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Potassium Phosphate Monobasic
- Iupac Name：potassium;dihydrogen phosphate
- CAS No.: 7778-77-0
- Molecular Weight：136.085541
- Modify Date.: 2022-11-09 13:05
- Introduction: (1) As feed phosphorus additives; In the food industry, it is used for the manufacture of baked goods, for leavening agent, flavoring agent, fermentation additives, nutritional fortifiers, yeast food. Also used as a buffer, chelating agent.(2) It can be used as fertilizer, flavoring agent and the culture agent of brewing yeast; used for the preparation of buffer solution, also used in medicine and manufacturing of potassium metaphosphate.(3) It can be used for the fertilization of rice, wheat, cotton, rape, tobacco, sugar cane, apple and other crops.(4) It can be used as chromatography reagents and buffer, but also for the synthesis of medicine.As a highly efficient fertilizer, it is suitable for all kinds of soil and crops. It can also used as a bacterial culture agent, the flavoring agent for the synthesis of sake and the raw material for making potassium metaphosphate. In medicine, it is used for the uric acidification as a nutritional agent.(5) Used as feed nutritional supplements;As a quality improver, it has effects of improving the complexation metal ions and pH value, increasing the ionic strength of food, and thus improving the adhesion and water holding capacity of food. China provides that it can be used for wheat flour with the maximum usage amount of 5.0g/kg and 2.0 g/kg in the beverage.
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1. Names and Identifiers
- 1.1 Name
- Potassium Phosphate Monobasic
- 1.2 Synonyms
dihydrogène phosphate de potassium EINECS 231-913-4 Kaliumdihydrogen-phosphat MFCD00011401 Monopotassium dihydrogen phosphate Monopotassium monophosphate Monopotassium orthophosphate PHOSPHATE LOW NO 1 PHOSPHATE LOW NO 2 PHOSPHATE STANDARD SOLUTION Phosphoric acid monopotassium salt PHOSPHORIC ACID, POTASSIUM SALT Phosphoric acid, potassium salt (2:1) Potassium dihydrogen phosphate Potassium dihydrogen phosphate anhydrous 99.995 Suprapur Potassium dihydrogen phosphate cryst. suitable for the biopharmaceutical production EMPROVE bio Ph Eur,BP,JPC,NF potassium dihydrogen-phosphate Potassium diphosphate Potassium hydrogen phosphate (1:2:1) Potassium orthophosphate Potassium phosphate Potassium Phosphate, Monobasic, Molecular Biology Grade
- 1.3 CAS No.
- 7778-77-0
- 1.4 CID
- 516951
- 1.5 EINECS(EC#)
- 231-913-4
- 1.6 Molecular Formula
- H2KO4P (isomer)
- 1.7 Inchi
- InChI=1S/K.H3O4P/c;1-5(2,3)4/h;(H3,1,2,3,4)/q+1;/p-1
- 1.8 InChkey
- GNSKLFRGEWLPPA-UHFFFAOYSA-M
- 1.9 Canonical Smiles
- OP(=O)(O)[O-].[K+]
- 1.10 Isomers Smiles
- OP(=O)(O)[O-].[K+]
2. Properties
- 2.1 Density
- 2.338
- 2.1 Melting point
- 252.6℃
- 2.1 Boiling point
- 158 °C at 760 mmHg
- 2.1 Refractive index
- Index of refraction: 1.5093, 1.4682, both at 589 nm
- 2.1 Precise Quality
- 135.93300
- 2.1 PSA
- 90.40000
- 2.1 logP
- -0.49040
- 2.1 Solubility
- 222 g/L (20 oC)
- 2.2 Appearance
- White powder
- 2.3 Storage
- Hygroscopic. Ambient temperatures.
- 2.4 Chemical Properties
- White powder
- 2.5 Color/Form
- Colorless crystals or white granular powder
White tetragonal crystals
- 2.6 Odor
- Odorless
- 2.7 PH
- Between 4,2 and 4,8 (1?% solution)
- 2.8 pKa
- (1) 2.15, (2) 6.82, (3) 12.38 (at 25℃)
- 2.9 Water Solubility
- H2O: 1.5?M at?20?°C, clear, colorless | 222 g/L (20 oC)
- 2.10 Spectral Properties
- Index of refraction: 1.510, 1.4864
- 2.11 Stability
- Stable under normal temperatures and pressures.
- 2.12 StorageTemp
- Store at +5°C to +30°C.
3. Use and Manufacturing
- 3.1 Purification Methods
- Dissolve it in boiling distilled water (2mL/g), keep on a boiling water-bath for several hours, then filter it through paper pulp to remove any turbidity. Cool rapidly with constant stirring, and the crystals are collected on to hardened filter paper, using suction, washed twice with ice-cold water, once with 50% EtOH, and dried at 105o. Alternative crystallisations are from water, then 50% EtOH, and again water, or from concentrated aqueous solution by addition of EtOH. It is freed from traces of Cu by extracting its aqueous solution with diphenylthiocarbazone in CCl4, followed by repeated extraction with CCl4 to remove traces of diphenylthiocarbazone. Potassium Phosphate Monobasic Preparation Products And Raw materials Preparation Products
- 3.2 Usage
- (1) As feed phosphorus additives; In the food industry, it is used for the manufacture of baked goods, for leavening agent, flavoring agent, fermentation additives, nutritional fortifiers, yeast food. Also used as a buffer, chelating agent.(2) It can be used as fertilizer, flavoring agent and the culture agent of brewing yeast; used for the preparation of buffer solution, also used in medicine and manufacturing of potassium metaphosphate.(3) It can be used for the fertilization of rice, wheat, cotton, rape, tobacco, sugar cane, apple and other crops.(4) It can be used as chromatography reagents and buffer, but also for the synthesis of medicine.As a highly efficient fertilizer, it is suitable for all kinds of soil and crops. It can also used as a bacterial culture agent, the flavoring agent for the synthesis of sake and the raw material for making potassium metaphosphate. In medicine, it is used for the uric acidification as a nutritional agent.(5) Used as feed nutritional supplements;As a quality improver, it has effects of improving the complexation metal ions and pH value, increasing the ionic strength of food, and thus improving the adhesion and water holding capacity of food. China provides that it can be used for wheat flour with the maximum usage amount of 5.0g/kg and 2.0 g/kg in the beverage.
4. Safety and Handling
- 4.1 Hazard Codes
- F; T; C; Xn
- 4.1 Risk Statements
- R36/38
- 4.1 Safety Statements
- S24/25
- 4.1 Exposure Standards and Regulations
- The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed prescription drug products, incl potassium phosphate, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act.
Potassium phosphate (mono, di, and tribasic) is an indirect food additive for use only as a component of adhesives.
- 4.2 Cleanup Methods
- When cleaning, plating and coating wastewaters containing 25 ppm monopotassium phosphate mixed with 200 g hydrotalcite-based chem compound, 99.9% of PO4 3- ion removed by sorption and/or ion exchange.
- 4.3 DisposalMethods
- SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
- 4.4 RIDADR
- 25kgs
- 4.4 Formulations/Preparations
- Injection, 4.4 meq of potassium ion and 3 millimolar of phosphorus (provided by potassium phosphate, monobasic 224 mg and potassium phosphate, dibasic 236 mg/mL. /as potassium supplement/
Grades: CP /chemically pure: a grade designation signifying a minimum of impurities, but not 100% purity/; FCC /Food Chemicals Codex/
- 4.5 WGK Germany
- 2
- 4.5 RTECS
- TC6615500
- 4.5 Safety
-
Hazard Codes: 
F,
T,
C,
Xi
Risk Statements: 36/38-35-22
R36/38:Irritating to eyes and skin.
R35:Causes severe burns.
R22:Harmful if swallowed.
Safety Statements: 24/25-45-36/37/39-26
S24/25:Avoid contact with skin and eyes.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: 3260
WGK Germany: 2
RTECS: TC6615500
F: 8-10
HS Code: 28352400
- 4.6 Sensitive
- Hygroscopic
- 4.7 Specification
-
Potassium dihydrogen phosphate , its cas register number is 7778-77-0. It also can be called Monobasic potassium phosphate ; Monopotassium dihydrogen phosphate ; Monopotassium monophosphate ; Monopotassium orthophosphate ; Monopotassium phosphate ; Orthophosphoric acid, monopotassium salt ; hosphoric acid, monopotassium salt ; Potassium acid phosphate ; Potassium dihydrogen orthophosphate ; Potassium orthophosphate, dihydrogen ; Potassium phosphate, monobasic ; Sorensen's potassium phosphate . Potassium dihydrogen phosphate (CAS NO.7778-77-0) is a white powder.
- 4.8 Toxicity
-
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| rabbit |
LD50 |
skin |
> 4640mg/kg (4640mg/kg) |
|
National Technical Information Service. Vol. OTS0571153, |
| rat |
LDLo |
oral |
4640mg/kg (4640mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
GASTROINTESTINAL: OTHER CHANGES |
National Technical Information Service. Vol. OTS0571153, |
5. MSDS
2.Hazard identification
2.1 Classification of the substance or mixture
Not classified.
2.2 GHS label elements, including precautionary statements
| Pictogram(s) | No symbol. |
| Signal word | No signal word. |
| Hazard statement(s) | none |
| Precautionary statement(s) | |
| Prevention | none |
| Response | none |
| Storage | none |
| Disposal | none |
2.3 Other hazards which do not result in classification
none
6. Synthesis Route
7778-77-0Total: 1 Synthesis Route
8. Other Information
- 8.0 Solubility in water
- Dissolved grams per 100 ml of water at different temperatures (° C):
14.8 g/0 ° C; 18.3 g/10 ° C; 22.6 g/20 ° C; 28 g/30 ° C; 35.5 g /
50.2 g/60 ° C; 70.4 g/80 ° C; 83.5 g/90 ° C
- 8.1 Uses
- (1) As feed phosphorus additives; In the food industry, it is used for the manufacture of baked goods, for leavening agent, flavoring agent, fermentation additives, nutritional fortifiers, yeast food. Also used as a buffer, chelating agent.
(2) It can be used as fertilizer, flavoring agent and the culture agent of brewing yeast; used for the preparation of buffer solution, also used in medicine and manufacturing of potassium metaphosphate.
(3) It can be used for the fertilization of rice, wheat, cotton, rape, tobacco, sugar cane, apple and other crops.
(4) It can be used as chromatography reagents and buffer, but also for the synthesis of medicine.
As a highly efficient fertilizer, it is suitable for all kinds of soil and crops. It can also used as a bacterial culture agent, the flavoring agent for the synthesis of sake and the raw material for making potassium metaphosphate. In medicine, it is used for the uric acidification as a nutritional agent.
(5) Used as feed nutritional supplements;As a quality improver, it has effects of improving the complexation metal ions and pH value, increasing the ionic strength of food, and thus improving the adhesion and water holding capacity of food. China provides that it can be used for wheat flour with the maximum usage amount of 5.0g/kg and 2.0 g/kg in the beverage.
- 8.2 Toxicity
- Adl: 0 to 70 mg/kg (calculated as phosphorus, FA0 HO, 1985). It is generally recognized as being safe (US Food and Drug Administration, 1975). Cooked meat, cooked ham, cooked minced meat: 3 g/kg; low concentration milk, sweet condensed milk, cream 2 g/kg; milk powder, cream powder 5 g/kg; processed cheese 9 g/kg; quick-frozen Haddock, perch, ferret fish, hake fillet 5 g/kg; ready-to-eat broth, soup 1000 mg/kg; cold drink 2 g/kg. Adl: 0 to 70 mg/kg (total phosphate, in terms of phosphorus; FAO/WHO, 2001). ADI: no restriction (EEC, 1990).
- 8.3 Chemical Properties
- White powder
- 8.4 Physical properties
- Colorless crystals or white granular powder; tetragonal structure; deliquesces; density 2.338 g/cm3; melts at 252.6°C; soluble in water 33 g/100mL at 25°C; pH 4.4-4.7; insoluble in alcohol.
- 8.5 Uses
- potassium phosphate is a humectant and pH adjuster used in cosmetic formulations. Potassium phosphate is an inorganic salt.
- 8.6 Uses
- Potassium Dihydrogen is a buffer, neutralizing agent, and sequestrant. It is mildly acid, with a ph of 4.5, and fairly soluble in water, with a solubility of 25 g in 100 ml at 25°c. It is used in whole eggs for color preservation and is also used in low-sodium products, milk products, and meat products. Typical usage ranges from 0.1 to 0.5%. It is also termed monopotassium phosphate or thophosphate, potassium phosphate monobasic, and monopotassium monophosphate.
- 8.7 Uses
- Monopotassium phosphate (MKP) is a specialty fertilizer that is a good source of phosphorus and potassium.It is an acid, chloride-free, dry soluble fertilizer,and is a natural pH buffer with a buffer pH in pure water of 4.5.Monopotassium phosphate can be solubilized and blended with liquid fertilizers that will not salt out at a low pH, and is also safe to use as a foliar fertilizer.
- 8.8 Uses
- In buffers for determination of pH. Pharmaceutic aid (buffering agent).
- 8.9 Preparation
- Monopotassium phosphate may be prepared by partial neutralization of phosphoric acid with potassium hydroxide in equimolar amounts:H3PO4+ KOH →KH2PO4+ H2O.
- 8.10 General Description
-
Monobasic potassium phosphate crystals are colorless, soluble in water and hygroscopic in nature.Upon heating through 187°C, phase transition occurs in KH2PO4, crystal system changes from tetragonal to monoclinic, lattice parameters at 195°C are α=7.47?, b =7.33?, c =14.49?, α=?=90° and γ=92.2.
- 8.11 Merck
- 14,7659
- 8.12 Introduction
- Potassium dihydrogen phosphate is a kind of highly efficient and rapid dissolving phosphorus and potassium compound fertilizer containing, phosphorus and potassium, two elements for providing the necessary nutrients for plant growth and development, being applicable to any soil and crop, especially being applicable to the treatment of regions of simultaneous lack of phosphorus and potassium nutrients and phosphorus-preferred and potassium-preferred crops. It is mostly used for root top dressing, seed soaking, and seed dressing, being able to yield significant effect. If it sued for the roots fertilization, it can be used as basal fertilizer, seed fertilizer or moderate-late phase topdressing.
Its aqueous solution can react with silver nitrate, generating yellow phosphorus dihydrogen phosphate precipitation, being able to be used as a differential reaction.
As potassium dihydrogen phosphate is expensive, there is less agricultural production. Therefore, it is generally applied of the soaking or root top dressing for application. For crop soaking, the commonly used concentration is 0.2%. After dipping 18~20h, the field can be sown after drying. For root top dressing, if spraying alone, the highest concentration can be 0.5%. If within the range of jointing-booting stage of wheat and rice, we can spray for 1 or 2 times during the cotton, rape early flowering phase. Upon spraying 2 times, the interval can be about 7 to 10 days with the liquid usage amount per acre being about 100~150kg. It can also be combined with other nutrients to be formulated into compound nutrition for foliage top-dressing. For example, the leaf fertilizer used for field crops in North China has its main ingredient be exactly potassium dihydrogen phosphate, urea and the addition inclusion of some trace elements. In recent years, the use of blade complex nutrition also mostly adopts the potassium dihydrogen phosphate as a high concentration and excellent hydrophilic phosphate and potassium fertilizer source. With the development of facilities of horticultural crops and drip irrigation, fertilizer irrigation, the increasing daily demand for potassium dihydrogen phosphate is also increasing.
- 8.13 Usage
- Potassium dihydrogen phosphate is used as a food additive, fertilizer (NPK), paint additive, coating additive, adhesive, buffering agent and in optical modulators. It is extensively used in research and analytical laboratories as a buffer in mobile/sample preparations for analysis by high pressure liquid chromatography (HPLC) and also in organic synthesis. MKP, monopotassium phosphate, owing to its non-linear optical properties, is used in optical modulators and for second-harmonic generation (SHG).
- 8.14 Usage
- In buffers for pH determination.Potassium dihydrogen phosphate is used as a food additive, fertilizer (NPK), paint additive, coating additive, adhesive, buffering agent and in optical modulators. It is extensively used in research and analytical laboratories as a buffer in mobile/sample preparations for analysis by high pressure liquid chromatography (HPLC) and also in organic synthesis. MKP, monopotassium phosphate, owing to its non-linear optical properties, is used in optical modulators and for second-harmonic generation (SHG).
- 8.15 Usage
- Potassium phosphate is typically used as a component in the preparation of phosphate based buffers. It is convenient stock solution for making phosphate buffers. The pKa of 6.82 (25 C) for phosphate buffers make them a universal buffer for biological applications such as cell culture media, column eluent solutions and reagents used in molecular biology. Specific applications include buffers for protein purification, bioprocessing and diagnostic reagent production. Potassium salts are used where sodium content needs to be minimized or controlled.
- 8.16 Usage
- Potassium phosphate buffer is typically used as a component for a wide variety of media used in the culture of microorganisms, as a component in phosphate buffered saline (PBS). In addition to helping maintain pH, it supplies essential phosphate.
- 8.17 Usage
- Potassium phosphate is used as a buffer for the determination of pH. It is also used in pharmaceutical production, urinary acidifier, paper processing, nutrient solutions and yeast foods.
- 8.18 Usage
- Potassium phosphate buffer is typically used as a component for a wide variety of media used in the culture of microorganisms, as a component in phosphate buffered saline. In addition to helping maintain pH, it supplies essential phosphate.
9. Computational chemical data
- Molecular Weight: 136.085541g/mol
- Molecular Formula: H2KO4P
- Compound Is Canonicalized: True
- XLogP3-AA: null
- Exact Mass: 135.93277702
- Monoisotopic Mass: 135.93277702
- Complexity: 61.9
- Rotatable Bond Count: 0
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 4
- Topological Polar Surface Area: 80.6
- Heavy Atom Count: 6
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count: 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Isotope Atom Count: 0
- Covalently-Bonded Unit Count: 2
- CACTVS Substructure Key Fingerprint: AAADcQAAOAIAQAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACCAAAAAAAAAAAAAAABAAQAAAAIAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA==
10. Question & Answer
-
What is potassium phosphate? Phosphorus is a naturally occurring substance that is important in every cell of the body. Phosphorous is contained in all body cells and is used for growth and repair of cells and tissues. Potassium phosphate is used to treat or prevent hypophosphatemia (low blood leve...
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