JERVINE

(2′R,3S,3′R,3′aS,6′S,6aS,6bS,7′aR,11aS,11bR)-2,3,3′a,4,4′,5′,6,6′,6a,6b,7,7′,7′a,8,11a,11b-Hexadecahydro-3-hydroxy-3′,6′,10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2′(3′H)-furo[3,2-b]pyridin]-11(1H)-one Jervin Jervine(8CI) NSC 23898 NSC 7520 Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-,[3S-(3a,6aa,6bb,9a(3'S*,3'aR*,6'R*,7'aS*),11ab,11ba)]- Spiro[9H-benzo[a]fluorene-9,2′(3′H)-furo[3,2-b]pyridin]-11(1H)-one, 2,3,3′a,4,4′,5′,6,6′,6a,6b,7,7′,7′a,8,11a,11b-hexadecahydro-3-hydroxy-3′,6′,10,11b-tetramethyl-, (2′R,3S,3′R,3′aS,6′S,6aS,6bS,7′aR,11aS,11bR)- Spiro[9H-benzo[a]fluorene-9,2′(3′H)-furo[3,2-b]pyridin]-11(1H)-one, 2,3,3′a,4,4′,5′,6,6′,6a,6b,7,7′,7′a,8,11a,11b-hexadecahydro-3-hydroxy-3′,6′,10,11b-tetramethyl-, [3S-(3α,6aα,6bβ,9α(3′S*,3′aR*,6′R*,7′aS*),11aβ,11bα)]- Veratraman-11-one, 17,23-epoxy-3-hydroxy-, (3b,23b)- Veratraman-11-one, 17,23-epoxy-3-hydroxy-, (3β,23β)-

1.Removal in wastewater treatment of Jervine (CAS NO.469-59-0):
Total removal:23.33  percent
Total biodegradation:0.27  percent
Total sludge adsorption:23.06  percent
Total to air:0.00  percent
(using 10000 hr Bio P,A,S)
2.Physiological effects
 Jervine (CAS NO.469-59-0) is a potent teratogen causing birth defects in vertebrates. In severe cases it can cause cyclopia and holoprosencephaly. Similar to cyclopamine, which also occurs in the veratrum genus, it is a teratogen implicated in birth defects when consumed by animals during a certain period of their gestation.
3.Mechanism of action
 The biological activity of  Jervine (CAS NO.469-59-0) is mediated via its interaction with the 7 pass trans membrane protein smoothened. Jervine binds with and inhibits smoothened, when smoothened inhibited, the GLI1 trancription cannot be activated and hedgehog target genes cannot be transcribed.