Potassium Acetate
- Iupac Name：potassium;acetate
- CAS No.: 127-08-2
- Molecular Weight：98.14232
- Modify Date.: 2022-10-31 02:30
- Introduction: Potassium acetate is the potassium salt of acetic acid. It is manufactured through the reaction between a potassium base such as potassium hydroxide or potassium carbonate with acetic acid. It is an important macromineral with many physiological functions and is required for nerve conduction, cardiac, skeletal and smooth muscle contraction, energy generation, nucleic acid synthesis as well as mainlining the blood pressure and normal renal function. It can be taken as a nutritional supplement with antihypertensive effects and prevention effects against hypokalemia. It has several other common applications: (1) as a deicer; (2) as a food additive; (3) molecular biology applications such as DNA purification, tissue preservation, fixation and mummification; (4) Death penalty (5) as the catalyst during the production of polyurethanes.
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1. Names and Identifiers
- 1.1 Name
- Potassium Acetate
- 1.2 Synonyms
Acetic acid potassium salt acetic acid, potassium salt Acetic acid, potassium salt (1:1) Acetic acid,pota Acetic acid,potassium salt Catacyst LB EINECS 204-822-2 ethanoic acid potassium salt KOAc MFCD00012458 Potassium acetate [JAN] POTASSIUM ETHANOATE Potassiumacetate
- 1.3 CAS No.
- 127-08-2
- 1.4 CID
- 517044
- 1.5 EINECS(EC#)
- 204-822-2
- 1.6 Molecular Formula
- C2H3KO2 (isomer)
- 1.7 Inchi
- InChI=1S/C2H4O2.K/c1-2(3)4;/h1H3,(H,3,4);/q;+1/p-1
- 1.8 InChkey
- SCVFZCLFOSHCOH-UHFFFAOYSA-M
- 1.9 Canonical Smiles
- CC(=O)[O-].[K+]
- 1.10 Isomers Smiles
- CC(=O)[O-].[K+]
2. Properties
- 2.1 Density
- 1.57
- 2.1 Melting point
- 292℃
- 2.1 Boiling point
- 117.1 °C at 760 mmHg
- 2.1 Refractive index
- n20/D 1.370
- 2.1 Flash Point
- 40 °C
- 2.1 Precise Quality
- 97.97700
- 2.1 PSA
- 40.13000
- 2.1 logP
- -1.24380
- 2.1 Solubility
- 2694 g/L (25 oC)
- 2.2 Appearance
- colourless crystals or white powder
- 2.3 Storage
- Hygroscopic. Ambient temperatures.
- 2.4 Chemical Properties
- Potassium acetate, KC2H302, is a white, deliquescent solid, soluble in water and alcohol, insoluble in ether, that melts at 292°C. It is used as an analytical reagent, dehydrating agent, in medicine, and in crystal glass manufacture.
- 2.5 Color/Form
- White to light brown
- 2.6 Odor
- Odorless
- 2.7 PH
- 7,5-9,0 (5 % aqueous solution)
- 2.8 pKa
- 9.7 (0.1M solution)
- 2.9 Water Solubility
- 2694 g/L (25 oC)
- 2.10 Stability
- Deliquescent. Stable. Incompatible with strong oxidizing agents.
- 2.11 StorageTemp
- Store at RT.
3. Use and Manufacturing
- 3.1 Definition
- ChEBI: A potassium salt comprising equal numbers of potassium and acetate ions Potassium Acetate Preparation Products And Raw materials Preparation Products
- 3.2 Usage
- 1) Potassium acetate, crystalline powder, USP is, as its name suggests, the potassium salt of acetic acid and is used as a catalyst for producing polyurethanes2) In the food industry it is used as a food additive, an acidity regulator and a preservative
4. Safety and Handling
- 4.1 Hazard Codes
- Xi; T
- 4.1 Risk Statements
- R36/37/38
- 4.1 Safety Statements
- S24/25
- 4.1 RIDADR
- NONH for all modes of transport
- 4.1 WGK Germany
- 1
- 4.1 RTECS
- AJ3325000
- 4.1 Report
-
Reported in EPA TSCA Inventory.
- 4.2 Safety
-
Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of K2O.
Hazard Codes of Potassium Acetate (CAS NO.127-08-2):?
Xi,
T
Risk Statements: 36/37/38-25-23/24/25-21
R36/37/38:Irritating to eyes, respiratory system and skin.?
R25 :Toxic if swallowed.?
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.?
R21:Harmful in contact with skin.
Safety Statements: 26-36-24/25-45-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.?
S24/25:Avoid contact with skin and eyes.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany: 1
RTECS: AJ3325000
Hazard Note: Hygroscopic
TSCA: Yes
- 4.3 Sensitive
- Hygroscopic
- 4.4 Specification
-
? Potassium Acetate , with CAS number of 127-08-2, can be called Polycat 46 ; Acetic acid,compounds,potassium salt ; Catacyst LB ; Kaliumazetat ; Potassium acetate (TN) ; Potassium Acetate, Granular, U.S.P ; Potassium acetate ; Acetic acid, potassium salt . It is a?colourless crystals or white powder.
- 4.5 Toxicity
- ORL-RAT LD50 3250 mg kg-1
5. MSDS
2.Hazard identification
2.1 Classification of the substance or mixture
Not classified.
2.2 GHS label elements, including precautionary statements
| Pictogram(s) | No symbol. |
| Signal word | No signal word. |
| Hazard statement(s) | none |
| Precautionary statement(s) | |
| Prevention | none |
| Response | none |
| Storage | none |
| Disposal | none |
2.3 Other hazards which do not result in classification
none
7. Synthesis Route
127-08-2Total: 12 Synthesis Route
8. Other Information
- 8.0 Usage
- Potassium acetate is used as deicer to remove snow and ice from the surface and considered as a replacement for calcium chloride or magnesium chloride. It is used as a food additive, as a buffer in biological research, as an extinguishing agent used in class K fire extinguishers and as a catalyst to produce polyurethane polymers. It is utilized for the precipitation of dodecyl sulfate bound proteins, thereby removal of proteins from DNA. It plays an important role in preserving tissues, fixation and mummification.
- 8.1 Usage
- Potassium Acetate is a potassium salt employed to replenish electrolytes, for restoration of water-electrolyte balance, as well as a urinary and systemic alkalizer. Potassium Acetate can be administered orally or by intravenous infusion. Formerly, It was employed in diuretics and expectorants. A potassium source employed in DNA and protein purification. Some other applications includes as buffering agent, neutralizer, preservative, color retention agent(protect natural color of animals and plants).
- 8.2 Usage
- Potassium acetate is used as deicer to remove snow and ice from the surface and is considered as a replacement for calcium chloride or magnesium chloride. It is used as a food additive; as a buffer in biological research; as extinguishing agent used in class K fire extinguishers and as a catalyst to produce polyurethane polymers. It is utilized for the precipitation of dodecyl sulfate bound proteins thereby removal of proteins from DNA. It plays an important role for preserving tissues, fixation and mummification. .
9. Computational chemical data
- Molecular Weight: 98.14232g/mol
- Molecular Formula: C2H3KO2
- Compound Is Canonicalized: True
- XLogP3-AA: null
- Exact Mass: 97.97701082
- Monoisotopic Mass: 97.97701082
- Complexity: 34.6
- Rotatable Bond Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 2
- Topological Polar Surface Area: 40.1
- Heavy Atom Count: 5
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count: 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Isotope Atom Count: 0
- Covalently-Bonded Unit Count: 2
- CACTVS Substructure Key Fingerprint: AAADcQBAMAAAQAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGgAAAAAAAACAgAACCAAAAAAIAACQCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA==
10. Question & Answer
-
In the synthesis of N-ethoxycarbonyl L-proline methyl ester from L-proline and ethyl chloroformate, I use K X 2 C O X 3 K X 2 C O X 3 to neutralize H C l H C l . Can I use C H X 3 C O X 2 K C H X 3 C O X 2 K instead of K X 2 C O X 3 K X 2 C O X 3 ? I think I cannot use it because it reacts with H C...
-
Prepared by acid-base neutralization reaction between potassium hydroxide or potassium carbonate and acetic acid, potassium acetate (KOAc) was white crystalline powder in form. Salty in taste. KOAc is hygroscopic. It is easily soluble in water, ethanol and methanol, but insoluble in ether. The solu...
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