3D Mol Similar

Nicarbazin

Iupac Name：1,3-bis(4-nitrophenyl)urea;4,6-dimethyl-1H-pyrimidin-2-one

CAS No.: 330-95-0

Molecular Weight：426.38282

Modify Date.: 2022-11-10 17:15

Introduction: Nicarbazin is an effective anticoccidial agent for chickens. View more+

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1. Names and Identifiers

1.1 Name: Nicarbazin
1.2 Synonyms: 1,3-bis(4-nitrophenyl)urea-4,6-dimethylpyrimidin-2-ol (1:1) EINECS 206-359-1 MK 75 mk75 n,n’-bis(4-nitrophenyl)ureacompd.with4,6-dimethyl-2-pyrimidinol(1:1) N,N'-BIS(4-NITROPHENYL)UREA COMPOUND WITH 4,6-DIMETHYL-2-PYRIMIDINONE nicarb Nicarbasin NICARBAZINE NICARBAZINUM Nicoxin Nicrazin Nicrazine Nirazin

1.3 CAS No.: 330-95-0

1.4 CID: 9507

1.5 EINECS(EC#): 206-359-1

1.6 Molecular Formula: C19H18N6O6 (isomer)

1.7 Inchi: InChI=1S/C13H10N4O5.C6H8N2O/c18-13(14-9-1-5-11(6-2-9)16(19)20)15-10-3-7-12(8-4-10)17(21)22;1-4-3-5(2)8-6(9)7-4/h1-8H,(H2,14,15,18);3H,1-2H3,(H,7,8,9)

1.8 InChkey: UKHWDRMMMYWSFL-UHFFFAOYSA-N

1.9 Canonical Smiles: CC1=CC(=NC(=O)N1)C.C1=CC(=CC=C1NC(=O)NC2=CC=C(C=C2)[N+](=O)[O-])[N+](=O)[O-]

1.10 Isomers Smiles: CC1=CC(=NC(=O)N1)C.C1=CC(=CC=C1NC(=O)NC2=CC=C(C=C2)[N+](=O)[O-])[N+](=O)[O-]

2. Properties

2.1 Density: 0.5 g/ml

2.1 Melting point: decomposes 265-275 deg C

2.1 Boiling point: 414.8 °C at 760 mmHg

2.1 Refractive index: 1.6000 (estimate)

2.1 Flash Point: 204.7 °C

2.1 Precise Quality: 426.12900

2.1 PSA: 178.78000

2.1 logP: 5.13840

2.1 Solubility: DMSO: soluble0.5mg/mL

2.2 Appearance: Yellow or greenish yellow powder, odorless , with a bit of smell

2.3 Storage: 0-6°C

2.4 Chemical Properties: Forms crystals.Insoluble in water

2.5 Color/Form: Powder

2.6 Odor: Characteristic odor

2.7 PH: pH = 5-7 (1% suspension in water)

2.8 Water Solubility: DMSO: soluble0.5mg/mL

2.9 Spectral Properties: UV/vis absorption max: 300-360 nm
UV max (concd H2SO4): 298 nm (A 1%/1cm 670)

2.10 StorageTemp: 0-6°C

3. Use and Manufacturing

3.1 Usage: Coccidiostat.

4. Safety and Handling

4.1 Symbol: GHS07

4.1 Hazard Codes: Xi

4.1 Signal Word: Warning

4.1 Risk Statements: R36/37/38

4.1 Safety Statements: S26;S36

4.1 Exposure Standards and Regulations: New animal drugs for use in animal feeds. Nicarbazin. a) Specifications. Type A medicated articles containing 25 percent nicarbazin. (b) Approvals. See Nos. 000986, 060728, and 066104 in ?510.600(c) of this chapter for use as in paragraph (d) of this section. (c) Related tolerances. See ?556.445 of this chapter. (d) Conditons of use. It is used in chicken feed as follows: Nicarbazin in grams per ton Combination in grams per ton Indications for use Limitations 27 to 45 Narasin 27 to 45 Broiler chickens; prevention of coccidiosis caused by Eimeria tenella, E. necatrix, E. acervulina, E. maxima, E. brunetti, E. mivati.. Sec. 558.363(d)(1)(iii) Narasin 27 to 45 and bacitracin methylene disalicylate 4 to 50 Broiler chickens; prevention of coccidiosis caused by Eimeria tenella, E. necatrix, E. acervulina, E. maxima, E. brunetti, E. mivati; for increased rate of weight gain and improved efficiency. Feed continuously as sole ration. Withdraw 5 days before slaughter. Do not allow turkeys, horses, or other equines access to formulations containing narasin. Ingestion of narasin by these species has been fatal. Do not feed to laying hens. Narasin and nicarbazin as provided by 000986, bacitracin methylene disalicylate by 046573. Narasin 27 to 45 and bacitracin methylene disalicylate 50 Broiler chickens: For prevention of coccidiosis caused by Eimeria tenella, E. necatrix, E. acervulina, E. maxima, E. brunetti, and E. mivati; as an aid in the prevention of necrotic enteritis caused or complicated by Clostridium spp. or other organisms susceptible to bacitracin. Feed continuously as sole ration. Do not feed to laying hens. Withdraw 5 days before slaughter. Do not allow turkeys, horses or other equines access to formulations containing narasin. Ingestion of narasin by these species has been fatal. Narasin and nicarbazin as provided by No. 000986, bacitracin methylene disalicylate by No. 046573 in § 510.600(c) of this chapter. Narasin 27 to 45 and bacitracin methylene disalicylate 100 to 200 Broiler chickens: For prevention of coccidiosis caused by Eimeria tenella, E. necatrix, E. acervulina, E. maxima, E. brunetti, and E. mivati; as an aid in the control of necrotic enteritis caused or complicated by Clostridium spp. or other organisms susceptible to bacitracin. To control necrotic enteritis, start medication at first clinical signs of disease; vary dosage based . on the severity of infection; administer continuously for 5 to 7 days or as long as clinical signs persist, then reduce bacitracin to prevention level (50 g/ton). Do not feed to laying hens. Withdraw 5 days before slaughter. Do not allow turkeys, horses or other equines access to formulations containing narasin. Ingestion of narasin by these species has been fatal. Narasin and nicarbazin as provided by No. 000986, bacitracin methylene disalicylate by No. 046573 in § 510.600(c) of this chapter. Narasin 27 to 45, bacitracin methylene disalicylate 50, and roxarsone 22.7 to 45.4 Broiler chickens; prevention of coccidiosis caused by Eimeria tenella, E. necatrix, E. acervulina, E. maxima, E. brunetti, and E. mivati, as an aid in the prevention of necrotic enteritis caused or complicated by Clostridium spp. or other organisms susceptible to bacitracin, for increased rate of weight gain, improved feed efficiency, and improved pigmentation. Feed continuously as sole ration. Withdraw 5 days before slaughter. Do not allow turkeys, horses or other equines access to formulations containing narasin. Ingestion narasin by these species has been fatal. Do not feed to laying hens. Use as sole source of organic arsenic. Narasin and nicarbazin as provided by 000986, bacitracin methylene disalicylate and roxarsone by 046573. Narasin 27 to 45, and bambermycins 1 to 2 Broiler chickens: As an aid in preventing outbreaks of cecal (Eimeria tenella) and intestinal (E. acervulina, E. maxima, E. necatrix, and E. brunetti) coccidiosis; and for increased rate of weight gain and improved feed efficiency. Feed continuously as sole ration from time chicks are placed on litter until past the time when coccidiosis is ordinarily a hazard; do not use as a treatment for coccidiosis; do not use in flushing mashes; do not feed to laying hens; withdraw 4 days before slaughter. Bambermycins provided by No. 016592; nicarbazin and narasin by No. 066104 in § 510.600(c) of this chapter. Narasin 27 to 45 and Lincomycin 2 to 4 Broiler chickens; prevention of coccidiosis caused by Eimeria tenella, E. necatrix, E. acervulina, E. maxima, E. brunetti, E. mivati; for increased rate of weight gain and improved feed efficiency. Feed continuously as sole ration. Withdraw 5 days before slaughter. Do not allow turkeys, horses, or other equines access to formulations containing narasin. Ingestion of narasin by these species has been fatal. Do not feed to laying hens. Do not allow rabbits, hamsters, guinea pigs, horses, or ruminants access to feeds containing lincomycin. Ingestion by these species may result in severe gastrointestinal effects. Narasin and nicarbazin as provided by 000986, lincomycin by 000009. Narasin 27 to 45 and roxarsone 22.7 to 45.4 Broiler chickens; for prevention of coccidiosis caused Eimeria tenella, E. necatrix, E. acervulina, E. maxima, E. brunetti, and E. mivati; for increased rate of weight gain, improved feed efficiency, and improved pigmentation. Feed continuously as sole ration. Use as sole source of organic arsenic. Withdraw 5 days before slaughter. Do not allow turkeys, horses or other equines access to formulations containing narasin. Ingestion of narasin by these species has been fatal. Do not feed to laying hens. Use as sole source of organic arsenic. Narasin and nicarbazin as provided by 000986, roxarsone by 046573. 90.8 to 181.6 (0.01 to 0.02 pct) Bacitracin methylene disalicylate 4 to 50 and roxarsone 22.7 to 45.4 Broiler chickens: As an aid in preventing outbreaks of cecal (Eimeria tenella) and intestinal (E. acervulina, E. maxima, E. necatrix, and E. brunetti) coccidiosis, and for increased rate of weight gain and improved feed efficiency, and improved pigmentation. Feed continuously as sole ration from time chicks are placed on litter until past the time when coccidiosis is ordinarily a hazard; do not use as a treatment for outbreaks of coccidiosis. Feed as the sole source of organic arsenic; drug overdose or lack of water may result in leg weakness; do not use in flushing mashes. Discontinue medication 5 days before marketing the birds for human consumption to allow for elimination of the drug from edible tissue. Do not feed to laying hens in production. Nicarbazin as provided by No. 066104; bacitracin methylene disalicylate and roxarsone by No. 046573 in § 510.600(c) of this chapter. Penicillin 2.4 to 50 Broiler chickens: As an aid in preventing outbreaks of cecal (Eimeria tenella) and intestinal (E. acervulina, E. maxima, E. necatrix, and E. brunetti) coccidiosis, and for increased rate of weight gain and improved feed efficiency. Feed continuously as sole ration from time chicks and are placed on litter u

4.2 Other Preventative Measures: Causes moderate eye irritation. Remove and wash contaminated clothing before reuse. Avoid contact with eyes or clothing. Wear protective eyewear. Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, or using tobacco. Wear: Long-sleeved shirt and long pants, Socks, Shoes, and gloves.
Wear the items of protective clothing the label requires: for example, non-absorbent gloves (not leather or fabric), rubber footwear (not canvas or leather), a hat, goggles, or a dust-mist filter. If no specific clothing is listed, gloves, long-sleeved shirts and long pants, and closed shoes are recommended. You can buy protective clothing and equipment at hardware stores or building supply stores.
Indoor Applications. If the label directions permit, leave all windows open and fans operating after the application is completed. If the pesticide product is only effective in an unventilated (sealed) room or house, do not stay there. Put all pets outdoors, and take yourself any your family away from treated areas for at least the length of time prescribed on the label. Apply most surface sprays only to limited areas such as cracks; don't treat entire floors, walls, or ceilings. Don't let pesticides get on any surfaces that are used for food preparation. Wash any surfaces that may have pesticide residue before placing food on them.
Outdoor Applications. Never apply pesticides outdoors on a windy day (winds higher than 10 mph). Position yourself so that a light breeze does not blow pesticide spray or dust into your face.

4.3 Hazard Declaration: H315-H319-H335

4.3 Cleanup Methods: If a spill occurs, clean it up promptly. Don't wash it away. Instead, sprinkle the spill with sawdust, vermiculite, or kitty litter. Sweep it into a plastic garbage bag, and dispose of it as directed on the pesticide product label.
After Applying a Pesticide, Indoors or Outdoors. To remove pesticide residues, use a bucket to rinse tools or equipment three times, including any containers or utensils that you used when mixing the pesticide. Then pour the rinsewater into the pesticide sprayer and reuse the solution by applying it according to the pesticide product label directions. After applying any pesticide wash your hands and any other parts of your body that may have come in contact with the pesticide..To prevent tracking pesticides inside, remove or rinse your boots or shoes before entering your home. Wash any clothes that have been exposed to a lot of pesticide separately from your regular wash.

4.4 DisposalMethods: SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.
Safe Disposal of Pesticides. The best way to dispose of small amounts of excess pesticides is to use them - apply them - according to the directions on the label. If you cannot use them, ask your neighbors whether they have a similar pest control problem and can use them. If all of the remaining pesticide cannot be properly used, check with your local solid waste management authority, environmental agency, or health department to find out whether your community has a household hazardous waste collection program or a similar program for getting rid of unwanted, leftover pesticides. These authorities can also inform you of any local requirements for pesticide waste disposal.
Safe Disposal of Pesticides. An empty pesticide container can be as hazardous as a full one because of residues left inside. Never reuse such a container. When empty, a pesticide container should be rinsed carefully three times and the rinsewater thoroughly drained back onto the sprayer or the container previously used to mix the pesticide. Use the rinsewater as a pesticide, following label directions. Replace the cap or closure securely. Dispose of the container according to label instructions. Do not puncture or burn a pressurized container like an aerosol - it could explode. Do cut or puncture other empty pesticide containers made of metal or plastic to prevent someone from reusing them. Wrap the empty container and put it in the trash after you have rinsed it.

4.5 RIDADR: NONH for all modes of transport

4.5 FirePotential: Neither flammable or explodable based on formulation ingredients.

4.6 Caution Statement: P261-P305 + P351 + P338

4.6 Formulations/Preparations: OvoControl-G (0.25% bait); Nicarbazin 30% Granulated premix

4.7 WGK Germany: 3

4.7 RTECS: FE0900000

4.7 Protective Equipment and Clothing: Causes moderate eye irritation.

4.8 Skin, Eye, and Respiratory Irritations: Causes moderate eye irritation.

5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity \u2013 single exposure, Category 3

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Precautionary statement(s)
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P313 If skin irritation occurs: Get medical advice/attention. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313 If eye irritation persists: Get medical advice/attention. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P312 Call a POISON CENTER/doctor/\u2026if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

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6. Other Information

6.0 体内研究: Nicarbazin does not adversely affect the development of immunity or resistance to re-infection with E. acervulina oocysts.

6.1 Chemical Properties: Forms crystals.Insoluble in water

6.2 Uses: Nicarbazine, is a coccidiostat, which is an antiprotozoal agent that acts upon Coccidia parasites.

6.3 Uses: Coccidiostat.

6.4 Definition: Equimolar complex of 4,4′-dinitrocarbanilide and 2-hydroxy-4,6-dimethylpyrimidine

7. Computational chemical data

Molecular Weight: 426.38282g/mol
Molecular Formula: C₁₉H₁₈N₆O₆
Compound Is Canonicalized: True
XLogP3-AA: null
Exact Mass: 426.12878232
Monoisotopic Mass: 426.12878232
Complexity: 582
Rotatable Bond Count: 2
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 6
Topological Polar Surface Area: 174
Heavy Atom Count: 31
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Isotope Atom Count: 0
Covalently-Bonded Unit Count: 2
CACTVS Substructure Key Fingerprint: AAADceB7uAAAAAAAAAAAAAAAAAAAAAAAAAAwYIAAAAAAAAABQAAAHgAUAAAACAiBEAAzwILQQACpASRiVwCCAAAhAgAoiAAQZJqIICLAkZGEIAholAJIyCcQAAAAAACAAAAAAAAAAQAAAAAAAAAAAAAAAA==

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