3D Mol Similar

(R)-(-)-Epichlorohydrin

: Iupac Name：(2R)-2-(chloromethyl)oxirane; CAS No.: 51594-55-9; Molecular Weight：92.522; Modify Date.: 2022-11-06 23:06; Introduction: ((R)-Epichlorohydrin) R-enantiomer of Epichlorohydrin, an important industrial chemical, is a bifunctional alkylating agent with the potential to form DNA cross-links. It is used as a solvent for natural and synthetic resins, gums, cellulose esters and ethers, paints, varnishes, nail enamels and lacquers, cement for Celluloid. Also, it is used as stabilizer. (R)-(-)-EpichlorohydrinSupplier View more+

Request For Quotation

1. Names and Identifiers

: 1.1 Name; (R)-(-)-Epichlorohydrin; 1.2 Synonyms; (-)-2-(Chloromethyl)oxirane (-)-Epichlorohydrin (2R)-2-(Chloromethyl)oxirane (R)-(-)-2-(Chloromethyl)oxirane (R)-(-)-Epichlorohydrin (R)-(Chloromethyl)oxirane (R)-1-Chloro-2,3-epoxypropane (R)-2-(Chloromethyl)oxirane (R)-3-Chloro-1,2-epoxypropane (R)-Epichlorohydrin Oxirane, (chloromethyl)-, (2R)- Oxirane, (chloromethyl)-, (R)- Oxirane, 2-(chloromethyl)-, (2R)-; View all

1.3 CAS No.: 51594-55-9

1.4 CID: 2734062

1.5 EINECS(EC#): 424-280-2

1.6 Molecular Formula: C3H5ClO (isomer)

1.7 Inchi: InChI=1S/C3H5ClO/c4-1-3-2-5-3/h3H,1-2H2/t3-/m0/s1

1.8 InChIkey: BRLQWZUYTZBJKN-VKHMYHEASA-N

1.9 Canonical Smiles: C1C(O1)CCl

1.10 Isomers Smiles: C1[C@@H](O1)CCl

2. Properties

2.1 Density: 1.183

2.1 Melting point: -48°C

2.1 Boiling point: 114℃

2.1 Refractive index: 1.4365-1.4385

2.1 Flash Point: 33℃

2.2 Precise Quality: 92.00290

2.2 PSA: 12.53000

2.2 logP: 0.62400

2.2 VaporDensity: 3.29 (vs air)

2.3 Appearance: colorless to light yellow liquid

2.4 Storage: Keep Cold.

2.5 Chemical Properties: Colorless to light yellow liqui

2.6 Color/Form: Colorless liquid

2.7 Water Solubility: insoluble

2.8 Spectral Properties: Index of refraction: 1.44195 at 11.6 deg C/D; 1.43969 at 16 deg C/D; 1.43585 at 25 deg C/D
IR: 946 (Coblentz Society Spectral Collection)
NMR: 16 (Sadtler Research Laboratories Spectral Collection)
MASS: 185 (Atlas of Mass Spectral Data, John Wiley & Sons, New York)
IR: 2:124F (Aldrich Library of Infrared Spectra, Aldrich Chemical Co, Milwaukee, WI)
RAMAN: 289 (Sadtler Research Laboratories Spectral Collection)

2.9 StorageTemp: 2-8°C

3. Use and Manufacturing

3.1 GHS Classification: Signal: Danger
GHS Hazard Statements
H226: Flammable liquid and vapor [Warning Flammable liquids]
H301: Toxic if swallowed [Danger Acute toxicity, oral]
H311: Toxic in contact with skin [Danger Acute toxicity, dermal]
H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
H317: May cause an allergic skin reaction [Warning Sensitization, Skin]
H331: Toxic if inhaled [Danger Acute toxicity, inhalation]
H350: May cause cancer [Danger Carcinogenicity]

Precautionary Statement Codes
P201, P202, P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P272, P280, P281, P301+P310, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P308+P313, P310, P311, P312, P321, P322, P330, P333+P313, P361, P363, P370+P378, P403+P233, P403+P235, P405, and P501; View all

3.2 Usage: ((R)-Epichlorohydrin) R-enantiomer of Epichlorohydrin, an important industrial chemical, is a bifunctional alkylating agent with the potential to form DNA cross-links. It is used as a solvent for natural and synthetic resins, gums, cellulose esters and ethers, paints, varnishes, nail enamels and lacquers, cement for Celluloid. Also, it is used as stabilizer. (R)-(-)-EpichlorohydrinSupplier

4. Safety and Handling

4.1 Hazard Codes: T

4.1 Risk Statements: R10;R23/24/25;R34;R43;R45

4.1 Safety Statements: S45;S53

4.1 Packing Group: II

4.1 Octanol/Water Partition Coefficient: log Kow = 0.45

4.2 Other Preventative Measures: PRECAUTIONS FOR "CARCINOGENS": Smoking, drinking, eating, storage of food or of food & beverage containers or utensils, & the application of cosmetics should be prohibited in any laboratory. All personnel should remove gloves, if worn, after completion of procedures in which carcinogens have been used. They should ... wash ... hands, preferably using dispensers of liq detergent, & rinse ... thoroughly. Consideration should be given to appropriate methods for cleaning the skin, depending on nature of the contaminant. No standard procedure can be recommended, but the use of organic solvents should be avoided. Safety pipettes should be used for all pipetting. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": In animal laboratory, personnel should remove their outdoor clothes & wear protective suits (preferably disposable, one-piece & close-fitting at ankles & wrists), gloves, hair covering & overshoes. ... Clothing should be changed daily but ... discarded immediately if obvious contamination occurs ... /also,/ workers should shower immediately. In chemical laboratory, gloves & gowns should always be worn ... however, gloves should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, & disposable plastic aprons might provide addnl protection. If gowns are of distinctive color, this is a reminder that they should not be worn outside of lab. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": ... Operations connected with synth & purification ... should be carried out under well-ventilated hood. Analytical procedures ... should be carried out with care & vapors evolved during ... procedures should be removed. ... Expert advice should be obtained before existing fume cupboards are used ... & when new fume cupboards are installed. It is desirable that there be means for decreasing the rate of air extraction, so that carcinogenic powders can be handled without ... powder being blown around the hood. Glove boxes should be kept under negative air pressure. Air changes should be adequate, so that concn of vapors of volatile carcinogens will not occur. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": Vertical laminar-flow biological safety cabinets may be used for containment of in vitro procedures ... provided that the exhaust air flow is sufficient to provide an inward air flow at the face opening of the cabinet, & contaminated air plenums that are under positive pressure are leak-tight. Horizontal laminar-flow hoods or safety cabinets, where filtered air is blown across the working area towards the operator, should never be used ... Each cabinet or fume cupboard to be used ... should be tested before work is begun (eg, with fume bomb) & label fixed to it, giving date of test & avg air-flow measured. This test should be repeated periodically & after any structural changes. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": Principles that apply to chem or biochem lab also apply to microbiological & cell-culture labs ... Special consideration should be given to route of admin. ... Safest method of administering volatile carcinogen is by injection of a soln. Admin by topical application, gavage, or intratracheal instillation should be performed under hood. If chem will be exhaled, animals should be kept under hood during this period. Inhalation exposure requires special equipment. ... unless specifically required, routes of admin other than in the diet should be used. Mixing of carcinogen in diet should be carried out in sealed mixers under fume hood, from which the exhaust is fitted with an efficient particulate filter. Techniques for cleaning mixer & hood should be devised before expt begun. When mixing diets, special protective clothing &, possibly, respirators may be required. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": When ... admin in diet or applied to skin, animals should be kept in cages with solid bottoms & sides & fitted with a filter top. When volatile carcinogens are given, filter tops should not be used. Cages which have been used to house animals that received carcinogens should be decontaminated. Cage-cleaning facilities should be installed in area in which carcinogens are being used, to avoid moving of ... contaminated /cages/. It is difficult to ensure that cages are decontaminated, & monitoring methods are necessary. Situations may exist in which the use of disposable cages should be recommended, depending on type & amt of carcinogen & efficiency with which it can be removed. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": To eliminate risk that ... contamination in lab could build up during conduct of expt, periodic checks should be carried out on lab atmospheres, surfaces, such as walls, floors & benches, & ... interior of fume hoods & airducts. As well as regular monitoring, check must be carried out after cleaning-up of spillage. Sensitive methods are required when testing lab atmospheres. ... Methods ... should ... where possible, be simple & sensitive. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": Rooms in which obvious contamination has occurred, such as spillage, should be decontaminated by lab personnel engaged in expt. Design of expt should ... avoid contamination of permanent equipment. ... Procedures should ensure that maintenance workers are not exposed to carcinogens. ... Particular care should be taken to avoid contamination of drains or ventilation ducts. In cleaning labs, procedures should be used which do not produce aerosols or dispersal of dust, ie, wet mop or vacuum cleaner equipped with high-efficiency particulate filter on exhaust, which are avail commercially, should be used. Sweeping, brushing & use of dry dusters or mops should be prohibited. Grossly contaminated cleaning materials should not be re-used ... If gowns or towels are contaminated, they should not be sent to laundry, but ... decontaminated or burnt, to avoid any hazard to laundry personnel. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": Doors leading into areas where carcinogens are used ... should be marked distinctively with appropriate labels. Access ... limited to persons involved in expt. ... A prominently displayed notice should give the name of the Scientific Investigator or other person who can advise in an emergency & who can inform others (such as firemen) on the handling of carcinogenic substances. /Chemical Carcinogens/
SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Use water spray to disperse vapors and dilute standing pools of liquid.
Personnel protection: Avoid breathing vapors. Keep upwind. ... Avoid bodily contact with the material. Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. If contact with the material anticipated, wear appropriate chemical protective clothing.
The worker should immediately wash the skin when it becomes contaminated.
Work clothing that becomes wet should be immediately removed due to its flammability hazard (i.e., for liquids with a flash point
If material leaking (not on fire) consider evacuation from downwind area based on amount of material spilled, location and weather conditions.
Evacuation: If fire becomes uncontrollable or container is exposed to direct flame-consider evacuation of one-third (1/3) mile radius.
SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a POTW is acceptable only after review by the governing authority. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must meet Hazardous Material Criteria for disposal.
SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.; View all

4.3 Hazard Class: 6.1

4.3 Cleanup Methods: Remove all ignition sources. Ventilate area of spill or leak.
For small quantities, absorb on paper towels. Evaporate in a safe place (such as a fume hood). Allow sufficient time for evaporating vapors to completely clear the hood ductwork. Burn the paper in suitable location away from combustible materials.
... It should not be allowed to enter a confined space, such as a sewer, because of the possibility of an explosion. Sewers designed to preclude the formation of explosive concentrations of epichlorhydrin vapors are permitted.
PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/
Eliminate all ignition sources. Approach release from upwind. Releases may require isolation or evacuation. Use appropriate foam to blanket release and suppress vapors. Use water spray to cool and disperse vapors, protect personnel, and dilute spills to form nonflammable mixtures. Do not use clay absorbents in cleanup. Control runoff and isolate discharged material for proper disposal.
/SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./Environmental Consideration: Land spill Dig a pit, pond, lagoon, holding area to contain liquid or solid material. Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash, cement powder, or commercial sorbents. Apply "universal" gelling agent to immobilize spill. Apply appropriate foam to diminish vapor and fire hazard.
Environmental considerations: Water spill Use natural deep water pockets, excavated lagoons, or sand bag barriers to trap material at bottom. If dissolved, in region of 10ppm or greater concentration, apply activated carbon at ten times the spilled amount. Remove trapped material with suction hoses. Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates.
Environmental Considerations: Air spill Apply water spray or mist to knock down vapors. Combustion products include corrosive or toxic vapors.; View all

4.4 DisposalMethods: [40 CFR 240-280, 300-306, 702-799 (7/1/2008)] Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U014, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.
Epichlorohydrin is a waste chemical stream constituent which may be subjected to ultimate disposal by controlled incineration. Incineration, preferably after mixing with another combustible fuel. Care must be exercised to assure complete combustion to prevent the formation of phosgene. An acid scrubber is necessary to remove the halo acids produced.
A potential candidate for liquid injection incineration at a temperature range of 650 to 1,600 deg C and a residence time of 0.1 to 2 seconds. A potential candidate for rotary kiln incineration at a temperature range of 820 to 1,600 deg C and residence times of seconds for liquids and gases, and hours for solids. A potential candidate for fluidized bed incineration at a temperature range of 450 to 980 deg C and residence times of seconds for liquids and gases, and longer for solids.
PRECAUTIONS FOR "CARCINOGENS": There is no universal method of disposal that has been proved satisfactory for all carcinogenic compounds & specific methods of chem destruction ... published have not been tested on all kinds of carcinogen-containing waste. ... summary of avail methods & recommendations ... /given/ must be treated as guide only. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": ... Incineration may the be only feasible method for disposal of contaminated laboratory waste from biological expt. However, not all incinerators are suitable for this purpose. The most efficient type ... is probably the gas-fired type, in which a first-stage combustion with a less than stoichiometric air:fuel ratio is followed by a second stage with excess air. Some ... are designed to accept ... aqueous & organic-solvent solutions, otherwise it is necessary ... to absorb soln onto suitable combustible material, such as sawdust. Alternatively, chem destruction may be used, esp when small quantities ... are to be destroyed in laboratory. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": HEPA (high-efficiency particulate arrestor) filters ... can be disposed of by incineration. For spent charcoal filters, the adsorbed material can be stripped off at high temp & carcinogenic wastes generated by this treatment conducted to & burned in an incinerator. ... LIQUID WASTE: ... Disposal should be carried out by incineration at temp that ... ensure complete combustion. SOLID WASTE: Carcasses of lab animals, cage litter & misc solid wastes ... should be disposed of by incineration at temp high enough to ensure destruction of chem carcinogens or their metabolites. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": ... Small quantities of ... some carcinogens can be destroyed using chem reactions ... but no general rules can be given. ... As a general technique ... treatment with sodium dichromate in strong sulfuric acid can be used. The time necessary for destruction ... is seldom known ... but 1-2 days is generally considered sufficient when freshly prepd reagent is used. ... Carcinogens that are easily oxidizable can be destroyed with milder oxidative agents, such as saturated soln of potassium permanganate in acetone, which appears to be a suitable agent for destruction of hydrazines or of compounds containing isolated carbon-carbon double bonds. Concn or 50% aqueous sodium hypochlorite can also be used as an oxidizing agent. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": Carcinogens that are alkylating, arylating or acylating agents per se can be destroyed by reaction with appropriate nucleophiles, such as water, hydroxyl ions, ammonia, thiols & thiosulfate. The reactivity of various alkylating agents varies greatly ... & is also influenced by sol of agent in the reaction medium. To facilitate the complete reaction, it is suggested that the agents be dissolved in ethanol or similar solvents. ... No method should be applied ... until it has been thoroughly tested for its effectiveness & safety on material to be inactivated. For example, in case of destruction of alkylating agents, it is possible to detect residual compounds by reaction with 4(4-nitrobenzyl)-pyridine. /Chemical Carcinogens/; View all

4.5 DOT Emergency Guidelines: /GUIDE 131P: FLAMMABLE LIQUIDS-TOXIC/ Health: TOXIC; may be fatal if inhaled, ingested or absorbed through skin. Inhalation or contact with some of these materials will irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
/GUIDE 131P: FLAMMABLE LIQUIDS-TOXIC/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion and poison hazard indoors, outdoors or in sewers. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
/GUIDE 131P: FLAMMABLE LIQUIDS-TOXIC/ Public Safety: CALL Emergency Response Telephone Number ... As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.
/GUIDE 131P: FLAMMABLE LIQUIDS-TOXIC/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.
/GUIDE 131P: FLAMMABLE LIQUIDS-TOXIC/ Evacuation: ... Fire: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.
/GUIDE 131P: FLAMMABLE LIQUIDS-TOXIC/ Fire: CAUTION: All these products have a very low flash point. Use of water spray when fighting fire may be inefficient. Small fires: Dry chemical, CO2, water spray or alcohol-resistant foam. Large fires: Water spray, fog or alcohol-resistant foam. Move containers from fire area if you can do it without risk. Dike fire control water for later disposal; do not scatter the material. Use water spray or fog; do not use straight streams. Fire involving tanks or car/trailer loads: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. For massive fire use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn.
/GUIDE 131P: FLAMMABLE LIQUIDS-TOXIC/ Spill or Leak: Fully encapsulating, vapor protective clothing should be worn for spills and leaks with no fire. ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor suppressing foam may be used to reduce vapors. Small spills: Absorb with earth, sand or other non-combustible material and transfer to containers for later disposal. Use clean non-sparking tools to collect absorbed material. Large spills: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor; but may not prevent ignition in closed spaces.
/GUIDE 131P: FLAMMABLE LIQUIDS-TOXIC/ First Aid: Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. Wash skin with soap and water. Keep victim warm and quiet. In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves.; View all

4.6 RIDADR: UN 2023

4.6 Fire Fighting Procedures: Avoid use of dry chemical if fire occurs in container with confined vent. Containers may explode in fire because of polymerization.
Approach fire from upwind to avoid hazardous vapors and toxic decomposition products. Fight fire from protected location or maximum possible distance. Use water spray, dry chemical, "alcohol resistant" foam, or carbon dioxide. Use water spray to keep fire-exposed containers cool.
If material on fire or involved in fire Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide.
Evacuation: If fire becomes uncontrollable or container is exposed to direct flame consider evacuation of one-third (1/3) mile radius.

4.7 FirePotential: Flammable liquid when exposed to heat or flame.

4.8 Formulations/Preparations: Commercial specifications for a product sold by one USA manufacturer are a minimum of 98.0% wt purity and a max of 0.2% wt water.

4.9 WGK Germany: 3

4.9 RTECS: RR0427000

4.9 Protective Equipment and Clothing: Skin, eye, and respiratory contact must be avoided & protective clothing including PVC suits, plastic gloves, goggles or face shield, hat, & neoprene or PVC boots should be worn. Air concn should not exceed recommended limits of exposure. Where more exposure ... expected, positive pressure respirator ... worn.
Gloves made of butyl rubber, when exposed to epichlorhydrin, protected the hands better than surgical rubber, polyethylene, polyvinyl alcohol, saranex-lamenated tyvek, neoprene and others. [Stampfer JF et al; Am Ind Hyg Assoc J 45 (9): 642-54 (1984)] PubMed Abstract
PRECAUTIONS FOR "CARCINOGENS": ... Dispensers of liq detergent /should be available./ ... Safety pipettes should be used for all pipetting. ... In animal laboratory, personnel should ... wear protective suits (preferably disposable, one-piece & close-fitting at ankles & wrists), gloves, hair covering & overshoes. ... In chemical laboratory, gloves & gowns should always be worn ... however, gloves should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, & disposable plastic aprons might provide addnl protection. ... Gowns ... /should be/ of distinctive color, this is a reminder that they are not to be worn outside the laboratory. /Chemical Carcinogens/
Wear appropriate personal protective clothing to prevent skin contact.
Wear appropriate eye protection to prevent eye contact.
Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection.
Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.]
Respirator Recommendations: At concentrations above the NIOSH REL, or where there in no REL, at any detectable concentration: Assigned Protection Factor (APF) Respirator Recommendation APF = 10,000 Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode. APF = 10,000 Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus.
Respirator Recommendations: Escape conditions: Assigned Protection Factor (APF) Respirator Recommendation APF = 50 Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor and acid gas canister/Any appropriate escape-type, self-contained breathing apparatus.; View all

4.10 Reactivities and Incompatibilities: Strong oxidizers, strong acids, certain salts, caustics, zinc, aluminum, water [Note: May polymerize in presence of strong acids and bases particularly when hot.].
Epichlorohydrin can violently react with compounds carrying an active hydrogen atom, including water.
Epichlorohydrin liberates heat in the presence of ... alkalis, and certain salts ...
WITH SLOW MIXING /OF EPICHLOROHYDRIN & ISOPROPYLAMINE/ & ADEQUATE COOLING, SMOOTH CONDENSATION TO 1-CHLORO-3-ISOPROPYLAMINO-2-PROPANOL OCCURS. WITH RAPID MIXING & POOR COOLING, VARIABLE INDUCTION PERIOD ... SLOW WARMING PRECEDES RAPID, VIOLENT EXOTHERM (TO 350 DEG C IN 6 SEC). OTHER PRIMARY & SECONDARY AMINES BEHAVE SIMILARLY.
Interaction /between epichlorohydrin and an N-substituted aniline/ is exothermic and mixt was normally maintained at 60 deg C by stirring and cooling. Malfunction caused temp incr to 70 deg C and cooling capacity was insufficient to regain control. Temp ... incr to 120 deg C, when explosive decomp occurred.
Mixing 2-aminoethanol and epichlorohydrin in a closed container caused the temperature and pressure to increase.
Mixing ethylene diamine and epichlorohydrin in a closed container caused the temperature and pressure to increase.
Mixing epichlorohydrin and ethyleneimine in a closed container caused the temperature and pressure to increase.
Mixing epichlorohydrin and 70% nitric acid in a closed container caused the temperature and pressure to increase.
Mixing epichlorohydrin and oleum in a closed container caused the temperature and pressure to increase.
Ignition occurs when potassium t-butoxide reacts with ... epichlorohydrin ...
Mixing epichlorohydrin and 96% sulfuric acid in a closed container caused the temperature and pressure to increase.
Ignition occurs on contact with potassium tert-butoxide. Violent reaction with sulfuric acid or isopropylamine. Exothermic polymerization on contact with strong acids, caustic alkalies, aluminum, aluminum chloride, iron(III) chloride, or zinc.
Contact with strong acids and bases, zinc, aluminium, metal chlorides, alcohol-containing materials, isopropylamine, trichloroethylene, and oxidizing agents may cause fire and explosions.; View all

4.11 Skin, Eye, and Respiratory Irritations: Marked nose & eye irritation occur only ... /above/ 100 ppm.
Epichlorohydrin effect on the skin, eyes, and respiratory tract may be delayed for several hours. Epichlorohydrin causes dermatitis.
Inhalation of epichlorohydrin causes irritation of the eyes and throat. ...

4.12 Specification

The Oxirane, (chloromethyl)-, (R)-, with its CAS registry number 51594-55-9, has the IUPAC name of (2R)-2-(chloromethyl)oxirane. For being a kind of colorless to light yellow liquid, its product categories are including Industrial/Fine Chemicals; Methyl Halides; chiral; Chiral compounds; Chiral Building Blocks; Glycidyl Compounds, etc. (Chiral); Oxiranes; Simple 3-Membered Ring Compounds; Synthetic Organic Chemistry; Chiral Compound; Methyl Halides; Ring Systems. Besides, it is usually used as chiral intermediate and chiral medicine synthesis.

The physical properties of this chemical are as below: (1)ACD/LogP: 0.45; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.45; (4)ACD/LogD (pH 7.4): 0.45; (5)ACD/BCF (pH 5.5): 1.29; (6)ACD/BCF (pH 7.4): 1.29; (7)ACD/KOC (pH 5.5): 41.84; (8)ACD/KOC (pH 7.4): 41.84; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 12.53; (13)Index of Refraction: 1.443; (14)Molar Refractivity: 20.37 cm³; (15)Molar Volume: 76.7 cm³; (16)Polarizability: 8.07×10^-24 cm³; (17)Surface Tension: 35.6 dyne/cm; (18)Density: 1.205 g/cm³; (19)Flash Point: 33.9 °C; (20)Enthalpy of Vaporization: 33.98 kJ/mol; (21)Boiling Point: 116.1 °C at 760 mmHg; (22)Vapour Pressure: 22 mmHg at 25°C; (23)Exact Mass: 92.002892; (24)MonoIsotopic Mass: 92.002892; (25)Topological Polar Surface Area: 12.5; (26)Heavy Atom Count: 5; (27)Complexity: 37.9.

When you are dealing with this chemical, you should be very careful. For being toxic which may at low levels cause damage to health, it will be dangerous if by inhalation, in contact with skin and if swallowed. And this chemical tends to cause sensitisation by skin contact and burns and then even cause cancer. Therefore, you should avoid exposure - obtain special instructions before use. And if in case of accident or if you feel unwell seek medical advice immediately (show the label where possible).

In addition, you could convert the following datas into the molecular structure:
(1)Canonical SMILES: C1C(O1)CCl
(2)Isomeric SMILES: C1[C@@H](O1)CCl
(3)InChI: InChI=1S/C3H5ClO/c4-1-3-2-5-3/h3H,1-2H2/t3-/m0/s1
(4)InChIKey: BRLQWZUYTZBJKN-VKHMYHEASA-N?

View all

5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Flammable liquids, Category 3

Acute toxicity - Oral, Category 3

Acute toxicity - Dermal, Category 3

Skin corrosion, Category 1B

Skin sensitization, Category 1

Acute toxicity - Inhalation, Category 3

Carcinogenicity, Category 1B

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Danger
Hazard statement(s)	H226 Flammable liquid and vapour H301 Toxic if swallowed H311 Toxic in contact with skin H314 Causes severe skin burns and eye damage H317 May cause an allergic skin reaction H331 Toxic if inhaled H350 May cause cancer
Precautionary statement(s)
Prevention	P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P280 Wear protective gloves/protective clothing/eye protection/face protection. P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P271 Use only outdoors or in a well-ventilated area. P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood.
Response	P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower]. P370+P378 In case of fire: Use ... to extinguish. P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/\u2026 P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P312 Call a POISON CENTER/doctor/\u2026if you feel unwell. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 Wash contaminated clothing before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P310 Immediately call a POISON CENTER/doctor/\u2026 P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P333+P313 If skin irritation or rash occurs: Get medical advice/attention. P362+P364 Take off contaminated clothing and wash it before reuse. P311 Call a POISON CENTER/doctor/\u2026 P308+P313 IF exposed or concerned: Get medical advice/ attention.
Storage	P403+P235 Store in a well-ventilated place. Keep cool. P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

View all

6. Synthesis Route

51594-55-9Total: 17 Synthesis Route

96-23-1 118 Suppliers

67843-74-7 227 Suppliers

51594-55-9 213 Suppliers

Literatures:
Tetrahedron, , vol. 36, p. 3391 - 3398
Yield: null

107-05-1 91 Suppliers

51594-55-9 213 Suppliers

Literatures:
Wu, Jinyue; Liu, Chen; Jiang, Yucheng; Hu, Mancheng; Li, Shuni; Zhai, Quanguo Catalysis Communications, 2010 , vol. 11, # 8 p. 727 - 731
Yield: ~91%

106-89-8 224 Suppliers

51594-55-9 213 Suppliers

Literatures:
Schaus, Scott E.; Branalt, Jonas; Jacobsen, Eric N. Journal of Organic Chemistry, 1998 , vol. 63, # 15 p. 4876 - 4877
Yield: ~84%

View all

7. Precursor and Product

precursor:

107-05-1

70987-78-9

67800-61-7

616-23-9

106-89-8

95548-93-9

83398-53-2

96-23-1

product :

2238-07-5

452105-35-0

133397-54-3

71031-03-3

181140-34-1

851528-84-2

67006-99-9

105780-38-9

67843-74-7

57090-45-6

198226-53-8

70987-79-0

161596-47-0

56715-28-7

61249-00-1

27905-76-6

22910-07-2

95093-95-1

30569-34-7

70987-80-3

104605-97-2

62501-72-8

130232-97-2

118166-40-8

622-04-8

View all

8. Computational chemical data

Molecular Weight: 92.522g/mol
Molecular Formula: C₃H₅ClO
Compound Is Canonicalized: True
XLogP3-AA: null
Exact Mass: 92.0028925
Monoisotopic Mass: 92.0028925
Complexity: 37.9
Rotatable Bond Count: 1
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 1
Topological Polar Surface Area: 12.5
Heavy Atom Count: 5
Defined Atom Stereocenter Count: 1
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Isotope Atom Count: 0
Covalently-Bonded Unit Count: 1
CACTVS Substructure Key Fingerprint: AAADcYBAIAAEAAAAAAAAAAAAEgAAAAAAAAAAAAAAAAAAAAAAAAAAGgIAAAAACBeggEIAAAAABAAAAAAAAAAAAAAAAAAAAAAAAwAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA==

9. Recommended Suppliers

Global206SuppliersView all >>

Wuhan Ceteng Biological Technology Co., LTD Diamond member

1YR

Products:Pharmaceutical retail; Calendar wholesale; Veterinary drug management
Tel:+86-156-30140657
Email:nancy@cetengbiology.com

CAS51594-55-9 (R)-(-)-Epichlorohydrin

Purity:99%Packing: 200kg/bag FOB
Price: 10 USD/kg
Time: 2023/09/21

Inquire

Hebei Crovell Biotech Co. Ltd Diamond member

3YRS

Products:Cosmetic Raw Materials,solvents,etc.
Tel:86-311-66562153
Email:Helen@crovellbio.com

(R)-(-)-Epichlorohydrin

Purity:99%Packing: 200kg/bag FOB
Price: 1 USD/kilogram
Time: 2023/09/20

Inquire

Hebei Yinsheng Technology Co., Ltd. Diamond member

1YR

Products:Hebei Yinsheng Technology Co., Ltd is a company dedicated to the research and development, production and sales of organic compounds, pharmaceutical intermediates and chemical raw materials
Tel:0086-03113-17367750398
Email:ella@hbyinsheng.com

Wholesale High quality (R)-(-)-Epichlorohydrin CAS: 51594-55-9 Organic chemical product