Roxatidine acetate hydrochloride
- Iupac Name：[2-oxo-2-[3-[3-(piperidin-1-ylmethyl)phenoxy]propylamino]ethyl] acetate;hydrochloride
- CAS No.: 93793-83-0
- Molecular Weight：384.89800
- Modify Date.: 2022-12-07 15:41
1. Names and Identifiers
- 1.1 Name
- Roxatidine acetate hydrochloride
- 1.2 Synonyms
2-(acetyloxy)-n-(3-(3-(1-piperidinylmethyl)phenoxy)propyl)-acetamidmonoh 2-acetoxy-n-(3-(m-(1-piperidinylmethyl)phenoxy)propyl)acetamidehydrochloride 2-hydroxy-n-(3-(m-(piperidinomethyl)phenoxy)propyl)-acetamidacetate(ester 2-hydroxy-n-(3-(m-(piperidinomethyl)phenoxy)propyl)acetamideacetate(ester) aceroxatidinehydrochloride acetamide,2-hydroxy-n-(3-(m-(1-piperidinylmethyl)phenoxy)propyl)-,acetate, ROXATIDINE HCL ACETATE tzu0460
- View all
- 1.3 CAS No.
- 93793-83-0
- 1.4 EINECS(EC#)
- 685-494-1
- 1.5 Molecular Formula
- C19H29ClN2O4 (isomer)
- 1.6 Inchi
- InChI=1S/C19H28N2O4.ClH/c1-16(22)25-15-19(23)20-9-6-12-24-18-8-5-7-17(13-18)14-21-10-3-2-4-11-21;/h5,7-8,13H,2-4,6,9-12,14-15H2,1H3,(H,20,23);1H
- 1.7 InChIkey
- FEWCTJHCXOHWNL-UHFFFAOYSA-N
- 1.8 Canonical Smiles
- Cl[H].CC(=O)OCC(=O)NCCCOC1=CC=CC(CN2CCCCC2)=C1
- 1.9 Isomers Smiles
- CC(=O)OCC(=O)NCCCOC1=CC=CC(=C1)CN2CCCCC2.Cl
2. Properties
- 2.1 Melting point
- 145-146°
- 2.1 StorageTemp
- under inert gas (nitrogen or Argon) at 2-8°C
4. MSDS
2.Hazard identification
2.1 Classification of the substance or mixture
Acute toxicity - Oral, Category 4
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |  |
| Signal word | Warning |
| Hazard statement(s) | H302 Harmful if swallowed |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. |
| Response | P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/\u2026if you feel unwell. P330 Rinse mouth. |
| Storage | none |
| Disposal | P501 Dispose of contents/container to ... |
2.3 Other hazards which do not result in classification
none
5. Synthesis Route
93793-83-0Total: 5 Synthesis Route
7. Other Information
- 7.0 Merck
- 14,8274
- 7.1 Target
- Value
- 7.2 Histamine H2 receptor
- 3.2 μM
- 7.3 体外研究
-
Roxatidine Acetate Hydrochloride (6.25 ?μM, 12.5?μM, and 25?μM; pre-treatment for 30?min) suppresses the PMACI-induced activation of p38 MAPK, but does not affect the phosphorylation of ERK or JNK. The total ERK 1/2, JNK, and p38 MAPK levels are unaffected by roxatidine in human mast-cells-1 (HMC-1) cells.
- 7.4 Animal Model:
- ICR male mice (6 weeks old)
- 7.5 Dosage:
- 20?mg/kg
- 7.6 Administration:
- Oral gavage; 20?mg/kg; single dose
- 7.7 Result:
- Suppressed compound 48/80-induced allergic inflammation in anaphylactic animal model.
- 7.8 Description
- Roxatidine acetate hydrochloride is an H2 antagonist, differing considerably in structure from other marketed agents(cimetidine, ranitidine and famotidine) in this category. It is useful in the treatment of gastric, duodenal and anastomotic ulcers, Zollinger-Ellison syndrome and peptic esophagitis.
- 7.9 Description
- Roxatidine acetate is a competitive histamine H2 receptor antagonist that upon oral absorption is rapidly converted to its active metabolite roxatidine. By inhibiting the binding of histamine to H2 receptors, roxatidine reduces both intracellular cAMP concentrations and gastric acid secretion by parietal cells.
- 7.10 Chemical Properties
- White Solid
- 7.11 Originator
- Teikoku Hormone (Japan)
- 7.12 Uses
- antibacterial
- 7.13 Uses
- A histamine H2-receptor antagonist. It is used to inhibit gastric acid secretion; an antiulcer agent.
- 7.14 Brand name
- ALTAT
8. Recommended Suppliers
-
- Products:API,fine chemical&its intermediates,biological chemistry
- Tel:0086-27-59207850
- Email:info@fortunachem.com
-
- Products:Cosmetic Raw Materials,solvents,etc.
- Tel:86-311-66562153
- Email:breeduan@crovellbio.com
-
- Products:Division I, the main production Lead acetate phenylacetamide Cyromazine quality is very good!
- Tel:86-185-31123677
- Email:xing@yan-xi.com
-
- Products:Chemical products
- Tel:86-571-88938639
- Email:sales-gc@dycnchem.com
-
- Products:Sulindac?Acid?;Roxadustat;Upadacitinib;Relugolix;Moxifloxacin;Ticagrelor;Valsartan;Ivabradine;Fingolimod;Fluvoxamine ;HPMC;PVP;Emagliflozine;D-Cycloserine;D-Proline;L-Proline;L-tert-Leucine
- Tel:86-571-86820258
- Email:kevin@utanpharma.com
9. Realated Product Infomation
skype
10YRS
