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1,4-BENZENEDIAMINE 1,4-DIAMINOBENZENE 1,4-phenyldiamine 1,4-PHENYLENEDIAMINE 4-AMINOANILINE BENZENE-1,4-DIAMINE C.I. 76060 EINECS 203-404-7 fur black 41866 JAROCOL PPD MFCD00007901 paraphenylenediamine para-phenylenediamine para-Phenylenediamine (PPD) p-Benzenediamine p-diaminobenzene Phenylenediamine
When tested by the United States Environmental Protection Agency, the EPA reported that in rats and mice chronically exposed to PPD in their diet, it simply depressed body weights, but there were no other clinical signs of toxicity, as were observed in several studies.?From?1992 to 2005 years, thirty-one published articles had been investigating a causal association between PPD and cancer . Associations between personal hair dye use and non-Hodgkin's lymphoma, multiple myeloma, acute leukemia, and bladder cancer ?were observed in at least one well-designed study with detailed exposure assessment, but were not consistently observed across studies.?
Hazard Codes:?T,
N,
T+,
Xn
Risk Statements: 23/24/25-36-43-50/53-63-36/37/38-45-40?
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.?
R36:Irritating to eyes.?
R43:May cause sensitization by skin contact.?
R50/53:Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.?
R63:Possible risk of harm to the unborn child.?
R36/37/38:Irritating to eyes, respiratory system and skin.?
R45:May cause cancer.?
R40:Limited evidence of a carcinogenic effect.
Safety Statements: 28-36/37-45-60-61-28A-24/25-23-53?
S28:After contact with skin, wash immediately with plenty of soap-suds.?
S36/37:Wear suitable protective clothing and gloves.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S60:This material and its container must be disposed of as hazardous waste.?
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.?
S24/25:Avoid contact with skin and eyes.?
S23:Do not breathe vapour.?
S53:Avoid exposure - obtain special instructions before use.
RIDADR: UN 1673 6.1/PG 3
WGK Germany: 3
RTECS: SS8050000
F: 8-10-23
HazardClass: 6.1
PackingGroup: III
HS Code: 29215119
?p-Phenylenediamine , its cas register number is 106-50-3. It also can be called 1,4-Benzenediamine ; 1,4-Phenylenediamine ; 4-Phenylenediamine ; CI 76060 ; p-Phenylenediamine ; 1,4-Diaminobenzene ; 4-Aminoaniline ; 6PPD ; AI3-00710 ; BASF ursol D ; Benzofur D ; C.I. 76060 ; C.I. Developer 13 ; C.I. Oxidation Base 10 ; CCRIS 509 ; Fenylenodwuamina ; Fouramine D ; Paraphenylenediamine ; Pelagol D ; p-Aminoaniline ; p-Benzenediamine ; p-Diaminobenzene ; p-Fenylendiamin ; p-Phenyldiamine ; p-Phenylenediamine ; 1,4-Benzenediamine ; Phenylenediamine, para- ; p-Phenylenediamine .It is a white to light purple solid.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
bird - wild | LD50 | oral | 100mg/kg (100mg/kg) | ? | Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983. |
cat | LDLo | oral | 100mg/kg (100mg/kg) | CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION |
Journal of Industrial Hygiene. Vol. 4, Pg. 386, 1923. |
dog | LDLo | intravenous | 17mg/kg (17mg/kg) | ? | Journal of Industrial Hygiene. Vol. 4, Pg. 386, 1923. |
dog | LDLo | subcutaneous | 100mg/kg (100mg/kg) | BEHAVIORAL: COMA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS GASTROINTESTINAL: NAUSEA OR VOMITING |
U.S. Public Health Service, Public Health Bulletin. Vol. 271, Pg. 40, 1941. |
guinea pig | LD50 | oral | 145mg/kg (145mg/kg) | ? | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 53(7), Pg. 62, 1988. |
guinea pig | LD50 | unreported | 145mg/kg (145mg/kg) | ? | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(8), Pg. 46, 1987. |
man | TDLo | oral | 71mg/kg (71mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Human Toxicology. Vol. 8, Pg. 345, 1989. |
mouse | LD50 | intraperitoneal | 50mg/kg (50mg/kg) | ? | National Technical Information Service. Vol. AD277-689, |
mouse | LD50 | unreported | 331mg/kg (331mg/kg) | BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 50(6), Pg. 78, 1985. |
mouse | LDLo | oral | 100mg/kg (100mg/kg) | ? | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 23(5), Pg. 14, 1958. |
mouse | LDLo | subcutaneous | 140mg/kg (140mg/kg) | ? | Journal of the Society of Cosmetic Chemists. Vol. 12, Pg. 500, 1961. |
quail | LD50 | oral | 100mg/kg (100mg/kg) | ? | Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983. |
rabbit | LDLo | intraperitoneal | 150mg/kg (150mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Journal of Infectious Diseases. Vol. 42, Pg. 473, 1928. |
rabbit | LDLo | intravenous | 300mg/kg (300mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS |
Archives of Internal Medicine. Vol. 36, Pg. 724, 1925. |
rabbit | LDLo | oral | 250mg/kg (250mg/kg) | CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION |
Journal of Industrial Hygiene. Vol. 4, Pg. 386, 1923. |
rabbit | LDLo | skin | 5gm/kg (5000mg/kg) | ? | Journal of Toxicology and Environmental Health. Vol. 2, Pg. 657, 1977. |
rabbit | LDLo | subcutaneous | 200mg/kg (200mg/kg) | CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION |
Journal of Industrial Hygiene. Vol. 4, Pg. 386, 1923. |
rat | LC50 | inhalation | 920mg/m3/4H (920mg/m3) | BEHAVIORAL: GENERAL ANESTHETIC KIDNEY, URETER, AND BLADDER: HEMATURIA GASTROINTESTINAL: NAUSEA OR VOMITING |
National Technical Information Service. Vol. OTS0530403, |
rat | LD50 | intraperitoneal | 37mg/kg (37mg/kg) | ? | Journal of Toxicology and Environmental Health. Vol. 2, Pg. 657, 1977. |
rat | LD50 | oral | 80mg/kg (80mg/kg) | ? | Journal of Toxicology and Environmental Health. Vol. 2, Pg. 657, 1977. |
rat | LD50 | unreported | 133mg/kg (133mg/kg) | ? | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(8), Pg. 46, 1987. |
rat | LDLo | intravenous | 50mg/kg (50mg/kg) | ? | Bulletin de la Societe Royale des Sciences de Liege. Vol. 41, Pg. 302, 1972. |
rat | LDLo | subcutaneous | 170mg/kg (170mg/kg) | CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION |
Journal of Industrial Hygiene. Vol. 4, Pg. 386, 1923. |
Acute toxicity - Oral, Category 3
Acute toxicity - Dermal, Category 3
Eye irritation, Category 2
Skin sensitization, Category 1
Acute toxicity - Inhalation, Category 3
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
Pictogram(s) | ![]() ![]() |
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Signal word | Danger |
Hazard statement(s) | H301 Toxic if swallowed H311 Toxic in contact with skin H319 Causes serious eye irritation H317 May cause an allergic skin reaction H331 Toxic if inhaled H410 Very toxic to aquatic life with long lasting effects |
Precautionary statement(s) | |
Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. |
Response | P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/\u2026 P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P312 Call a POISON CENTER/doctor/\u2026if you feel unwell. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313 If eye irritation persists: Get medical advice/attention. P333+P313 If skin irritation or rash occurs: Get medical advice/attention. P362+P364 Take off contaminated clothing and wash it before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P311 Call a POISON CENTER/doctor/\u2026 P391 Collect spillage. |
Storage | P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed. |
Disposal | P501 Dispose of contents/container to ... |
none
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