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9-({(2E)-4-[(2S,3R,4R,5S)-3,4-Dihydroxy-5-({(2R,3S)-3-[(2S,3S)-3-hydroxy-2-butanyl]-2-oxiranyl}methyl)tetrahydro-2H-pyran-2-yl]-3-methyl-2-butenoyl}oxy)nonanoic acid Bactoderm Bactroban Bactroban Ointment BRL 4910A L-talo-Non-2-enonic acid, 5,9-anhydro-2,3,4,8-tetradeoxy-8-(2S,3S)-3-(1S,2S)-2-hydroxy-1-methylpropyloxiranylmethyl-3-methyl-, 8-carboxyoctyl ester, (2E)- L-talo-Non-2-enonic acid, 5,9-anhydro-2,3,4,8-tetradeoxy-8-[[(2S,3S)-3-[(1S,2S)-2-hydroxy-1-methylpropyl]oxiranyl]methyl]-3-methyl-, 8-carboxyoctyl ester, (2E)- L-talo-Non-2-enonic acid, 5,9-anhydro-2,3,4,8-tetradeoxy-8-[[(2S,3S)-3-[(1S,2S)-2-hydroxy-1-methylpropyl]oxiranyl]methyl]-3-methyl-, 8-carboxyoctyl ester, (2E)- (9CI) L-talo-Non-2-enonic acid, 5,9-anhydro-2,3,4,8-tetradeoxy-8-[[3-(2-hydroxy-1-methylpropyl)oxiranyl]methyl]-3-methyl-, 8-carboxyoctyl ester, [2E,8[2S,3S(1S,2S)]]- MUPIROCIN CALCIUM Mupirocin Neo-Sensitabs MUPIROCIN,USP Mupricin Pseudomonic acid Pseudomonic acid A trans-Pseudomonic acid Turixin
The?IUPAC name of?Mupirocin is?9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl]oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoic acid. With the?CAS registry number 12650-69-0,?it is also named as Pseudomonic acid.?The product's categories are?active pharmaceutical ingredients; intermediates & fine chemicals; pharmaceuticals.?It is white crystalline solid?which is an antibiotic originally isolated from Pseudomonas fluorescens NCIMB 10586, developed by Beecham.
The other characteristics of this product can be summarized as:?(1)ACD/LogP: 3.44; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): 2.64; (4)ACD/LogD (pH 7.4): 0.85; (5)ACD/BCF (pH 5.5): 38.7; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 282.5; (8)ACD/KOC (pH 7.4): 4.53; (9)#H bond acceptors: 9; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 20; (12)Index of Refraction: 1.524; (13)Molar Refractivity: 129.51 cm3; (14)Molar Volume: 423 cm3; (15)Polarizability: 51.34×10-24 cm3; (16)Surface Tension: 49 dyne/cm; (17)Enthalpy of Vaporization: 113.01 kJ/mol; (18)Vapour Pressure: 5.91E-21 mmHg at 25°C; (19)Rotatable Bond Count: 17; (20)Exact Mass: 500.298533; (21)MonoIsotopic Mass: 500.298533; (22)Topological Polar Surface Area: 146; (23)Heavy Atom Count: 35.
Preparation of Mupirocin: It is?obtained by the Pseudomonas fluorescens which produces a class of substances, including Pseudomonas acid A, B, C, D. Mupirocin is one of the major metabolites Pseudomonas acid A.
Uses of Mupirocin:?is bacteriostatic at low concentrations and bactericidal at high concentrations. It is used topically and is effective against Gram-positive bacteria, including MRSA.?treatment for bacterial skin infections
People can use the following data to convert to the molecule structure.
1. SMILES:O=C(O)CCCCCCCCOC(=O)\C=C(/C)C[C@@H]2OC[C@H](C[C@@H]1O[C@H]1[C@@H](C)[C@@H](O)C)[C@@H](O)[C@H]2O
2.?InChI:InChI=1/C26H44O9/c1-16(13-23(30)33-11-9-7-5-4-6-8-10-22(28)29)12-20-25(32)24(31)19(15-34-20)14-21-26(35-21)17(2)18(3)27/h13,17-21,24-27,31-32H,4-12,14-15H2,1-3H3,(H,28,29)/b16-13+/t17-,18-,19-,20-,21-,24+,25-,26-/m0/s1
The following are the toxicity data which has been tested.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intravenous | 1638mg/kg (1638mg/kg) | ? | United States Patent Document. Vol. #4206224, |
mouse | LD50 | oral | 5gm/kg (5000mg/kg) | ? | United States Patent Document. Vol. #4206224, |
mouse | LD50 | subcutaneous | 4gm/kg (4000mg/kg) | ? | United States Patent Document. Vol. #4206224, |
rat | LD50 | intravenous | 1310mg/kg (1310mg/kg) | ? | United States Patent Document. Vol. #4206224, |
rat | LD50 | oral | 5gm/kg (5000mg/kg) | ? | United States Patent Document. Vol. #4206224, |
rat | LD50 | subcutaneous | 5gm/kg (5000mg/kg) | ? | United States Patent Document. Vol. #4206224, |
no data available
Pictogram(s) | no data available |
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Signal word | no data available |
Hazard statement(s) | no data available |
Precautionary statement(s) | |
Prevention | no data available |
Response | no data available |
Storage | no data available |
Disposal | no data available |
no data available
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