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1-Chloro-2,5-piperidinedione 1-Chloro-2,5-pyrrolidinedione 1-chloropyrrolidine-2,5-dione 2,5-Pyrrolidinedione, 1-chloro- Chlorosuccinimide EINECS 204-878-8 MFCD00005511 N-chlorobutanimide N-Chlorosuccini1mide Pyrrolidinedione, 1-chloro- Succinic N-chloroimide succinicn-chloroimide Succinimide, N-chloro- Succinimide, N-chloro- (8CI) Succinochlorimide
EPA Genetic Toxicology Program.
Hazard Codes:?C,
Xi
Risk Statements: 22-34?
R22:Harmful if swallowed.?
R34:Causes burns.
Safety Statements: 26-36/37/39-45-37/39?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S37/39:Wear suitable gloves and eye/face protection.
?N-Chlorosuccinimide (CAS NO.128-09-6) is a white crystal, soluble in water and alcohols, it can be used as pharmaceutical intermediates, organic synthesis chlorinating agent, it can also be used to prepare rubber additives, synthesis as chlorinating agent, antibiotic drugs intermediates.
?Production method is through the ammoniated acid chloride derived. Through dropping ammonia,react with succinic acid , stirring heated at 102°C steam to get rid of water. Vacuum distillation, collecting 180°C after the distillate to get succinimide. Molten succinimide increased to acetic acid aqueous solution, stirring cooled to 0-5°C, dropping sodium hypochlorite, control reaction in the 8°C below (otherwise there is risk of explosion). To clarify the reaction solution that is reached when the end point, centrifugation, filter cake and washing to neutral, drying, drying to get.
1. | ??? |
orl-rat LDLo:1000?mg/kg |
??? | PHRPA6 ?? Public Health Reports. 59 (1944),541. |
2. | ??? |
ivn-rat LDLo:200?mg/kg |
??? | PHRPA6 ?? Public Health Reports. 59 (1944),541. |
Acute toxicity - Oral, Category 4
Skin corrosion, Category 1B
Pictogram(s) | ![]() ![]() |
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Signal word | Danger |
Hazard statement(s) | H302 Harmful if swallowed H314 Causes severe skin burns and eye damage |
Precautionary statement(s) | |
Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P280 Wear protective gloves/protective clothing/eye protection/face protection. |
Response | P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/\u2026if you feel unwell. P330 Rinse mouth. P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower]. P363 Wash contaminated clothing before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P310 Immediately call a POISON CENTER/doctor/\u2026 P321 Specific treatment (see ... on this label). P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
Storage | P405 Store locked up. |
Disposal | P501 Dispose of contents/container to ... |
none
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Literatures:
Journal of the Chemical Society [Section] B: Physical Organic, , p. 626 - 631 ![]() Yield: null |
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Literatures:
Journal of the Chemical Society [Section] B: Physical Organic, , p. 626 - 631 ![]() Yield: null |