Potassium Phosphate Dibasic
- Iupac Name:dipotassium;hydrogen phosphate
- CAS No.: 7758-11-4
- Molecular Weight:174.175901
- Modify Date.: 2022-10-31 06:28
- Introduction: Dipotassium phosphate (K2HPO4) is a common source of phosphorus and potassium, which is often used as a fertilizer. It is also widely applied in the food industry, such as food additive and electrolyte replenisher for workout supplement. Another usage of dipotassium phosphate is as a medicine, who serves as a diuretic or laxative. Besides, it is employed in the production of imitation dairy creamers to prevent coagulation and used in certain powders to prepare beverages. In addition, it is commonly seen in chemical laboratories for producing buffer solutions and trypticase soy agar which is used to make agar plates for culturing bacteria.
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1. Names and Identifiers
- 1.1 Name
- Potassium Phosphate Dibasic
- 1.2 Synonyms
DIBASIC POTASSIUM PHOSPHATE dikaliumphosphate DI-POTASSIUM HYDROGEN ORTHOPHOSPHATE di-Potassium hydrogen orthophosphate anhydrous Dipotassium hydrogen phosphate DIPOTASSIUM PHOSPHATE DI-POTASSIUM PHOSPHATE DIBASIC dipotassium-o-phosphate Di-PotassiumPhosphateAr DKP EINECS 231-834-5 Isolyte Mediject P MFCD00011383 phosphate dipotassium POTASSIUM BIPHOSPHATE Potassium hydrogen phosphate (2:1:1) POTASSIUM MONOPHOSPHATE potassiumdibasicphosphate potassiummonohydrogenorthophosphate potassiumorthophosphate,mono-h SEC-POTASSIUM PHOSPHATE
- 1.3 CAS No.
- 7758-11-4
- 1.4 CID
- 24450
- 1.5 EINECS(EC#)
- 231-834-5
- 1.6 Molecular Formula
- HK2O4P (isomer)
- 1.7 Inchi
- InChI=1S/2K.H3O4P/c;;1-5(2,3)4/h;;(H3,1,2,3,4)/q2*+1;/p-2
- 1.8 InChkey
- ZPWVASYFFYYZEW-UHFFFAOYSA-L
- 1.9 Canonical Smiles
- OP(=O)([O-])[O-].[K+].[K+]
- 1.10 Isomers Smiles
- OP(=O)([O-])[O-].[K+].[K+]
2. Properties
- 2.1 Density
- 2.44
- 2.1 Melting point
- 340℃
- 2.1 Boiling point
- 158 °C at 760 mmHg
- 2.1 Precise Quality
- 173.88900
- 2.1 PSA
- 93.23000
- 2.1 logP
- -0.05220
- 2.1 Solubility
- 1600 g/L (20 oC)
- 2.2 Appearance
- White Crystal
- 2.3 Storage
- Store at RT.
- 2.4 Chemical Properties
- White crystalline powder
- 2.5 Color/Form
- White crystals
Colorless or white granules or powder
- 2.6 Odor
- Odorless
- 2.7 PH
- Between 8,7 and 9,4 (1 % solution)
- 2.8 pKa
- (1) 2.15, (2) 6.82, (3) 12.38 (at 25℃)
- 2.9 Water Solubility
- 1600 g/L (20 oC)
- 2.10 Stability
- Stable. Hygroscopic.
- 2.11 StorageTemp
- Store at +5°C to +30°C.
3. Use and Manufacturing
- 3.1 Definition
- ChEBI: A potassium salt that is the dipotassium salt of phosphoric acid.
- 3.2 Usage
- Buffer solutions.
4. Safety and Handling
- 4.1 Hazard Codes
- Xi; C; T; F
- 4.1 Risk Statements
- R36
- 4.1 Safety Statements
- S24/25
- 4.1 Exposure Standards and Regulations
- Dipotassium phosphate used as a sequestrant in food for human consumption is generally recognized as safe when used in accordance with good manufacturing practice.
Dipotassium phosphate used as a sequestrant in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.
Potassium phosphates (mono-, di-, and tribasic) are indirect food additives for use only as a component of adhesives. /Potassium phosphates (mono-, di-, and tribasic)/
- 4.2 DisposalMethods
- SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
- 4.3 RIDADR
- HAZARD
- 4.3 Formulations/Preparations
- INJECTION, 2 MEQ OF POTASSIUM ION AND 1 MEQ OF HYDROGEN PHOSPHATE ION PER ML WITH BENZYL ALCOHOL 0.9%; 30 ML VIALS; POWDER NATIONAL FORMULARY.
Grades: commercial; pure; highest purity; NF /National Formulary/; FCC /Food Chemicals Codex/
Solid and 50% active solution
- 4.4 WGK Germany
- 3
- 4.4 RTECS
- TC8450000
- 4.4 Safety
-
Hazard Codes:?
Xi,?
C,?
T,?
F
Risk Statements: 36-35-22?
R36:Irritating to eyes.?
R35:Causes severe burns.?
R22:Harmful if swallowed.
Safety Statements: 22-24/25-36-26-45-36/37/39?
S22:Do not breathe dust.?
S24/25:Avoid contact with skin and eyes.?
S36:Wear suitable protective clothing.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany: 3
RTECS: TC8450000
F: 3
HS Code: 28352400
Hazardous Substances Data: 7758-11-4(Hazardous Substances Data)
- 4.5 Sensitive
- Hygroscopic
- 4.6 Specification
-
?Dipotassium phosphate (CAS NO.7758-11-4) is also named as CCRIS 6544 ; DKP ; Dibasic potassium phosphate ; Dipotassium hydrogen phosphate ; Dipotassium monohydrogen phosphate ; Dipotassium monophosphate ; Dipotassium orthophosphate ; Dipotassium-O-phosphate ; HSDB 935 ; Hydrogen dipotassium phosphate ; Isolyte ; Phosphoric acid, dipotassium salt ; Potassium dibasic phosphate ; Potassium monohydrogen phosphate ; Potassium monophosphate ; Potassium phosphate, dibasic ; UNII-CI71S98N1Z .?Dipotassium phosphate (CAS NO.7758-11-4) is white crystalline powder.
- 4.7 Toxicity
- LD50 orally in Rabbit: 8000 mg/kg
5. MSDS
2.Hazard identification
2.1 Classification of the substance or mixture
Not classified.
2.2 GHS label elements, including precautionary statements
Pictogram(s) | No symbol. |
Signal word | No signal word. |
Hazard statement(s) | none |
Precautionary statement(s) | |
Prevention | none |
Response | none |
Storage | none |
Disposal | none |
2.3 Other hazards which do not result in classification
none
6. Other Information
- 6.0 Usage
- It is used as a fertilizer, food additive, buffering agent, in molecular biology, biochemistry and chromatography. It is useful to increase the partition coefficients of amino acids in aqueous two-phase systems. It plays an important role for increase in rice grain yield by spraying chemicals including ferric chloride, di-potassium hydrogen phosphate and salicylic acid.
- 6.1 Merck
- 14,7658
- 6.2 Description
- Dipotassium phosphate (K2HPO4) is a common source of phosphorus and potassium, which is often used as a fertilizer. It is also widely applied in the food industry, such as food additive and electrolyte replenisher for workout supplement. Another usage of dipotassium phosphate is as a medicine, who serves as a diuretic or laxative. Besides, it is employed in the production of imitation dairy creamers to prevent coagulation and used in certain powders to prepare beverages. In addition, it is commonly seen in chemical laboratories for producing buffer solutions and trypticase soy agar which is used to make agar plates for culturing bacteria.
- 6.3 Chemical Properties
- White crystalline powder
- 6.4 Physical properties
- White amorphous powder; deliquesces; decomposes on heating; converts to pyrophosphate when ignited; very soluble in water, 167 g/100mL at 20°C; very soluble in alcohol; aqueous solution slightly alkaline.
- 6.5 Uses
- Buffer solutions.
- 6.6 Uses
- Buffering agent in antifreeze solutions; nutrient in the culturing of antibiotics; ingredient of instant fertilizers; as sequestrant in the preparation of non-dairy powdered coffee creams.
- 6.7 Uses
- dipotassium phosphate is used as a buffering agent to control the degree of acidity in solutions.
- 6.8 Uses
- Dipotassium Phosphate is the dipotassium salt of phosphoric acid which functions as a stabilizing salt, buffer, and sequestrant. It is mildly alkaline with a ph of 9 and is soluble in water with a solubility of 170 g/100 ml of water at 25°c. It improves the colloidal solubility of proteins. It acts as a buffer against variation in ph. For example, it is used in coffee whiteners as a buffer against ph variation in hot coffee and to prevent feathering. It also functions as an emulsifier in specified cheeses and as a buffering agent for processed foods. It is also termed dipotassium monohydrogen orthophosphate, potassium phosphate dibasic, and dipotassium monophosphate.
- 6.9 Definition
- ChEBI: A potassium salt that is the dipotassium salt of phosphoric acid.
- 6.10 Preparation
- Dipotassium phosphate is prepared by partial neutralization of phosphoric acid with potassium hydroxide, followed by crystallization:
H3PO4+ 2KOH →K2HPO4+ 2H2O.
- 6.11 General Description
-
Potassium phosphate dibasic is a useful biological buffer having a pH in the range of 8.5-9.6. Potassium phosphate is present in various forms: monobasic (KH2PO4), dibasic (KH2PO4), and tribasic (K3PO4). Potassium phosphate buffers are widely employed in equilibrium dialysis, high performance liquid chromatography (HPLC) and affinity capillary electrophoresis studies.
7. Computational chemical data
- Molecular Weight: 174.175901g/mol
- Molecular Formula: HK2O4P
- Compound Is Canonicalized: True
- XLogP3-AA: null
- Exact Mass: 173.88865848
- Monoisotopic Mass: 173.88865848
- Complexity: 46.5
- Rotatable Bond Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 4
- Topological Polar Surface Area: 83.4
- Heavy Atom Count: 7
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count: 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Isotope Atom Count: 0
- Covalently-Bonded Unit Count: 3
- CACTVS Substructure Key Fingerprint: AAADcQAAOAIAYAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACCAAAAAAAAAAAAAAABAAQAAAAIAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA==
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