Guidechem | China Chemical Manufacturers,suppliers,B2B Marketplace
Encyclop..
  • Products
  • Encyclopedia
  • Buy offers
  • Suppliers
Home> Encyclopedia >   /  Pharmaceutical Intermediates  /  Organic Intermediate  /  Others  /  Pharmaceutical  /  Other Chemicals
p-Hydroxybenzaldehyde structure
p-Hydroxybenzaldehyde structure

p-Hydroxybenzaldehyde

Iupac Name:4-hydroxybenzaldehyde
CAS No.:123-08-0
Molecular Weight:122.123
Introduction: 1. It can be used for the synthesis of organic compounds and medicine. 2. The good is also the intermediate of the pharmaceutical, perfume, and liquid crystal. p-Hydroxybenzaldehyde can be used for the production of TMP (trimethoprim), amoxicillin, cefadroxil cephalosporins, artificial gastrodin, farrerol, bezafibrate, and esmolol; it can also be used for the production of perfume anisaldehyde, vanillin, ethyl vanillin, and raspberry ketone.3. It is the key raw material for the production of p-hydroxy phenylglycine (p-hydroxy phenylglycine is the key intermediate of the new generation of semi-synthetic penicillin amoxicillin). It is also the key intermediate raw material of the production of pesticides-bromoxynil.4. p-Hydroxybenzaldehyde is an important intermediate of the pharmaceutical industry and the perfume industry.5. It is an important intermediate of medicine, perfume, and pesticides for the synthesis of drugs like hydroxyl ampicillin, trimethoprim, and 3-methoxy benzaldehyde. It can also used for synthesizing polymers and producing pharmaceutical raw materials.
1. Names and Identifiers
1.1 Name
p-Hydroxybenzaldehyde
1.2 Synonyms

4-Hydroxy benzaldehy 4-Hydroxybenzaldehyde ,99% 4-HYDROXYBENZALDEHYDE FOR SYNTHESIS 4-Hydroxybenzaldehyde, 98+% 4-Hydroxybenzaldehyde, 99% 250GR 4-Hydroxybenzaldehyde, 99% 50GR HYDROXYBENZALDEHYDE, 4-(RG) P-Hydroxy Benzaldehyde 99.5%min

1.3 CAS No.
123-08-0
1.4 CID
126
1.5 EINECS(EC#)
204-599-1
1.6 Molecular Formula
C7H6O2 (isomer)
1.7 Inchi
InChI=1S/C7H6O2/c8-5-6-1-3-7(9)4-2-6/h1-5,9H
1.8 InChkey
RGHHSNMVTDWUBI-UHFFFAOYSA-N
1.9 Canonical Smiles
C1=CC(=CC=C1C=O)O
1.10 Isomers Smiles
C1=CC(=CC=C1C=O)O
2. Properties
3.1 Density
1.129
3.2 Melting Point
114-118℃
3.3 Boiling Point
246.6 °C at 760 mmHg
3.4 Vapour
0.0171mmHg at 25°C
3.5 Refractive Index
1.57055 (130 C)
3.6 Flash Point
101.3 °C
3.7 Appearance
yellow to light brown crystalline powder
3.8 Color/Form
Powder
3.9 Physical
Solid
3.10 pKa
7.61(at 25℃)
3.11 Solubility
13.8g/l
3.12 Stability
Stable at room temperature in closed containers under normal storage and handling conditions.
3.13 StorageTemp
Store at 2-8°C
3.14 Water Solubility
13 g/L (30 °C) in water
3. Use and Manufacturing
4.1 Definition
ChEBI: A hydroxybenzaldehyde that is benzaldehyde substituted with a hydroxy group at position C-4.
4.2 GHS Classification
Signal: Warning
GHS Hazard Statements
Aggregated GHS information provided by 922 companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria by 873 of 922 companies. For more detailed information, please visit ECHA C&L website

Of the 10 notification(s) provided by 49 of 922 companies with hazard statement code(s):

H315 (97.96%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (97.96%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (83.67%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

Precautionary Statement Codes
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501
4.3 Purification Methods
Crystallise it from water (containing some H2SO4). Dry it over P2O5 under vacuum. [Beilstein 8 H 64, 8 IV 251.] p-Hydroxybenzaldehyde Preparation Products And Raw materials Raw materials
4.4 Storage
Air Sensitive. Ambient temperatures.
4.5 Usage
1. It can be used for the synthesis of organic compounds and medicine. 2. The good is also the intermediate of the pharmaceutical, perfume, and liquid crystal. p-Hydroxybenzaldehyde can be used for the production of TMP (trimethoprim), amoxicillin, cefadroxil cephalosporins, artificial gastrodin, farrerol, bezafibrate, and esmolol; it can also be used for the production of perfume anisaldehyde, vanillin, ethyl vanillin, and raspberry ketone.3. It is the key raw material for the production of p-hydroxy phenylglycine (p-hydroxy phenylglycine is the key intermediate of the new generation of semi-synthetic penicillin amoxicillin). It is also the key intermediate raw material of the production of pesticides-bromoxynil.4. p-Hydroxybenzaldehyde is an important intermediate of the pharmaceutical industry and the perfume industry.5. It is an important intermediate of medicine, perfume, and pesticides for the synthesis of drugs like hydroxyl ampicillin, trimethoprim, and 3-methoxy benzaldehyde. It can also used for synthesizing polymers and producing pharmaceutical raw materials.
4. Safety and Handling
5.1 Hazard Codes
Xi
5.2 Risk Statements
R36/37/38
5.3 Safety Statements
S24/25
5.4 PackingGroup
I; II; III
5.5 Transport
25kgs
5.6 Report

Reported in EPA TSCA Inventory.

5.7 Safety

Hazard Codes:?IrritantXi
Risk Statements: 36/37/38?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-24/25-37/39?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.?
S24/25:Avoid contact with skin and eyes.?
S37/39:Wear suitable gloves and eye/face protection.
WGK Germany: 2
RTECS: CU6475000
Hazard Note: Irritant/Air Sensitive
HS Code: 29124900
Moderately toxic by intraperitoneal route. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

5.8 Sensitive
Air Sensitive
5.9 Specification

?p-Hydroxybenzaldehyde (CAS NO.123-08-0) is also named as 4-Formylphenol ; 4-Hydroxybenzaldehyde ; AI3-15366 ; BRN 0471352 ; CCRIS 8911 ; NSC 2127 ; Parahydroxybenzaldehyde ; UNII-O1738X3Y38 ; USAF M-6 ; p-Formylphenol ; p-Oxybenzaldehyde .?p-Hydroxybenzaldehyde (CAS NO.123-08-0) is yellow to light brown crystalline powder?with aromatic odor.

5.10 Toxicity
1. ???

sce-hmn:lym 1?mmol/L

??? MUREAV ?? Mutation Research. 206 (1988),17.
2. ???

ipr-mus LD50:500?mg/kg

??? NTIS** ?? National Technical Information Service . (Springfield, VA 22161)(Formerly U.S. Clearinghouse for Scientific and Technical Information) AD277-689 .
5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Not classified.

2.2 GHS label elements, including precautionary statements

Pictogram(s) No symbol.
Signal word

No signal word.

Hazard statement(s)

none

Precautionary statement(s)
Prevention

none

Response

none

Storage

none

Disposal

none

2.3 Other hazards which do not result in classification

none

9. Computational chemical data
  • Molecular Weight:122.123g/mol
  • Molecular Formula:C7H6O2
  • Compound Is Canonicalized:True
  • XLogP3-AA:
  • Exact Mass:122.036779430
  • Monoisotopic Mass:122.036779430
  • Complexity:93.1
  • Rotatable Bond Count:1
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:2
  • Topological Polar Surface Area:37.3
  • Heavy Atom Count:9
  • Defined Atom Stereocenter Count:0
  • Undefined Atom Stereocenter Count:0
  • Defined Bond Stereocenter Count:0
  • Undefined Bond Stereocenter Count:0
  • Isotope Atom Count:0
  • Covalently-Bonded Unit Count:1
10. Question & Answer
  • Acidity is dependent on charge dispersal. Greater the charge dispersal in conjugate base greater the acidity (assuming that both acids being compared have similar stablities). So in the case of 4-Hydroxybenzaldehyde, in the conjugate base the charge would delocalise over two oxygen atoms as well as...
  • 4-Hydroxybenzaldehyde is colorless crystalline powder. Melting point: 115-116 ℃, the relative density is 1.129 (30/4℃). In the air, 4-Hydroxybenzaldehyde is easily to be sublimated. 4-Hydroxybenzaldehyde is easily soluble in alcohol, ether, acetone, and ethyl acetate, slightly soluble in water (a...
11. Recommended Suppliers
Global424SuppliersView all >>
  • Products:Chemical products, pharmaceutical intermediates, health food, fitness and muscle products research and development
  • Tel:86-0000000-19932103556
  • Email:larissa@ylbosstech.com
Buy hot sale 4-hydroxybenzaldehyde 99.9% white powder CAS 123-08-0
  • Purity:99%Packing: 200kg/bag FOB
  • Price: 1 USD/Gram
  • Time: 2021/12/30
Inquire
  • Products:pharmaceutical intermediate,anesthetic,ethyl alcohol,dimethocaine,procaine and so on
  • Tel:86-21-16601796662
  • Email:Lucy@shanghaihg.cn
High-quality 4-hydroxybenzaldehyde
  • Purity:99%Packing: 200kg/bag FOB
  • Price: 1 USD/Metric Ton
  • Time: 2021/07/14
Inquire
  • Products:Cosmetic Raw Materials,solvents,etc.
  • Tel:86-311-66562153
  • Email:breeduan@crovellbio.com
Factory supply p-Hydroxybenzaldehyde / PHBA CAS 123-08-0
  • Purity:99%Packing: 200kg/bag FOB
  • Price: 10 USD/Kilogram
  • Time: 2021/06/18
Inquire
  • Products:Division I, the main production Lead acetate phenylacetamide Cyromazine quality is very good!
  • Tel:86-311-66561638
  • Email:xing@yan-xi.com
p-Hydroxybenzaldehyde CAS NO.123-08-0
  • Purity:99%Packing: 200kg/bag FOB
  • Price: 1000 USD/Metric Ton
  • Time: 2021/01/29
Inquire
  • Products:Manufacture & Supply Biopharm Chemical, Specialty Chemical, PetroChemical.
  • Tel:86-592-8883942
  • Email:sale@amitychem.com
Factory Supply 4-Hydroxybenzaldehyde
  • Purity:99%Packing: 200kg/bag FOB
  • Price: 0.1 USD/Kilogram
  • Time: 2021/03/09
Inquire