Phosphoric acid

Iupac Name：phosphoric acid

Molecular Weight：97.995181

Modify Date.: 2022-11-06 02:49

Introduction: Phosphoric acid was prepared first by Robert Boyle in 1694 by dissolving phosphorus pentoxide in water. Phosphoric acid is probably the most important compound of phosphorus. It is the second largest inorganic chemical by volume, after sulfuric acid, marketed in the United States.The single most important application of Phosphoric acid is manufacturing phosphate salts for fertilizers. Such fertilizer phosphates include sodium, calcium, ammonium, and potassium phosphates. Other applications are in metal pickling and surface treatment for removal of metal oxides from metal surfaces; electropolishing of aluminum; as a bonding agent in various refractory products such as alumina and magnesia; as a catalyst in making nylon and gasoline; as a dehydrating agent; in fireproofing wood and fabrics; in lithographic engraving; in textile dyeing; in dental cement; in coagulating rubber latex; in purifying hydrogen peroxide; and as a laboratory reagent. Dilute solutions of phosphoric acid are used as additives to carbonated beverages for a pleasing sour taste. Also, dilute acid is used in refining sugar; as a nutrient; and as a buffering agent in preparing jam, jelly, and antibiotics. The commercial phosphoric acid is 85% (w/w) in strength. View more+

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1. Names and Identifiers

1.1 Name: Phosphoric acid
1.2 Synonyms: EINECS 231-633-2 EVITs FEMA 2900 H3PO4 Marphos MFCD00011340 NFB PHOS ACID Phosphoric phosphoric acid for technical phosphoric acid，technical，highly purified phosphoricacidsolutions Phosphorous acid Phosphorsaeureloesungen Sonac U.N. 1805 wc-reiniger White phosphoric acid whitephosphoricacid

1.3 CAS No.: 7664-38-2

1.4 CID: 1004

1.5 EINECS(EC#): 231-633-2

1.6 Molecular Formula: H3O4P (isomer)

1.7 Inchi: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)

1.8 InChkey: NBIIXXVUZAFLBC-UHFFFAOYSA-N

1.9 Canonical Smiles: OP(=O)(O)O

1.10 Isomers Smiles: OP(=O)(O)O

2. Properties

2.1 Density: 1.685 g/mL at 25℃ (lit.)

2.1 Melting point: 21℃

2.1 Boiling point: 158℃

2.1 Refractive index: n20/D 1.433

2.2 Precise Quality: 97.97690

2.2 PSA: 87.57000

2.2 logP: -0.92860

2.2 Solubility: H2O: soluble

2.3 Viscosity: 3.86 mPa.s (40% solution at 20 deg C).

2.4 VaporDensity: 3.4 (vs air)

2.5 Appearance: Clear liquid

2.6 Storage: Ambient temperatures.

2.7 Autoignition Temperature: Not flammable (USCG, 1999)

2.8 Carcinogenicity: Phosphoric acid was not mutagenic in bacterial assays.

2.9 Chemical Properties: Phosphoric acid is a colorless, odorless, crystalline solid or a thick syrupy liquid. Physical state is strength and temperature dependent.Concentrated phosphoric acid occurs as a colorless, odorless, syrupy liquid. It has a pleasing acid taste when suitably diluted.Pure phosphoric acid, also called orthophosphoric acid, is a clear, colorless, mineral acid with moderate strength. It is normally marketed as an aqueous solution of 75–85% in which it exists as a clear, viscous liquid.

2.10 Color/Form: ≤10(APHA)

2.11 Corrosivity: Corrosive to ferrous metals and alloys

2.12 Decomposition: Combustion by-products include oxides of phosphorus.

2.13 Odor: Odorless

2.14 PH: pH = 1.5 (0.1 N aqueous solution)

2.15 pKa: 2.1-7.2-12.3(at 25℃)

2.16 Water Solubility: MISCIBLE

2.17 Spectral Properties: Index of refraction: 1.34203 @ 17.5 deg C/D, 10% soln; 1.35032 @ 17.5 deg C/D, 20% soln; 1.35846 @ 17.5 deg C/D, 30% soln

2.18 Stability: Stable at room temperature in closed containers under normal storage and handling conditions.

2.19 StorageTemp: no restrictions.

3. Use and Manufacturing

3.1 Agricultural Uses: Phosphoric acid (H3PO4), also known as orthophosphoricacid, is the most significant source ofphosphate fertilizers. Phosphoric acid based fertilizersmainly include ammonium phosphate, diammoniumphosphate and monoammonium phosphate. Phosphoric acid is deliquescent and commercially themost important derivative of phosphorus, accounting forover 90% of the phosphate rock mined. The whiterhombic solid is highly soluble in water and ethanol, andthe concentrated aqueous solution is generally availablefor use. Phosphoric acid is used in several industries otherthan the fertilizer industry. Most elemental phosphorus isconverted into phosphoric acid for non-fertilizer use.There are two basic processes for the production ofphosphoric acid. Metaphosphoric acid is obtained by heatingphosphoric acid until dense white fumes begin to appear.The product is highly deliquescent and glassy inappearance. Its salts are known as metaphosphates.Orthophosphoric acid is the most common and is usedas an important phosphate ingredient in commercialfertilizers.

3.2 Definition: ChEBI: A phosphorus oxoacid that consits of one oxo and three hydroxy groups joined covalently to a central phosphorus atom.

3.3 History: Phosphoric acid was produced but not identified by alchemists in ancient times. It derives its name from the element phosphorus, which was discovered in 1669 by Henning Brand (1630 1710).Scheele subsequently isolated phosphorus from bone ash and produced phosphoric acid by reacting phosphorus and nitric acid. Scheele's method replaced bone as the main source of phosphorus rather than urine. John Bennett Lawes (1814 1900) patented a process in 1841 of making superphosphate from bones and later extended his process to phosphates obtained from rock. Superphosphates are made by treating Ca3(PO4)2 with sulfuric acid to make more soluble calcium hydrogen phosphates: Ca3(PO4)2 + 2H2SO4 Ca(H2PO4)2 + 2CaSO4. In this reaction Ca(H2PO4)2 is monobasic calcium phosphate, which is also called superphosphate. Calcium hydrogen phosphates (superphosphates) are more water soluble and therefore more readily available to plants.

3.4 Polymerization: Violent polymerization with: Azo compounds; Epoxides; And polymerizable compounds.

3.5 Potential Exposure: Phosphoric acid is used in the manufacture of fertilizers, phosphate salts; polyphosphates, detergents, activated carbon; animal feed; ceramics, dental cement; pharmaceuticals, soft drinks; gelatin, rust inhibitors; wax, and rubber latex. Exposure may also occur during electropolishing, engraving, photoengraving, lithographing, metal cleaning; sugar refining; and water-treating.

3.6 Produe Method: The majority of phosphoric acid is made by digesting phosphaterock (essentially tricalcium phosphate) with sulfuric acid; thephosphoric acid is then separated by slurry filtration. Purificationis achieved via chemical precipitation, solvent extraction, crystallization,or ion exchange.

3.7 Shipping: UN1805 Phosphoric acid solution, Hazard class: 8; Labels: 8-Corrosive material. UN3543 Phosphoric acid solid, Hazard class: 8; Labels: 8-Corrosive material.

3.8 Usage: Phosphoric acid is second only to sulfuric acid as an industrial acid and consistently ranksin the top 10 chemicals used globally.States, but it is used in a number of other applications. Phosphateswere used as builders and water softeners. A builder is a substance added to soaps or detergentsto increase their cleansing power.Phosphoric acid is used as an intermediate in the production of animal feed supplements,water treatment chemicals, metal surface treatments, etching agent, and personal care productssuch as toothpaste. It is used as a catalyst in the petroleum and polymer industry. Phosphoricacid is used in food as a preservative, an acidulant, and flavor enhancer; it acidifies carbonateddrinks such as Coca Cola and Pepsi, giving them a tangy flavor. Phosphoric acid is used as arust remover and metal cleaner. Naval Jelly is approximately 25% phosphoric acid. Other usesfor phosphoric acid include opacity control in glass production, textile dyeing, rubber latexcoagulation, and dental cements.

3.9 Waste Disposal: Add slowly to solution of soda ash and slaked lime with stirring, then flush to sewer with large volumes of water.

4. Safety and Handling

4.1 Symbol: GHS05

4.1 Hazard Codes: C

4.1 Signal Word: Danger

4.1 Risk Statements: R34

4.1 Safety Statements: S26;S45

4.1 Exposure Standards and Regulations: Phosphoric acid used as a general purpose food additive in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.

4.2 Packing Group: III

4.2 Fire Hazard: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.

4.3 Other Preventative Measures: Ventilation control: acid cleaning: nature & extent of ventilation control required depends on rate of acid mist escape; where exposure mild addn of inhibitor may make process or slot ventilation unnecessary. inhibitors should never be added to automatically timed conveyorized job without adjustment.
Phosphoric acid soln in water is used alone or with a mixture of alcohols and ethers, including butyl cellosolve, to remove light rust on steel. If mists, fogs, or elevated temperatures are involved, ventilation control is necessary.
In presence of impurities in metals, nascent hydrogen may be generated which could lead to formation of phosphine gas. It is necessary to avoid inhalation of vapors coming from phosphoric acid metal cleaning tanks. Slotted local exhaust ventilation @ upper edges of tanks recommended.
Clothing contaminated with phosphoric acid should be placed in closed containers for storage until it can be discarded or until provision is made for the removal of phosphoric acid from the clothing. If the clothing is to be laundered or otherwise cleaned to remove the phosphoric acid, the person performing the operation should be informed of phosphoric acid's hazardous properties.
Non-impervious clothing which becomes contaminated with phosphoric acid should be removed immediately and not reworn until the phosphoric acid is removed from the clothing.
Avoid breathing vapors. keep upwind. Avoid bodily contact with the material. do not handle broken packages without protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water.
The worker should immediately wash the skin when it becomes contaminated.
Work clothing that becomes wet or significantly contaminated should be removed and replaced.
Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premises.
SRP: the scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. in those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
SRP: contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.

4.4 Hazard Class: 8

4.4 Hazard Declaration: H290-H314

4.4 Cleanup Methods: 1. Ventilate area of spill or leak. 2. If in the solid form, collect spilled material in the most convenient and safe manner for reclamation or for disposal in a secured sanitary landfill. 3. If in the liquid form, collect for reclamation or absorb in vermiculite, dry sand, earth, or a similar material.
Cellosized absorbent material may be used for vapor suppression and containment of spills.
Air spill: Apply water spray or mist to knock down vapors. Vapor knockdown water is corrosive or toxic and should be diked for containment.
Water spill: Neutralize with agricultural lime (slaked lime), crushed limestone, or sodium bicarbonate. Adjust pH to neutral (pH-7). Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates.
Land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash or cement powder. Neutralize with agricultural lime, crushed limestone, or sodium bicarbonate.

4.5 DisposalMethods: SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
Following cleanup, separate solids then precipitate with lime pH 11.0. ... An anionic polymer may be added to assist in settling of the solids. ... If necessary, the water, after treatment with lime, can pass through dual media filtration to remove the solids and then neutralize with hydrochloric acid. ... Following neutralization either at the spill site or at a waste management facility, the resultant sludge can be disposed of in a secure landfill.
Technology appropriate for incineration: Rotary kiln.
Technology appropriate for incineration: Venturi scrubber.
Neutralization & landfill: Neutralize with soda ash or soda ash-slaked lime mixture (1:1) and bury in an approved landfill.

4.6 DOT Emergency Guidelines: /GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Health: TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. /Phosphoric acid; Phosphoric acid, liquid; Phosphoric acid, solid; Phosphoric acid, solution/
/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Fire or Explosion: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. /Phosphoric acid; Phosphoric acid, liquid; Phosphoric acid, solid; Phosphoric acid, solution/
/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number. As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas. /Phosphoric acid; Phosphoric acid, liquid; Phosphoric acid, solid; Phosphoric acid, solution/
/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Phosphoric acid; Phosphoric acid, liquid; Phosphoric acid, solid; Phosphoric acid, solution/
/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Evacuation: Fire: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. /Phosphoric acid; Phosphoric acid, liquid; Phosphoric acid, solid; Phosphoric acid, solution/
/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Fire: Small fires: Dry chemical, CO2 or water spray. Large fires: Dry chemical, CO2, alcohol-resistant foam or water spray. Move containers from fire area if you can do it without risk. Dike fire control water for later disposal; do not scatter the material. Fire involving tanks or car/trailer loads: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. /Phosphoric acid; Phosphoric acid, liquid; Phosphoric acid, solid; Phosphoric acid, solution/
/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Spill or Leak: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. /Phosphoric acid; Phosphoric acid, liquid; Phosphoric acid, solid; Phosphoric acid, solution/
/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ First Aid: Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. /Phosphoric acid; Phosphoric acid, liquid; Phosphoric acid, solid; Phosphoric acid, solution/

4.7 RIDADR: UN 3453 8/PG 3

4.7 Fire Fighting Procedures: Use water spray to keep fire-exposed containers cool. Extinguish fire using agent suitable for surrounding fire.
If material /is/ on fire or involved in /a/ fire, extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Cool all containers with flooding quantities of water. Apply water from as far a distance as possible.

4.8 FirePotential: Not combustible.

4.9 Safety Profile: Human poison by ingestion. Moderately toxic by skin contact. A corrosive irritant to eyes, skin, and mucous membranes, and a systemic irritant by inhalation. A common air contaminant. A strong acid. Mixtures with nitromethane are explosive. Reacts with chlorides + stainless steel to form explosive hydrogen gas. Potentially violent reaction with solum tetrahydroborate. Dangerous; when heated to decomposition it emits toxic fumes of POx

4.10 Caution Statement: P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338

4.10 Formulations/Preparations: Commercial phosphoric acid, containing 68.8% or less of phosphoric anhydride, is composed only of monomeric phosphoric acid, h3po4. Commercial compositions containing more than 68.8% phosphoric anhydride contain increasing quantities of polymers of phosphoric acid.
Pure solid phosphoric acid contains 72.44% phosphoric anhydride. Max concn of liq phosphoric acid is 88% phosphoric acid, or 63.75% phosphoric anhydride.
Polyphosphoric acid (mixture of orthophosphoric acid with pyrophosphoric, triphosphoric, and higher acids and is sold on the basis of its calculated hspo4 content, e.g.; 115% phosphoric acid. super phosphoric acid is a similar mixtur solid at 105% hspo4.
Wet-process acid, merchant grade, has min assay of 53.1%; purified wet-process acid, tech grade, has min assay of 54%; thermal acid, tech grade, has min assay of 54.32%
Wet acid (merchant grade) is 53-54% phosphoric anhydride and superacid grade is 68-70% phosphoric anhydride.
Reagent grade concentrated phosphoric acid is 85-87% (wt/wt) phosphoric acid (equivalent to about 17 m).

4.11 Incompatibilities: Phosphoric acid is a strong acid and reacts with alkaline substances.Mixtures with nitromethane are explosive.

4.12 WGK Germany: 3

4.12 RTECS: TB6300000

4.12 Protective Equipment and Clothing: Goggles or face shield
Wear rubber gloves, and overalls prepared with a total seal.
Wear special protective clothing and positive pressure self-contained breathing apparatus.
Respiratory protection (supplied-air respirator with full facepiece or self-contained breathing apparatus) should be available where these compounds are manufactured or used and should be worn in case of emergency and overexposure. /Phosphorus compounds/
Wear appropriate personal protective clothing to prevent skin contact.
Wear appropriate eye protection to prevent eye contact.
Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to liquids containing > 1.6% of contaminant; this is irrespective of the recommendation involving the wearing of eye protection.
Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure with liquids containing > 1.6% of contaminant. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.]
Recommendations for respirator selection. Max concn for use: 25 mg/cu m. Respirator Class(es): Any supplied-air respirator operated in a continuous flow mode. May require eye protection.
Recommendations for respirator selection. Max concn for use: 50 mg/cu m. Respirator Class(es): Any air-purifying, full-facepiece respirator with a high-efficiency particulate filter. Any self-contained breathing apparatus with a full facepiece. Any supplied-air respirator with a full facepiece.
Recommendations for respirator selection. Max concn for use: 1000 mg/cu m. Respirator Class(es): Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode.
Recommendations for respirator selection. Condition: Emergency or planned entry into unknown concn or IDLH conditions: Respirator Class(es): Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode. Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive-pressure mode.
Recommendations for respirator selection. Condition: Escape from suddenly occurring respiratory hazards: Respirator Class(es): Any air-purifying, full-facepiece respirator with a high-efficiency particulate filter. Any appropriate escape-type, self-contained breathing apparatus.

4.13 Reactivities and Incompatibilities: Reacts with metals to liberate flammable hydrogen gas.
With sodium tetrahydroborate: Interaction of sodium and other tetrahydroborates with anhydrous acids (phosphoric acid) to generate diborane is very exothermic, and may be dangerously violent with rapid mixing.
Heat generated with: Alcohols and glycols; Aldehydes; Amides; Amines; Azo-compounds; Carbamates; Caustics; Esters; Ketones; Phenols and cresols; Organophosphates; Epoxides; Combustible materials; Explosives; Unsaturated halides; And organic peroxides.
Formation of flammable gases with: Aldehydes; Cyanides; Mercaptans; and sulfides. Formation of toxic fumes with: Cyanides; Fluorides; Halogenated organics; Sulfides; And organic peroxides.
With chlorides and stainless steel: Presence of traces of chloride ion in technical 75% phosphoric acid in a closed stainless storage tank caused corrosive liberation of hydrogen which later exploded at a sparking contact.
Hot, dilute phosphoric acid reacts with nickel carbonate to form trinickel orthophosphate.
Reacts with strong alkalies and most metals.
Strong caustics, most metals [Note: Readily reacts with metals to form flammable hydrogen gas. DO NOT MIX WITH SOLUTIONS CONTAINING BLEACH OR AMMONIA].
Mixtures with nitromethane are explosive. Reacts with chlorides + stainless steel to form explosive hydrogen gas.

4.14 Report: Community Right-To-Know List. Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

4.15 Skin, Eye, and Respiratory Irritations: Causes severe eye and skin irritation.
Phosphoric acid mist is an irritant to the eyes, upper respiratory tract, and skin. The solid is especially irritating to the skin in the presence of moisture. A dilute solution buffered to pH 2.5 caused a moderate, brief stinging sensation but no injury when dropped in the human eye. A 75% solution will cause severe skin burns.

4.16 Safety: Safety Information
Hazard Codes:CXnTF
Risk Statements: 34-35-22-39/23/24/25-36/38-11
R11: Highly flammable.
R22: Harmful if swallowed.
R34: Causes burns.
R35: Causes severe burns.
R36/38: Irritating to eyes and skin.
R39/23/24/25: Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed
Safety Statements: 7-16-26-45-36/37/39-1/2-24/25
S7: Keep container tightly closed.
S16: Keep away from sources of ignition.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S1/2: Keep locked up and out of the reach of children.
S24/25: Avoid contact with skin and eyes.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: UN 3453 8/PG 3
WGK Germany: 3
RTECS: TB6300000
F: 3-10
HazardClass: 8
PackingGroup: III
Human poison by ingestion. Moderately toxic by skin contact. A corrosive irritant to eyes, skin, and mucous membranes, and a systemic irritant by inhalation. A common air contaminant. A strong acid. Mixtures with nitromethane are explosive. Reacts with chlorides + stainless steel to form explosive hydrogen gas. Potentially violent reaction with sodium tetrahydroborate. Dangerous; when heated to decomposition it emits toxic fumes of PO_x.

4.17 Specification: General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Wear appropriate protective clothing to prevent contact with skin and eyes. Wear a self-contained breathing apparatus (SCBA) to prevent contact with thermal decomposition products. Substance is noncombustible.
Extinguishing Media: For small fires, use water spray, dry chemical, carbon dioxide or chemical foam. Use water spray to cool fire-exposed containers. Use water spray, dry chemical, carbon dioxide, or chemical foam.
Handling: Wash thoroughly after handling. Use only in a well-ventilated area. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Corrosives area.

4.18 Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	LDLo	unreported	220mg/kg (220mg/kg)		"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
rabbit	LD50	skin	2740mg/kg (2740mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT	BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 17-4/1970,
rat	LC50	inhalation	> 850mg/m³/1H (850mg/m³)		BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 17-4/1970,
rat	LD50	oral	1530mg/kg (1530mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) KIDNEY, URETER, AND BLADDER: HEMATURIA SKIN AND APPENDAGES (SKIN): HAIR: OTHER	BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 17-4/1970,

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5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Skin corrosion, Category 1B

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Danger
Hazard statement(s)	H314 Causes severe skin burns and eye damage
Precautionary statement(s)
Prevention	P260 Do not breathe dust/fume/gas/mist/vapours/spray. P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection.
Response	P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower]. P363 Wash contaminated clothing before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P310 Immediately call a POISON CENTER/doctor/\u2026 P321 Specific treatment (see ... on this label). P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

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6. Synthesis Route

7664-38-2Total: 307 Synthesis Route

58-64-0 86 Suppliers

7664-38-2 1091 Suppliers

Literatures:
Gulland; Walsh Journal of the Chemical Society, 1945 , p. 169,171
Yield: null

83-86-3 249 Suppliers

7664-38-2 1091 Suppliers

Literatures:
Winterstein Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1908 , vol. 58, p. 119 Full Text Show Details Contardi Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1909 , vol. <5> 18 I, p. 66
Yield: null

71-43-2 200 Suppliers

7664-38-2 1091 Suppliers

1571-33-1 104 Suppliers

Literatures:
Journal of the American Chemical Society, , vol. 76, p. 1045,1047, 1051 Journal of the American Chemical Society, , vol. 78, p. 5018,5022
Yield: null

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7. Precursor and Product

precursor:

3366-72-1

58-64-0

688-62-0

904-73-4

83-86-3

2617-47-2

71-43-2

101-02-0

132-06-9

7647-19-0

1189-11-3

940-71-6

2465-65-8

488-69-7

6303-21-5

138-08-9

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product :

470-67-7

141-79-7

1623-24-1

13598-52-2

5707-55-1

120-80-9

83-86-3

112-05-0

107-01-7

470-82-6

503-74-2

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8. Other Information

8.0 Merck: 14,7344

8.1 BRN: 1921286

8.2 Description: Phosphoric acid was prepared first by Robert Boyle in 1694 by dissolving phosphorus pentoxide in water. Phosphoric acid is probably the most important compound of phosphorus. It is the second largest inorganic chemical by volume, after sulfuric acid, marketed in the United States.
The single most important application of Phosphoric acid is manufacturing phosphate salts for fertilizers. Such fertilizer phosphates include sodium, calcium, ammonium, and potassium phosphates. Other applications are in metal pickling and surface treatment for removal of metal oxides from metal surfaces; electropolishing of aluminum; as a bonding agent in various refractory products such as alumina and magnesia; as a catalyst in making nylon and gasoline; as a dehydrating agent; in fireproofing wood and fabrics; in lithographic engraving; in textile dyeing; in dental cement; in coagulating rubber latex; in purifying hydrogen peroxide; and as a laboratory reagent. Dilute solutions of phosphoric acid are used as additives to carbonated beverages for a pleasing sour taste. Also, dilute acid is used in refining sugar; as a nutrient; and as a buffering agent in preparing jam, jelly, and antibiotics. The commercial phosphoric acid is 85% (w/w) in strength.

8.3 Chemical Properties: Phosphoric acid is a colorless, odorless, crystalline solid or a thick syrupy liquid. Physical state is strength and temperature dependent.
Concentrated phosphoric acid occurs as a colorless, odorless, syrupy liquid. It has a pleasing acid taste when suitably diluted.
Pure phosphoric acid, also called orthophosphoric acid, is a clear, colorless, mineral acid with moderate strength. It is normally marketed as an aqueous solution of 75–85% in which it exists as a clear, viscous liquid.

Food-grade phosphoric acid is used to acidify foods and beverages. It provides a tangy or sour taste and, being a mass-produced chemical, is available cheaply and in large quantities. Phosphoric acid, used in many soft drinks, has been linked to lower bone density in epidemiological studies. In brief, phosphoric acid is a strong acid and common industrial chemical used in the manufacture of a wide number of products, notably porcelain and metal cleaners, detergents, and fertilisers. It is also used as a food additive and is a major constituent of many soft drinks. Low phosphate concentrations are found in drinking water to which it is added in some areas in order to reduce lead solubility.

8.4 Physical properties: Chemists refer to orthophosphoric acid as phosphoric acid, which is the IUPAC name for this compound. The prefix “ortho” is used to distinguish the acid from other phosphoric acids, which are generally called polyphosphoric acids. Orthophosphoric acid is a nontoxic, rather weak triprotic acid. When pure, it is a solid at STP. Orthophosphoric acid is a very polar molecule which makes it highly soluble in water. The valence state of phosphorous in orthophosphoric acid and other phosphoric acids is ＋5. Triprotic means that the orthophosphoric acid molecule can dissociate up to three times, producing a hydrogen cation, H⁺, each time.

8.5 Occurrence: Phosphoric acid is a natural constituent of many fruits and their juices.

8.6 History: Phosphoric acid was produced but not identified by alchemists in ancient times. It derives its name from the element phosphorus, which was discovered in 1669 by Henning Brand (1630 1710).Scheele subsequently isolated phosphorus from bone ash and produced phosphoric acid by reacting phosphorus and nitric acid. Scheele's method replaced bone as the main source of phosphorus rather than urine.
John Bennett Lawes (1814 1900) patented a process in 1841 of making superphosphate from bones and later extended his process to phosphates obtained from rock. Superphosphates are made by treating Ca3(PO4)2 with sulfuric acid to make more soluble calcium hydrogen phosphates: Ca3(PO4)2 + 2H2SO4 Ca(H2PO4)2 + 2CaSO4. In this reaction Ca(H2PO4)2 is monobasic calcium phosphate, which is also called superphosphate. Calcium hydrogen phosphates (superphosphates) are more water soluble and therefore more readily available to plants.

8.7 Uses: Phosphoric acid is second only to sulfuric acid as an industrial acid and consistently ranksin the top 10 chemicals used globally.States, but it is used in a number of other applications. Phosphateswere used as builders and water softeners. A builder is a substance added to soaps or detergentsto increase their cleansing power.
Phosphoric acid is used as an intermediate in the production of animal feed supplements,water treatment chemicals, metal surface treatments, etching agent, and personal care productssuch as toothpaste. It is used as a catalyst in the petroleum and polymer industry. Phosphoricacid is used in food as a preservative, an acidulant, and flavor enhancer; it acidifies carbonateddrinks such as Coca Cola and Pepsi, giving them a tangy flavor. Phosphoric acid is used as arust remover and metal cleaner. Naval Jelly is approximately 25% phosphoric acid. Other usesfor phosphoric acid include opacity control in glass production, textile dyeing, rubber latexcoagulation, and dental cements.

8.8 Uses: Phosphoric acid (H₃PO₄) is the most important oxoacid of phosphorus and its main use is in the manufacture of fertilisers.
Within the human body, phosphate is the main phosphorus-containing compound. Phosphate is an inorganic compound and is the salt of phosphoric acid. It can form organic esters with a variety of compounds and these are important in many biochemical processes. Phosphate has the empirical formula PO₄^3-. It is a tetrahedral molecule, where the central phosphorus atom is surrounded by four oxygen atoms.
In biological systems, phosphate is often found either as the free ion (inorganic phosphate) or as an ester after reaction with organic compounds (often referred to as organic phosphates). Inorganic phosphate (mostly denoted as Pi) is a mixture of HPO₄^2- and H₂PO₄^- at physiological pH.

8.9 Uses: In the manufacture of superphosphates for fertilizers, other phosphate salts, polyphosphates, detergents. Acid catalyst in making ethylene, purifying hydrogen peroxide. As acidulant and flavor, synergistic antioxidant and sequestrant in food. Pharmaceutic aid (solvent). In dental cements; process engraving; rustproofing of metals before painting; coagulating rubber latex; as analytical reagent.

8.10 Uses: Phosphoric Acid is an acidulant that is an inorganic acid produced by burning phosphorus in an excess of air, producing phosphorus pentoxide which is dissolved in water to form orthophosphoric acid of varying concentrations. it is a strong acid which is soluble in water. the acid salts are termed phosphates. it is used as a flavoring acid in cola and root beer beverages to provide desirable acidity and sourness. it is used as a synergistic antioxidant in vegetable shorten- ings. in yeast manufacture, it is used to maintain the acidic ph and provide a source for phosphorus. it also functions as an acidulant in cheese. it is also termed orthophosphoric acid.

8.11 Definition: ChEBI: A phosphorus oxoacid that consits of one oxo and three hydroxy groups joined covalently to a central phosphorus atom.

8.12 Preparation: Low-purity technical grade phosphoric acid for use in fertilizers is produced from phosphate rocks by digestion with concentrated sulfuric acid. The apatite types, primarily consisting of calcium phosphate phosphate rocks, are used: Ca3(PO4)2 + 3H2SO4 + 6H2O → 2H3PO4 + 3(CaSO4?2H2O)
The insoluble calcium sulfate slurry is filtered out. Acid from this wet process is impure but can be purified by various methods. Purification steps involve precipitation, solvent extraction, crystallization, and ion exchange techniques.
Phosphoric acid also can be made by many different methods. Dissolution of phosphorus pentoxide in water and boiling yields phosphoric acid. Pure phosphoric acid can be obtained by burning phosphorus in a mixture of air and steam:
P4 (l) + 5O2 (g) →P4O10 (s)
P4O10 (s) + H2O (g) → 4H3PO4 (l)
The acid also may be prepared by heating violet phosphorus with 33% nitric acid:
4P + 10HNO3 + H2O → 4H3PO4 + 5NO ↑ + 5NO2 ↑
or by heating red phosphorus with nitric acid (1:1). The overall equation is:
P + 3HNO3 → H3PO4 + NO + 2NO2

8.13 Production Methods: The majority of phosphoric acid is made by digesting phosphate rock (essentially tricalcium phosphate) with sulfuric acid; the phosphoric acid is then separated by slurry filtration. Purification is achieved via chemical precipitation, solvent extraction, crystallization, or ion exchange.

8.14 Production Methods: The major sources of H3PO4 traditionally have been mineral deposits of phosphate rock. Mining operations are extensive in a number of locations, including the United States (Florida), the Mediterranean area, and Russia, among others. The major constituent of most phosphate rocks is fluorapatite, 3Ca3(PO4)2·CaF2. The supply of high-grade phosphates, the raw material of choice for producing high-purity phosphoric acid by the wet process, is rapidly decreasing in some areas.
Two major methods are utilized for the production of phosphoric acid from phosphate rock. The wet process involves the reaction of phosphate rock with sulfuric acid to produce phosphoric acid and insoluble calcium sulfates. Many of the impurities present in the phosphate rock are also solubilized and retained in the acid so produced. While they are of no serious disadvantage when the acid is to be used for fertilizer manufacture, their presence makes the product unsuitable for the preparation of phosphatic chemicals.
In the other method, the furnace process, phosphate rock is combined with coke and silica and reduced at high temperature in an electric furnace, followed by condensation of elemental phosphorus. Phosphoric acid is produced by burning the elemental phosphorus with air and absorbing the P2O5 in water. The acid produced by this method is of high purity and suitable for nearly all uses with little or no further treatment.

8.15 Brand name: Pharmaceutic aid (solvent).

8.16 General Description: A clear colorless liquid or transparent crystalline solid. The pure solid melts at 42.35°C and has a density of 1.834 g / cm3. Liquid is usually an 85% aqueous solution. Shipped as both a solid and liquid. Corrosive to metals and tissue. Used in making fertilizers and detergents and in food processing.

8.17 Air & Water Reactions: Soluble in water with small release of heat.

8.18 Reactivity Profile: Phosphorous acid reacts exothermically with bases. May react with active metals, including such structural metals as aluminum and iron, to release hydrogen, a flammable gas. Can initiate the polymerization of certain classes of organic compounds. Reacts with cyanide compounds to release gaseous hydrogen cyanide. May generate flammable and/or toxic gases in contact with dithiocarbamates, isocyanates, mercaptans, nitrides, nitriles, sulfides, and strong reducing agents. Forms explosive mixture with nitromethane. Reacts violently with sodium tetrahydroborate. In the presence of chlorides can corrode stainless steel to form explosive hydrogen gas. Emits toxic and irritating fumes of oxides of phosphorus when heated to decomposition [Lewis, 3rd ed., 1993, p. 1029].

8.19 Hazard: Phosphoric acid is water soluble and absorbs oxygen readily, and the specific gravity is 1.89, which is heavier than water. It is toxic by ingestion and inhalation and an irritant to the skin and eyes, with a TLV of 1 mg/m3 of air. The four-digit UN identification number is 1805. The NFPA 704 designation is health 3, flammability 0, and reactivity 0. The primary use of phosphoric acid is in chemical analysis and as a reducing agent.

8.20 Health Hazard: Phosphoric acid is less corrosive and hazardous than is concentrated sulfuric or nitricacid. Its concentrated solutions are irritantsto the skin and mucous membranes. Thevapors (P2O5 fumes) can cause irritation tothe throat and coughing but could be tolerated at <10 mg/m³.The acute oral toxicity in rats is reported tobe low, the LD50 value being 1530 mg/kg(NIOSH 1986).

8.21 Fire Hazard: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.

8.22 Agricultural Uses: Phosphoric acid (H₃PO₄), also known as orthophosphoric acid, is the most significant source of phosphate fertilizers. Phosphoric acid based fertilizers mainly include ammonium phosphate, diammonium phosphate and monoammonium phosphate.
Phosphoric acid is deliquescent and commercially the most important derivative of phosphorus, accounting for over 90% of the phosphate rock mined. The white rhombic solid is highly soluble in water and ethanol, and the concentrated aqueous solution is generally available for use.
Phosphoric acid is used in several industries other than the fertilizer industry. Most elemental phosphorus is converted into phosphoric acid for non-fertilizer use. There are two basic processes for the production of phosphoric acid.
Metaphosphoric acid is obtained by heating phosphoric acid until dense white fumes begin to appear. The product is highly deliquescent and glassy in appearance. Its salts are known as metaphosphates. Orthophosphoric acid is the most common and is used as an important phosphate ingredient in commercial fertilizers.

8.23 Pharmaceutical Applications: Phosphoric acid is widely used as an acidifying agent in a variety of pharmaceutical formulations. It is used in pharmaceutical products as part of a buffer system when combined with a phosphate salt such as sodium phosphate, monobasic or dibasic. It is also widely used in food preparations as an acidulant, flavor, and synergistic antioxidant (0.001–0.005%) and sequestrant.
Therapeutically, dilute phosphoric acid has been used welldiluted in preparations used in the treatment of nausea and vomiting. Phosphoric acid 35% gel has also been used to etch tooth enamel and to enhance delivery of drugs through the nail.
) Nanosized hydroxyapatite powder was made by combining phosphoric acid with egg shells.

8.24 Industrial uses: As a cleanser for metals, phosphoric acid produces a light etch on steel, aluminum, or zinc, which aids paint adhesion. Deoxidine is a phosphoric acid cleanser for metals. Nielite D is phosphoric acid with a rust inhibitor, used as a nonfuming pickling acid for steel. Albrite is available in 75, 80, and 85% concentrations in food and electronic grades, both high-purity specifications. DAB and Phosbrite are called Bright Dip grades, for cleaning applications. Phosphoric anhydride, or phosphorus pentoxide, P2O5, is a white, water-soluble powder used as a dehydrating agent and also as an opalizer for glass. It is also used as a catalyst in asphalt coatings to prevent softening at elevated temperatures and brittleness at low temperatures.

8.25 Biochem/physiol Actions: Phosphoric acid is commonly used in fertilizer industry. It is also used in the manufacture of insecticide and pesticide.

8.26 Safety Profile: Human poison by ingestion. Moderately toxic by skin contact. A corrosive irritant to eyes, skin, and mucous membranes, and a systemic irritant by inhalation. A common air contaminant. A strong acid. Mixtures with nitromethane are explosive. Reacts with chlorides + stainless steel to form explosive hydrogen gas. Potentially violent reaction with solum tetrahydroborate. Dangerous; when heated to decomposition it emits toxic fumes of POx

8.27 Safety: In the concentrated form, phosphoric acid is an extremely corrosive and harmful acid. However, when used in pharmaceutical formulations it is usually very diluted and is generally regarded as an essentially nontoxic and nonirritant material.
The lowest lethal oral dose of concentrated phosphoric acid in humans is reported to be 1286 mL/kg.
(rabbit, skin): 2.74 g/kg
(rat, oral): 1.53 g/kg

8.28 Usage: Phosphoric acid is used mainly in fertilizers. It is used as an external standard for phosphorus-31 Nuclear magnetic resonance (NMR); as an electrolyte in phosphoric acid fuel cells and as a catalyst in the hydration of alkenes to produce alcohols, predominantly ethanol. It finds application as a buffer agent in biology and chemistry; as a solution for anodizing and as a cleaner by construction trades to remove mineral deposits, cementitious smears and hard water stains. It is also used as a pH adjuster in cosmetics and skin-care products and a dispersing agent in detergents and leather treatment. It plays an important role in the preparation of albumin derivatives. It is an important starting material used in the preparation of disodium hydrogen phosphate, trisodium phosphate, calcium dihydrogen phosphate and monohydrogen phosphate. It is also used in dentistry and orthodontics as an etching solution as well as a sanitizing agent in dairy, food and brewing industries. It serves as an acidic fruitlike flavoring in food products. It is widely used to remove rust in steel tools or surfaces by converting the rusted ion in to water soluble phosphate compound.

8.29 Usage: Phosphoric acid is used mainly in fertilizers. It is used as an external standard for phosphorus-31 Nuclear magnetic resonance (NMR); as an electrolyte in phosphoric acid fuel cells and as a catalyst in the hydration of alkenes to produce alcohols, predominantly ethanol. It finds application as a buffer agent in biology and chemistry; as a solution for anodizing and as a cleaner by construction trades to remove mineral deposits, cementitious smears and hard water stains. It is also used as a pH adjuster in cosmetics and skin-care products and a dispersing agent in detergents and in leather treatment. It plays an important role in the preparation of albumin derivatives. It is an important starting material used in the preparation of disodium hydrogen phosphate, trisodium phosphate, calcium dihydrogen phosphate and monohydrogen phosphate. It is also used in dentistry and orthodontics as an etching solution as well as a sanitizing agent in dairy, food and brewing industries. It serves as an acidic fruitlike flavoring in food products. It is widely used to remove rust in steel tools or surfaces by converting the rusted ion into a water soluble phosphate compound.

8.30 Chemical Synthesis: The elemental phosphorus is burned to produce phosphorous pentoxide (P2O5), which is then hydrated. The heat is then removed and the phosphoric acid (H3PO4) is collected as a fine mist. Another important source of phosphoric acid is from phosphate rocks by treatment with sulfuric acid; this is the so-called wet-acid process. The synthesis of pure phosphoric acid involves several steps including a time-consuming, expensive step, the sublimation of white phosphorus.

8.31 Potential Exposure: Phosphoric acid is used in the manufacture of fertilizers, phosphate salts; polyphosphates, detergents, activated carbon; animal feed; ceramics, dental cement; pharmaceuticals, soft drinks; gelatin, rust inhibitors; wax, and rubber latex. Exposure may also occur during electropolishing, engraving, photoengraving, lithographing, metal cleaning; sugar refining; and water-treating.

8.32 Carcinogenicity: Phosphoric acid was not mutagenic in bacterial assays.

8.33 storage: When stored at a low temperature, phosphoric acid may solidify, forming a mass of colorless crystals, comprising the hemihydrate, which melts at 28°C. Phosphoric acid should be stored in an airtight container in a cool, dry place. Stainless steel containers may be used.

8.34 Shipping: UN1805 Phosphoric acid solution, Hazard class: 8; Labels: 8-Corrosive material. UN3543 Phosphoric acid solid, Hazard class: 8; Labels: 8-Corrosive material.

8.35 Incompatibilities: Phosphoric acid is a strong acid and reacts with alkaline substances. Mixtures with nitromethane are explosive.

8.36 Waste Disposal: Add slowly to solution of soda ash and slaked lime with stirring, then flush to sewer with large volumes of water.

8.37 Regulatory Status: GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (infusions, injections, oral solutions, topical creams, lotions, ointments and solutions, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

9. Computational chemical data

Molecular Weight: 97.995181g/mol
Molecular Formula: H₃O₄P
Compound Is Canonicalized: True
XLogP3-AA: -2.1
Exact Mass: 97.97689557
Monoisotopic Mass: 97.97689557
Complexity: 49.8
Rotatable Bond Count: 0
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 4
Topological Polar Surface Area: 77.8
Heavy Atom Count: 5
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Isotope Atom Count: 0
Covalently-Bonded Unit Count: 1
CACTVS Substructure Key Fingerprint: AAADcQAAOAIAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACCAAAAAAAAAAAAAAABAAQAAAAIAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA==

10. Question & Answer

Does repeatedly drinking soda every day weaken the teeth by phosphoric acid? Apr 23 2022
I’m afraid that you are going to have to answer to the Coca Cola company now. Hope you like the weather in Atlanta, Georgia. I had a medical doctor send me a note on this very subject back in 1976. I didn’t have a good answer then, but I do now (I hope). Enamel is built to resist and be damaged b...
Phosphoric acid is usually obtained as an 87% (w/w) phosphoric acid solution. If it is 13M, what is the density of the solution and what is its molality? Apr 11 2022
Take 1 litre of this solution This litre will contain 13 mol H3PO4 Molar mass H3PO4 = 98 g/mol Mass of H3PO4 in solution = 13 mol * 98 g/mol = 1274 g H3PO4 The solution is 87% (m/m) ( not (w/w) Total mass of solution = 1274 g * 100% / 87 % = 1464.4 g Mass of water in solution = 1464.4 g - 1274 g = ...
What is the hydrochloric acid and phosphoric acid formula? Apr 05 2022
Hydrochloric acid = HCl Phosphoric acid = H3PO4 If you are asking what the chemical equation is when the two are mixed, they will not chemically combine. The pH might change depending on the starting pH's of each and the quantities mixed, but that is it. No chemical reaction.
Can the copper in copper chloride react with phosphoric acid? Mar 31 2022
Yes, if you dissolve them both in the same solution and the concentrations are high enough, the copper ions from the copper chloride and phosphate ions from the phosphoric acid will combine to form an insoluble blue solid, copper phosphate. The concentrations don’t have to be very high for this to...

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