Guidechem | China Chemical Manufacturers,suppliers,B2B Marketplace
  • Products
  • Encyclopedia
  • Buy offers
  • Suppliers
Home> Encyclopedia >Pharmaceutical Intermediates>Gastrointestinal Agents>Pharmaceutical
Ranitidine hydrochloride structure
Ranitidine hydrochloride structure

Ranitidine hydrochloride

Iupac Name:1-N'-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-1-N-methyl-2-nitroethene-1,1-diamine;hydrochloride
CAS No.: 71130-06-8
Molecular Weight:350.862
Modify Date.: 2022-11-25 02:23

Ranitidine Hydrochloride is a member of the class of histamine H2-receptor antagonists with antacid activity. Ranitidine is a competitive and reversible inhibitor of the action of histamine, released by enterochromaffin-like (ECL) cells, at the histamine H2-receptors on parietal cells in the stomach, thereby inhibiting the normal and meal-stimulated secretion of stomach acid. In addition, other substances that promote acid secretion have a reduced effect on parietal cells when the H2 receptors are blocked.|A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.

View more+
1. Names and Identifiers
1.1 Name
Ranitidine hydrochloride
1.2 Synonyms

[(Dimethylamino)methyl]furfuryl]thio]ethyl]-N'-methyl-2-nitrovinylidenediamine monohydrochloride 1,1-Ethenediamine, N-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-, hydrochloride (1:1) Azantac EINECS 275-207-4 MFCD00069339 -N-(2-(((5-((Dimethylamino) N-[2-[[[5-[(DIMETHYLAMINO)METHYL]-2-FURANYL]METHYL]THIO]ETHYL]-N'-METHYL-2-NITRO-1,1-ETHANEDIAMINE HYDROCHLORIDE N-{2-[({5-[(Dimethylamino)methyl]-2-furyl}methyl)sulfanyl]ethyl}-N'-methyl-2-nitro-1,1-ethenediamine hydrochloride (1:1) -N-methyl-2-nitroethene-1,1-diamine Noctone Raniben Ranidil Raniplex RANITIDINE (ranitidine) RANITIDINE HCL Ranitidine HCl salt Sostril Taural Terposen Trigger Ulcex Ultidine UNII-BK76465IHM ZANTAC Zantic

1.3 CAS No.
1.4 CID
266-333-0; 275-207-4
1.6 Molecular Formula
C13H23ClN4O3S (isomer)
1.7 Inchi
1.8 InChkey
1.9 Canonical Smiles
1.10 Isomers Smiles
2. Properties
2.1 Boiling point
437.1 °C at 760 mmHg
2.1 Flash Point
218.2 °C
2.1 Precise Quality
2.1 PSA
2.1 logP
2.1 Solubility
H2O: 1.8?mg/mL
2.2 Color/Form
2.3 Water Solubility
H2O: 1.8?mg/mL
3. Use and Manufacturing
3.1 Usage
A histamine H2-receptor antagonist
4. Safety and Handling
4.1 Risk Statements
4.1 Safety Statements
4.1 WGK Germany

2.Hazard identification

2.1 Classification of the substance or mixture

Skin irritation, Category 2

Skin sensitization, Category 1

Eye irritation, Category 2

Respiratory sensitization, Category 1

Specific target organ toxicity \u2013 single exposure, Category 3

2.2 GHS label elements, including precautionary statements

Signal word


Hazard statement(s)

H315 Causes skin irritation

H317 May cause an allergic skin reaction

H319 Causes serious eye irritation

H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335 May cause respiratory irritation

Precautionary statement(s)

P264 Wash ... thoroughly after handling.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P272 Contaminated work clothing should not be allowed out of the workplace.

P284 [In case of inadequate ventilation] wear respiratory protection.

P271 Use only outdoors or in a well-ventilated area.


P302+P352 IF ON SKIN: Wash with plenty of water/...

P321 Specific treatment (see ... on this label).

P332+P313 If skin irritation occurs: Get medical advice/attention.

P362+P364 Take off contaminated clothing and wash it before reuse.

P333+P313 If skin irritation or rash occurs: Get medical advice/attention.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P337+P313 If eye irritation persists: Get medical advice/attention.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P342+P311 If experiencing respiratory symptoms: Call a POISON CENTER/doctor/...

P312 Call a POISON CENTER/doctor/\u2026if you feel unwell.


P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P405 Store locked up.


P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification


7. Other Information
7.0 Mesh
Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)|Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood. (See all compounds classified as Histamine H2 Antagonists.)
7.1 Mesh Entry Terms
AH 19065
7.2 Use Classification
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
7.3 Uses
A histamine H2-receptor antagonist
7.4 Veterinary Drugs and Treatments
In veterinary medicine, ranitidine has been used for the treatment and/or prophylaxis of gastric, abomasal, and duodenal ulcers, uremic gastritis, stress-related or drug-induced erosive gastritis, esophagitis, duodenal gastric reflux and esophageal reflux. It has also been employed to treat hypersecretory conditions associated with gastrinomas and systemic mastocytosis. Because of its effects on gastric motility, ranitidine may be useful in increasing gastric emptying, particularly when delayed gastric emptying is associated with gastric ulcer disease. Ranitidine may also be useful to stimulate colonic activity in cats via its prokinetic effects.
8. Computational chemical data
  • Molecular Weight: 350.862g/mol
  • Molecular Formula: C13H23ClN4O3S
  • Compound Is Canonicalized: True
  • XLogP3-AA: null
  • Exact Mass: 350.1179395
  • Monoisotopic Mass: 350.1179395
  • Complexity: 347
  • Rotatable Bond Count: 9
  • Hydrogen Bond Donor Count: 3
  • Hydrogen Bond Acceptor Count: 7
  • Topological Polar Surface Area: 112
  • Heavy Atom Count: 22
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count: 0
  • Defined Bond Stereocenter Count: 1
  • Undefined Bond Stereocenter Count: 0
  • Isotope Atom Count: 0
  • Covalently-Bonded Unit Count: 2
9. Recommended Suppliers
Global186SuppliersView all >>
  • Products:My whatsapp:+86 13043111536 cas no.1451-82-7,79099-07-3,5449-12-7,5337-93-9,49851-31-2,288573-56-8
  • Tel:86-311-13043111536
High Quality Ranitidine hydrochloride Cas 71130-06-8
  • Purity:99%Packing: 200kg/bag FOB
  • Price: 20 USD/kg
  • Time: 2023/05/30
  • Products:Top quality and high purity with safe transportation and low price
  • Tel:+86153-92039515-15392039515
Lower Price Higher Quality CAS:71130-06-8 Ranitidine hydrochloride
  • Purity:99%Packing: 200kg/bag FOB
  • Price: 40 USD/kg
  • Time: 2023/05/30
  • Products:API,fine chemical&its intermediates,biological chemistry
  • Tel:0086-27-59207850
High purity Ranitidine hydrochloride Cas 71130-06-8 with favorable price
  • Purity:99%Packing: 200kg/bag FOB
  • Price: 150 USD/kilogram
  • Time: 2023/05/29
  • Products:Division I, the main production Lead acetate phenylacetamide Cyromazine quality is very good!
  • Tel:86-185-31123677
Ranitidine hydrochlorideCAS NO.: 71130-06-8
  • Purity:99%Packing: 200kg/bag FOB
  • Price: 5600 USD/kilogram
  • Time: 2023/05/11
  • Products:Veterinary products,Nutrition products,Agrochemicals,Active pharmaceutical Ingredients,Custom systhesis,Contract manufacturing
  • Tel:86-571-85829052
Ranitidine hydrochloride
  • Purity:99%Packing: 200kg/bag FOB
  • Price: 100 USD/gram
  • Time: 2023/03/14
10. Realated Product Infomation