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Home> Encyclopedia >   /  Pharmaceutical Intermediates  /  Pharmaceutical  /  Hormones and synthetic substitutes  /  Organic Intermediate  /  Laboratory Chemicals
MK-677 structure
MK-677 structure

MK-677

Iupac Name:2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide;methanesulfonic acid
CAS No.:159752-10-0
Molecular Weight:624.7692
Introduction: MK-677(also known as ibutamoren),promotes the secretion of the growth hormone (GH)andincreases insulin-like growth factor 1 (IGF-1). Ibutamoren increases growth hormone levels by mimicking the action of the hormoneghrelinand binding to one of the ghrelin receptors (GHSR) in the brain. Activated GHSR stimulates growth hormone release from the brain. Clinical studies describe only the effects ibutamoren has onappetite and as expected, like ghrelin, ibutamoren increases it. GHSR is found in brain regions that control appetite, pleasure, mood, biological rhythms, memory, and cognition. View more+
1. Names and Identifiers
1.1 Name
MK-677
1.2 Synonyms

1'-(2-Methylalanyl-O-benzyl-D-seryl)-1-(methylsulfonyl)-1,2-dihydrospiro[indole-3,4'-piperidine] methanesulfonate (1:1) 2-Amino-N-[(1R)-2-[1,2-dihydro-1-(methylsulfonyl)spiro[3H-indole-3,4'-piperidin]-1'-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methylpropanamide methanesulfonate CRESCENDO CS-1402 Ibutamoren Ibutamoren (Mesylate) Ibutamoren mesilate Ibutamoren mesylate Ibutamoren mesylate (USAN) MK 0677 MK 677 MK-0667 MK0677 MK-0677 MK677 MK677 MK 677 IBUTAMOREN mk677 mk 677 Ibutamoren,whnohe_lucy(at)163.com MK677 POWDER MK677(Ibutamoren Mesylate) MK677,Mk677 Propanamide, 2-amino-N-[(1R)-2-[1,2-dihydro-1-(methylsulfonyl)spiro[3H-indole-3,4'-piperidin]-1'-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methyl-, methanesulfonate (1:1) S1151_Selleck UNII-R90JB6QJ2B

1.3 CAS No.
159752-10-0
1.4 CID
6450830
1.5 EINECS(EC#)
1308068-626-2
1.6 Molecular Formula
C28H40N4O8S2 (isomer)
1.7 Inchi
InChI=1S/C27H36N4O5S.CH4O3S/c1-26(2,28)25(33)29-22(18-36-17-20-9-5-4-6-10-20)24(32)30-15-13-27(14-16-30)19-31(37(3,34)35)23-12-8-7-11-21(23)27;1-5(2,3)4/h4-12,22H,13-19,28H2,1-3H3,(H,29,33);1H3,(H,2,3,4)/t22-;/m1./s1
1.8 InChkey
DUGMCDWNXXFHDE-VZYDHVRKSA-N
1.9 Canonical Smiles
CC(C)(C(=O)NC(COCC1=CC=CC=C1)C(=O)N2CCC3(CC2)CN(C4=CC=CC=C34)S(=O)(=O)C)N.CS(=O)(=O)O
1.10 Isomers Smiles
CC(C)(C(=O)N[C@H](COCC1=CC=CC=C1)C(=O)N2CCC3(CC2)CN(C4=CC=CC=C34)S(=O)(=O)C)N.CS(=O)(=O)O
2. Properties
3.1 Boiling point
868.9°C at 760 mmHg
3.1 Flash Point
479.3°C
3.1 Vapour pressure
3.05E-32mmHg at 25°C
3.1 Precise Quality
624.228760
3.1 PSA
196.66000
3.1 logP
4.97440
3.1 Solubility
H2O: soluble5mg/mL, clear
3.2 Appearance
white to beige
3.3 Color/Form
white to beige
3.4 Water Solubility
H2O: soluble5mg/mL, clear
3.5 StorageTemp
2-8°C
3. Use and Manufacturing
4.1 Usage
Growthhormone releasing factor.MK-677 is a potent, non-peptide ghrelin receptor agonist. MK-677Supplier
4. Safety and Handling
5.1 RIDADR
NONH for all modes of transport
5.1 WGK Germany
3
5.1 RTECS
TX1404490
5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

no data available

2.2 GHS label elements, including precautionary statements

Pictogram(s) no data available
Signal word

no data available

Hazard statement(s)

no data available

Precautionary statement(s)
Prevention

no data available

Response

no data available

Storage

no data available

Disposal

no data available

2.3 Other hazards which do not result in classification

no data available

6. Other Information
6.0 Uses
Growth hormone releasing factor.
6.1 体内研究

Ibutamoren mesylate (5 mg/kg/day) results in a statistically significant increases body weight gain and increases serum IGF-1 and GH levels in dogs. Ibutamoren mesylate results in no significant increase in CSF IGF-1 or GH levels on days 7 or 15 of the study. Pretreating mice with GH blocks activation of these neurons by Ibutamoren mesylate (50 μg, i.p.). In the knockout mice, both GH and octreotide fail to inhibit Ibutamoren mesylate activation of arcuate neurons. Chronic oral administration of MK-0677 is associated with significant increases in GH and IGF-I levels that are maintained for the duration of the treatment. The GH profile following MK-0677 administration consists of episodic increases above control. MK-0677 significantly increases peak GH concentrations after oral administration. MK-0677 is a potent GH secretagogue that induces an immediate, large, long lasting increase in GH levels when administered orally or i.v.

6.2 Description
MK-677 (also known as ibutamoren), promotes the secretion of the growth hormone (GH) and increases insulin-like growth factor 1 (IGF-1). Ibutamoren increases growth hormone levels by mimicking the action of the hormone ghrelin and binding to one of the ghrelin receptors (GHSR) in the brain. Activated GHSR stimulates growth hormone release from the brain. Clinical studies describe only the effects ibutamoren has on appetite and as expected, like ghrelin, ibutamoren increases it. GHSR is found in brain regions that control appetite, pleasure, mood, biological rhythms, memory, and cognition.
6.3 Benefits
The benefits of MK-677 include muscle-building, a reduction in muscle wasting, better bone density, improved sleep, and anti-aging properties. It may also have nootropic effects and it can be beneficial in treating growth hormone deficiencies. Read on for a more in-depth look at these benefits.
6.4 Uses
Growth hormone releasing factor.MK-677 is a potent, non-peptide ghrelin receptor agonist.
6.5 Biochem/physiol Actions
It is also known as ibutamoren mesylate. MK-677 is a mimic of growth hormone (GH)-releasing peptide and is orally active.
7. Computational chemical data
  • Molecular Weight:624.7692g/mol
  • Molecular Formula:C28H40N4O8S2
  • Compound Is Canonicalized:True
  • XLogP3-AA:
  • Exact Mass:624.22875659
  • Monoisotopic Mass:624.22875659
  • Complexity:1010
  • Rotatable Bond Count:8
  • Hydrogen Bond Donor Count:3
  • Hydrogen Bond Acceptor Count:10
  • Topological Polar Surface Area:193
  • Heavy Atom Count:42
  • Defined Atom Stereocenter Count:1
  • Undefined Atom Stereocenter Count:0
  • Defined Bond Stereocenter Count:0
  • Undefined Bond Stereocenter Count:0
  • Isotope Atom Count:0
  • Covalently-Bonded Unit Count:2
8. Question & Answer
  • Benefits of MK-677 Feb 21 2021
    MK-677, otherwise known as Ibutamoren Mesylate, works in the body by binding to GHSR receptors in the brain. These receptors are associated with several functions, including mood, appetite, homeostasis, cognition, memory, and biological body rhythm. By stimulating these receptors, MK-677 enhances a...
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