Methylamine hydrochloride
- Iupac Name：methanamine;hydrochloride
- CAS No.: 593-51-1
- Molecular Weight：67.52
- Modify Date.: 2022-12-06 15:15
1. Names and Identifiers
- 1.1 Name
- Methylamine hydrochloride
- 1.2 Synonyms
CH3NH3Cl(MACl) MERCURIALIN HYDROCHLORIDE Methylamine-hydrogenchloride(1/1) MONOMETHYLAMINE HYDROCHLORIDE
- 1.3 CAS No.
- 593-51-1
- 1.4 EINECS(EC#)
- 209-795-0
- 1.5 Molecular Formula
- CH5N.ClH (isomer)
- 1.6 Inchi
- InChI=1S/CH5N.ClH/c1-2;/h2H2,1H3;1H
- 1.7 InChIkey
- NQMRYBIKMRVZLB-UHFFFAOYSA-N
- 1.8 Canonical Smiles
- Cl[H].CN
- 1.9 Isomers Smiles
- CN.Cl
2. Properties
- 2.1 Density
- 0.8306 (rough estimate)
- 2.1 Melting point
- 231-233?°C(lit.)
- 2.1 Boiling point
- 225-230?°C15?mm Hg(lit.)
- 2.1 Flash Point
- 225-230°C/15mm
- 2.1 StorageTemp
- Store below +30°C.
3. Safety and Handling
- 3.1 Hazard Codes
- Xn
- 3.1 Risk Statements
- 22-36/37/38
- 3.1 Safety Statements
- 26-37/39
- 3.1 WGK Germany
- 1
- 3.1 RTECS
- PA0603000
4. MSDS
2.Hazard identification
2.1 Classification of the substance or mixture
Acute toxicity - Oral, Category 4
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |  |
| Signal word | Warning |
| Hazard statement(s) | H302 Harmful if swallowed |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. |
| Response | P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/\u2026if you feel unwell. P330 Rinse mouth. |
| Storage | none |
| Disposal | P501 Dispose of contents/container to ... |
2.3 Other hazards which do not result in classification
none
6. Synthesis Route
593-51-1Total: 65 Synthesis Route
8. Other Information
- 8.0 Merck
- 14,6014
- 8.1 BRN
- 3588822
- 8.2 Chemical Properties
- white to light tan solid
- 8.3 Uses
- Methylamine is used as a building block for the synthesis of other organic compounds. It is on the DEA watchlist for chemical precursors because of clandestine use in manufacture of the drug MDMA (ecstasy) and methamphetamine.
The HCl salt is in the form of white deliquescent crystals, and is frequently substitutable for the aq. soln. in many synthesis preparations. Methylamines are used directly as catalysts or as raw materials to produce other compounds with catalytic activity. Fuel additives are used to improve engine performance in a variety of ways. Trimethylamine is used to make paper chemicals. The manufacture of intermediates to make pharmaceuticals is one of the most diverse uses of methylamines.
- 8.4 Preparation
- Methylamine hydrochloride is prepared by heating a mixture of aqueous formaldehyde and ammonium chloride; the residual water and the formic acid produced in the reaction are removed via vacuum distillation. This leaves behind solid methylamine hydrochloride. The solid is then purified by organic extractions and additional vacuum distillations. Methylamine gas for the reaction with P2P is generated in situ by heating the hydrochloride salt with sodium hydroxide. Alternatively, methylamine can be liberated from the hydrochloride with base and collected in a cold finger or flask immersed in a dry ice bath.
- 8.5 Definition
- ChEBI: The hydrochloride formed from methylamine.
- 8.6 Purification Methods
- Crystallise the salt from n-butanol, absolute EtOH or MeOH/CHCl3. Wash it with CHCl3 to remove traces of dimethylamine hydrochloride. Dry it under vacuum first with H2SO4 then P2O5. It is deliquescent; store it in a desiccator over P2O5. [Beilstein 4 IV 122.]
9. Question & Answer
-
Methylamine hydrochloride, also known as Methylamine hydrochloride, is a white crystalline powder. It is soluble in water and ethanol, insoluble in ether, acetone, and chloroform. It is hygroscopic an..
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Methylamine is an organic compound with a formula of CH3NH2. This colorless gas is a derivative of ammonia, but with one hydrogen atom being replaced by a methyl group. It is the simplest primary amin..
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Overview[1] Methylamine hydrochloride, also known as Methylamine hydrochloride, is a colorless plate-like crystal. It is soluble in water and ethanol, but insoluble in ether, acetone, and chloroform. ..
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Methylamine, with the chemical formula CH3NH2, is an organic compound that is derived from ammonia by replacing one hydrogen atom with a methyl group. This primary amine is widely used in the producti..
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11. Realated Product Infomation
![METHYLAMINE HYDROCHLORIDE, [14C]](https://structimg.guidechem.com/11/23/345502.png)
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