3D Mol Similar

Naphazoline hydrochloride

: Iupac Name：2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole;hydrochloride; CAS No.: 550-99-2; Molecular Weight：246.738; Modify Date.: 2023-02-27 20:50; Introduction: This product is a vasoconstrictor. Rat subcutaneous injection is LD50 385 mg/kg. View more+

Request For Quotation

1. Names and Identifiers

: 1.1 Name; Naphazoline hydrochloride; 1.2 Synonyms; 1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)-, conjugate monoacid 1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)-, hydrochloride (1:1) 2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole chloride 2-(1-Naphthylmethyl)-2-imidazoline hydrochloride 2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazol-1-ium 2-(1-naphthylmethyl)-4,5-dihydro-1H-imidazole hydrochloride 2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole hydrochloride (1:1) 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole hydrochloride (1:1) 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole,hydrochloride EINECS 208-989-2 MFCD00012554 naphazoline Naphazoline (hydrochloride) Naphcon naphconforte naphthasoliumchloride niazol privinehydrochloride prizolehydrochloride rhinantin rhinoperd; View all

1.3 CAS No.: 550-99-2

1.4 CID: 11079

1.5 EINECS(EC#): 208-989-2

1.6 Molecular Formula: C14H15ClN2 (isomer)

1.7 Inchi: InChI=1S/C14H14N2.ClH/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14;/h1-7H,8-10H2,(H,15,16);1H

1.8 InChIkey: DJDFFEBSKJCGHC-UHFFFAOYSA-N

1.9 Canonical Smiles: C1CN=C(N1)CC2=CC=CC3=CC=CC=C32.Cl

1.10 Isomers Smiles: C1CN=C(N1)CC2=CC=CC3=CC=CC=C32.Cl

2. Properties

2.1 Density: 1.15

2.1 Melting point: 254-260℃

2.1 Boiling point: 440.5 °C at 760 mmHg

2.1 Flash Point: 220.2 °C

2.1 Precise Quality: 246.09200

2.1 PSA: 24.39000

2.1 logP: 2.95040

2.1 Solubility: 170 g/L (20 oC)

2.2 AnalyticLaboratory Methods: COLORIMETRIC DETERMINATION OF NAPHAZOLINE; IN SOME PHARMACEUTICAL PREPARATIONS. MAX ABSORBANCE @ 550 NM.

2.3 Appearance: white crystalline powder

2.4 Storage: Ambient temperatures.

2.5 Color/Form: WHITE CRYSTALLINE POWDER

2.6 Odor: ODORLESS

2.7 PH: A 1% aqueous solution has a pH of about 6.2

2.8 pKa: pKa (25°C) 10.35 ±0.02, (35°C) 10.13 ±0.02, (45°C) 9.92 ±0.03; pKa (25°C) 10.35 ±0.02, (35°C) 10.13 ±0.02, (45°C) 9.92 ±0.03

2.9 Water Solubility: 170 g/L (20 oC)

2.10 Spectral Properties: UV max (ethanol): 223, 270, 280, 287, and 291 nm (E 1% 1cm = 3622, 239, 286, 196, 198)
IR: 20260 (Sadtler Research Laboratories IR grating collection)
UV: 18667 (Sadtler Research Laboratories spectral collection)
H-1 NMR: 10150 (Sadtler Research Laboratories spectral collection)

2.11 Stability: Stable under normal temperatures and pressures.

2.12 StorageTemp: Keep containers tightly closed. Store in a cool, dry area away from incompatible substances.

3. Use and Manufacturing

3.1 GHS Classification: Signal: Danger
GHS Hazard Statements
Aggregated GHS information provided by 32 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

H300 (81.25%): Fatal if swallowed [Danger Acute toxicity, oral]
H302 (12.5%): Harmful if swallowed [Warning Acute toxicity, oral]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

Precautionary Statement Codes
P264, P270, P301+P310, P301+P312, P321, P330, P405, and P501; View all

3.2 Methods of Manufacturing: IN ALMOST QUANTITATIVE YIELDS BY HEATING 1-NAPHTHYLACETONITRILE; WITH ETHYLENEDIAMINE MONOHYDROCHLORIDE; @ 175 TO 200 DEG C FOR 1 HR. AMMONIA; IS...BY-PRODUCT.

3.3 Usage: This product is a vasoconstrictor. Rat subcutaneous injection is LD50 385 mg/kg.

4. Safety and Handling

4.1 Symbol: GHS06

4.1 Hazard Codes: T

4.1 Signal Word: Danger

4.1 Risk Statements: R20/21/22;R23/24/25

4.1 Safety Statements: S24/25;S36/37/39;S45

4.1 Exposure Standards and Regulations: Nasal decongestant active ingredients. The active ingredient of the product consists of any of the following when used within the dosage limits and in the dosage forms established for each ingredient: ... Topical nasal decongestants: naphazoline hydrochloride.
Ophthalmic vasoconstrictors. The active ingredient of the product consists of one of the following, within the established concentration for each ingredient: ... Naphazoline hydrochloride, 0.01 to 0.03 percent.
The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed prescription and over-the-counter drug products, incl naphazoline hydrochloride, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act.

4.2 Packing Group: III

4.2 Hazard Class: 6.1

4.2 Hazard Declaration: H300

4.2 DisposalMethods: SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

4.3 DOT Emergency Guidelines: /GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Health: TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. /Poisonous solid, organic, NOS; Toxic solid, organic, NOS (Naphazoline hydrochloride)/
/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Fire or Explosion: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. /Poisonous solid, organic, NOS; Toxic solid, organic, NOS (Naphazoline hydrochloride)/
/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas. /Poisonous solid, organic, NOS; Toxic solid, organic, NOS (Naphazoline hydrochloride)/
/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Poisonous solid, organic, NOS; Toxic solid, organic, NOS (Naphazoline hydrochloride)/
/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Evacuation: ... Fire: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. /Poisonous solid, organic, NOS; Toxic solid, organic, NOS (Naphazoline hydrochloride)/
/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Fire: Small fires: Dry chemical, CO2 or water spray. Large fires: Dry chemical, CO2, alcohol-resistant foam or water spray. Move containers from fire area if you can do it without risk. Dike fire control water for later disposal; do not scatter the material. Fire involving tanks or car/trailer loads: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. /Poisonous solid, organic, NOS; Toxic solid, organic, NOS (Naphazoline hydrochloride)/
/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Spill or Leak: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. /Poisonous solid, organic, NOS; Toxic solid, organic, NOS (Naphazoline hydrochloride)/
/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ First Aid: Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. /Poisonous solid, organic, NOS; Toxic solid, organic, NOS (Naphazoline hydrochloride)/; View all

4.4 RIDADR: UN 2811

4.4 Caution Statement: Missing Phrase - N15.00950417

4.4 Formulations/Preparations: Ophthalmic: Solution: 0.012% All Clear ( with benzalkonium chloride), (Bausch & Lomb), Clear Eyes ( with benzalkonium chloride and glycerin 0.2%), (Prestige Brands), Naphcon ( with benzalkonium chloride), (Alcon); 0.03% All Clear AR ( with benzalkonium chloride), (Bausch & Lomb); 0.1% AK-Con ( with benzalkonium chloride), (Akorn), Albalon ( with benzalkonium chloride), (Allergan), Naphazoline Hydrochloride Ophthalmic Solution, (Bausch & Lomb).
Ophthalmic: Solution: 0.012% with Zinc Sulfate 0.25% Clear Eyes ACR ( with benzalkonium chloride and glycerin 0.2%), (Prestige Brands); 0.025% with Pheniramine Maleate 0.3% Naphcon-A (with benzalkonium chloride), (Alcon) Visine A , (Pfizer); 0.027% with Pheniramine Maleate 0.315% Opcon A, (Bausch & Lomb); 0.05% with Antazoline Phosphate 0.5% Vasocon-A ( with benzalkonium chloride), (Novartis).
Trade names: Ak-Con (Akorn); Albalon (Allergan); Allerest Eye Drops (Pharmacraft); Allergy Drops (Bausch & Lomb); Clear Eyes (Ross); Clera (Person and Covey); Comfort Eye Drops, Degest 2 (Barnes-Hind); Imidazyl (Allergan); Naphcon (Alcon); I-Naphline (Americal); Opcon (Bausch & Lomb); Optazine (Lederle); Otrivin, Privin, Privina, Privine (Ciba); Vasocon Regular (IOLAB).; View all

4.5 WGK Germany: 3

4.5 RTECS: NJ4375000

4.5 Sensitive: Hygroscopic

4.6 Specification

The IUPAC name?of?Niazol is?2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole hydrochloride. With the?CAS registry number 550-99-2, it is also named as?Naphazoline. The product's categorie is?Adrenoceptor.?It is white crystalline powder?which is soluble in ethanol, slightly soluble in chloroform, insoluble in benzene and ether. This product is vasoconstrictor drug.?When heated to decomposition it emits very toxic fumes of NO_x and HCl.

The other characteristics of this product can be summarized as:?(1)ACD/LogP: 3.88; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.88; (4)ACD/LogD (pH 7.4): 1.94; (5)ACD/BCF (pH 5.5): 5.25; (6)ACD/BCF (pH 7.4): 5.94; (7)ACD/KOC (pH 5.5): 30.82; (8)ACD/KOC (pH 7.4): 34.89; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 2; (12)Flash Point: 220.2 °C; (13)Enthalpy of Vaporization: 67.07 kJ/mol; (14)Boiling Point: 440.5 °C at 760 mmHg; (15)Vapour Pressure: 1.52E-07 mmHg at 25°C; (16)Rotatable Bond Count: 2; (17)Exact Mass: 246.092376; (18)MonoIsotopic Mass: 246.092376; (19)Topological Polar Surface Area: 24.4; (20)Heavy Atom Count: 17; (21)Complexity: 272.

Preparation of Niazol: The condensation and cyclization of ethylenediamine?and α-naphthylacetic acid?to get 2-(1-naphthylmethyl) imidazoline (C₁₄H₁₄N₂, [CAS NO.835-31-4]), and then?salifing to obtain?Niazol.?Adding?α-naphthylacetic acid and ethylenediamine into the reaction pot, stirring and heating?to 120?°C for 1 hour, then heating to 130 °C for 1 hour.?Distilling out?ethylenediamine and water, collecting 180-240 °C (1.33-4 kPa) fractions to get?2-(1- naphthylmethyl) imidazoline. Then dissolved in the mixture of acetone and ethanol,?leading to?hydrogen chloride gas in the 10-12 °C to?salify,?then we can obtain?Niazol crystals.

When you are using this chemical, please be cautious about it as the following:
It is harmful by inhalation, in contact with skin and if swallowed, so people should avoid contact with skin and eyes.?If you want to contact this product, you must wear suitable protective clothing, gloves and eye/face protection.?In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

People can use the following data to convert to the molecule structure.
1. SMILES:Cl.N\1=C(\NCC/1)Cc2cccc3c2cccc3
2. InChI:InChI=1/C14H14N2.ClH/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14;/h1-7H,8-10H2,(H,15,16);1H

The following are the toxicity data which has been tested.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	oral	2uL/kg (0.002mL/kg)	VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Japanese Journal of Toxicology. Vol. 9, Pg. 295, 1996.
mouse	LD50	intraperitoneal	50mg/kg (50mg/kg)	?	European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 28, Pg. 761, 1993.
mouse	LD50	intravenous	16500ug/kg (16.5mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 341, 1955. ?
mouse	LD50	subcutaneous	170mg/kg (170mg/kg)	?	Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 280, 1946.
rabbit	LD50	intramuscular	950ug/kg (0.95mg/kg)	?	Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 284, 1946.
rabbit	LD50	intravenous	800ug/kg (0.8mg/kg)	?	Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 284, 1946.
rabbit	LD50	oral	50mg/kg (50mg/kg)	LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Schweizerische Medizinische Wochenschrift. Vol. 71, Pg. 554, 1941.
rabbit	LD50	subcutaneous	4mg/kg (4mg/kg)	LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Schweizerische Medizinische Wochenschrift. Vol. 71, Pg. 554, 1941.
rat	LD50	intraperitoneal	50mg/kg (50mg/kg)	?	Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 284, 1946.
rat	LD50	intravenous	6mg/kg (6mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 341, 1955. ?
rat	LD50	subcutaneous	200mg/kg (200mg/kg)	LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Schweizerische Medizinische Wochenschrift. Vol. 71, Pg. 554, 1941.

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4.7 Toxicity

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NJ4375000

CHEMICAL NAME :: 2-Imidazoline, 2-(1-naphthylmethyl)-, monohydrochloride

CAS REGISTRY NUMBER :: 550-99-2

LAST UPDATED :: 199610

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C14-H14-N2.Cl-H

MOLECULAR WEIGHT :: 246.76

WISWESSER LINE NOTATION :: L66J B1- BT5M CN BUTJ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 86,284,1946

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co., Steintorst 13, 4010 Basel, Switzerland) V.50- 1920- Volume(issue)/page/year: 71,554,1941

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 113,341,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 28,761,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 170 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 86,280,1946

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 16500 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 113,341,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co., Steintorst 13, 4010 Basel, Switzerland) V.50- 1920- Volume(issue)/page/year: 71,554,1941

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 4 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co., Steintorst 13, 4010 Basel, Switzerland) V.50- 1920- Volume(issue)/page/year: 71,554,1941

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 86,284,1946

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 950 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 86,284,1946 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3737 No. of Facilities: 73 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1374 (estimated) No. of Female Employees: 1038 (estimated)

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5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 2

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Danger
Hazard statement(s)	H300 Fatal if swallowed
Precautionary statement(s)
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product.
Response	P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/\u2026 P321 Specific treatment (see ... on this label). P330 Rinse mouth.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

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6. NMR Spectrum

13C NMR : in DMSO-d6

1H NMR : 400 MHz in DMSO-d6

IR : KBr disc

IR : nujol mull

Mass

7. Other Information

7.0 Usage: Naphazoline hydrochloride produces ionotropic effects via α-adrenoceptor stimulation. It is an activator of AR and Nischarin. It is used as a nasal decongestant and ocular vasoconstrictor.

8. Computational chemical data

Molecular Weight: 246.738g/mol
Molecular Formula: C₁₄H₁₅ClN₂
Compound Is Canonicalized: True
XLogP3-AA: null
Exact Mass: 246.0923762
Monoisotopic Mass: 246.0923762
Complexity: 272
Rotatable Bond Count: 2
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 1
Topological Polar Surface Area: 24.4
Heavy Atom Count: 17
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Isotope Atom Count: 0
Covalently-Bonded Unit Count: 2
CACTVS Substructure Key Fingerprint: AAADccBzAAAEAAAAAAAAAAAAAAAAAQAAAAAwYAAAAAAAAADBUAAAHAAQAAAADADBGAQxAMLAAACgAiJiJAACAAEgAAAJiIA4AIgIYCKAmRGUIAAgkACIiAcQgMAOgAACAAAQAAAAAAQAACAAAAAAAAAAAA==

9. Question & Answer

What are the features of Naphazoline hydrochloride nasal drops? Jan 26 2023
1. Naphazoline hydrochloride nasal drops effectively constrict the blood vessels in the nasal mucosa, reducing congestion, swelling, and nasal congestion. 2. Convenient to use and provides quick relie..
Does Naphazoline Hydrochloride Nasal Drops Contain Hormones? Aug 17 2022
It is undeniable that hormone drugs can affect the normal endocrine system of the human body and play a certain regulatory role in physiological processes. However, the use of hormone-containing drugs..

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