Metandienone

(17b)-17-Hydroxy-17-methylandrosta-1,4-dien-3-one (17Β)-17-Hydroxy-17-methylandrosta-1,4-dien-3-one (8α,9β,17α)-17-Hydroxy-17-methylandrosta-1,4-dien-3-one 1,2-Dimethoxyethane (test Methandienone, 1.0 )mg/mL 1,4-Androstadien-17a-Methyl-17-ol-3-one-2,4,6a-d3 1,4-Androstadien-17a-Methyl-17-ol-3-one-d3 17a-Methyl-17b-hydroxyandrosta-1,4-dien-3-one 17-Β-hydroxy-17-methyl-androsta-1,4-dien-3-one 17-Β-hydroxy-17-methyl-androsta-1,4-dien-3-one (9CI) 1-Dehydro-17a-methyltestosterone 1-Dehydro-17α-methyltestosterone Androsta-1,4-dien-3-one, 17-hydroxy-17-methyl-, (17Β)- Androsta-1,4-dien-3-one, 17-hydroxy-17-methyl-, (8α,9β,17α)- Androsta-1,4-dien-3-one, 17Β-hydroxy-17-methyl- Androsta-1,4-dien-3-one, 17Β-hydroxy-17α-methyl- Dianabol Tablet EINECS 200-787-2 Metandienone (Dianabol) Tablet Methandienone Methandienone/Methandrostenolone / DBOL(Dianabol ) Methandrostenolone Methandrostenolone 1-Dehydro-17alpha-methyltestosterone Dianabol Methandienone Methandrostenolone/Dianabol/Methandienone MFCD00003650 Nabolin

The IUPAC name of?Metandienone is?(8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13,17-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one. With the?CAS registry number 72-63-9, it is also named as?1,2-Dehydro-17-methyltestosterone.?The product's categories are?biochemistry; hydroxyketosteroids; steroids. It is?white to off-white crystalline powder?which is almost insoluble in water, soluble in alcohol and?chloroform, and slightly soluble in ether. Additionally,?Metandienone can be obtained by?Sisal sapogenin.?When heated to decomposition it emits acrid smoke and irritating fumes.

The other characteristics of this product can be summarized as:?(1)ACD/LogP: 4.04; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 4.04; (4)ACD/LogD (pH 7.4): 4.04; (5)ACD/BCF (pH 5.5): 691.04; (6)ACD/BCF (pH 7.4): 691.04; (7)ACD/KOC (pH 5.5): 3750.76; (8)ACD/KOC (pH 7.4): 3750.76; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 1; (12)Index of Refraction: 1.572; (13)Molar Refractivity: 87.68 cm³; (14)Molar Volume: 266.3 cm³; (15)Polarizability: 34.76×10^-24 cm³; (16)Surface Tension: 44.9 dyne/cm; (17)Enthalpy of Vaporization: 80 kJ/mol; (18)Vapour Pressure: 1.87E-09 mmHg at 25°C; (19)Tautomer Count: 3; (20)Exact Mass: 300.20893; (21)MonoIsotopic Mass: 300.20893; (22)Topological Polar Surface Area: 37.3; (23)Heavy Atom Count: 22; (24)Complexity: 589.

Uses of Metandienone: It?is?androgen, assimilation hormone metandienone which is used for treatment of chronic wasting disease, stunted children, osteoporosis, hyperlipidemia?and negative nitrogen balance which is cauded by severe infection, burns, etc.

People can use the following data to convert to the molecule structure.
1. SMILES:O=C\1\C=C/[C@]4(/C(=C/1)CC[C@@H]3[C@@H]4CC[C@]2([C@H]3CC[C@@]2(O)C)C)C
2. InChI:InChI=1/C20H28O2/c1-18-9-6-14(21)12-13(18)4-5-15-16(18)7-10-19(2)17(15)8-11-20(19,3)22/h6,9,12,15-17,22H,4-5,7-8,10-11H2,1-3H3/t15-,16+,17+,18+,19+,20+/m1/s1

The following are the toxicity data which has been tested.

The IUPAC name of?Metandienone is?(8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13,17-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one. With the?CAS registry number 72-63-9, it is also named as?1,2-Dehydro-17-methyltestosterone.?The product's categories are?biochemistry; hydroxyketosteroids; steroids. It is?white to off-white crystalline powder?which is almost insoluble in water, soluble in alcohol and?chloroform, and slightly soluble in ether. Additionally,?Metandienone can be obtained by?Sisal sapogenin.?When heated to decomposition it emits acrid smoke and irritating fumes.

The other characteristics of this product can be summarized as:?(1)ACD/LogP: 4.04; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 4.04; (4)ACD/LogD (pH 7.4): 4.04; (5)ACD/BCF (pH 5.5): 691.04; (6)ACD/BCF (pH 7.4): 691.04; (7)ACD/KOC (pH 5.5): 3750.76; (8)ACD/KOC (pH 7.4): 3750.76; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 1; (12)Index of Refraction: 1.572; (13)Molar Refractivity: 87.68 cm³; (14)Molar Volume: 266.3 cm³; (15)Polarizability: 34.76×10^-24 cm³; (16)Surface Tension: 44.9 dyne/cm; (17)Enthalpy of Vaporization: 80 kJ/mol; (18)Vapour Pressure: 1.87E-09 mmHg at 25°C; (19)Tautomer Count: 3; (20)Exact Mass: 300.20893; (21)MonoIsotopic Mass: 300.20893; (22)Topological Polar Surface Area: 37.3; (23)Heavy Atom Count: 22; (24)Complexity: 589.

Uses of Metandienone: It?is?androgen, assimilation hormone metandienone which is used for treatment of chronic wasting disease, stunted children, osteoporosis, hyperlipidemia?and negative nitrogen balance which is cauded by severe infection, burns, etc.

People can use the following data to convert to the molecule structure.
1. SMILES:O=C\1\C=C/[C@]4(/C(=C/1)CC[C@@H]3[C@@H]4CC[C@]2([C@H]3CC[C@@]2(O)C)C)C
2. InChI:InChI=1/C20H28O2/c1-18-9-6-14(21)12-13(18)4-5-15-16(18)7-10-19(2)17(15)8-11-20(19,3)22/h6,9,12,15-17,22H,4-5,7-8,10-11H2,1-3H3/t15-,16+,17+,18+,19+,20+/m1/s1

The following are the toxicity data which has been tested.

CHEMICAL IDENTIFICATION

RTECS NUMBER :

BV8000000

CHEMICAL NAME :

Androsta-1,4-dien-3-one, 17-beta-hydroxy-17-alpha-methyl-

CAS REGISTRY NUMBER :

72-63-9

LAST UPDATED :

199504

WISWESSER LINE NOTATION :

L E5 B666 OV AHTTT&J A1 E1 FQ F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>1 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

425 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - man

DOSE/DURATION :

561 mg/kg/7Y-C

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

13 mg/kg

SEX/DURATION :

male 60 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

200 mg/kg

SEX/DURATION :

female 10 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

200 mg/kg

SEX/DURATION :

male 10 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - other effects on male

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

7 mg/kg

SEX/DURATION :

female 14 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Fertility - other measures of fertility

MUTATION DATA

TEST SYSTEM :

Rodent - mouse

DOSE/DURATION :

200 mg/kg/10D (Intermittent)

REFERENCE :

VPITAR Voprosy Pitaniya. Problems of Nutrition. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1932-41; V.11- 1952- Volume(issue)/page/year: 38(4),63,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5642 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 157 (estimated) No. of Female Employees: 72 (estimated)