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Sodium metabisulfite
- CAS No.: 7681-57-4
- Molecular Weight：190.095
- Modify Date.: 2022-10-31 06:22
- Introduction: Sodium metabisulfite (chemical formula: Na2S2O5) appears as a white crystalline or powder solid with a slight sulfur odor. It is toxic upon inhalation and can strongly irritate skin and tissue. It can be decomposed to release toxic oxide fumes of sulfur and sodium upon high temperature. It can be mixed with water to form a corrosive acid. It is generally used as disinfectant, antioxidant, and preservative agent as well as a laboratory reagent. As a kind of food additive, it can be used as a preservative and antioxidant in food. It can also be applied to the wine and beer making. Moreover, it can be used to sanitize the equipment of homebrew and winemaking as a cleaning agent. It also have various kinds of other applications, e.g. being applied to photography, as an excipients in some tablets, for water treatment, as a source of SO2 in wine, as a bactericide and as a bleaching reagent as well as reducing agent. It can be manufactured through the evaporation of a sodium bisulfite which has been saturated with sulfur dioxide. It should be warned that sodium metabisulfite has certain acute effects on the respiratory system, eyes and skin. In severe case, it can cause breathing difficulty and even pulmonary damage which finally leads to death. Therefore, effective protective measures and attention should be taken during the operation.
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1. Names and Identifiers
- 1.1 Name
- Sodium metabisulfite
- 1.2 Synonyms
Campden Tablets Disodium disulfite disodiummetabisulfite disodiumpyrosulphite EINECS 231-673-0 fertisilo metabisulfitedesodium MFCD00213787 Natrii disulfis Natrium pyrosulfit Natriumbisulfit Sodium disulfite Sodium pyrosulfite Sodiummetabisufite SodiumMetabisulphiteAcs SodiumMetabisulphiteExtraPure
- 1.3 CAS No.
- 7681-57-4
- 1.4 CID
- 656671
- 1.5 EINECS(EC#)
- 231-673-0
- 1.6 Molecular Formula
- Na2O5S2 (isomer)
- 1.7 Inchi
- InChI=1S/2Na.H2O5S2/c;;1-6(2)7(3,4)5/h;;(H,1,2)(H,3,4,5)/q2*+1;/p-2
- 1.8 InChkey
- HRZFUMHJMZEROT-UHFFFAOYSA-L
- 1.9 Canonical Smiles
- [O-]S(=O)S(=O)(=O)[O-].[Na+].[Na+]
- 1.10 Isomers Smiles
- [O-]S(=O)S(=O)(=O)[O-].[Na+].[Na+]
2. Properties
- 2.1 Density
- 1.48
- 2.1 Melting point
- 150℃
- 2.1 Boiling point
- greater than 302° F (Decomposes) (NIOSH, 2016)
- 2.1 Precise Quality
- 189.89800
- 2.1 PSA
- 124.92000
- 2.1 logP
- 0.27220
- 2.1 Solubility
- 540 g/L (20 oC)
- 2.2 AnalyticLaboratory Methods
- The determination of ascorbate;, bromate; and metabisulfite; in bread improvers using high performance ion-exchange chromatography. /Metabisulfite;/
- 2.3 Appearance
- White to yellowish crystals or powder with an odor of sulfur dioxide.
- 2.4 Storage
- On exposure to air and moisture, sodium metabisulfite is slowlyoxidized to sodium sulfate with disintegration of the crystals.Addition of strong acids to the solid liberates sulfur dioxide. In water, sodium metabisulfite is immediately converted tosodium (Na+) and bisulfite (HSO3-) ions. Aqueous sodiummetabisulfite solutions also decompose in air, especially on heating.Solutions that are to be sterilized by autoclaving should be filled intocontainers in which the air has been replaced with an inert gas, suchas nitrogen. The addition of dextrose to aqueous sodiummetabisulfite solutions results in a decrease in the stability of themetabisulfite. The bulk material should be stored in a well-closed container,protected from light, in a cool, dry place.
- 2.5 Carcinogenicity
- Sodium metabisulfite was genotoxic inmice in vivo as determined by chromosomalaberration, micronucleus, and sperm shapeassays. It was not mutagenic in bacterialassays.
- 2.6 Chemical Properties
- white crystalline powder with a sulfur smell
- 2.7 Color/Form
- White hexagonal crystals or powder
- 2.8 Contact Allergens
- This agent is frequently used as a preservative in pharmaceutical products, in the bread-making industry as an antioxidant, and it can induce contact dermatitis. It can be used as a reducing agent in photography and caused dermatitis in a photographic technician, probably acting as an aggravating irritative factor. Sodium metabisulfite contains a certain amount of sodium sulfite and sodium sulfate.
- 2.9 Decomposition
- Decomposes on heating with ultimate formation of sodium sulfate;.
- 2.10 Odor
- In the presences of traces of water;, it develops an odor of sulfur dioxide;
- 2.11 PH
- Aqueous solution is acid
- 2.12 Physical
- SODIUM METABISULFITE; is a white crystalline or powder solid with a slight sulfur; odor. Toxic by inhalation . Strongly irritates skin and tissue. Noncombustible, but may decompose to emit toxic oxide fumes of sulfur; and sodium; when heated to high temperature. A corrosive acid when mixed with water;. Used as a food preservative and as a laboratory reagent.
- 2.13 Water Solubility
- 540 g/L (20 oC)
- 2.14 Stability
- Stable. Incompatible with strong oxidizing agents, strong acids. Contact with strong acids releases a poisonous gas. May be moisture and air sensitive.
- 2.15 StorageTemp
- Store at +5°C to +30°C.
3. Use and Manufacturing
- 3.1 Definition
- ChEBI: An inorganic sodium salt composed of sodium and disulfite ions in a 2:1 ratio.
- 3.2 GHS Classification
- Signal: Danger
GHS Hazard Statements
H302: Harmful if swallowed [Warning Acute toxicity, oral]
H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]
Precautionary Statement Codes
P264, P270, P280, P301+P312, P305+P351+P338, P310, P330, and P501
- 3.3 Methods of Manufacturing
- Sodium disulfite; is produced by treating 50-70% sodium hydroxide; or a suspension of sodium carbonate; with sulfur-dioxide;-containing gases in saturated sodium hydrogen sulfite; solution. The sodium disulfite; is removed by centrifugation and then dried.
- 3.4 Potential Exposure
- Sodium metabisulfite is used as an antioxidant in pharmaceutical preparations and as a preservative in foods. People with asthma have a greater chance of having an allergic reaction with this chemical. Individuals allergic to sodium bisulfite (a food preservative found in some wine, fresh shrimp; packaged foods; and restaurant salads and potatoes) may have a severe reaction when exposed to sodium metabisulfite.
- 3.5 Produe Method
- Sodium metabisulfite is prepared by saturating a solution of sodiumhydroxide with sulfur dioxide and allowing crystallization to occur;hydrogen is passed through the solution to exclude air. Sodiummetabisulfite may also be prepared by saturating a solution ofsodium carbonate with sulfur dioxide and allowing crystallizationto occur, or by thermally dehydrating sodium bisulfite.
- 3.6 Shipping
- UN1759 Corrosive solids, n.o.s., Hazard class: 8; Labels: 8-Corrosive material, Technical Name required. UN2693 Bisulfites, inorganic, aqueous solutions, n.o.s., Hazard class: 8; Labels: 8-Corrosive material.
- 3.7 Usage
- Sodium metabisulfite (SMBS, Sodium disulfite) is a white, granular solid sodium salt. an inorganic compound made up of sodium, sulfur, and oxygen, and used in many industries:in the pulp and paper industry, in the photographic industry and in the various other industries as a bleach or dechlorinator.Food Grade sodium metabisulfite may be used as a food preservative. It is also commonly added to various food products and wines as a preservative.Sodium metabisulfite can also be used in the manufacture of other chemicals, Used in production of cleaning agents, detergents, and soaps.It also acts as a corrosion inhibitor in oil and gas industry, as a bleaching agent in the production of coconut cream, as the source of sulfur dioxide and in the destruction of cyanide in commercial gold cyanidation processes.Gold mining industry: It is utilized in the precipitation of gold from auric acid as well as in the waste water treatment to remove hexavaent chromium as trivalent chromium by precipitation after reduction.Preservative in photo developer solutions, it is used in photography.Oxygen scavenge:it plays as an oxygen scavenger to eliminate the dissolved oxygen in wastewater and in pipes.Sodium metabisulfite may be used as an initiator during the cross-linking polymerization of polybutadiene in the cores of the vesicle membranes.It may be added as an antioxidant during the preparation of stock solutions of 6-hydroxydopamine in various studies.Dechlorination in municipal wastewater, pulp & paper, power, and textile water treatment plants.
4. Safety and Handling
- 4.1 Symbol
- GHS05;GHS07;
- 4.1 Hazard Codes
- Xn
- 4.1 Signal Word
- DANGER
- 4.1 Risk Statements
- R22;R31;R41
- 4.1 Safety Statements
- S26;S39;S46
- 4.1 Packing Group
- III
- 4.1 Hazard Declaration
- H302; H318
- 4.1 RIDADR
- UN 2693
- 4.1 Safety Profile
- An inhalation hazard. Poison by intravenous route. Moderately toxic by parenteral route. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of SOx and Na2O.
- 4.2 Caution Statement
- P280-P301 + P312 + P330-P305 + P351 + P338 + P310
- 4.2 Incompatibilities
- A strong reducing agent. Keep away from oxidizers. Mixtures with water forms a strong corrosive. Contact with acids releases toxic fumes. Heat causes decomposition. Slowly oxidized to the sulfate on exposure to air and moisture. Attacks metals
- 4.3 WGK Germany
- 1
- 4.3 RTECS
- UX8225000
- 4.3 Safety
-
Hazard Codes:?
Xn,?
Xi
Risk Statements: 22-31-41-36/37/38?
R22:Harmful if swallowed.?
R31 :Contact with acids liberates toxic gas.?
R41:Risk of serious damage to the eyes.?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-39-46-36?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S39:Wear eye / face protection.?
S46:If swallowed, seek medical advice immediately and show this container or label.?
S36:Wear suitable protective clothing.
RIDADR: 3260
WGK Germany: 1
RTECS: UX8225000
PackingGroup: III
- 4.4 Specification
-
?Sodium Metabisulphite (CAS NO.7681-57-4) is also named as AI3-51684 ; CCRIS 3951 ; Campden Tablets ; Disodium disulfite ; Disodium metabisulfite ; Disodium pyrosulfite ; Disulfurous acid, disodium salt ;?Fertisilo ; HSDB 378 ; Natrii disulfis ; Natrium metabisulfurosum ; Natrium pyrosulfit ; Natriumbisulfit ; Natriummetabisulfit ; Pyrosulfurous acid, disodium salt ; Sodium bisulfite anhydrous ; Sodium disulfite ; Sodium metabisulfite ; Sodium metabisulfite (Na2-S2O5) ; Sodium pyrosulfite ; Sodium pyrosulfite (Na2S2O5)?.?Sodium Metabisulphite (CAS NO.7681-57-4) is white crystalline powder with a sulfur smell. It is soluble in water and?glycerine, slightly soluble in ethanol.
- 4.5 Toxicity
-
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| guinea pig |
LD50 |
skin |
> 1gm/kg (1000mg/kg) |
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
National Technical Information Service. Vol. OTS0556695, |
| mouse |
LD50 |
parenteral |
910mg/kg (910mg/kg) |
? |
Russian Pharmacology and Toxicology Vol. 31, Pg. 120, 1968. |
| rabbit |
LDLo |
intravenous |
192mg/kg (192mg/kg) |
? |
Toxicology and Applied Pharmacology. Vol. 24, Pg. 266, 1973.
? |
| rat |
LD50 |
intravenous |
115mg/kg (115mg/kg) |
? |
"Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986Vol. 6, Pg. 1418, 1991. |
| rat |
LD50 |
oral |
1131mg/kg (1131mg/kg) |
BEHAVIORAL: FOOD INTAKE (ANIMAL)
BEHAVIORAL: MUSCLE WEAKNESS
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
National Technical Information Service. Vol. OTS0556695, |
| rat |
LD50 |
skin |
> 2gm/kg (2000mg/kg) |
? |
National Technical Information Service. Vol. OTS0557608, |
5. MSDS
2.Hazard identification
2.1 Classification of the substance or mixture
Acute toxicity - Oral, Category 4
Serious eye damage, Category 1
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |   |
| Signal word | Danger |
| Hazard statement(s) | H302 Harmful if swallowed H318 Causes serious eye damage |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection. |
| Response | P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/\u2026if you feel unwell. P330 Rinse mouth. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310 Immediately call a POISON CENTER/doctor/\u2026 |
| Storage | none |
| Disposal | P501 Dispose of contents/container to ... |
2.3 Other hazards which do not result in classification
none
6. Other Information
- 6.0 Usage
- Sodium metabisulfite is used as an active ingredient in campden tablets, as a cleaning agent for potable water reverse osmosis membranes, as a preservative and an antioxidant in food. It also acts as a corrosion inhibitor in oil and gas industry, as a bleaching agent in the production of coconut cream, as the source of sulfur dioxide and in the destruction of cyanide in commercial gold cyanidation processes. It is utilized in the precipitation of gold from auric acid as well as in the waste water treatment to remove hexavaent chromium as trivalent chromium by precipitation after reduction. Further, it is used in photography. In addition, it plays as an oxygen scavenger to eliminate the dissolved oxygen in wastewater and in pipes.
- 6.1 Merck
- 14,8638
- 6.2 Description
- Sodium metabisulfite (chemical formula: Na2S2O5) appears as a white crystalline or powder solid with a slight sulfur odor. It is toxic upon inhalation and can strongly irritate skin and tissue. It can be decomposed to release toxic oxide fumes of sulfur and sodium upon high temperature. It can be mixed with water to form a corrosive acid. It is generally used as disinfectant, antioxidant, and preservative agent as well as a laboratory reagent. As a kind of food additive, it can be used as a preservative and antioxidant in food. It can also be applied to the wine and beer making. Moreover, it can be used to sanitize the equipment of homebrew and winemaking as a cleaning agent. It also have various kinds of other applications, e.g. being applied to photography, as an excipients in some tablets, for water treatment, as a source of SO2 in wine, as a bactericide and as a bleaching reagent as well as reducing agent. It can be manufactured through the evaporation of a sodium bisulfite which has been saturated with sulfur dioxide. It should be warned that sodium metabisulfite has certain acute effects on the respiratory system, eyes and skin. In severe case, it can cause breathing difficulty and even pulmonary damage which finally leads to death. Therefore, effective protective measures and attention should be taken during the operation.
sodium metabisulfite powder
- 6.3 Uses
- Sodium metabisulfite (SMBS, Sodium disulfite) is a white, granular solid sodium salt. an inorganic compound made up of sodium, sulfur, and oxygen, and used in many industries:
- in the pulp and paper industry, in the photographic industry and in the various other industries as a bleach or dechlorinator.
- Food Grade sodium metabisulfite may be used as a food preservative. It is also commonly added to various food products and wines as a preservative.
- Sodium metabisulfite can also be used in the manufacture of other chemicals, Used in production of cleaning agents, detergents, and soaps.
- It also acts as a corrosion inhibitor in oil and gas industry, as a bleaching agent in the production of coconut cream, as the source of sulfur dioxide and in the destruction of cyanide in commercial gold cyanidation processes.
- Gold mining industry: It is utilized in the precipitation of gold from auric acid as well as in the waste water treatment to remove hexavaent chromium as trivalent chromium by precipitation after reduction.
- Preservative in photo developer solutions, it is used in photography.
- Oxygen scavenge:it plays as an oxygen scavenger to eliminate the dissolved oxygen in wastewater and in pipes.
- Sodium metabisulfite may be used as an initiator during the cross-linking polymerization of polybutadiene in the cores of the vesicle membranes.
- It may be added as an antioxidant during the preparation of stock solutions of 6-hydroxydopamine in various studies.
- Dechlorination in municipal wastewater, pulp & paper, power, and textile water treatment plants.
- 6.4 Preparation
- manufactures sodium metabisulfite by reacting sulfur dioxide with sodium carbonate (soda ash), purifying and drying to form crystals or powder.
Na2CO3 + 2SO2→Na2S2O5 + CO2
- 6.5 Product Specification
-
7. Computational chemical data
- Molecular Weight: 190.095g/mol
- Molecular Formula: Na2O5S2
- Compound Is Canonicalized: True
- XLogP3-AA: null
- Exact Mass: 189.89825401
- Monoisotopic Mass: 189.89825401
- Complexity: 136
- Rotatable Bond Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 6
- Topological Polar Surface Area: 125
- Heavy Atom Count: 9
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count: 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Isotope Atom Count: 0
- Covalently-Bonded Unit Count: 3
- CACTVS Substructure Key Fingerprint: AAADcQAAODBgAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAADAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA==
8. Question & Answer
-
Aqua regia WILL dissolve, i.e. oxidize gold … it does not necessarily have to contain gold … Aqua regia is a mix of conc. nitric, and conc. hydrochloric acids, which affords the oxidizing nitrosyl cation… And for the oxidation of gold metal ….
-
I am doing an experiment where I perform an iodine clock reaction between sodium metabisulfite and potassium iodate. I have an experimental value for this reaction but I need a theoretical literature value to compare this value to calculate discrepancy.
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