Ranitidine hydrochloride

Iupac Name：1-N'-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-1-N-methyl-2-nitroethene-1,1-diamine;hydrochloride

CAS No.: 71130-06-8

Molecular Weight：350.862

Modify Date.: 2022-11-25 02:23

Introduction:

Ranitidine Hydrochloride is a member of the class of histamine H2-receptor antagonists with antacid activity. Ranitidine is a competitive and reversible inhibitor of the action of histamine, released by enterochromaffin-like (ECL) cells, at the histamine H2-receptors on parietal cells in the stomach, thereby inhibiting the normal and meal-stimulated secretion of stomach acid. In addition, other substances that promote acid secretion have a reduced effect on parietal cells when the H2 receptors are blocked.|A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.

View more+

Request For Quotation

1. Names and Identifiers

1.1 Name: Ranitidine hydrochloride
1.2 Synonyms: [(Dimethylamino)methyl]furfuryl]thio]ethyl]-N'-methyl-2-nitrovinylidenediamine monohydrochloride 1,1-Ethenediamine, N-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-, hydrochloride (1:1) Azantac EINECS 275-207-4 MFCD00069339 -N-(2-(((5-((Dimethylamino) N-[2-[[[5-[(DIMETHYLAMINO)METHYL]-2-FURANYL]METHYL]THIO]ETHYL]-N'-METHYL-2-NITRO-1,1-ETHANEDIAMINE HYDROCHLORIDE N-{2-[({5-[(Dimethylamino)methyl]-2-furyl}methyl)sulfanyl]ethyl}-N'-methyl-2-nitro-1,1-ethenediamine hydrochloride (1:1) -N-methyl-2-nitroethene-1,1-diamine Noctone Raniben Ranidil Raniplex RANITIDINE (ranitidine) RANITIDINE HCL Ranitidine HCl salt Sostril Taural Terposen Trigger Ulcex Ultidine UNII-BK76465IHM ZANTAC Zantic

1.3 CAS No.: 71130-06-8

1.4 CID: 3033332

1.5 EINECS(EC#): 266-333-0; 275-207-4

1.6 Molecular Formula: C13H23ClN4O3S (isomer)

1.7 Inchi: InChI=1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9+;

1.8 InChkey: GGWBHVILAJZWKJ-KJEVSKRMSA-N

1.9 Canonical Smiles: CNC(=C[N+](=O)[O-])NCCSCC1=CC=C(O1)CN(C)C.Cl

1.10 Isomers Smiles: CN/C(=C\[N+](=O)[O-])/NCCSCC1=CC=C(O1)CN(C)C.Cl

2. Properties

2.1 Boiling point: 437.1 °C at 760 mmHg

2.1 Flash Point: 218.2 °C

2.1 Precise Quality: 350.11800

2.1 PSA: 111.56000

2.1 logP: 3.56600

2.1 Solubility: H2O: 1.8?mg/mL

2.2 Color/Form: tan

2.3 Water Solubility: H2O: 1.8?mg/mL

3. Use and Manufacturing

3.1 Usage: A histamine H2-receptor antagonist

4. Safety and Handling

4.1 Risk Statements: R20/21/22

4.1 Safety Statements: S22;S24/25

4.1 WGK Germany: 2

4.1 RTECS: KM6557000

5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Skin irritation, Category 2

Skin sensitization, Category 1

Eye irritation, Category 2

Respiratory sensitization, Category 1

Specific target organ toxicity \u2013 single exposure, Category 3

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Danger
Hazard statement(s)	H315 Causes skin irritation H317 May cause an allergic skin reaction H319 Causes serious eye irritation H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled H335 May cause respiratory irritation
Precautionary statement(s)
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P284 [In case of inadequate ventilation] wear respiratory protection. P271 Use only outdoors or in a well-ventilated area.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P313 If skin irritation occurs: Get medical advice/attention. P362+P364 Take off contaminated clothing and wash it before reuse. P333+P313 If skin irritation or rash occurs: Get medical advice/attention. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313 If eye irritation persists: Get medical advice/attention. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P342+P311 If experiencing respiratory symptoms: Call a POISON CENTER/doctor/... P312 Call a POISON CENTER/doctor/\u2026if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

View all

6. NMR Spectrum

13C NMR : Predict

1H NMR : Predict

Predict 1H proton NMR

7. Other Information

7.0 Mesh: Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)|Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood. (See all compounds classified as Histamine H2 Antagonists.)

7.1 Mesh Entry Terms: AH 19065

7.2 Use Classification: Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

7.3 Uses: A histamine H2-receptor antagonist

7.4 Veterinary Drugs and Treatments: In veterinary medicine, ranitidine has been used for the treatment and/or prophylaxis of gastric, abomasal, and duodenal ulcers, uremic gastritis, stress-related or drug-induced erosive gastritis, esophagitis, duodenal gastric reflux and esophageal reflux. It has also been employed to treat hypersecretory conditions associated with gastrinomas and systemic mastocytosis. Because of its effects on gastric motility, ranitidine may be useful in increasing gastric emptying, particularly when delayed gastric emptying is associated with gastric ulcer disease. Ranitidine may also be useful to stimulate colonic activity in cats via its prokinetic effects.

8. Computational chemical data

Molecular Weight: 350.862g/mol
Molecular Formula: C₁₃H₂₃ClN₄O₃S
Compound Is Canonicalized: True
XLogP3-AA: null
Exact Mass: 350.1179395
Monoisotopic Mass: 350.1179395
Complexity: 347
Rotatable Bond Count: 9
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 7
Topological Polar Surface Area: 112
Heavy Atom Count: 22
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 1
Undefined Bond Stereocenter Count: 0
Isotope Atom Count: 0
Covalently-Bonded Unit Count: 2
CACTVS Substructure Key Fingerprint: AAADceBzsABEAAAAAAAAAAAAAAAAASAAAAAAAAAAAAAAAAABgAAAHgQUAAAACATF0ASzBIPQREiJAKBWQwCCCAAkIhAIiIGODMiOJjKktTuHGSjs0BM4qYeYEQIAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA==

9. Recommended Suppliers

Global186SuppliersView all >>

Wuhan Xiju Biotechnology Co., Ltd. Diamond member

2YRS

Products:My whatsapp:+86 13043111536 cas no.1451-82-7,79099-07-3,5449-12-7,5337-93-9,49851-31-2,288573-56-8
Tel:86-311-13043111536
Email:Rachel@wh-xiju.com

High Quality Ranitidine hydrochloride Cas 71130-06-8

Purity:99%Packing: 200kg/bag FOB
Price: 20 USD/kg
Time: 2023/05/30

Inquire

Xiamen wonderful Biotechnology Co., Ltd. Diamond member

1YR

Products:Top quality and high purity with safe transportation and low price
Tel:+86153-92039515-15392039515
Email:victoria@xmwonderfulbio.com

Lower Price Higher Quality CAS:71130-06-8 Ranitidine hydrochloride

Purity:99%Packing: 200kg/bag FOB
Price: 40 USD/kg
Time: 2023/05/30

Inquire

Wuhan Fortuna Chemical Co., Ltd. Diamond member

10YRS

Products:API,fine chemical&its intermediates,biological chemistry
Tel:0086-27-59207850
Email:info@fortunachem.com

High purity Ranitidine hydrochloride Cas 71130-06-8 with favorable price

Purity:99%Packing: 200kg/bag FOB
Price: 150 USD/kilogram
Time: 2023/05/29

Inquire

Hebei Yanxi Chemical Co.,Ltd Diamond member

5YRS

Products:Division I, the main production Lead acetate phenylacetamide Cyromazine quality is very good!
Tel:86-185-31123677
Email:xing@yan-xi.com

Ranitidine hydrochlorideCAS NO.: 71130-06-8

Purity:99%Packing: 200kg/bag FOB
Price: 5600 USD/kilogram
Time: 2023/05/11

Inquire

Jinlan Pharm-Drugs Technology Co., Limited Diamond member

10YRS

Products:Veterinary products,Nutrition products,Agrochemicals,Active pharmaceutical Ingredients,Custom systhesis,Contract manufacturing
Tel:86-571-85829052
Email:market@royalpharms.com

Ranitidine hydrochloride