Sodium salicylate 54-21-7 wiki

1. Names and Identifiers

: 1.1 Name; Sodium salicylate; 1.2 Synonyms; alysine ardall aroall clin diuretin EINECS 200-198-0 kerosal magsalyl MFCD00002440 nadisal NASAL salicylic acid monosodium salt salicylic acid sodium salt salisod Sdium salicylate sodium 2-hydroxybenzoate Sodium Salicylate 2-Hydroxybenzoic acid monosodium salt Sodium o-hydroxybenzoate Sodium salicylate BP98 SODIUM SALICYLATE R. G., REAG. PH. EUR. SODIUM SALICYLATE, PH EUR SodiumSalicylatePurified; View all

1.3 CAS No.: 54-21-7

1.4 CID: 16760658

1.5 EINECS(EC#): 200-198-0

1.6 Molecular Formula: C7H5NaO3 (isomer)

1.7 Inchi: InChI=1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1

1.8 InChIkey: ABBQHOQBGMUPJH-UHFFFAOYSA-M

1.9 Canonical Smiles: C1=CC=C(C(=C1)C(=O)[O-])O.[Na+]

1.10 Isomers Smiles: C1=CC=C(C(=C1)C(=O)[O-])O.[Na+]

2. Properties

2.1 Density: 0.32 g/cm3 (20℃)

2.1 Melting point: 200℃

2.1 Boiling point: 336.3°Cat760mmHg

2.1 Refractive index: 1.435

2.1 Flash Point: 144.5°C

2.1 Precise Quality: 160.01400

2.1 PSA: 60.36000

2.1 logP: -0.24430

2.1 Solubility: 1000g/l

2.2 Appearance: DryPowder; Liquid

2.3 Storage: Light Sensitive. Ambient temperatures.

2.4 Chemical Properties: Sodium salicylate, HOC6H4COONa, is a shiny, white powder with sweetish taste and mild aromatic aroma that is soluble in water,glycerol, and alcohol.Used in medicine and as a preservative.

2.5 Color/Form: White

2.6 PH: 6.5 (100g/l, H2O, 20℃)

2.7 Water Solubility: H2O: 1000 g/L (20 oC)

2.8 Stability: Stable. Incompatible with mineral acids, metallic salts, iodine. May be light-sensitive.

2.9 StorageTemp: Store at +15°C to +25°C.

3. Use and Manufacturing

3.1 Definition: A salt orester of salicylic acid.

3.2 General Description: Sodium salicylate may be prepared by the reaction, in aqueoussolution, by adding equal molar ratio of salicylic acidand sodium bicarbonate; evaporating to dryness yields thewhite salt. In solution, particularly in the presence of sodiumbicarbonate, the salt will darken on standing. This is the saltof choice for salicylate medication and usually is administeredwith sodium bicarbonate to lessen gastric distress, or itis administered in enteric coated tablets. However, the useof sodium bicarbonate is ill advised, because it decreases theplasma levels of salicylate and increases the excretion offree salicylate in the urine.Sodium salicylate, even though not as potent as aspirinfor pain relief, also has less GI irritation and is useful for patientswho are hypersensitive to aspirin.

3.3 Usage: keratolytic

4. Safety and Handling

4.1 Symbol: GHS07

4.1 Hazard Codes: Xn

4.1 Signal Word: Warning

4.1 Risk Statements: R22

4.1 Safety Statements: 26-36

4.1 Hazard Declaration: H302-H319

4.1 RIDADR: 25kgs

4.1 Safety Profile: Experimental poison by subcutaneous route. Moderately toxic to humans by ingestion. Moderately toxic experimentally by ingestion, intraperitoneal, and intravenous routes. An experimental teratogen. Human systemic effects by multiple and unspecified routes: toxic psychosis, excitement, respiratory stimulation, nausea or vomiting, and sweating. Experimental reproductive effects. Mutation data reported. A powerful irritant which affects the central nervous system. Incompatible with ferric salts, mineral acids, iodme, lead acetate, silver nitrate, sodium phosphate powder. When heated to decomposition it emits toxic fumes of Na2O. Sodium salicylate Preparation Products And Raw materials Raw materials

4.2 Caution Statement: P301 + P312 + P330-P305 + P351 + P338

4.2 WGK Germany: 1

4.2 RTECS: VO5075000

4.2 Report

The Sodium salicylate, with the?CAS registry number 54-21-7, is a kind of white powder. This is easily soluble in water(1：0.8，25℃) and glycerol while insoluble in ether, chloroform and? benzene. Being stable chemically while incompatible with mineral acids and metallic salts, this chemical is light-sensitive.

The physical properties of this chemical are as follows: (1)ACD/LogP: 2.06; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.93; (4)ACD/LogD (pH 7.4): -1.09; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 3; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 46.53; (13)Flash Point: 144.5 °C; (14)Enthalpy of Vaporization: 61.16 kJ/mol; (15)Boiling Point: 336.3 °C at 760 mmHg; (16)Vapour Pressure: 4.45E-05 mmHg at 25°C; (17)Exact Mass: 160.013639; (18)MonoIsotopic Mass: 160.013639; (19)Topological Polar Surface Area: 60.4; (20)Heavy Atom Count: 11; (21)Complexity: 138.

The production method of this chemical: Add salicylic acid and sodium bicarbonate into the distilled water with the temperature of 60℃, and then add EDTA and sodium hydrosulfite with defined amount; Next heat it to 85℃ and react for about half an hour; Lastly filter the qualified reaction liquid into the fluidized bed and then dry to 85℃ to get this product.

As to its usage, it is widely applied in many ways. It could be used in organic synthetic materials, antiseptic, the reagent testing the gastric acid in the free agents; It could also be used as the drug with the function of being antifebrile and anti-rheumatic. In addition, it is also a potential replacement for aspirin for people sensitive to it.

When you are dealing with this chemical, you should be much more cautious. For one thing, it is irritant to eyes, respiratory system and skin, which may also cause inflammation to the skin or other mucous membranes. For another thing, it is harmful which may cause damage to health and it may have risk of serious damage to eyes. Therefore, you should wear suitable protective clothing. If in case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

In addition, you could convert the following datas into the molecular structure:
(1)Canonical SMILES: C1=CC=C(C(=C1)C(=O)[O-])O.[Na+]
(2)InChI: InChI=1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1
(3)InChIKey: ABBQHOQBGMUPJH-UHFFFAOYSA-M?

Below are the toxicity information of this chemical:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	multiple routes	2970mg/kg/13D (2970mg/kg)	BEHAVIORAL: EXCITEMENT GASTROINTESTINAL: NAUSEA OR VOMITING	American Journal of Diseases of Children. Vol. 69, Pg. 37, 1945.
dog	LD50	intravenous	562mg/kg (562mg/kg)	BEHAVIORAL: ANALGESIA	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 571, 1964. ?
dog	LDLo	intraperitoneal	990mg/kg (990mg/kg)	?	"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1392, 1935.
dog	LDLo	oral	450mg/kg (450mg/kg)	?	"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1392, 1935.
dog	LDLo	subcutaneous	200mg/kg (200mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Revue Medicale de la Suisse Romande. Vol. 15, Pg. 561, 1895.
frog	LDLo	subcutaneous	250mg/kg (250mg/kg)	?	"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1392, 1935.
guinea pig	LDLo	intraperitoneal	900mg/kg (900mg/kg)	?	"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1392, 1935.
guinea pig	LDLo	subcutaneous	800mg/kg (800mg/kg)	CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Revue Medicale de la Suisse Romande. Vol. 15, Pg. 561, 1895.
human	LDLo	oral	700mg/kg (700mg/kg)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	New England Journal of Medicine. Vol. 232, Pg. 617, 1945.
mouse	LD50	intramuscular	760mg/kg (760mg/kg)	?	Acta Paediatrica Scandinavica. Vol. 59, Pg. 517, 1970. ?
mouse	LD50	intraperitoneal	500mg/kg (500mg/kg)	?	Strahlentherapie. Vol. 127, Pg. 245, 1965. ?
mouse	LD50	intravenous	500mg/kg (500mg/kg)	?	British Patent Document. Vol. #1009195,
mouse	LD50	oral	540mg/kg (540mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 572, 1955. ?
mouse	LD50	subcutaneous	550mg/kg (550mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 25, 1958. ?
rabbit	LD50	intravenous	415mg/kg (415mg/kg)	?	Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 791, 1979.
rabbit	LD50	oral	1700mg/kg (1700mg/kg)	?	Journal of Pharmacology and Experimental Therapeutics. Vol. 89, Pg. 205, 1947.
rat	LD50	intraperitoneal	542mg/kg (542mg/kg)	?	Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 791, 1979.
rat	LD50	oral	930mg/kg (930mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. Vol. 36(1-4), Pg. 10, 1989.
women	TDLo	unreported	1400mg/kg (1400mg/kg)	BEHAVIORAL: TOXIC PSYCHOSIS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION SKIN AND APPENDAGES (SKIN): SWEATING: OTHER	JAMA, Journal of the American Medical Association. Vol. 126, Pg. 806, 1944.

View all

4.3 Sensitive: Light Sensitive

4.4 Specification

The Sodium salicylate, with the?CAS registry number 54-21-7, is a kind of white powder. This is easily soluble in water(1：0.8，25℃) and glycerol while insoluble in ether, chloroform and? benzene. Being stable chemically while incompatible with mineral acids and metallic salts, this chemical is light-sensitive.

The physical properties of this chemical are as follows: (1)ACD/LogP: 2.06; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.93; (4)ACD/LogD (pH 7.4): -1.09; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 3; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 46.53; (13)Flash Point: 144.5 °C; (14)Enthalpy of Vaporization: 61.16 kJ/mol; (15)Boiling Point: 336.3 °C at 760 mmHg; (16)Vapour Pressure: 4.45E-05 mmHg at 25°C; (17)Exact Mass: 160.013639; (18)MonoIsotopic Mass: 160.013639; (19)Topological Polar Surface Area: 60.4; (20)Heavy Atom Count: 11; (21)Complexity: 138.

The production method of this chemical: Add salicylic acid and sodium bicarbonate into the distilled water with the temperature of 60℃, and then add EDTA and sodium hydrosulfite with defined amount; Next heat it to 85℃ and react for about half an hour; Lastly filter the qualified reaction liquid into the fluidized bed and then dry to 85℃ to get this product.

As to its usage, it is widely applied in many ways. It could be used in organic synthetic materials, antiseptic, the reagent testing the gastric acid in the free agents; It could also be used as the drug with the function of being antifebrile and anti-rheumatic. In addition, it is also a potential replacement for aspirin for people sensitive to it.

When you are dealing with this chemical, you should be much more cautious. For one thing, it is irritant to eyes, respiratory system and skin, which may also cause inflammation to the skin or other mucous membranes. For another thing, it is harmful which may cause damage to health and it may have risk of serious damage to eyes. Therefore, you should wear suitable protective clothing. If in case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

In addition, you could convert the following datas into the molecular structure:
(1)Canonical SMILES: C1=CC=C(C(=C1)C(=O)[O-])O.[Na+]
(2)InChI: InChI=1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1
(3)InChIKey: ABBQHOQBGMUPJH-UHFFFAOYSA-M?

Below are the toxicity information of this chemical:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	multiple routes	2970mg/kg/13D (2970mg/kg)	BEHAVIORAL: EXCITEMENT GASTROINTESTINAL: NAUSEA OR VOMITING	American Journal of Diseases of Children. Vol. 69, Pg. 37, 1945.
dog	LD50	intravenous	562mg/kg (562mg/kg)	BEHAVIORAL: ANALGESIA	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 571, 1964. ?
dog	LDLo	intraperitoneal	990mg/kg (990mg/kg)	?	"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1392, 1935.
dog	LDLo	oral	450mg/kg (450mg/kg)	?	"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1392, 1935.
dog	LDLo	subcutaneous	200mg/kg (200mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Revue Medicale de la Suisse Romande. Vol. 15, Pg. 561, 1895.
frog	LDLo	subcutaneous	250mg/kg (250mg/kg)	?	"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1392, 1935.
guinea pig	LDLo	intraperitoneal	900mg/kg (900mg/kg)	?	"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1392, 1935.
guinea pig	LDLo	subcutaneous	800mg/kg (800mg/kg)	CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Revue Medicale de la Suisse Romande. Vol. 15, Pg. 561, 1895.
human	LDLo	oral	700mg/kg (700mg/kg)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	New England Journal of Medicine. Vol. 232, Pg. 617, 1945.
mouse	LD50	intramuscular	760mg/kg (760mg/kg)	?	Acta Paediatrica Scandinavica. Vol. 59, Pg. 517, 1970. ?
mouse	LD50	intraperitoneal	500mg/kg (500mg/kg)	?	Strahlentherapie. Vol. 127, Pg. 245, 1965. ?
mouse	LD50	intravenous	500mg/kg (500mg/kg)	?	British Patent Document. Vol. #1009195,
mouse	LD50	oral	540mg/kg (540mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 572, 1955. ?
mouse	LD50	subcutaneous	550mg/kg (550mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 25, 1958. ?
rabbit	LD50	intravenous	415mg/kg (415mg/kg)	?	Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 791, 1979.
rabbit	LD50	oral	1700mg/kg (1700mg/kg)	?	Journal of Pharmacology and Experimental Therapeutics. Vol. 89, Pg. 205, 1947.
rat	LD50	intraperitoneal	542mg/kg (542mg/kg)	?	Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 791, 1979.
rat	LD50	oral	930mg/kg (930mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. Vol. 36(1-4), Pg. 10, 1989.
women	TDLo	unreported	1400mg/kg (1400mg/kg)	BEHAVIORAL: TOXIC PSYCHOSIS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION SKIN AND APPENDAGES (SKIN): SWEATING: OTHER	JAMA, Journal of the American Medical Association. Vol. 126, Pg. 806, 1944.

View all

4.5 Toxicity: LD50 i.p. in rats: 780 mg/kg (Goldenthal)

5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 4

Eye irritation, Category 2

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed H319 Causes serious eye irritation
Precautionary statement(s)
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection.
Response	P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/\u2026if you feel unwell. P330 Rinse mouth. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313 If eye irritation persists: Get medical advice/attention.
Storage	none
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

View all

6. NMR Spectrum

13C NMR : Predict

1H NMR : Predict

Predict 1H proton NMR

IR : KBr disc

IR : nujol mull

Raman : 4880 A,200 M,powder

7. Synthesis Route

54-21-7Total: 9 Synthesis Route

532-32-1 928 Suppliers

7720-19-6 15 Suppliers

54-21-7 339 Suppliers

114-63-6 68 Suppliers

Literatures:
Chemical and Pharmaceutical Bulletin, , vol. 41, # 10 p. 1842 - 1845
Yield: null

102-09-0 129 Suppliers

124-38-9 151 Suppliers

139-02-6 24 Suppliers

54-21-7 339 Suppliers

108-95-2 255 Suppliers

Literatures:
Journal fuer Praktische Chemie (Leipzig), , vol. <2> 27, p. 43 Chemische Berichte, , vol. 45, p. 59
Yield: null

85531-25-5

54-21-7 339 Suppliers

119-36-8 451 Suppliers

Literatures:
Chemische Berichte, , vol. 52, p. 1891
Yield: null

View all

8. Other Information

8.0 Merck: 14,8332

8.1 BRN: 3732792

8.2 Description: Sodium salicylate is a sodium salt of salicylic acid. It can be prepared from sodium phenolate and carbon dioxide under higher temperature and pressure. Historically, it has been synthesized from methyl salicylate (found in wintergreen plants or the bark of sweet birch tree) by reacting it with an excess of sodium hydroxide and heating it under reflux.

8.3 Chemical Properties: Sodium salicylate, HOC6H4COONa, is a shiny, white powder with sweetish taste and mild aromatic aroma that is soluble in water,glycerol, and alcohol.Used in medicine and as a preservative.

8.4 Chemical Properties: Sodium salicylate is of the salicylate family and this compound is known to trigger Reye's Syndrome in children and adults, usually following a viral infection such as influenza or chicken pox. Products containing such salicylates should not be given to children under the age of 19.

8.5 Uses: keratolytic

8.6 Uses: In manufacture of aspirin, methyl salicylate, and other salicylates. Coupling agent for azo dyes. Has been used as food preservative.

8.7 Uses: It is used in medicine as an analgesic and antipyretic. Sodium salicylate also acts as non - steroidal anti - inflammatory drug (NSAID), and induces apoptosis in cancer cells and also necrosis. It is also a potential replacement for aspirin for people sensitive to it. It may also be used as a phosphor for the detection of vacuum ultra violet radiation and electrons.

8.8 Definition: A salt or ester of salicylic acid.

8.9 Brand name: Alysine (Marion Merrell Dow).

8.10 General Description: Sodium salicylate may be prepared by the reaction, in aqueoussolution, by adding equal molar ratio of salicylic acidand sodium bicarbonate; evaporating to dryness yields thewhite salt. In solution, particularly in the presence of sodiumbicarbonate, the salt will darken on standing. This is the saltof choice for salicylate medication and usually is administeredwith sodium bicarbonate to lessen gastric distress, or itis administered in enteric coated tablets. However, the useof sodium bicarbonate is ill advised, because it decreases theplasma levels of salicylate and increases the excretion offree salicylate in the urine.
Sodium salicylate, even though not as potent as aspirinfor pain relief, also has less GI irritation and is useful for patientswho are hypersensitive to aspirin.

8.11 Biochem/physiol Actions: Cell permeable: yes

8.12 Safety Profile: Experimental poison by subcutaneous route. Moderately toxic to humans by ingestion. Moderately toxic experimentally by ingestion, intraperitoneal, and intravenous routes. An experimental teratogen. Human systemic effects by multiple and unspecified routes: toxic psychosis, excitement, respiratory stimulation, nausea or vomiting, and sweating. Experimental reproductive effects. Mutation data reported. A powerful irritant which affects the central nervous system. Incompatible with ferric salts, mineral acids, iodme, lead acetate, silver nitrate, sodium phosphate powder. When heated to decomposition it emits toxic fumes of Na2O.

8.13 Usage: Sodium salicylate is used as an analgesic and antipyretic. It also acts as a non-steroidal anti-inflammatory drug (NSAID). Further, it is used as a phosphor for the detection of vacuum ultraviolet radiation and electrons. It serves as a neurofibromatosis kappa B inhibitor and reducer of oxidative stress. It finds applications as a drug with the function of being antifebrile and anti-rheumatic.

8.14 Collision Cross Section: 122.9 ?2 [M-H]-

8.15 Mesh: Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)|Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes. (See all compounds classified as Cyclooxygenase Inhibitors.)

8.16 Mesh Entry Terms: Salicylate, Sodium

8.17 Production: 500,000 - 1,000,000 lb

8.18 Manufacturing Info: Agriculture, forestry, fishing and hunting|Benzoic acid, 2-hydroxy-, sodium salt (1:1): ACTIVE

8.19 Use Classification: Cosmetics -> Preservative

9. Computational chemical data

Molecular Weight: 160.10257g/mol
Molecular Formula: C₇H₅NaO₃
Compound Is Canonicalized: True
XLogP3-AA: null
Exact Mass: 160.01363830
Monoisotopic Mass: 160.01363830
Complexity: 138
Rotatable Bond Count: 1
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 3
Topological Polar Surface Area: 60.4
Heavy Atom Count: 11
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Isotope Atom Count: 0
Covalently-Bonded Unit Count: 2
CACTVS Substructure Key Fingerprint: AAADcYBgMCAAAAAAAAAAAAAAAAAAAAAAAAAwAAAAAAAAAAABAAAAGgAACAAADASAmAAwDoAAAgCIAiDSCAACAAAkIAAIiAEGCMgIJzaCFRKAcUAl4BEImYeIyCCOAAAAAAAIAAAAAAAAABAAAAAAAAAAAA==

10. Question & Answer

What is the mechanism of action of Sodium salicylate and its applications? Mar 14 2023
Sodium salicylate is a commonly used antipyretic and non-steroidal anti-inflammatory analgesic. Its mechanism of action is similar to aspirin, as it inhibits cyclooxygenase and reduces prostaglandin s..
Can pregnant women use Sodium salicylate tablets? Jun 13 2022
During pregnancy, women often worry about the occurrence of diseases because many medications are not recommended for use during pregnancy, making it difficult to ensure their health. However, not all..
What Makes Sodium Salicylate a Unique Nonprescription Salicylate? Jan 20 2022
Sodium salicylate, a metabolite of acetylsalicylic acid (sc-217570), acts as an inhibitor of NF κ B and reduces oxidative stress. This compound has demonstrated its ability to protect against glutama..
Would sodium salicylate dissolve in HCl? Jul 16 2021
I've been searching around the web and the consensus seems to be sodium salicylate dissolves poorly in HCl because it would form salicylic acid. However, I don't understand why forming salicylic acid..

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