Sodium Phosphate, Dibasic
- Iupac Name：disodium;hydrogen phosphate
- CAS No.: 7558-79-4
- Molecular Weight：141.958841
- Modify Date.: 2022-11-29 04:01
- Introduction: Sodium phosphate dibasic is highly hygroscopic and water soluble. Useful in conjunction with Sodium Phosphate, Monobasic in the preparation of biological buffers. It is commonly used in biological assay buffers.Sodium is required for nerve and muscle functioning. Sodium Phosphate Dibasic can be used as a dietary supplement and as a nutrient. Sodium hydrogen phosphate is used in food and water treatment in conjunction with trisodium phosphate.In foods, it is used to adjust pH. In water treatment, It retards calcium scale formation. It is also found in some detergents and cleaning agents. This product is known to be Used in many applications including the purification of antibodies. It is used as a saline laxative to treat constipation or to clean the bowel before a colonoscopy.
View more+
1. Names and Identifiers
- 1.1 Name
- Sodium Phosphate, Dibasic
- 1.2 Synonyms
buffer solution from di-sodium hydrogen phosphate DIBASICSODIUMPHOSPHATE,DRIED,USP Disodium hydrogenorthophosphate disodium,hydrogen phosphate MFCD00003496 sodium hydrogen phosphate, anhydrous, acs sodium phosphate dibasic solution SODIUM PHOSPHATE, DIBASIC ANHYDROUS, TECHNICAL SODIUM PHOSPHATE, DIBASIC BIO-REFINED SODIUMPHOSPHATE,DIBASIC,ANHYDROUS,BIOTECHGRADE
- 1.3 CAS No.
- 7558-79-4
- 1.4 CID
- 24203
- 1.5 EINECS(EC#)
- 231-448-7
- 1.6 Molecular Formula
- HNa2O4P (isomer)
- 1.7 Inchi
- InChI=1S/2Na.H3O4P/c;;1-5(2,3)4/h;;(H3,1,2,3,4)/q2*+1;/p-2
- 1.8 InChkey
- BNIILDVGGAEEIG-UHFFFAOYSA-L
- 1.9 Canonical Smiles
- OP(=O)([O-])[O-].[Na+].[Na+]
- 1.10 Isomers Smiles
- OP(=O)([O-])[O-].[Na+].[Na+]
2. Properties
- 2.1 Density
- 1.064 g/mL at 20 °C
- 2.1 Melting point
- 243-245 °C
- 2.1 Boiling point
- 158 °C at 760 mmHg
- 2.1 Refractive index
- Rhombic bispheroidal crystals; Index of refraction: 1.463 /Disodium phosphate dihydrate/
- 2.2 Precise Quality
- 141.94100
- 2.2 PSA
- 93.23000
- 2.2 logP
- -0.05220
- 2.2 Solubility
- >=10 g/100 mL at 20 oC
- 2.3 VaporDensity
- 4.9 (vs air)
- 2.4 Appearance
- Sodium phosphate, dibasic appears as a colorless to white crystalline solid. Soluble in water. The primary hazard is the threat to the environment. Immediate steps should be taken to limit spread to the environment. Used as a fertilizer, in pharmaceuticals, in food processing, and for many other uses.
- 2.5 Storage
- Hygroscopic. Ambient temperatures.
- 2.6 Chemical Properties
- The anhydrous compound is white crystalline powder; hygroscopic; density 1.70 g/cm3; converts to sodium pyrophosphate at 240°C; soluble in water; 874 SODIUM PHOSPHATE, DIBASIC insoluble in alcohol. The dihydrate is a crystalline powder or granular solid; density 2.066 g/cm3 at 15°C; loses water of crystallization at 92.5°C. The heptahydrate is a powdered or granular crystalline solid; density 1.679 g/cm3; loses five molecules of water at 48°C. The dodecahydrate is made up of translucent crystals or granules; density 1.524 g/cm3; readily loses five water molecules on exposure to air at ambient temperature; melts at 35°C when the salt contains all water of crystallization; loses all water at 100°C. All the hydrates are soluble in water and insoluble in alcohol.
- 2.7 Color/Form
- Colorless, translucent crystals or white powder.
White, hygroscopic powder
- 2.8 Decomposition
- When heated to decomposition it emits toxic fumes of /phosphorous and sodium oxides/.
- 2.9 Odor
- NONE
- 2.10 PH
- Between 8,4 and 9,6 (1 % solution)
- 2.11 pKa
- (1) 2.15, (2) 6.82, (3) 12.38 (at 25℃)
- 2.12 Water Solubility
- H2O: >=10 g/100 mL at 20 oC
- 2.13 Stability
- Stable. Incompatible with strong acids. Hygroscopic.
- 2.14 StorageTemp
- Store at +5°C to +30°C.
3. Use and Manufacturing
- 3.1 Purification Methods
- Crystallise the salt twice from warm water, by cooling. Dry in air, then in an oven overnight at 130o. It should be dried before use as it is slightly hygroscopic. It forms di-, hepta-and deca-hydrates. Sodium Phosphate, Dibasic Preparation Products And Raw materials Raw materials
- 3.2 Usage
- Sodium Phosphate, Dibasic is used as a laboratory reagent and a buffer in chemical analysis. Other uses are in manufacturing ceramics, detergents, and enamels; as a mordant in dyeing; for fireproofing paper and wood; for weighting and printing silk; in the treatment of boiler water; as a sequestrant in food; as a dietary supplement; in soldering enamels; and in fertilizers. It is used therapeutically as a cathartic.
4. Safety and Handling
- 4.1 Hazard Codes
- Xi
- 4.1 Risk Statements
- R36/37/38
- 4.1 Safety Statements
- S24/25;S36
- 4.1 Exposure Standards and Regulations
- Drug products containing certain active ingredients offered over-the-counter (OTC) for certain uses. A number of active ingredients have been present in OTC drug products for various uses, as described below. However, based on evidence currently available, there are inadequate data to establish general recognition of the safety and effectiveness of these ingredients for the specified uses: sodium phosphate is included in anticaries drug products.
- 4.2 Other Preventative Measures
- SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
If material is not on fire and not involved in fire: Keep material out of water sources and sewers. Build dikes to contain flow as necessary.
Personnel Protection: Keep upwind. Wear appropriate chemical protective gloves, boots and goggles. Avoid breathing vapors or dusts. Wash away any material which may have contacted the body with copious amounts of water or soap and water.
- 4.3 Hazard Declaration
- H318
- 4.3 Cleanup Methods
- /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./Environmental Consideration: Land spill Dig a pit, pond, lagoon, holding area to contain liquid or solid material. Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water.
Environmental Consideration: Neutralize with agricultural lime (CaO), crushed limestone (CaCO3), or sodium bicarbonate (NaHCO3). Adjust pH to neutral (pH=7). Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates.
- 4.4 DisposalMethods
- SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.
- 4.5 RIDADR
- UN 3077 9 / PGIII
- 4.5 Fire Fighting Procedures
- If material is on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.)
- 4.6 FirePotential
- Nonflammable
- 4.7 Safety Profile
- Poison by intravenous route. Moderately toxic by intraperitoneal, subcutaneous, and intramuscular routes. Mildly toxic by ingestion. A skin and eye irritant. When heated to decomposition it emits toxic fumes of POx and Na2O. See also PHOSPHATES.
- 4.8 Caution Statement
- P264, P280, P305+P351+P338, P310, P33, P313
- 4.8 Formulations/Preparations
- Sodium Phosphates Injection, USP, 3 mM P/mL (millimoles/mL)... Each mL contains 276 mg of monobasic sodium phosphate, monohydrate and 142 mg of dibasic sodium phosphate, anhydrous (equivalent to 268 mg of dibasic sodium phosphate, heptahydrate). ... It contains no bacteriostat, antimicrobial agent or added buffer.
Sodium Phosphate preparations: (AHFS, 2009) Sodium Phosphate preparations: (AHFS, 2009)
Route Dosage Form Strength Brand or Generic Name (Manufacturer) Oral Tablet Dibasic Sodium Phosphate (anhydrous) 0.398 g with Monobasic Sodium Phosphate (monohydrate) 1.102 g OsmoPrep (Salix) Oral Tablet Dibasic Sodium Phosphate (anhydrous) 0.398 g with Monobasic Sodium Phosphate (monohydrate) 1.102 g Visicol (Salix) Rectal Solution Dibasic Sodium Phosphate 60 mg/mL with Monobasic Sodium Phosphate 160 mg/mL Fleet Enema (Fleet) Rectal Solution Dibasic Sodium Phosphate 60 mg/mL with Monobasic Sodium Phosphate 160 mg/mL Fleet Pediatric Enema (Fleet)
Visicol (sodium phosphate monobasic monohydrate, USP, and sodium phosphate dibasic anhydrous, USP)... Each tablet contains 1.102 grams of sodium phosphate monobasic monohydrate, USP and 0.398 grams of sodium phosphate dibasic anhydrous, USP for a total of 1.5 grams of sodium phosphate per tablet. Inert ingredients include microcrystalline cellulose (MCC), NF; magnesium stearate, NF; and colloidal silicon dioxide, NF. Visicol is gluten-free.
Sodium phosphate and sodium biphosphate enema USP ... dosage forms-- enema USP: 6% sodium phosphate and 16% sodium biphosphate; sodium phosphate and sodium biphosphate oral solution USP ... dosage forms-- solution USP: 18% sodium phosphate and 48% sodium biphosphate.
Sorensen's phosphate, Sorensen's sodium phosphate. /Disodium phosphate dihydrate/
Fleet's enema: solution (sodium phosphate 6 g and sodium biphosphate 16 g). Fleet's phospho-soda: (sodium phosphate 18 g and sodium biphosphate 48 g).
... An oral soln (FLEET PHOSPHO-SODA) contains 1.8 g of dibasic sodium phosphate and 4.8 g of monobasic sodium phosphate in 10 mL ... /Saline laxatives/
Grade: Commercial, NF /National formulary grade of chemical/ (sodium phosphate, dibasic anhydrous and heptahydrate), FCC /Food chemicals Codex/ (sodium phosphate, dibasic anhydrous or dihydrate)
Available as anhydrous or dihydric salts.
- 4.9 WGK Germany
- 3
- 4.9 RTECS
- WC4500000
- 4.9 Protective Equipment and Clothing
- Dust: Irritating to eyes, nose and throat. If inhaled will cause coughing or difficult breathing. Solid: Irritating to skin and eyes.
A skin and eye irritant.
- 4.10 Report
-
Reported in EPA TSCA Inventory.
- 4.11 Skin, Eye, and Respiratory Irritations
- Dust: Irritating to eyes, nose and throat. If inhaled will cause coughing or difficult breathing. Solid: Irritating to skin and eyes.
A skin and eye irritant.
- 4.12 Safety
-
Safety Information of Disodium hydrogenorthophosphate (CAS NO.7558-79-4):
Hazard Codes: Xi
Risk Statements: 36/37/38??
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-24/25
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.?
S24/25:Avoid contact with skin and eyes.
WGK Germany: 3
- 4.13 Sensitive
- Hygroscopic
- 4.14 Specification
-
?Disodium hydrogenorthophosphate , its CAS NO. is 7558-79-4, the synonyms are Dibasic sodium phosphate ; Disodium acid orthophosphate ; Disodium acid phosphate ; Disodium hydrogen phosphate ; Disodium hydrogen phosphate, anhydrous ; Disodium hydrophosphate ; Disodium monohydrogen phosphate ; Disodium orthophosphate ; Disodium phosphate ; Disodium phosphate, anhydrous ; Disodium phosphoric acid ; Exsiccated sodium phosphate ; Natriumphosphat? ; Phosphate of soda ; Phosphoric acid, disodium salt ; Soda phosphate ; Sodium acid phosphate, anhydrous ; Sodium hydrogen phosphate ; Sodium monohydrogen phosphate ; Sodium orthophosphate, secondary ; Sodium phosphate? ; Sodium phosphate, dibasic ; Sodium phosphate, exsiccated ; secondary Sodium phosphate .
- 4.15 Toxicity
- LD50 orally in Rabbit: > 2000 mg/kg
5. MSDS
2.Hazard identification
2.1 Classification of the substance or mixture
Not classified.
2.2 GHS label elements, including precautionary statements
| Pictogram(s) | No symbol. |
| Signal word | No signal word. |
| Hazard statement(s) | none |
| Precautionary statement(s) | |
| Prevention | none |
| Response | none |
| Storage | none |
| Disposal | none |
2.3 Other hazards which do not result in classification
none
7. Other Information
- 7.0 Usage
- Sodium hydrogen phosphate is used in food and water treatment in conjunction with trisodium phosphate. It is used as an emulsifier and buffer in foods and pharmaceuticals, anti-caking additive in powdered products, dietary supplement, scale inhibitor, reagent and buffer in analytical chemistry. It finds application in detergents, cleaning agents, textile, leather auxiliary, fertilizers and galvanoplastics. Further, it is used as a saline laxative to treat constipation. It inhibits the calcium scale formation in water treatment plants.
- 7.1 Storage features
- Separated from strong acids.
- 7.2 Merck
- 14,8659
- 7.3 Description
- Sodium phosphate dibasic is highly hygroscopic and water soluble. Useful in conjunction with Sodium Phosphate, Monobasic in the preparation of biological buffers. It is commonly used in biological assay buffers. Sodium is required for nerve and muscle functioning. Sodium Phosphate Dibasic can be used as a dietary supplement and as a nutrient. Sodium hydrogen phosphate is used in food and water treatment in conjunction with trisodium phosphate.In foods, it is used to adjust pH. In water treatment, It retards calcium scale formation. It is also found in some detergents and cleaning agents. This product is known to be Used in many applications including the purification of antibodies. It is used as a saline laxative to treat constipation or to clean the bowel before a colonoscopy.
- 7.4 Chemical Properties
- The anhydrous compound is white crystalline powder; hygroscopic; density 1.70 g/cm3; converts to sodium pyrophosphate at 240°C; soluble in water; 874 SODIUM PHOSPHATE, DIBASIC insoluble in alcohol. The dihydrate is a crystalline powder or granular solid; density 2.066 g/cm3 at 15°C; loses water of crystallization at 92.5°C. The heptahydrate is a powdered or granular crystalline solid; density 1.679 g/cm3; loses five molecules of water at 48°C. The dodecahydrate is made up of translucent crystals or granules; density 1.524 g/cm3; readily loses five water molecules on exposure to air at ambient temperature; melts at 35°C when the salt contains all water of crystallization; loses all water at 100°C. All the hydrates are soluble in water and insoluble in alcohol.
- 7.5 Chemical Properties
- Sodium hydrogen phosphate,NaH2P04·H20, is hygroscopic, transparent, water-soluble crystals. Used as a purgative, reagent,and buffer.
- 7.6 Chemical Properties
- Disodium phosphate is anhydrous or contains two molecules of water of hydration
- 7.7 Uses
- Sodium Phosphate, Dibasic is used as a laboratory reagent and a buffer in chemical analysis. Other uses are in manufacturing ceramics, detergents, and enamels; as a mordant in dyeing; for fireproofing paper and wood; for weighting and printing silk; in the treatment of boiler water; as a sequestrant in food; as a dietary supplement; in soldering enamels; and in fertilizers. It is used therapeutically as a cathartic.
- 7.8 Uses
- It is used in pH buffer solutions.
- 7.9 Uses
- Sodium Phosphate Dibasic is used as an in conjunction with trisodium phosphate in foods and water treatment. In foods, it is used to adjust pH. In water treatment, It retards calcium scale formation. It is also found in some detergents and cleaning agents. Sodium Phosphate Dibasic is used as a saline laxative to treat constipation or to clean the bowel before a colonoscopy.
- 7.10 Preparation
- Dibasic sodium phosphate is prepared by treating phosphoric acid with a slight excess of sodium carbonate. The solution is boiled to expel carbon dioxide. Upon cooling dodecahydrate crystallizes out. Heating dodecahydrate at 100°C forms the anhydrous salt.
H3PO4 + Na2CO3 → Na2HPO4 + CO2 + H2O
Dibasic sodium phosphate also is prepared by reacting dibasic calcium phosphate with sodium carbonate. The product calcium carbonate precipitates leaving dibasic sodium salt in the solution. The solution on cooling yields crystals of hydrated product.
CaHPO4 + Na2CO3 → CaCO3 + Na2HPO4
- 7.11 General Description
-
Sodium phosphate dibasic in combination with sodium phosphate monobasic is used in the preparation of oral sodium phosphate solution (OSPS), which is a purgative used for bowel cleansing before colonoscopy.
8. Computational chemical data
- Molecular Weight: 141.958841g/mol
- Molecular Formula: HNa2O4P
- Compound Is Canonicalized: True
- XLogP3-AA: null
- Exact Mass: 141.94078407
- Monoisotopic Mass: 141.94078407
- Complexity: 46.5
- Rotatable Bond Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 4
- Topological Polar Surface Area: 83.4
- Heavy Atom Count: 7
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count: 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Isotope Atom Count: 0
- Covalently-Bonded Unit Count: 3
- CACTVS Substructure Key Fingerprint: AAADcQAAODIAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACCAAAAAAAAAAAAAAABAAQAAAAIAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA==
9. Recommended Suppliers
-
- Products:API,fine chemical&its intermediates,biological chemistry
- Tel:0086-27-59207850
- Email:info@fortunachem.com
-
- Products:chemicals, pharmaceutical intermediates,
- Tel:00-86-8615603117060
- Email:sales01@cn-js.cn
-
- Products:xylazine hcl,phenacetin,4-Methylpropiophenone,(2-Bromoethyl)benzene,4-Methoxybenzoyl chloride
- Tel:86-311-19933070948
- Email:claire@hbyingong.com
-
- Products:We are engaged in the development, marketing and sales of apis, intermediates, natural products (extracts), fine chemicals, food additives, agricultural chemicals and other products.
- Tel:0086-0319-19133539026
- Email:ZHANGZHANG@chengcaibio.com
-
- Products:Pharmaceutical intermediates
- Tel:173-31933971-17331933971
- Email:deasea125996@gmail.com
10. Realated Product Infomation
skype
-113YR
