J 147
- Iupac Name：N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N-[(E)-(3-methoxyphenyl)methylideneamino]acetamide
- CAS No.: 1146963-51-0
- Molecular Weight：350.341
- Modify Date.: 2022-11-01 08:55
- Introduction: J 147 is a novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. J 147 is an exceptionally potent, orally active and broadly neuroprotective compound has the ability to enhance memory in normal animals as well as to prevent memory deficits in Alzheimer's disease (AD) transgenic mice. The neurotrophic and memory-enhancing activities of J147 are associated with an increase in brain derived neurotrophic factor (BDNF) levels and the expression of BDNF responsive proteins, the enhancement of LTP, the preservation of synaptic protein, the reduction of amyloid plaques. J 147Supplier
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1. Names and Identifiers
- 1.1 Name
- J 147
- 1.2 Synonyms
2,2,2-Trifluoroacetic acid 1-(2,4-DiMethylphenyl)-2-[(3-Methoxyphenyl)Methylene]hydrazide CS-1446 J 147 2,2,2-Trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide J147/J-147 Nootropic J147
- 1.3 CAS No.
- 1146963-51-0
- 1.4 CID
- 25229652
- 1.5 Molecular Formula
- C18H17F3N2O2 (isomer)
- 1.6 Inchi
- InChI=1S/C18H17F3N2O2/c1-12-7-8-16(13(2)9-12)23(17(24)18(19,20)21)22-11-14-5-4-6-15(10-14)25-3/h4-11H,1-3H3/b22-11+
- 1.7 InChIkey
- HYMZAYGFKNNHDN-SSDVNMTOSA-N
- 1.8 Canonical Smiles
- CC1=CC(=C(C=C1)N(C(=O)C(F)(F)F)N=CC2=CC(=CC=C2)OC)C
- 1.9 Isomers Smiles
- CC1=CC(=C(C=C1)N(C(=O)C(F)(F)F)/N=C/C2=CC(=CC=C2)OC)C
2. Properties
- 2.1 Density
- 1.18±0.1 g/cm3(Predicted)
- 2.1 Boiling point
- 412.8±55.0 °C(Predicted)
- 2.1 Refractive index
- 1.515
- 2.1 Flash Point
- 203.5±31.5 °C
- 2.1 PSA
- 41.90000
- 2.1 logP
- 4.24140
- 2.1 Solubility
- Insuluble (9.8E-4 g/L) (25 oC),
- 2.2 pKa
- 0.80±0.50(Predicted)
3. Use and Manufacturing
- 3.1 Usage
- J 147 is a novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. J 147 is an exceptionally potent, orally active and broadly neuroprotective compound has the ability to enhance memory in normal animals as well as to prevent memory deficits in Alzheimer's disease (AD) transgenic mice. The neurotrophic and memory-enhancing activities of J147 are associated with an increase in brain derived neurotrophic factor (BDNF) levels and the expression of BDNF responsive proteins, the enhancement of LTP, the preservation of synaptic protein, the reduction of amyloid plaques. J 147Supplier
4. MSDS
2.Hazard identification
2.1 Classification of the substance or mixture
no data available
2.2 GHS label elements, including precautionary statements
| Pictogram(s) | no data available |
| Signal word | no data available |
| Hazard statement(s) | no data available |
| Precautionary statement(s) | |
| Prevention | no data available |
| Response | no data available |
| Storage | no data available |
| Disposal | no data available |
2.3 Other hazards which do not result in classification
no data available
5. Synthesis Route
1146963-51-0Total: 2 Synthesis Route
7. Other Information
- 7.0 Uses
- J 147 is a novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. J 147 is an exceptionally potent, orally active and broadly neuroprotective compound has the ability to enhance memory in normal animals as well as to prevent memory deficits in Alzheimer's disease (AD) transgenic mice. The neurotrophic and memory-enhancing activities of J147 are associated with an increase in brain derived neurotrophic factor (BDNF) levels and the expression of BDNF responsive proteins, the enhancement of LTP, the preservation of synaptic protein, the reduction of amyloid plaques.
8. Computational chemical data
- Molecular Weight: 350.341g/mol
- Molecular Formula: C18H17F3N2O2
- Compound Is Canonicalized: True
- XLogP3-AA: 4.7
- Exact Mass: 350.12421228
- Monoisotopic Mass: 350.12421228
- Complexity: 481
- Rotatable Bond Count: 4
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 6
- Topological Polar Surface Area: 41.9
- Heavy Atom Count: 25
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count: 0
- Defined Bond Stereocenter Count: 1
- Undefined Bond Stereocenter Count: 0
- Isotope Atom Count: 0
- Covalently-Bonded Unit Count: 1
- CACTVS Substructure Key Fingerprint: AAADceB7MYAAAAAAAAAAAAAAAAAAAAAAAAAwYAAAAAAAAAABQAAAHwAIAAAADAzBmBYyxoIABACoAjVzUACSDAAhIgAaiAAmbJgMJqLEsZuEMChkzBHI6AeQwFAOCAADAAACAAAQAAYAAAQAAAAAAAAAAA==
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J147
- Purity:99%Packing: 200kg/bag FOB
- Price: 11800 USD/kg
- Time: 2023/08/28
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