Trenbolone

Iupac Name：(8S,13S,14S,17S)-17-hydroxy-13-methyl-2,6,7,8,14,15,16,
17-octahydro-1H-cyclopenta[a]phenanthren-3-one

Molecular Weight：270.36608

Modify Date.: 2022-11-22 16:54

Introduction: Trenbolone is a kind of anabolic androgenic steroid belonging to the 19-nortestosterone group. It can be supplied to veterinary medicine of livestock in order the boost muscle growth and appetite. It can also enhance the performance of athletes. It has several physiological effects: (1) enhance protein synthesis and nitrogen retention in the muscle tissues, which boost enhanced anabolism; (2) greatly promote insulin-like growth factor-1 (IGF-1) which is a highly effective anabolic hormone; (3) Greatly increase the red blood cell count to boost blood oxygenation which leads to improved muscular endurance; (4) Inhibit glucocorticoid hormones which inhibit the growth of muscle tissue and promote fat. (5) Improve food efficiency. View more+

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1. Names and Identifiers

1.1 Name: Trenbolone
1.2 Synonyms: (13S,17S)-17-Hydroxy-13-methyl-1,2,6,7,8,13,14,15,16,17-decahydro-cyclopenta[a]phenanthren-3-one (17Β)-17-Hydroxyestra-4,9,11-trien-3-one (8S,13S,14S,17S)-17-hydroxy-13-methyl-2,6,7,8,14,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-3-one (8ξ,14ξ,17β)-17-Hydroxyestra-4,9,11-trien-3-one 17BETA-HYDROXYESTRA-4,9,11-TRIEN-3-ONE 17b-Hydroxy-19-norandrosta-4,9,11-trien-3-one 17-HYDROXYESTRA-4,9,11-TRIEN-3-ONE 17Β-hydroxy-estra-4,9,11-trien-3-one 17-Β-Trenbolone 19-Norandrosta-4,9,11-trien-17b-ol-3-one 4,9,11-ESTRATRIEN-17-BETA-OL-3-ONE 4,9,11-Estratrien-17b-ol-3-one BETA-TRENBOLONE Estra-4,9,11-trien-3-one, 17-hydroxy-, (17Β)- Estra-4,9,11-trien-3-one, 17-hydroxy-, (17-Β)- (9CI) Estra-4,9,11-trien-3-one, 17-hydroxy-, (8ξ,14ξ,17β)- MFCD00214395 TRENBOLONE:17-HYDROXYESTRA-4,9,11-TRIEN-3-ONE TrenboloneEnanthateBase Trenbolonemissing Trienolone

1.3 CAS No.: 10161-33-8

1.4 CID: 25015

1.5 EINECS(EC#): 600-229-1

1.6 Molecular Formula: C18H22O2 (isomer)

1.7 Inchi: InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h8-10,15-17,20H,2-7H2,1H3/t15-,16+,17+,18+/m1/s1

1.8 InChkey: MEHHPFQKXOUFFV-OWSLCNJRSA-N

1.9 Canonical Smiles: CC12C=CC3=C4CCC(=O)C=C4CCC3C1CCC2O

1.10 Isomers Smiles: C[C@]12C=CC3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O

2. Properties

2.1 Density: 1.19

2.1 Melting point: 170℃

2.1 Boiling point: 490.8 °C at 760 mmHg

2.1 Refractive index: 1.605

2.1 Flash Point: 208.2 °C

2.1 Precise Quality: 270.16200

2.1 PSA: 37.30000

2.1 logP: 3.32930

2.1 Solubility: 43 mg/L (25 C)

2.2 Appearance: DEA Schedule III item.

2.3 Chemical Properties: Yellow Solid

2.4 Color/Form: Powder

2.5 pKa: 14.73±0.40(Predicted)

2.6 Water Solubility: 43 mg/L (25 C)

2.7 Stability: Stable at normal temperatures and pressures.

2.8 StorageTemp: 2-8°C

3. Use and Manufacturing

3.1 Usage: Controlled substance (anabolic steroid).

4. Safety and Handling

4.1 Symbol: GHS08

4.1 Hazard Codes: T

4.1 Signal Word: Danger

4.1 Risk Statements: R60

4.1 Safety Statements: 53-22-36/37/39-45

4.1 Hazard Declaration: H360

4.1 RIDADR: UN 1648 3 / PGII

4.1 Safety Profile: When heated todecomposition it emits acrid smoke andirritating fumes.

4.2 Caution Statement: P201-P308 + P313

4.2 WGK Germany: 3

4.2 RTECS: KG7752000

4.2 Safety: Hazard Codes:?T
Risk Statements: 60?
R60:May impair fertility.
Safety Statements: 53-22-36/37/39-45?
S53:Avoid exposure - obtain special instructions before use.?
S22:Do not breathe dust.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
RTECS: KG7752000

4.3 Specification: ?Trenbolone , its cas register number 10161-33-8. It also can be called?17-beta-Hydroxyestra-4,9,11-trien-3-one ; 17-beta-Trenbolone ; 17beta-Trenbolone ; Trembolona ; Trembolona [INN-Spanish] ; Trenbolonum ; Trenbolonum [INN-Latin] ; and Trienbolone .?Its classification code are?Anabolic Agents; Hormone; Hormones; Hormones, Hormone Substitutes, and Hormone Antagonists and?Mutation data.

5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Reproductive toxicity, Category 1B

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Danger
Hazard statement(s)	H360 May damage fertility or the unborn child
Precautionary statement(s)
Prevention	P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P280 Wear protective gloves/protective clothing/eye protection/face protection.
Response	P308+P313 IF exposed or concerned: Get medical advice/ attention.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

View all

6. Synthesis Route

10161-33-8Total: 4 Synthesis Route

5210-14-0

10161-33-8 369 Suppliers

Literatures:
Chemistry of Natural Compounds, , vol. 24, # 2 p. 263 - 264 Khimiya Prirodnykh Soedinenii, , vol. 24, # 2 p. 306 - 307
Yield: null

5210-13-9

10161-33-8 369 Suppliers

Literatures:
Chemistry of Natural Compounds, , vol. 24, # 2 p. 263 - 264 Khimiya Prirodnykh Soedinenii, , vol. 24, # 2 p. 306 - 307
Yield: null

10516-35-5

10161-33-8 369 Suppliers

Literatures:
Chemistry of Natural Compounds, , vol. 24, # 2 p. 263 - 264 Khimiya Prirodnykh Soedinenii, , vol. 24, # 2 p. 306 - 307
Yield: null

View all

7. Precursor and Product

precursor:

117605-69-3

10516-35-5

5210-14-0

5210-13-9

8. Other Information

8.0 Originator: Parabolan,Negma,France,1980

8.1 Manufacturing Process: Stage A: Preparation of 17β-Benzoyloxy-Estra-4,9,11-Trien-3-one - 0.400 g of 17β-benzoyloxy-4,5-seco-estra-9,11-diene-3,5-dione is dissolved in 4 cc of toluene under an inert atmosphere. The solution is cooled to 3°C, then 0.48 cc is added of the solution of sodium tert-amylate in anhydrous toluene, diluted by the addition of a further 4.8 cc of anhydrous toluene.
This reaction mixture is kept between 0°C and +5°C for six hours, with agitation and under an inert atmosphere, then 5 cc of a 0.2 N solution of acetic acid in toluene are added. The mixture is extracted with toluene, and the extracts are washed with water and evaporated to dryness. The residue is taken up in ethyl acetate, and then the solution is evaporated to dryness in vacuo, yielding a resin which is dissolved in methylene chloride, and the solution passed through a column of 40 g of magnesium silicate. Elution is carried out first with methylene chloride, then with methylene chloride containing 0.5% of acetone, and 0.361 g is thus recovered of a crude product, which is dissolved in 1.5 cc of isopropyl ether; then hot methanol is added and the mixture left at 0°C for one night.
0.324 g of the desired 17β-benzoyloxy-estra-4,9,11-trien-3-one are thus finally obtained, being a yield of 85%, melting point is 154°C.
Stage B: Preparation of 17β-Hydroxy-Estra-4,9,11-Trien-3-one - 3 g of 17β- benzoyloxy-estra-4,9,11-trien-3-one, obtained as described in Stage A are dissolved in 15 cc of methanol. 0.03 g of hydroquinone is added, and the mixture is taken to reflux while bubbling in nitrogen. Then 1.2 cc of 11% methanolic caustic potash is added and reflux is maintained for three hours, after which the reaction product is acidified with 0.36 cc of acetic acid. The methyl benzoate thus formed is eliminated by steam distillation, and 2.140 g of crude product are obtained, which are dissolved in 20 cc of methylene chloride. This solution is passed through 10 parts of magnesium silicate, elution being performed with 250 cc of methylene chloride containing 5% of acetone. After evaporation of the solvent 2.050 g of product is recovered, which is recrystallized from isopropyl ether.
In this way 1.930 g of the desired 17β-hydroxy-estra-4,9,11-trien-3-one is obtained being a yield of 89%, melting point is 186°C. It is converted to the acetate by acetic anhydride.

8.2 Therapeutic Function: Anabolic steroid

8.3 Collision Cross Section: 163.3 ?2 [M+H]+ [CCS Type: TW]

8.4 Mesh: These compounds stimulate anabolism and inhibit catabolism. They stimulate the development of muscle mass, strength, and power. (See all compounds classified as Anabolic Agents.)

8.5 Mesh Entry Terms: 17 beta-acetoxyestra-4,9,11-trien-3-one

8.6 Dea Controlled Substances: Trenbolone|Finaplix-S, Finajet, Parabolan|4000|Schedule III - Substances in the DEA Schedule III have a potential for abuse less than substances in Schedules I or II and abuse may lead to moderate or low physical dependence or high psychological dependence.|No

8.7 Use Classification: Pharmaceuticals

8.8 Description: Trenbolone is a kind of anabolic androgenic steroid belonging to the 19-nortestosterone group. It can be supplied to veterinary medicine of livestock in order the boost muscle growth and appetite. It can also enhance the performance of athletes. It has several physiological effects: (1) enhance protein synthesis and nitrogen retention in the muscle tissues, which boost enhanced anabolism; (2) greatly promote insulin-like growth factor-1 (IGF-1) which is a highly effective anabolic hormone; (3) Greatly increase the red blood cell count to boost blood oxygenation which leads to improved muscular endurance; (4) Inhibit glucocorticoid hormones which inhibit the growth of muscle tissue and promote fat. (5) Improve food efficiency.

8.9 Chemical Properties: Yellow Solid

8.10 Uses: Controlled substance (anabolic steroid).

8.11 Brand name: [Trenbolone is INN and BAN.

8.12 Safety Profile: When heated to decomposition it emits acrid smoke and irritating fumes.

8.13 References: https://en.wikipedia.org/wiki/Trenbolone
https://www.steroid.com/Trenbolone.php
?korjanc, D, M. Brus, and I. Vojtic. "A short review of chain controlling systems in livestock production technology. " Agricultura (2005).

9. Computational chemical data

Molecular Weight: 270.36608g/mol
Molecular Formula: C₁₈H₂₂O₂
Compound Is Canonicalized: True
XLogP3-AA: 1.9
Exact Mass: 270.161979940
Monoisotopic Mass: 270.161979940
Complexity: 566
Rotatable Bond Count: 0
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 2
Topological Polar Surface Area: 37.3
Heavy Atom Count: 20
Defined Atom Stereocenter Count: 4
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Isotope Atom Count: 0
Covalently-Bonded Unit Count: 1
CACTVS Substructure Key Fingerprint: AAADceB4MAAAAAAAAAAAAAAAAAAAAYAAAAAgQIAAAAAAAECAAAAAGgAACAAADxSggAICAAAAAgCIAqBSAAAAAAAgAAAICAEAAEgIEBIAAQAAQAAEwAAIgQOIyPCPgAAAAAAAAAAAAAAAAAAAAIAADAAAAA==

10. Question & Answer

Will trenbolone acetate in the presence of methanol yield trenbolone acetate if distilled water is subsequently added thereafter? [closed] Aug 26 2021
The method will not convert trenbolone acetate to trenbolone, the ester is not cleaved under these conditions. It is however possible to separate the steroid from a mixture with other, water-soluble compounds this way. Unless you are a veterinarian and use trenbolone or its acetate as a growth prom...

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12. Realated Product Infomation

10616-33-8 TRENBOLONE Trenbolone

10161-34-9 Trenbolone acetate

23454-33-3 Trenbolone cyclohexylmethylcarbonate

1629618-98-9 Trenbolone Enanthate

5218-51-9 Trenbolone Acetate Process Impurity 4

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