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Glipizide
- Iupac Name：N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-5-methylpyrazine-2-carboxamide
- CAS No.: 29094-61-9
- Molecular Weight：445.53518
- Modify Date.: 2022-10-30 18:41
- Introduction: Glipizide is an oral rapid- and short-acting anti-diabetic medication classified as a second-generation sulfonylurea. It is commonly used as an adjunct to diet in combination with proper exercise program for controlling high blood sugar and its associated symptomatology in people with type II diabetes (non-insulin-dependent diabetes mellitus). Besides, it is effective to lessen the risk of heart attack or stroke and help prevent kidney damage, blindness, nerve problems, loss of limbs, sexual function problems, which can be resulted from hypertension.Glipizide is an oral hypoglycemic drug that is rapidly absorbed and completely metabolized in human body. It is occasionally be administrated with other diabetes pharmaceuticals but it is not a cure for diabetes. Glipizide lowers blood glucose by stimulating the pancreas to release more natural insulin. The FDA approved glipizide in May 1984.
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1. Names and Identifiers
- 1.1 Name
- Glipizide
- 1.2 Synonyms
1-Cyclohexyl-3-{4-[2-(5-methylpyrazine-2-carboxamido)ethyl]phenylsulfonyl}urea 2-Pyrazinecarboxamide, N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-5-methyl- 2-Pyrazinecarboximidic acid, N-[2-[4-[[[(E)-(cyclohexylimino)hydroxymethyl]amino]sulfonyl]phenyl]ethyl]-5-methyl- Aldiab Digrin EINECS 249-427-6 exylurea Glibenese Glican Glidiab Glipid Glipizide Solution, 100ppm Glucotrol GLYDIAZINAMIDE k4024 Melizide MFCD00072159 Mindiab N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phényl}éthyl)-5-méthylpyrazine-2-carboxamide N-(2-{4-[(Cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-5-methyl-2-pyrazinecarboxamide N-(2-{4-[(Cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-5-methylpyrazin-2-carboxamid N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-5-methylpyrazine-2-carboxamide n-(4-(beta-(5-methylpyrazine-2-carboxamido)ethyl)benzenesulphonyl)-n’-cycloh N-[2-(4-{[(E)-(Cyclohexylimino)(hydroxy)methyl]sulfamoyl}phenyl)ethyl]-5-methyl-2-pyrazinecarboximidic acid N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-5-methyl-2-pyrazinecarboxamide N-[4-(3-Cyclohexylureidosulfonyl)phenethyl]-5-methyl-2-pyrazinecarboxamide Ozidia Pyrazinecarboxamide, N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-5-methyl- tk1320 urea,1-cyclohexyl-3-((p-(2-(5-methylpyrazinecarboxamido)ethyl)phenyl)sulfonyl)
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- 1.3 CAS No.
- 29094-61-9
- 1.4 CID
- 3478
- 1.5 EINECS(EC#)
- 249-427-6
- 1.6 Molecular Formula
- C21H27N5O4S (isomer)
- 1.7 Inchi
- InChI=1S/C21H27N5O4S/c1-15-13-24-19(14-23-15)20(27)22-12-11-16-7-9-18(10-8-16)31(29,30)26-21(28)25-17-5-3-2-4-6-17/h7-10,13-14,17H,2-6,11-12H2,1H3,(H,22,27)(H2,25,26,28)
- 1.8 InChIkey
- ZJJXGWJIGJFDTL-UHFFFAOYSA-N
- 1.9 Canonical Smiles
- CC1=CN=C(C=N1)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3
- 1.10 Isomers Smiles
- CC1=CN=C(C=N1)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3
2. Properties
- 2.1 Density
- 1.34
- 2.1 Melting point
- 208-209°C
- 2.1 Boiling point
- 676.0±65.0 °C at 760 mmHg
- 2.1 Refractive index
- 1.597
- 2.1 Flash Point
- 362.6±34.3 °C
- 2.1 Precise Quality
- 445.17800
- 2.1 PSA
- 138.53000
- 2.1 logP
- 4.33160
- 2.1 Solubility
- methanol: 1.9?mg/mL
- 2.2 Appearance
- White or off-white crystalline powder
- 2.3 Storage
- Ambient temperatures.
- 2.4 Chemical Properties
- Crystalline Solid
- 2.5 Color/Form
- white
- 2.6 pKa
- [5.9]
- 2.7 Water Solubility
- methanol: 1.9?mg/mL
- 2.8 StorageTemp
- Store in a tightly closed container. Store in a dry area. Store at around 20 C.
3. Use and Manufacturing
- 3.1 Definition
- ChEBI: An N-sulfonylurea that is glyburide in which the (5-chloro-2-methoxybenzoyl group is replaced by a (5-methylpyrazin-2-yl)carbonyl group. An oral hypoglycemic agent, it is used in the treatment of type 2 diabetes mellitus.
- 3.2 Usage
- sweetener, treatment of portoencephalopathy
4. Safety and Handling
- 4.1 Hazard Codes
- Xi; Xn
- 4.1 Risk Statements
- R21
- 4.1 Safety Statements
- S24/25
- 4.1 RIDADR
- NONH for all modes of transport
- 4.1 WGK Germany
- 3
- 4.1 RTECS
- YS7640000
- 4.1 Safety
-
Safety Information of? Glipizide (CAS NO.29094-61-9):
Hazard Codes:?
Xn,
Xi
Risk Statements: 21-36/38-46-62-63
21:Harmful in contact with skin
36/38:Irritating to eyes and skin?
46:May cause heritable genetic damage
62:Possible risk of impaired fertility?
63:Possible risk of harm to the unborn child?
Safety Statements: 24/25-53-36/37-26-25
24/25:Avoid contact with skin and eyes
53:Avoid exposure - obtain special instruction before use
36/37:Wear suitable protective clothing and gloves
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice?
25:Avoid contact with eyes????
WGK Germany: 3
RTECS: YS7640000
F: 10
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- 4.2 Specification
-
? Glipizide , with CAS number of 29094-61-9, can be called 2-pyrazinecarboxamide, N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-5-methyl- ; N-(2-{4-[(Cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-5-methyl-2-pyrazinecarboxamide ; Pyrazinecarboxamide, N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-5-methyl- .?Glipizide (CAS NO.29094-61-9) is an oral medium-to-long acting anti-diabetic drug.
- 4.3 Toxicity
-
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YS7640000
- CHEMICAL NAME :
- Urea,
1-cyclohexyl-3-((p-(2-(5-methylpyrazinecarboxamido)et
hyl)phenyl)sulfonyl)-
- CAS REGISTRY NUMBER :
- 29094-61-9
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C21-H27-N5-O4-S
- MOLECULAR WEIGHT :
- 445.59
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 21,208,1971
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 21,208,1971
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 21,208,1971
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >3 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 21,208,1971
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- >4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 21,208,1971
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 2400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 21,208,1971
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5. MSDS
2.Hazard identification
2.1 Classification of the substance or mixture
Not classified.
2.2 GHS label elements, including precautionary statements
| Pictogram(s) | No symbol. |
| Signal word | No signal word. |
| Hazard statement(s) | none |
| Precautionary statement(s) | |
| Prevention | none |
| Response | none |
| Storage | none |
| Disposal | none |
2.3 Other hazards which do not result in classification
none
7. Other Information
- 7.0 Usage
- An ATP-dependent potassium channel blocker
8. Computational chemical data
- Molecular Weight: 445.53518g/mol
- Molecular Formula: C21H27N5O4S
- Compound Is Canonicalized: True
- XLogP3-AA: null
- Exact Mass: 445.17837553
- Monoisotopic Mass: 445.17837553
- Complexity: 697
- Rotatable Bond Count: 7
- Hydrogen Bond Donor Count: 3
- Hydrogen Bond Acceptor Count: 6
- Topological Polar Surface Area: 139
- Heavy Atom Count: 31
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count: 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Isotope Atom Count: 0
- Covalently-Bonded Unit Count: 1
- CACTVS Substructure Key Fingerprint: AAADceB7uABAAAAAAAAAAAAAAAAAAAAAAAA8YIAAAAAAAAABwAAAHgQQQAAADCjB3gQ/gZLIEAKoAzV3VHDCgDQ3EiAI2Jm4dMiIYGrA0TGUIIgglgLIiMcQgIAOEAAAAAAAAAAgAAAAAAAAAAAAAAAAAA==
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