 10min at 55 ℃. Add 0.3ml of acetic acid and 100ml of brine, and extract with dichloromethane (2 × 100ml). Complex solution, combine, wash with 100ml brine, dry with anhydrous sodium sulfate, and concentrate. The residue (1.727g) by column chromatography on silica gel, wash with hexane-ethyl acetate (7: 3) to give 715mg formestane, yield 47%, mp 200~202 ℃ (acetone).
- 9.4 Description
- 4-hydroxy Androstenedione (4-HAD) is a steroidal inhibitor of aromatase (also known as cytochrome P450 19A1; Ki = 27 nM).1 As aromatase catalyzes the conversion of androgens to estrogens, aromatase inhibitors, including 4-HAD, are used against hormone-sensitive breast cancer in menopausal women.2 They are also abused in combination with anabolic steroids in racehorses and athletes.3 This product is intended for forensic and research applications.
- 9.5 Description
- Formestane is a potent aromatase inhibitor launched in the UK as a second-line endocrine treatment for breast cancer. As a synthetic derivative of androstanedione, the natural substrate for the biosynthesis of estrogen by the enzyme aromatase, formastane selectively inhibits aromatase and binds to its steroid receptor site to cause a rapid and sustained fall in circulating estrogen level and, therefore, inhibits tumor growth. In patients with existing bulky primary tumors, formestane effectively reduces the size of the tumors. Formastane has apparent tolerability advantages and less side effects than other agents such as aminoglutethimide.
- 9.6 Chemical Properties
- Needles
- 9.7 Originator
- Ciba-Geigy (Switzerland)
- 9.8 Uses
- An antitumor drug. An aromatase inhibitor.
- 9.9 Uses
- antineoplastic, aromatase inhibitor
- 9.10 Definition
- ChEBI: A 17-oxo steroid that is androst-4-ene-3,17-dione in which the hydrogen at position 4 is replaced by a hydroxy group. Formestane was the first selective, type I steroidal aromatase inhibitor, suppressing oestrogen production from anabolic steroids or proho mones. It was formerly used in the treatment of oestrogen-receptor positive breast cancer in post-meopausal women. As it has poor oral bioavailability, it had to be administered by (fortnightly) intramuscular injection. It fell out of use with the subseque t development of cheaper, orally active aromatase inhibitors. Formestane is listed by the World Anti-Doping Agency as a substance prohibited from use by athletes.
- 9.11 Brand name
- Lentaron
10. Computational chemical data
- Molecular Weight: 302.40794g/mol
- Molecular Formula: C19H26O3
- Compound Is Canonicalized: True
- XLogP3-AA: null
- Exact Mass: 302.18819469
- Monoisotopic Mass: 302.18819469
- Complexity: 590
- Rotatable Bond Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 3
- Topological Polar Surface Area: 54.4
- Heavy Atom Count: 22
- Defined Atom Stereocenter Count: 5
- Undefined Atom Stereocenter Count: 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Isotope Atom Count: 0
- Covalently-Bonded Unit Count: 1
- CACTVS Substructure Key Fingerprint: AAADceB4MAAAAAAAAAAAAAAAAAAAAYAAAAAwYIAAAAAAAGDAAAAAGgAACAAADwSAgAACAAAAAgCIAoBQAAIAAAAgIAAACAFAAEgAABIAAAAAQAAEgAAIAQOIyPCPgAAAAAAAAACAAAQAACAAAAAACAAAAA==
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Formestane
- Purity:99%Packing: 200kg/bag FOB
- Price: 1 USD/kilogram
- Time: 2023/05/11
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12. Realated Product Infomation
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