3D Mol Similar

MK-677

: Iupac Name：2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide;methanesulfonic acid; CAS No.: 159752-10-0; Molecular Weight：624.7692; Modify Date.: 2022-10-26 20:08; Introduction: MK-677(also known as ibutamoren),promotes the secretion of the growth hormone (GH)andincreases insulin-like growth factor 1 (IGF-1). Ibutamoren increases growth hormone levels by mimicking the action of the hormoneghrelinand binding to one of the ghrelin receptors (GHSR) in the brain. Activated GHSR stimulates growth hormone release from the brain. Clinical studies describe only the effects ibutamoren has onappetite and as expected, like ghrelin, ibutamoren increases it. GHSR is found in brain regions that control appetite, pleasure, mood, biological rhythms, memory, and cognition. View more+

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1. Names and Identifiers

: 1.1 Name; MK-677; 1.2 Synonyms; 1'-(2-Methylalanyl-O-benzyl-D-seryl)-1-(methylsulfonyl)-1,2-dihydrospiro[indole-3,4'-piperidine] methanesulfonate (1:1) 2-Amino-N-[(1R)-2-[1,2-dihydro-1-(methylsulfonyl)spiro[3H-indole-3,4'-piperidin]-1'-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methylpropanamide methanesulfonate CRESCENDO CS-1402 Ibutamoren Ibutamoren (Mesylate) Ibutamoren mesilate Ibutamoren mesylate Ibutamoren mesylate (USAN) MK 0677 MK 677 MK-0667 MK0677 MK-0677 MK677 MK677 MK 677 IBUTAMOREN mk677 mk 677 Ibutamoren,whnohe_lucy(at)163.com MK677 POWDER MK677（Ibutamoren Mesylate） MK677,Mk677 Propanamide, 2-amino-N-[(1R)-2-[1,2-dihydro-1-(methylsulfonyl)spiro[3H-indole-3,4'-piperidin]-1'-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methyl-, methanesulfonate (1:1) S1151_Selleck UNII-R90JB6QJ2B; View all

1.3 CAS No.: 159752-10-0

1.4 CID: 6450830

1.5 EINECS(EC#): 1308068-626-2

1.6 Molecular Formula: C28H40N4O8S2 (isomer)

1.7 Inchi: InChI=1S/C27H36N4O5S.CH4O3S/c1-26(2,28)25(33)29-22(18-36-17-20-9-5-4-6-10-20)24(32)30-15-13-27(14-16-30)19-31(37(3,34)35)23-12-8-7-11-21(23)27;1-5(2,3)4/h4-12,22H,13-19,28H2,1-3H3,(H,29,33);1H3,(H,2,3,4)/t22-;/m1./s1

1.8 InChIkey: DUGMCDWNXXFHDE-VZYDHVRKSA-N

1.9 Canonical Smiles: CC(C)(C(=O)NC(COCC1=CC=CC=C1)C(=O)N2CCC3(CC2)CN(C4=CC=CC=C34)S(=O)(=O)C)N.CS(=O)(=O)O

1.10 Isomers Smiles: CC(C)(C(=O)N[C@H](COCC1=CC=CC=C1)C(=O)N2CCC3(CC2)CN(C4=CC=CC=C34)S(=O)(=O)C)N.CS(=O)(=O)O

2. Properties

2.1 Boiling point: 868.9°C at 760 mmHg

2.1 Flash Point: 479.3°C

2.1 Precise Quality: 624.228760

2.1 PSA: 196.66000

2.1 logP: 4.97440

2.1 Solubility: H2O: soluble5mg/mL, clear

2.2 Appearance: white to beige

2.3 Storage: 2-8°C

2.4 Color/Form: white to beige

2.5 Water Solubility: H2O: soluble5mg/mL, clear

2.6 StorageTemp: 2-8°C

3. Use and Manufacturing

3.1 Usage: Growthhormone releasing factor.MK-677 is a potent, non-peptide ghrelin receptor agonist. MK-677Supplier

4. Safety and Handling

4.1 RIDADR: NONH for all modes of transport

4.1 WGK Germany: 3

4.1 RTECS: TX1404490

5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

no data available

2.2 GHS label elements, including precautionary statements

Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Precautionary statement(s)
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

2.3 Other hazards which do not result in classification

no data available

View all

6. Other Information

6.0 Uses: Growth hormone releasing factor.

6.1 体内研究: Ibutamoren mesylate (5 mg/kg/day) results in a statistically significant increases body weight gain and increases serum IGF-1 and GH levels in dogs. Ibutamoren mesylate results in no significant increase in CSF IGF-1 or GH levels on days 7 or 15 of the study. Pretreating mice with GH blocks activation of these neurons by Ibutamoren mesylate (50 μg, i.p.). In the knockout mice, both GH and octreotide fail to inhibit Ibutamoren mesylate activation of arcuate neurons. Chronic oral administration of MK-0677 is associated with significant increases in GH and IGF-I levels that are maintained for the duration of the treatment. The GH profile following MK-0677 administration consists of episodic increases above control. MK-0677 significantly increases peak GH concentrations after oral administration. MK-0677 is a potent GH secretagogue that induces an immediate, large, long lasting increase in GH levels when administered orally or i.v.

6.2 Description: MK-677 (also known as ibutamoren), promotes the secretion of the growth hormone (GH) and increases insulin-like growth factor 1 (IGF-1). Ibutamoren increases growth hormone levels by mimicking the action of the hormone ghrelin and binding to one of the ghrelin receptors (GHSR) in the brain. Activated GHSR stimulates growth hormone release from the brain. Clinical studies describe only the effects ibutamoren has on appetite and as expected, like ghrelin, ibutamoren increases it. GHSR is found in brain regions that control appetite, pleasure, mood, biological rhythms, memory, and cognition.

6.3 Benefits: The benefits of MK-677 include muscle-building, a reduction in muscle wasting, better bone density, improved sleep, and anti-aging properties. It may also have nootropic effects and it can be beneficial in treating growth hormone deficiencies. Read on for a more in-depth look at these benefits.

6.4 Uses: Growth hormone releasing factor.MK-677 is a potent, non-peptide ghrelin receptor agonist.

6.5 Biochem/physiol Actions: It is also known as ibutamoren mesylate. MK-677 is a mimic of growth hormone (GH)-releasing peptide and is orally active.

7. Computational chemical data

Molecular Weight: 624.7692g/mol
Molecular Formula: C₂₈H₄₀N₄O₈S₂
Compound Is Canonicalized: True
XLogP3-AA: null
Exact Mass: 624.22875659
Monoisotopic Mass: 624.22875659
Complexity: 1010
Rotatable Bond Count: 8
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 10
Topological Polar Surface Area: 193
Heavy Atom Count: 42
Defined Atom Stereocenter Count: 1
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Isotope Atom Count: 0
Covalently-Bonded Unit Count: 2
CACTVS Substructure Key Fingerprint: AAADcfB7vABgAAAAAAAAAAAAAAAAAWAAAAA8YIAAAAAAAFgBQAAAHgQQSAAADqjhmAaywIPABIKIAiVSUHCCAAAhAgAIiIGIbIgKZibAsbmXMAhm9gHY6AeQwOAPgAAAAAACAAAAAAAAAAQAAAAAAAAAAA==

8. Question & Answer

What is MK-677 and how does it work? Jun 03 2023
MK-677, also known as Ibutamoren Mesylate, is a white or grayish-white solid powder that is an effective non-peptide growth hormone secretagogue receptor (GHSR) agonist. It is a selective androgen rec..
Is the medicinal value of MK-677 high? Mar 27 2023
The medicinal value of MK-677 is a key focus for us, as this product has outstanding biological activity. When purchasing the product, it is important to understand its safety performance and basic ph..
What Does Mk 677 Do? Everything You Need to Know About Ibutamoren Feb 25 2022
If you're curious about the effects of Mk 677, you've come to the right place. This post covers all the essential information about Ibutamoren, including its composition, benefits, dosage, and side ef..
Benefits of MK-677 Feb 21 2021
MK-677, otherwise known as Ibutamoren Mesylate, works in the body by binding to GHSR receptors in the brain. These receptors are associated with several functions, including mood, appetite, homeostasi..

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