Hydrocortisone sodium succinate

Iupac Name：4-[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoic acid

CAS No.: 125-04-2

Molecular Weight：462.539

Modify Date.: 2022-11-07 09:10

Introduction: Hydrocortisone sodium succinate is a derivative of the glucocorticoid Hydrocortisone (H714615). Hydrocortisone Hemisuccinate Sodium is used as an anti-inflammatory agent. Hydrocortisone sodium succinate is widely used in the treatment of asthma, endocrine disorders, dermatological disorders, allergic states, etc. View more+

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1. Names and Identifiers

1.1 Name: Hydrocortisone sodium succinate
1.2 Synonyms: (11b)-21-(3-Carboxy-1-oxopropoxy)-11,17-dihydroxypregn-4-ene-3,20-dione Monosodium Salt 11b,17a,21-trihydroxy-4-pregnene-3,20-dione 21-hemisuccinate sodium salt 11BETA,17ALPHA,21-TRIHYDROXY-4-PREGNENE-3,20-DIONE 21-HEMISUCCINATE SODIUM SALT 11BETA,17ALPHA,21-TRIHYDROXY-4-PREGNENE-3,20-DIONE 21-HEMISUCCINATE SODIUM-POTASSIUM SALT 4-{2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-diméthyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tétradécahydro-1H-cyclopenta[a]phénanthrén-17-yl]-2-oxoéthoxy}-4-oxobutanoate de sodium Buccalsone butanedioic acid, mono[(11Β)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl] ester, monosodium salt Butanedioic acid, mono[(11Β)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl] ester, sodium salt (1:1) Corlan EINECS 204-725-5 HYDROCORTISONE 21-HEMISUCCINATE SODIUM HYDROCORTISONE 21-HEMISUCCINATE SODIUM SALT Hydrocortisone 21-sodium succinate HYDROCORTISONE HEMISUCCINATE SODIUM SALT HYDROCORTISONE-HYDROGEN SUCCINATE SODIUM SALT Intracort MFCD00069472 Natrium-4-{2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy}-4-oxobutanoat Nordicort Pregn-4-ene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, monosodium salt, (11Β)- Saxizon Sodium 17-hydroxycorticosterone 21-succinate Sodium 4-{[(11Β)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl]oxy}-4-oxobutanoate sodium 4-{2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy}-4-oxobutanoate Solu-Glyc

1.3 CAS No.: 125-04-2

1.4 CID: 23694214

1.5 EINECS(EC#): 218-612-3; 204-725-5

1.6 Molecular Formula: C25H33NaO8 (isomer)

1.7 Inchi: InChI=1S/C25H34O8.Na/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30;/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30);/q;+1/p-1/t16-,17-,18-,22+,23-,24-,25-;/m0./s1

1.8 InChkey: HHZQLQREDATOBM-CODXZCKSSA-M

1.9 Canonical Smiles: CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)COC(=O)CCC(=O)[O-])O)C)O.[Na+]

1.10 Isomers Smiles: C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)COC(=O)CCC(=O)[O-])O)C)O.[Na+]

2. Properties

2.1 Melting point: 161-163°C

2.1 Boiling point: 685.5°Cat760mmHg

2.1 Flash Point: 231.1°C

2.1 Precise Quality: 484.20700

2.1 PSA: 141.03000

2.1 logP: 0.86260

2.1 Solubility: H2O: 50?mg/mL

2.2 Appearance: powder

2.3 Storage: ?20℃。

2.4 Water Solubility: H2O: 50?mg/mL

2.5 StorageTemp: ?20°C

3. Use and Manufacturing

3.1 GHS Classification: Signal: Warning
GHS Hazard Statements
Aggregated GHS information provided by 8 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria by 3 of 8 companies. For more detailed information, please visit ECHA C&L website

Of the 5 notification(s) provided by 5 of 8 companies with hazard statement code(s):

H302 (20%): Harmful if swallowed [Warning Acute toxicity, oral]
H312 (40%): Harmful in contact with skin [Warning Acute toxicity, dermal]
H315 (20%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (40%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H332 (20%): Harmful if inhaled [Warning Acute toxicity, inhalation]
H335 (20%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
H361 (60%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
H373 (20%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

Precautionary Statement Codes
P201, P202, P260, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P308+P313, P312, P314, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501

3.2 Usage: Hydrocortisone sodium succinate is a derivative of the glucocorticoid Hydrocortisone (H714615). Hydrocortisone Hemisuccinate Sodium is used as an anti-inflammatory agent. Hydrocortisone sodium succinate is widely used in the treatment of asthma, endocrine disorders, dermatological disorders, allergic states, etc.

4. Safety and Handling

4.1 RIDADR: NONH for all modes of transport

4.1 WGK Germany: 3

4.1 RTECS: GM9015000

4.1 Safety: Moderately toxic by intraperitoneal route. Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of Na2O. See also HYDROCORTISONE-21-ACETATE; HYDROCORTISONE-17-BUTYRATE; HYDROCORTISONE-17-BUTYRATE-21-PROPIONATE; HYDROCORTISONE-21-PHOSPHATE.

5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Not classified.

2.2 GHS label elements, including precautionary statements

Pictogram(s)	No symbol.
Signal word	No signal word.
Hazard statement(s)	none
Precautionary statement(s)
Prevention	none
Response	none
Storage	none
Disposal	none

2.3 Other hazards which do not result in classification

none

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6. NMR Spectrum

13C NMR : Predict

1H NMR : Predict

7. Other Information

7.0 Uses: Hydrocortisone sodium succinate is a derivative of the glucocorticoid Hydrocortisone (H714615). Hydrocortisone Hemisuccinate Sodium is used as an anti-inflammatory agent. Hydrocortisone sodium succinate is widely used in the treatment of asthma, endocrine disorders, dermatological disorders, allergic states, etc.

7.1 Uses: Hydrocortisone 21-hemisuccinate is a water-soluble form of the endogenous hormone cortisol. It can bind to glucocorticoid receptors, initiating the transcription of anti-inflammatory and immunosuppressive mediators and inhibiting proinflammatory cytokine activity (IC50 = 6.7 μM for IL-6). It is commonly used to supplement media for long-term epithelial or endothelial cell cultures and to differentiate pluripotent stem cells.

7.2 Uses: Hydrocortisone Hemisuccinate Sodium is a derivative of the glucocorticoid Hydrocortisone (H714615). Hydrocortisone Hemisuccinate Sodium is used as an anti-inflammatory agent. Hydrocortisone Hemisuccinate Sodium is widely used in the treatment of asthma, endocrine disorders, dermatological disorders, allergic states, etc.

7.3 Brand name: A-Hydrocort (Abbott); A-Hydrocort (Hospira); Solu-Cortef (Pharmacia & Upjohn).

7.4 General Description: Hydrocortisone for use in epithelial and endothelial adherent cell culture applications.

8. Computational chemical data

Molecular Weight: 462.539g/mol
Molecular Formula: C₂₅H₃₃NaO₈
Compound Is Canonicalized: True
XLogP3-AA: null
Exact Mass: 484.20731229
Monoisotopic Mass: 484.20731229
Complexity: 915
Rotatable Bond Count: 7
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 8
Topological Polar Surface Area: 141
Heavy Atom Count: 34
Defined Atom Stereocenter Count: 7
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Isotope Atom Count: 0
Covalently-Bonded Unit Count: 2
CACTVS Substructure Key Fingerprint: AAADcfB4PCAAAAAAAAAAAAAAAAAAAYAAAAAwYIAAAAAAAGDAAAAAGgAACAAAD1SggAICCAAABgCIAqDSCAIAAAAgAAAACAFAAEgAEBIAAQQCQAAFgAAIAQPLzPDPgAAAAAAAAADAAAYAADAAAYAADAAAAA==

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Hydrocortisone Hemisuccinate Sodium SaltCAS125-04-2