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Home> Encyclopedia >Pharmaceutical Intermediates>Pharmaceutical>Organic Intermediate
J 147 structure
J 147 structure

J 147

Iupac Name:N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N-[(E)-(3-methoxyphenyl)methylideneamino]acetamide
CAS No.: 1146963-51-0
Molecular Weight:350.341
Modify Date.: 2022-11-01 08:55
Introduction: J 147 is a novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. J 147 is an exceptionally potent, orally active and broadly neuroprotective compound has the ability to enhance memory in normal animals as well as to prevent memory deficits in Alzheimer's disease (AD) transgenic mice. The neurotrophic and memory-enhancing activities of J147 are associated with an increase in brain derived neurotrophic factor (BDNF) levels and the expression of BDNF responsive proteins, the enhancement of LTP, the preservation of synaptic protein, the reduction of amyloid plaques. J 147Supplier View more+
1. Names and Identifiers
1.1 Name
J 147
1.2 Synonyms

2,2,2-Trifluoroacetic acid 1-(2,4-DiMethylphenyl)-2-[(3-Methoxyphenyl)Methylene]hydrazide CS-1446 J 147 2,2,2-Trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide J147/J-147 Nootropic J147

1.3 CAS No.
1146963-51-0
1.4 CID
25229652
1.5 Molecular Formula
C18H17F3N2O2 (isomer)
1.6 Inchi
InChI=1S/C18H17F3N2O2/c1-12-7-8-16(13(2)9-12)23(17(24)18(19,20)21)22-11-14-5-4-6-15(10-14)25-3/h4-11H,1-3H3/b22-11+
1.7 InChIkey
HYMZAYGFKNNHDN-SSDVNMTOSA-N
1.8 Canonical Smiles
CC1=CC(=C(C=C1)N(C(=O)C(F)(F)F)N=CC2=CC(=CC=C2)OC)C
1.9 Isomers Smiles
CC1=CC(=C(C=C1)N(C(=O)C(F)(F)F)/N=C/C2=CC(=CC=C2)OC)C
2. Properties
2.1 Density
1.18±0.1 g/cm3(Predicted)
2.1 Boiling point
412.8±55.0 °C(Predicted)
2.1 Refractive index
1.515
2.1 Flash Point
203.5±31.5 °C
2.1 PSA
41.90000
2.1 logP
4.24140
2.1 Solubility
Insuluble (9.8E-4 g/L) (25 oC),
2.2 pKa
0.80±0.50(Predicted)
3. Use and Manufacturing
3.1 Usage
J 147 is a novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. J 147 is an exceptionally potent, orally active and broadly neuroprotective compound has the ability to enhance memory in normal animals as well as to prevent memory deficits in Alzheimer's disease (AD) transgenic mice. The neurotrophic and memory-enhancing activities of J147 are associated with an increase in brain derived neurotrophic factor (BDNF) levels and the expression of BDNF responsive proteins, the enhancement of LTP, the preservation of synaptic protein, the reduction of amyloid plaques. J 147Supplier
4. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

no data available

2.2 GHS label elements, including precautionary statements

Pictogram(s) no data available
Signal word

no data available

Hazard statement(s)

no data available

Precautionary statement(s)
Prevention

no data available

Response

no data available

Storage

no data available

Disposal

no data available

2.3 Other hazards which do not result in classification

no data available

6. Precursor and Product
7. Other Information
7.0 Uses
J 147 is a novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. J 147 is an exceptionally potent, orally active and broadly neuroprotective compound has the ability to enhance memory in normal animals as well as to prevent memory deficits in Alzheimer's disease (AD) transgenic mice. The neurotrophic and memory-enhancing activities of J147 are associated with an increase in brain derived neurotrophic factor (BDNF) levels and the expression of BDNF responsive proteins, the enhancement of LTP, the preservation of synaptic protein, the reduction of amyloid plaques.
8. Computational chemical data
  • Molecular Weight: 350.341g/mol
  • Molecular Formula: C18H17F3N2O2
  • Compound Is Canonicalized: True
  • XLogP3-AA: 4.7
  • Exact Mass: 350.12421228
  • Monoisotopic Mass: 350.12421228
  • Complexity: 481
  • Rotatable Bond Count: 4
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 6
  • Topological Polar Surface Area: 41.9
  • Heavy Atom Count: 25
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count: 0
  • Defined Bond Stereocenter Count: 1
  • Undefined Bond Stereocenter Count: 0
  • Isotope Atom Count: 0
  • Covalently-Bonded Unit Count: 1
  • CACTVS Substructure Key Fingerprint: AAADceB7MYAAAAAAAAAAAAAAAAAAAAAAAAAwYAAAAAAAAAABQAAAHwAIAAAADAzBmBYyxoIABACoAjVzUACSDAAhIgAaiAAmbJgMJqLEsZuEMChkzBHI6AeQwFAOCAADAAACAAAQAAYAAAQAAAAAAAAAAA==
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10. Realated Product Infomation