ISOPRINOSINE

Iupac Name：4-acetamidobenzoic acid;9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one;1-(dimethylamino)propan-2-ol

CAS No.: 36703-88-5

Molecular Weight：550.569

Modify Date.: 2022-12-08 12:20

Request For Quotation

1. Names and Identifiers

1.1 Name: ISOPRINOSINE
1.2 Synonyms: )(1:3) aviral delimmun imunovir inosine,compd.with1-(dimethylamino)-2-propanol4-(acetylamino)benzoate(salt inosinepranobex inosiplex

1.3 CAS No.: 36703-88-5

1.4 CID: 135449284

1.5 EINECS(EC#): 253-162-1

1.6 Molecular Formula: C24H34N6O9 (isomer)

1.7 Inchi: PBJNZCQJMWVIRT-WCYUCLFNNA-N

1.8 InChkey: PBJNZCQJMWVIRT-WCYUCLFNNA-N

1.9 Canonical Smiles: CC(O)CN(C)C.CC(=O)NC1=CC=C(C=C1)C(O)=O.OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1NC=NC2=O

1.10 Isomers Smiles: CC(O)CN(C)C.CC(=O)NC1=CC=C(C=C1)C(O)=O.OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1NC=NC2=O

2. Properties

2.1 Melting point: 140-142°C

2.1 StorageTemp: Inert atmosphere,Room Temperature

3. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Not classified.

2.2 GHS label elements, including precautionary statements

Pictogram(s)	No symbol.
Signal word	No signal word.
Hazard statement(s)	none
Precautionary statement(s)
Prevention	none
Response	none
Storage	none
Disposal	none

2.3 Other hazards which do not result in classification

none

View all

4. NMR Spectrum

13C NMR : Predict

1H NMR : Predict

5. Other Information

5.0 Merck: 14,4976

5.1 Description: ISOPRINOSINE (also known as inosine pranobex) an antiviral drug combing of inosine and dimepranol acedoben (a salt of acetamidobenzoic acid and dimethylaminoisopropanol) in a ratio of 1 to 3. It is mainly used for treating the rare measles complication subacute sclerosing panencephalitis in conjunction with intrathecal interferon therapy^1,2. In UK, it is also indicated for mucocutaneous infections due to herpes simplex virus (type 1 and type 2) and for treatment of genital warts as adjunctive therapy to podophyllin or carbon dioxide laser1. It also has certain efficacy in the treatment of AIDS and some other acquired immunodeficiency such as aged patients, cancer patients, severely burned patients, ill patients, and surgery patients³. Preclinical studies have demonstrated that isoprinosine can inhibit the growth of both DNA and RNA viruses as well as potentiate cell-mediated immune response both in vitro and in vivo^4,5.

5.2 Sources

https://en.wikipedia.org/wiki/Inosine_pranobex
Waldman, R. H., and R. Ganguly. "Therapeutic efficacy of inosiplex (Isoprinosine) in rhinovirus infection. " Annals of the New York Academy of Sciences 284.1(1977):153–160.
https://www.ncbi.nlm.nih.gov/pubmed/2446760
https://www.ncbi.nlm.nih.gov/pubmed/83189
https://www.drugbank.ca/drugs/DB13156

5.3 Chemical Properties: White Solid

5.4 Uses: Isoprinosine

5.5 Uses: Isoprinosine is a new combination of active substances for the treatment of chronic systemic diseases such as cancer. Isoprinosine is an immunomodulator; antiviral. The ratio is between 1: 2 : 2 to 1 : 3 : 3

5.6 Biological Activity: isoprinosine is a complex of acetaminobenzoic acid, dimethylaminoisopropanol, and inosine in a 3:3:1 ratio with immunomodulatory effects.immunotherapy is the treatment of disease by inducing, enhancing, or suppressing an immune response. immunomodulatory regimens usually have fewer side effects than existing drugs, such as less potential for creating resistance when treating microbial disease.

5.7 Clinical Use: Treatment of mucocutaneous herpes simplex, genital warts, subacute sclerosing panencephalitis

5.8 in vitro: previous study found that increasing concentrations of isoprinosine (50-400 μg/ml) could produce progressively growing inhibitory effect on hhv-1 replication. the combination of 1000 iu/ml ifn-α and isoprinosine could result in enhanced anti-hhv activity [1].

5.9 in vivo: previous study demonstrated the positive effect of isoprinosine treatment on persistent infection of balb/c mice with murine gammaherpesvirus 68. increased number of leukocytes, increased percentage of neutrophils, elevated levels of virus-neutralizing antibodies, reduced number of atypical lymphocytes and reduced virus titers were detected in the examined organs after a 14-day treatment. the positive effect of isoprinosine therapy vanished after 120-150 days [2].

5.10 Drug interactions: Potentially hazardous interactions with other drugs
None known

5.11 Metabolism: Hepatically metabolised. The major excretion product of the inosine moiety is uric acid, while the p-acetamidobenzoic acid and N,N-dimethylamino- 2-propanol components are excreted in the urine as glucuronidated and oxidised products, respectively, as well as being excreted unchanged

5.12 references: [1] majewska a, lasek w, janyst m, mynarczyk g. in vitro infibition of hhv-1 replication by inosine pranobex and interferon-α. acta pol pharm. 2016 may-jun;73(3):637-44.
[2] janíková o, anicová l, briestenská k, mistríková j. the effect of isoprinosine treatment on persistent infection of balb/c mice infected with murine gammaherpesvirus 68. acta virol. 2017;61(1):32-38. doi: 10.4149/av_2017_01_32.
[3] beran j, alapová e, pajdel m; isoprinosine study (ewo iso-2014/1) team. inosine pranobex is safe and effective for the treatment of subjects with confirmed acute respiratory viral infections: analysis and subgroup analysis from a phase 4, randomised, placebo-controlled, double-blind study. bmc infect dis. 2016 nov 7;16(1):648.

6. Computational chemical data

Molecular Weight: 550.569g/mol
Molecular Formula: C₂₄H₃₄N₆O₉
Compound Is Canonicalized: True
XLogP3-AA: null
Exact Mass: 1114.55464106
Monoisotopic Mass: 1114.55464106
Complexity: 658
Rotatable Bond Count: 14
Hydrogen Bond Donor Count: 13
Hydrogen Bond Acceptor Count: 22
Topological Polar Surface Area: 399
Heavy Atom Count: 79
Defined Atom Stereocenter Count: 4
Undefined Atom Stereocenter Count: 3
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Isotope Atom Count: 0
Covalently-Bonded Unit Count: 7
CACTVS Substructure Key Fingerprint: AAADcfB//gAAAAAAAAAAAAAAAAAAAWJAAAAwYMEAAAAAAEAB1AAAHgAQCAAADBzhngY3+JfMFgCoAyfzfACCgC03EqAJ2IGofMiLfjrA3bGecYhv1gPb2ef4+SOeCAAAAAAAAAAQAAAAAAAAAAAAAAAAAA==

7. Recommended Suppliers

Global144SuppliersView all >>

Jilin Tely Imp & Exp Co., Ltd Diamond member

4YRS

Products:Pharmaceutical raw materials,Chemical reagent, Food aditives,Plant ExtracPharmaceutical and pesticide intermediates.
Tel:86-431-81915458
Email:cathytan@jltely.com

Low price SOPRINOSINE

Purity:99%Packing: 200kg/bag FOB
Price: 1 USD/gram
Time: 2023/03/23

Inquire

Hebei Chengcai Biotechnology Co., LTD Diamond member

1YR

Products:We are engaged in the development, marketing and sales of apis, intermediates, natural products (extracts), fine chemicals, food additives, agricultural chemicals and other products.
Tel:0086-0319-19131200228
Email:17610795226@chengcaibio.com

Factory supplier high purity CAS 36703-88-5 Isoprinosine

Purity:99%Packing: 200kg/bag FOB
Price: 100 USD/kg
Time: 2023/03/23

Inquire

Hebei Bester Biotechnology Co., Ltd. Diamond member

1YR

Products:pmk powder ;pmk oil ;bmk powder ;bmk oil ;Protonitazene hcl ; Bromazolam ; Metonitazene; 2-Bromo-4'-methylpropiophenone ;
Tel:+86-181-32213264
Email:anna@chbbest.com

99% Purity CAS 36703-88-5 Inosine Pranobex Material Inosine Pranobex Powder Inosine Pranobex

Purity:99%Packing: 200kg/bag FOB
Price: 23 USD/kg
Time: 2023/03/23

Inquire

Henan Yuanlong Biotechnology Co.,Ltd. Diamond member

1YR

Products:PMK ethyl glycidate,28578-16-7 ,bmk,5449-12-7,71368-80-4,bromazolam
Tel:0371-2223354-+86
Email:henan1@yuanlongbio.com

Immunomodulatory drug Isoprinosine CAS 36703-88-5 The factory offers the lowest price

Purity:99%Packing: 200kg/bag FOB
Price: 10 USD/kg
Time: 2023/03/23

Inquire

Hebei Yingong New Material Technology Co.,Ltd. Diamond member

2YRS

Products:xylazine hcl,phenacetin,4-Methylpropiophenone,(2-Bromoethyl)benzene,4-Methoxybenzoyl chloride
Tel:86-311-19930599843
Email:cindy@hbyingong.com

Immunomodulatory drug Isoprinosine CAS 36703-88-5 with big discount

Purity:99%Packing: 200kg/bag FOB
Price: 15 USD/gram
Time: 2023/03/23

Inquire

Recently Updated : 2248859-24-5 1906970-49-7 461697-96-1 2248664-06-2 1906971-15-0 2760218-96-8 2677877-13-1 2595048-93-2 2055156-76-6 2817710-48-6