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Home> Encyclopedia >   /  Hormones and synthetic substitutes  /  Pharmaceutical Intermediates  /  Pharmaceutical  /  Endocrine System Agents  /  Other Chemicals
GROWTH HORMONE, HUMAN structure
GROWTH HORMONE, HUMAN structure

GROWTH HORMONE, HUMAN

CAS No.:12629-01-5
Molecular Weight:280.44548
Introduction: Somatotropin, a second-generation (methionine-free) human growth hormoneproduced by recombinant technology, was launched in the U.S.A. for the treatmentof growth failure in children due to chronic renal insufficiency before transplantationand for the long term treatment of short stature in children with growth failure due to alack of endogenous growth hormone secretion. The efficacy of somatotropin isreportedly comparable to the first biosynthetic growth hormone somatrem, whichcontains a methionyl residue, but with less frequent antibody formation and rarelycauses allergic effects or impairs growth response. Somatotropin is also in clinicaltrials for the treatment of growth hormone deficiency in adults and is currently underapproval review for Turner's syndrome.
1. Names and Identifiers
1.1 Name
GROWTH HORMONE, HUMAN
1.2 Synonyms

cb311 Growth hormone 1 Growth Hormone from chicken hgh HGH high quality Cas no.:12629-01-5 HGH somatropin CAS12629-01-5 Human Growth Hormone Recombinant human somatotropin Somatropin (8.63 USP Somatropin Units/vial) (INTERNATIONAL COLD CHAIN SHIPMENT REQUIRED)

1.3 CAS No.
12629-01-5
1.4 EINECS(EC#)
235-735-8
1.5 Molecular Formula
C18H32O2 (isomer)
2. Properties
2.1 Alpha
25 -38.7° (0.1M acetic acid)
2.2 Appearance
lyophilized powder
2.3 Chemical Properties
White or almost white powder.
2.4 StorageTemp
2-8°C
3. Use and Manufacturing
3.1 General Description
Somatropin for injection(Humatrope) is a natural-sequence human GH of rDNAorigin. Its composition and sequence of amino acids areidentical with those of human GH of pituitary origin. It isadministered intramuscularly or subcutaneously. Thedosage range is 0.05 to 0.1 IU.
3.2 Usage
Human Growth Hormone is a hormone (growth).
4. Safety and Handling
4.1 Toxicity
LD50 oral in rat: 160iu/kg
5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 3

Acute toxicity - Dermal, Category 4

Skin sensitization, Category 1

Acute toxicity - Inhalation, Category 4

Reproductive toxicity, Category 2

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H301 Toxic if swallowed

H312 Harmful in contact with skin

H317 May cause an allergic skin reaction

H332 Harmful if inhaled

H361 Suspected of damaging fertility or the unborn child

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P272 Contaminated work clothing should not be allowed out of the workplace.

P271 Use only outdoors or in a well-ventilated area.

P201 Obtain special instructions before use.

P202 Do not handle until all safety precautions have been read and understood.

Response

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/…

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P312 Call a POISON CENTER/doctor/…if you feel unwell.

P362+P364 Take off contaminated clothing and wash it before reuse.

P333+P313 If skin irritation or rash occurs: Get medical advice/attention.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P308+P313 IF exposed or concerned: Get medical advice/ attention.

Storage

P405 Store locked up.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

6. Computational chemical data
  • Molecular Weight:280.44548g/mol
  • Molecular Formula:C18H32O2
  • XLogP3-AA:7.1
  • Exact Mass:280.24023
  • Monoisotopic Mass:280.24023
  • Complexity:267
  • Rotatable Bond Count:14
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:2
  • Topological Polar Surface Area:37.3
  • Heavy Atom Count:20
  • Defined Atom Stereocenter Count:0
  • Undefined Atom Stereocenter Count:0
  • Defined Bond Stereocenter Count:2
  • Undefined Bond Stereocenter Count:0
  • Isotope Atom Count:0
  • Covalently-Bonded Unit Count:1
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