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Home> Encyclopedia >   /  Alcohol & Hydroxybenzene & Ether  /  Pharmaceutical Intermediates  /  Organic Intermediate
Poly(vinyl alcohol) structure
Poly(vinyl alcohol) structure

Poly(vinyl alcohol)

Iupac Name:ethenol
CAS No.: 9002-89-5
Molecular Weight:44.053
Modify Date.: 2022-11-06 19:58
Introduction: It is mainly used in the textile industry, as the raw materials of warp pulp, fabric finishing agent, vinylon fiber; interior and exterior wall paint of the building, adhesives; chemical industry use it as a polymerization emulsifier, dispersant and polyvinyl formal, acetal, butyrate aldehyde resin; paper industry use it as a paper binder; agriculture use it as soil improvers, pesticide adhesion synergist and polyvinyl alcohol film; it can also be used for daily cosmetics and high-frequency quenching agent and so on. View more+
1. Names and Identifiers
1.1 Name
Poly(vinyl alcohol)
1.2 Synonyms

EINECS 209-183-3 Ethenol hydroxyethylene MFCD00081922 Poly(1-hydroxyethylene) Poly(vinyl Alcohol) n=1750+/-50 POLYVINYL ALCOHOL 2000 vinyl alcohol

1.3 CAS No.
9002-89-5
1.4 CID
11199
1.5 EINECS(EC#)
209-183-3; 618-340-9
1.6 Molecular Formula
C2H4O (isomer)
1.7 Inchi
InChI=1S/C2H4O/c1-2-3/h2-3H,1H2
1.8 InChkey
IMROMDMJAWUWLK-UHFFFAOYSA-N
1.9 Canonical Smiles
C=CO
1.10 Isomers Smiles
C=CO
2. Properties
2.1 Density
1.3
2.1 Melting point
230-240℃
2.1 Boiling point
442° F (decomposes) (NTP, 1992)
2.1 Refractive index
1.3810 (estimate)
2.1 Flash Point
175° F (NTP, 1992)
2.1 Precise Quality
44.02620
2.1 PSA
20.23000
2.1 logP
0.68790
2.1 Solubility
H2O: soluble (hot)
2.2 Viscosity
Viscosity is a measure of a fluid's resistance to flow. It describes the internal friction of a moving fluid.
2.3 AnalyticLaboratory Methods
Spectrophotometric techniques in ultra-violet, visible and infrared regions have been used to identify polyvinyl alcohol; in paper coatings.
2.4 Appearance
white or cream solid
2.5 Storage
Ambient temperatures.
2.6 Chemical Properties
Polyvinyl alcohol is a hydrolysis product of polyvinyl acetate, rather than by the polymerization of monomers; the molecular backbone contains
2.7 Color/Form
CLEAR LIQUID
Colorless liquid.
2.8 Decomposition
When heated to decomposition it emits acrid smoke and irritating fumes.
2.9 Odor
Odorless
2.10 PH
Typically a 5% solution of polyvinyl alcohol; exhibits a pH in the range of 5.0 to 6.5
2.11 Physical
PHYSICAL DESCRIPTION: Odorless white to cream-colored granules or powder. Pure aqueous solutions are neutral or faintly acid and subject to mold growth. pH (4% aqueous solution): 5-8. Strongly hydrophilic. (NTP, 1992)
2.12 Water Solubility
soluble in hot water
2.13 Spectral Properties
Index of Refraction = 1.3719 at 20 deg C/D
MAX ABSORPTION (METHANOL): 209 NM (LOG E= 1.86); SADTLER REFERENCE NUMBER: 4 (IR, PRISM); 3 (IR, GRATING)
IR: 4802 (Coblentz Society Spectral Collection)
UV: 4-21 (Organic Electronic Spectral Data, Phillips et al, John Wiley & Sons, New York)
NMR: 79 (Varian Associates NMR Spectra Catalogue)
MASS: 158 (Atlas of Mass Spectral Data, John Wiley & Sons, New York)
Intense mass spectral peaks: 43 m/z, 61 m/z, 70 m/z, 73 m/z, 88 m/z
2.14 Stability
Stable. Combustible. Dust may form explosive mixtures with air. Incompatible with strong oxidizing agents.
2.15 StorageTemp
Keep away from heat, sparks, and flame. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area.
2.16 Toxicity Summary
IDENTIFICATION AND USE: Polyvinyl alcohol; (PVA) is a colorless amorphous powder. It is used in plastic industry in molding compounds, surface coatings, films resistant to gasoline, textile sizes and finishing compositions; can be compounded to yield elastomers to be used in manufacturing artificial sponges, fuel hoses. It is also used in printing inks for plastics and glass, in pharmaceutical finishing, cosmetics, water;-soluble film and sheeting. Pharmaceutic aid (viscosity increasing agent) and opthalmic lubricant. HUMAN EXPOSURE AND TOXICITY: 1.4% neutral solution of PVA with molecular wt over 100,000/ has been used in eyedrops on human eyes without difficulty. Concentrations as high as 10% also have not been irritating. A foreign-body type of reaction to an orbital sponge implant of formalinized polyvinyl alcohol; resin known as Ivalon has been described histologically in 1 patient. There is a single report connecting exposure of PVA to human carcinogenesis. Researchers report the case of a 40-year-old man with hemangiopericytoma of the bladder. This man had a 2-year history of daily dermal exposure to a solution of PVA in water; that did not contain solvents or plasticizers. The use of PVA sponge (Ivalon) prosthetic breast implants was abandoned in the 1950s in favor of silicon;. Histology of a 40-year-old PVA implant revealed dramatic structural changes to the prosthesis such as crystallization and calcification associated with dense fibrotic tissue and some multinucleated giant cells, probably indicating a chronic low grade inflammatory response to the foreign material. PVA injections are still occasionally called for in the therapeutic embolization of abnormal tissues. A mild chronic inflammatory response associated with the foreign- body response, infiltration of macrophages, and fibrosis were all found at autopsy of three cystic fibrosis patients who died 10-28 months following a bronchial embolization procedure. ANIMAL STUDIES: In eyedrops 1.4% neutral solution of polyvinyl alcohol; with molecular weight over 100,000 has been tested repeatedly by application to rabbit eyes and has been shown to be noninjurious and not to interfere with healing of experimental epithelial wounds. Doses of 2000, 3500 and 5000 mg/kg/day of PVA administered as a dietary admixture to male and female rats for up to 90 days did not result in any adverse, toxicological effects. Male rats were given sc implants of polyvinyl alcohol; (ivalon sponge) of unspecified size into abdominal wall and were observed for lifespan. 3 Local sarcomas were found in 34 animals still alive at appearance of first local sarcoma at 567 days. In 2 year study in mice, there was no evidence of carcinogenic activity of polyvinyl alcohol; in female mice administered 20 uL of a 25% solution intravaginally. There were no neoplasms or nonneoplastic lesions considered related to treatment with polyvinyl alcohol;. PVA was not mutagenic with and without rat liver S9 microsomal activation in Salmonella typhimurium strains TA98, TA100 and TA1537. The potential induction of micronuclei by PVA in bone marrow cells of mice was tested. PVA was administered orally to male and female mice at doses up to 2000 mg/kg. PVA did not show any evidence of causing chromosome damage or bone marrow cell toxicity. PVA was tested for mutagenic potential in an in vitro mammalian cell mutation assay, the detection and quantitation of forward mutation in a subline of mouse lymphoma L5178Y cells, from the heterozygous condition at the thymidine; kinase locus (TK +/-) to the thymidine; kinase-deficient genotype (TK -/-), in the presence and absence of S9 mix. PVA was not mutagenic in this in vitro cell mutation assay at concentrations up to 5000 mg/mL.
3. Use and Manufacturing
3.1 Definition
ChEBI: A homopolymer macromolecule obtained by polymerisation of vinyl alcohol.
3.2 GHS Classification
Signal: Danger
GHS Hazard Statements
Aggregated GHS information provided by 532 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria by 441 of 532 companies. For more detailed information, please visit ECHA C&L website

Of the 3 notification(s) provided by 91 of 532 companies with hazard statement code(s):

H225 (19.78%): Highly Flammable liquid and vapor [Danger Flammable liquids]
H301 (98.9%): Toxic if swallowed [Danger Acute toxicity, oral]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

Precautionary Statement Codes
P210, P233, P240, P241, P242, P243, P264, P270, P280, P301+P310, P303+P361+P353, P321, P330, P370+P378, P403+P235, P405, and P501
3.3 Methods of Manufacturing
Various indirect methods that involve alcoholysis (also called saponification or hydrolysis) of polyvinyl acetate are used to prepare polyvinyl alcohol;. Preparation can be carried out by dissolving polyvinyl acetate in methanol; or ethanol; with alkaline or acid or acid catalyst and heating to precipitate the polyvinyl alcohol; from the solution.
3.4 Produe Method
Polyvinyl alcohol is produced through the hydrolysis of polyvinylacetate. The repeating unit of vinyl alcohol is not used as the startingmaterial because it cannot be obtained in the quantities and purityrequired for polymerization purposes. The hydrolysis proceedsrapidly in methanol, ethanol, or a mixture of alcohol and methylacetate, using alkalis or mineral acids as catalysts.
3.5 Usage
It is mainly used in the textile industry, as the raw materials of warp pulp, fabric finishing agent, vinylon fiber; interior and exterior wall paint of the building, adhesives; chemical industry use it as a polymerization emulsifier, dispersant and polyvinyl formal, acetal, butyrate aldehyde resin; paper industry use it as a paper binder; agriculture use it as soil improvers, pesticide adhesion synergist and polyvinyl alcohol film; it can also be used for daily cosmetics and high-frequency quenching agent and so on.
4. Safety and Handling
4.1 Symbol
GHS08
4.1 Hazard Codes
Xn
4.1 Signal Word
Warning
4.1 Risk Statements
23/24/25-36/38-39/23/24/25
4.1 Safety Statements
S24/25
4.1 Exposure Standards and Regulations
Certification of this color additive when used as a diluent (in inks for marking fruit & vegetables) is not necessary for the protection of the public health and therefore batches thereof are exempt from the requirements of section 706(c) of the Federal Food, Drug, and Cosmetic Act. /Restrictions incl no residue./
Synthetic flavoring substances and adjuvants /for human consumption/ that are generally recognized as safe for their intended use, within the meaning of section 409 of the Act. Ethyl acetate is included on this list.
Synthetic flavoring substances and adjuvants /for animal drugs, feeds, and related products/ that are generally recognized as safe for their intended use, within the meaning of section 409 of the Act. Ethyl acetate is included on this list.
4.2 Packing Group
Z01
4.2 Octanol/Water Partition Coefficient
SOL IN ALCOHOL, ETHER, ACETONE, AND BENZENE
MISCIBLE WITH CHLOROFORM
MISCIBLE IN FIXED & VOLATILE OILS.
Very soluble in water (64 g/l at 25 deg C)
Miscible with oxygenated and chlorinated solvents.
In water, 8.01X10+4 mg/l at 25 deg C.
4.3 Fire Hazard
This chemical is combustible. The dusts of this chemical are a slight explosion hazard when exposed to flame. (NTP, 1992)
4.4 Other Preventative Measures
USE EFFECTIVE FUME REMOVAL DEVICE /IN LABORATORY/.
Employees should wash promptly when skin is wet or contaminated. Remove clothing immediately if wet or contaminated to avoid flammability hazard.
Avoid breathing vapors. Keep upwind. Wear appropriate chemical protective gloves, boots and goggles. Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water.
SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
If material not on fire and not involved in fire: Keep sparks, flames and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Use water spray to disperse vapors and dilute standing pools of liquid.
SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.
The worker should immediately wash the skin when it becomes contaminated.
Work clothing that becomes wet should be immediately removed due to its flammability hazard.
An analysis of breakthrough times of low boiling organic solvent vapors in a commercial respirator cartridge under steady state and pulsating flow conditions was performed. A KGC-8 respirator cartridge packed with 22.5 grams of activated charcoal was exposed to 0, 100, 300, or 900 ppm carbon-tetrachloride, ethyl-acetate, methyl-acetate, acetone, or dichloromethane vapor under steady state or pulsed flow conditions in custom built apparatus. The steady state flow condition was achieved by setting the respirator cartridge in its holder and passing each solvent vapor through it at a flow rate of 30 liter per minute (l/min). The pulsating flow condition was achieved placing the respirator cartridge in a Tedler bag, expanding the bag by introducing each test vapor, and 'inhaling' the test vapor through the respirator cartridge using a breathing machine drawing 1.5 liters air per cycle at the rate 20 cycles/min. The total flow rate was adjusted to be similar to the 301/min rate utilized the steady state flow experiments. Solvent vapor concentrations were measured upstream and downstream from the cartridge by gas chromatography. Breakthrough times were determined as the time required for the solvent vapor concentrations downstream from the cartridge to increase to 5 ppm. The data were analyzed by logistic regression techniques. After converting the data to logarithms, the breakthrough times of all five solvents were linearly, inversely proportional to their initial concentrations under both steady state and pulsed flow conditions. The slopes of the lines were smaller for the solvents with the lower boiling points. The ratios of the breakthrough times measured under the pulsating flow to the steady slate flow condition (B/A ratio) varied from 0.77 to 0.71 for dichloromethane. The B/A ratios for the lOO ppm initial concentrations of the other four solvents varied only from 0.95 to 1.01. This indicated that except in the case of dichloromethane, there are no large differences in breakthrough tire under the two different flow conditions at lOO ppm. At the other concentrations, in each experiment as the concentration of the test vapor increased the breakthrough times under the pulsating flow condition became shorter compared to the steady state flow condition. /It was/ concluded that breakthrough of low boiling solvent vapors in respirator cartridges occurs earlier under pulsating flow than under steady state conditions. [Tanaka S et al; Industrial Health 34 (2): 125-31 (1996)] PubMed Abstract
4.5 Hazard Declaration
H371
4.5 Cleanup Methods
1. REMOVE ALL IGNITION SOURCES. 2. VENTILATE AREA OF SPILL OR LEAK. 3. FOR SMALL QUANTITIES, ABSORB ON PAPER TOWELS. EVAPORATE IN A SAFE PLACE (SUCH AS A FUME HOOD). ALLOW SUFFICIENT TIME FOR EVAPORATING VAPORS TO COMPLETELY CLEAR THE HOOD DUCTWORK. BURN THE PAPER IN A SUITABLE LOCATION AWAY FROM COMBUSTIBLE MATERIALS. LARGE QUANTITIES CAN BE COLLECTED AND ATOMIZED IN A SUITABLE COMBUSTION CHAMBER. ETHYL ACETATE SHOULD NOT BE ALLOWED TO ENTER A CONFINED SPACE, SUCH AS A SEWER, BECAUSE OF THE POSSIBILITY OF AN EXPLOSION.
4.6 DisposalMethods
Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste numbers U112 and F003, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.
Incineration: Burn waste material in an approved waste disposal incinerator.
1. BY ABSORBING IT IN VERMICULITE, DRY SAND, EARTH, OR A SIMILAR MATERIAL. 2. BY ATOMIZING IN A SUITABLE COMBUSTION CHAMBER.
Ethyl acetate is a waste chemical stream constituent which may be subjected to ultimate disposal by controlled incineration.
A good candidate for rotary kiln incineration at a temperature range of 820 to 1,600 deg C and residence times of seconds for liquids and gases, and hours for solids. A good candidate for liquid injection incineration at a temperature range of 650 to 1,600 deg C and a residence time of 0.1 to 2 seconds. A good candidate for fluidized bed incineration at a temperature range of 450 to 980 deg C and residence times of seconds for liquids and gases, and longer for solids.
The following wastewater treatment technologies have been investigated for Ethyl acetate: Concentration process: Biological treatment.
The following wastewater treatment technologies have been investigated for Ethyl acetate: Concentration process: Activated carbon.
4.7 DOT Emergency Guidelines
/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with "P" may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Health: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.
/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection.
/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Evacuation: Large spill: Consider initial downwind evacuation for at least 300 meters (1000 feet). Fire: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.
/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Fire: Caution: All these products have a very low flash point: Use of water spray when fighting fire may be inefficient. Small fires: Dry chemical, CO2, water spray or alcohol-resistant foam. Do not use dry chemical extinguishers to control fires involving nitromethane or nitroethane. Large fires: Water spray, fog or alcohol-resistant foam. Do not use straight streams. Move containers from fire area if you can do it without risk. Fire involving tanks or car/trailer loads: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn.
/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Spill or Leak: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean non-sparking tools to collect absorbed material. Large spills: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor; but may not prevent ignition in closed spaces.
/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ First Aid: Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. Wash skin with soap and water. Keep victim warm and quiet. In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves.
4.8 RIDADR
无资料?
4.8 Fire Fighting Procedures
COOL EXPOSED CONTAINERS WITH WATER.
/USE/ CARBON DIOXIDE, DRY CHEM, OR ALCOHOL FOAM.
If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped or safely confined. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Apply water from as far a distance as possible. Cool all affected containers with flooding quantities of water. Use "alcohol" foam, dry chemical or carbon dioxide.
4.9 FirePotential
DANGEROUS WHEN EXPOSED TO HEAT OR FLAME
4.10 Safety Profile
Questionablecarcinogen with experimental carcinogenicand tumorigenic data by implant route.Flammable when exposed to heat or flame;can react with oxidizing materials. Slightexplosion hazard in the form of dust whenexposed to flame. To fight fire, use alcoholfoam, CO2, dry chemical. When heated todecomposition it emits acrid smoke andirritating fumes.
4.11 Caution Statement
P260
4.11 Formulations/Preparations
GRADES: COMMERCIAL, 85-88%; 95-98%; 99%; NF /NATIONAL FORMULARY GRADE OF CHEMICAL/ (99%); FCC /FOOD CHEMICAL CODEX/.
Nail polish remover typically 40 wt% ethyl acetate.
4.12 Incompatibilities
Polyvinyl alcohol undergoes reactions typical of a compound withsecondary hydroxy groups, such as esterification. It decomposes instrong acids, and softens or dissolves in weak acids and alkalis. It isincompatible at high concentration with inorganic salts, especiallysulfates and phosphates; precipitation of polyvinyl alcohol 5% w/vcan be caused by phosphates. Gelling of polyvinyl alcohol solutionmay occur if borax is present.
4.13 WGK Germany
1
4.13 RTECS
TR8100000
4.13 Protective Equipment and Clothing
ORGANIC VAPOR CANISTER OR AIR MASK; GOGGLES OR FACE SHIELD.
Wear appropriate clothing to prevent repeated or prolonged skin contact.
Breakthrough times greater than one hour reported by (normally) two or more testers for butyl rubber (Butyl). Some data usually from immersion tests suggesting breakthrough times greater than one hour are not likely for natural rubber (Nat Rub), polyethylene (PE) and polyvinyl alcohol (PVA). Breakthrough times less (usually significantly less) than one hour reported by (normally) two or more testers for neoprene (Neop), nitrile rubber (nitrile), and polyvinyl chloride (PVC). No data for neoprene /styrene-butadiene rubber (Neop/ SBR), nitrile rubber/polyvinyl chloride (Nitrile/PVC), chlorinated polyethylene (CPE), polyurethane (PU), styrene-butadiene rubber (SBR) and viton.
Wear appropriate personal protective clothing to prevent skin contact.
Wear appropriate eye protection to prevent eye contact.
Recommendations for respirator selection. Max concn for use: 2000 ppm. Respirator Class(es): Any supplied-air respirator operated in a continuous flow mode. Eye protection needed. Any powered, air-purifying respirator with organic vapor cartridge(s). Eye protection needed. Any chemical cartridge respirator with a full facepiece and organic vapor cartridge(s). Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister. Any self-contained breathing apparatus with a full facepiece. Any supplied-air respirator with a full facepiece.
Recommendations for respirator selection. Condition: Emergency or planned entry into unknown concn or IDLH conditions: Respirator Class(es): Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode. Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive-pressure mode.
Recommendations for respirator selection. Condition: Escape from suddenly occurring respiratory hazards: Respirator Class(es): Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister. Any appropriate escape-type, self-contained breathing apparatus.
Wear positive-pressure SCBA and protective equipment ... . If special chemical protective clothing is required, consult the chemical manufacturer or specific protective clothing compatibility charts. Delay entry until trained personnel and proper protective equipment are available. Remove patient from contaminated area. Quickly remove and isolate patient's clothing, jewelry, and shoes. Gently blot excess liquids with absorbent material. Rinse patient with warm water, 30 deg C/86 deg F, if possible. Wash patient with Tincture of Green Soap or a mild liquid soap and large quantities of water.
SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.
4.14 Reactivities and Incompatibilities
... CAN REACT VIGOROUSLY WITH CHLOROSULFONIC ACID, ... OLEUM, K-TERT-BUTOXIDE ...Explosive reaction with lithium tetrahydroaluminate.
Incompatible with nitrates, strong oxidizers, strong alkalies, strong acids.
Nitrates, strong oxidizers, alkalis & acids.
4.15 Skin, Eye, and Respiratory Irritations
Irritating to mucous surfaces, particularly the eyes, gums and respiratory passages ... . On repeated or prolonged exposures, it causes conjunctival irritation and corneal clouding.
4.16 Safety

Risk Statements?of Polyvinyl alcohol (CAS NO.9002-89-5): 23/24/25-36/38-39?
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed.?
R36/38: Irritating to eyes and skin.?
R39: Danger of very serious irreversible effects.
Safety Statements: 26-36/37-45-24/25?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36/37: Wear suitable protective clothing and gloves.?
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S24/25: Avoid contact with skin and eyes.
WGK Germany: 1
RTECS: TR8100000
HS Code: 39053000
Questionable carcinogen with experimental carcinogenic and tumorigenic data by implant route. Flammable when exposed to heat or flame; can react with oxidizing materials. Slight explosion hazard in the form of dust when exposed to flame. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes.

4.17 Specification

Synonyms of Polyvinyl alcohol (CAS NO.9002-89-5): Ethenol, homopolymer ; Lamicel ; Polyvinyl Alcohol [USAN] ; HypoTears ; Prefrin Liquifilm ; Refresh ; Relief ; Tears Plus ; VasoClear ; VasoClear A .
Handling and Storage of Polyvinyl alcohol (CAS NO.9002-89-5):
Storage: Keep away from heat, sparks, and flame. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area.
Handling: Wash hands before eating. Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Use with adequate ventilation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.?

4.18 Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 18750mg/kg (18750mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

LIVER: OTHER CHANGES
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 55(5), Pg. 9, 1990.
mouse LD50 oral 14270mg/kg (14270mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

LIVER: OTHER CHANGES
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 55(5), Pg. 9, 1990.
mouse LD50 oral 14700mg/kg (14700mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 51(10), Pg. 75, 1986.
rat LD50 oral > 20gm/kg (20000mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 51(10), Pg. 75, 1986.
rat LD50 oral 23854mg/kg (23854mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

LIVER: OTHER CHANGES
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 55(5), Pg. 9, 1990.

5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Not classified.

2.2 GHS label elements, including precautionary statements

Pictogram(s) No symbol.
Signal word

No signal word.

Hazard statement(s)

none

Precautionary statement(s)
Prevention

none

Response

none

Storage

none

Disposal

none

2.3 Other hazards which do not result in classification

none

6. NMR Spectrum
7. Other Information
7.0 Usage
Polyvinyl alcohol is used as a biological reagent to test the dispersion of zinc oxide nanoparticles. It is an effective protein resistant material and is used to stabilize gold colloids of diameter 3-8nm. It is used as an emulsion polymerization aid to make polyvinyl acetate, as a protective colloid, as a film used in the water transfer printing process, as a surfactant for the formation of polymer encapsulated nanobeads, as an embolization agent in medical procedures and as a fixative for specimen collection.
7.1 Usage
Polyvinyl alcohol is used in food industries as a binding and coating agent. Its viscosity favors the application as coating agent to tablets and capsules. Mixed-matrix membrane prepared by dispersion of NaA zeolite particles is used to study the pervaporative separation of water-butanol mixtures. Polyvinyl alcohol /gelatin based biocompatible polymeric scaffolds have been developed for 3D cancer models.
7.2 Usage
Polyvinyl alcohol is used in papermaking, textiles, and in a variety of coatings. It is used as an emulsion polymerization aid to make polyvinyl acetate, as a protective colloid, as a film used in the water transfer printing process, as a surfactant for the formation of polymer encapsulated nanobeads, as an embolization agent in medical procedures and as a fixative for specimen collection. It is an important raw material for polyvinyl nitrate (PVN). It is used in protective chemical-resistant gloves, in eye drops (such as artificial tears to treat dry eyes) and in hard contact lens solution as a lubricant and in 3D printing as a support structure that can then be dissolved away.
8. Computational chemical data
  • Molecular Weight: 44.053g/mol
  • Molecular Formula: C2H4O
  • Compound Is Canonicalized: True
  • XLogP3-AA: 0.5
  • Exact Mass: 44.026214747
  • Monoisotopic Mass: 44.026214747
  • Complexity: 10.3
  • Rotatable Bond Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 1
  • Topological Polar Surface Area: 20.2
  • Heavy Atom Count: 3
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count: 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Isotope Atom Count: 0
  • Covalently-Bonded Unit Count: 1
  • CACTVS Substructure Key Fingerprint: AAADcYBAIAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGgAACAAAAACggAIAAAAAAgCAAAACAAAAAAAAAAAIAAAAAAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA==
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