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Home> Encyclopedia >Pharmaceutical Intermediates>Animal Pharmaceuticals>Organic Intermediate
Tetramisole hydrochloride structure
Tetramisole hydrochloride structure

Tetramisole hydrochloride

Iupac Name:6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole;hydrochloride
CAS No.: 5086-74-8
Molecular Weight:204.29138
Modify Date.: 2022-11-29 06:54
Introduction: Biological response modifier with anthelmintic activity. Anthelmintic (nematodes); immunomodulator. View more+
1. Names and Identifiers
1.1 Name
Tetramisole hydrochloride
1.2 Synonyms

)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole Monohydrochloride)-Tetramisole hydrochloride (+-)-2,3,5,6-tetrahydro-6-phenylimidazo(2,1-b)thiazolemonohydrochloride (+-)-anthelvet 1-b)thiazole,2,3,5,6-tetrahydro-6-phenyl-,monohydrochloride,(+-)-imidazo( 6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole hydrochloride (1:1) 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride anthelvet bayer9051 citarin Concurat dl-6-phenyl-2,3,5,6-tetrahydroimidazole(2,1-b)thiazole-hydrochloride DL-6-Phenyl-2,3,5,6-tetrahydroimidazole[2,1-b]thiazole Hydrochloride DL-Tetramisole hydrochloride dl-tetramisolehydrochloride EINECS 225-799-5 Imidazo[2,1-b]thiazole, 2,3,5,6-tetrahydro-6-phenyl-, hydrochloride (1:1) Imidazo[2,1-b]thiazole, 2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride l-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride levamisole HCl levamisole hydrochloride mcn-jr 8299 McN-JR 8299-11 MFCD00005536 nilverm nilverom orovermol r8299 ripercol ripereol Tetramisole (hydrochloride) Tetramisole HCl

1.3 CAS No.
5086-74-8
1.4 CID
68628
1.5 EINECS(EC#)
225-799-5
1.6 Molecular Formula
C11H13ClN2S (isomer)
1.7 Inchi
InChI=1S/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H
1.8 InChkey
LAZPBGZRMVRFKY-UHFFFAOYSA-N
1.9 Canonical Smiles
C1CSC2=NC(CN21)C3=CC=CC=C3.Cl
1.10 Isomers Smiles
C1CSC2=NC(CN21)C3=CC=CC=C3.Cl
2. Properties
2.1 Melting point
266-267℃
2.1 Boiling point
344.4 °C at 760 mmHg
2.1 Flash Point
162.1 °C
2.1 Precise Quality
240.04900
2.1 PSA
40.90000
2.1 logP
2.32160
2.1 Solubility
200 g/L (20 ºC)
2.2 Appearance
white to pale cream crystalline powder
2.3 Chemical Properties
white to pale cream crystalline powder
2.4 Water Solubility
H2O: 200 g/L (20 oC)
2.5 Stability
Stable under normal temperatures and pressures.
2.6 StorageTemp
Keep containers tightly closed. Store in a cool, dry area away from incompatible substances.
3. Use and Manufacturing
3.1 Usage
Biological response modifier with anthelmintic activity. Anthelmintic (nematodes); immunomodulator.
4. Safety and Handling
4.1 Symbol
GHS07;
4.1 Hazard Codes
Xi
4.1 Signal Word
Warning
4.1 Risk Statements
R22;R36/37/38
4.1 Safety Statements
S26;S36
4.1 Hazard Declaration
H302; H315; H319; H335
4.1 RIDADR
NONH for all modes of transport
4.1 Caution Statement
P261-P305 + P351 + P338
4.1 WGK Germany
3
4.1 RTECS
NJ5950000
4.1 Safety

Hazard Codes: Xn,Xi
Risk Statements: 36/37/38-20/21/22
20/21/22: Tetramisole hydrochloride (5086-74-8) is harmful by inhalation, in contact with skin and if swallowed
36/37/38:  Irritating to eyes, respiratory system and skin
Safety Statements:  26-36
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:  Wear suitable protective clothing
WGK Germany:  3
RTECS:  NJ5950000

4.2 Specification

 Tetramisole hydrochloride , its cas register number is 5086-74-8. It also can be called Levamisole hydrochloride ; DL-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride ; and Nilverm . It is stable under normal temperatures and pressures. It is not compatible with strong oxidizing agents, and you must not take it with incompatible materials. And also prevent it to broken down into hazardous decomposition products: hydrogen chloride, nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide. Its hazardous polymerization will not occur. In addition, it should be stored in a cool, dry place.
 It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product : Wash mouth out with water, and get medical aid immediately. In addition, Tetramisole hydrochloride  (CAS NO.5086-74-8) could be stable under normal temperatures and pressures. It is not compatible with strong oxidizing agents, and you must not take it with incompatible materials. And also prevent it to broken down into hazardous decomposition products: hydrogen chloride, nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide.

4.3 Toxicity
LD50 in mice, rats (mg/kg): 22, 24 i.v.; 84, 130 s.c.; 210, 480 orally (Thienpoint)
5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 4

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity \u2013 single exposure, Category 3

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Warning

Hazard statement(s)

H302 Harmful if swallowed

H315 Causes skin irritation

H319 Causes serious eye irritation

H335 May cause respiratory irritation

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

Response

P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/\u2026if you feel unwell.

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P321 Specific treatment (see ... on this label).

P332+P313 If skin irritation occurs: Get medical advice/attention.

P362+P364 Take off contaminated clothing and wash it before reuse.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P337+P313 If eye irritation persists: Get medical advice/attention.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P312 Call a POISON CENTER/doctor/\u2026if you feel unwell.

Storage

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P405 Store locked up.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

8. Precursor and Product
9. Other Information
9.0 Mesh Entry Terms
Nilverm
9.1 Merck
13,5480
9.2 BRN
4358989
9.3 Chemical Properties
white to pale cream crystalline powder
9.4 Uses
Biological response modifier with anthelmintic activity. Anthelmintic (nematodes); immunomodulator.
9.5 Uses
Structure-activity relationship for tetramisole derivatives as alkaline phosphatase inhibitors.
10. Computational chemical data
  • Molecular Weight: 204.29138g/mol
  • Molecular Formula: C11H13ClN2S
  • Compound Is Canonicalized: True
  • XLogP3-AA: null
  • Exact Mass: 240.0487973
  • Monoisotopic Mass: 240.0487973
  • Complexity: 246
  • Rotatable Bond Count: 1
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 2
  • Topological Polar Surface Area: 40.9
  • Heavy Atom Count: 15
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count: 1
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Isotope Atom Count: 0
  • Covalently-Bonded Unit Count: 2
  • CACTVS Substructure Key Fingerprint: AAADccBzAABEAAAAAAAAAAAAAAAAAWIAAAAwAAAAAAAQAAABAAAAHAQAAAAADCjFWASxAIMAAAigAiBCJACCEAFgABAJiAAIBIgIYCKAmRGUIABggACIiAcQgIAOAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA==
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