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Home> Encyclopedia >Antioxidants>Organic Intermediate>Custom Manufacturing
UBIQUINOL structure
UBIQUINOL structure


Iupac Name:2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl]-5,6-dimethoxy-3-methylbenzene-1,4-diol
CAS No.: 992-78-9
Molecular Weight:865.4
Modify Date.: 2022-11-29 06:12
Introduction: Reduced coenzyme Q for improving nervous system cell functions UBIQUINOLSupplier View more+
1. Names and Identifiers
1.1 Name
1.2 Synonyms

1-((2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl)-5,6-dimethoxy-3-methylbenzene-1,4-diol 1,4-Benzenediol, 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaen-1-yl]-5,6-dimethoxy-3-methyl- 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-DecaMethyl -2,6,10,14,18 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-Decamethyl -2,6,10,14,18,22,26,30,34,38-tetracontadecaen-1-yl]-5,6-dimethoxy-3-methyl- 1,4-benzenediol 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-DecaMethyl -2,6,10,14,18 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-Decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaen-1-yl]-5,6-dimethoxy-3-methyl-1,4-benzenediol 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-Decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecenyl]-5,6-dimethoxy-3-methylbenzene-1,4-diol 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-Decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecenyl]-5,6-dimethoxy-3-methylhydroquinone coenzyme Q10-H2 Dihydrocoenzyme Q10 Reduced Coenzyme Q10 Reduced Ubiquinone Q10 Reduced ubiquinone-10 UBIQUINOL (Reduced coenzyme Q10) Ubiquinol 50 ubiquinol Q10 ubiquinol-10

1.3 CAS No.
1.4 CID
1.5 Molecular Formula
C59H92O4 (isomer)
1.6 Inchi
1.7 InChkey
1.8 Canonical Smiles
1.9 Isomers Smiles
2. Properties
2.1 Density
0.951±0.06 g/cm3(Predicted)
2.1 Melting point
48-49 °C
2.1 Boiling point
866.9±65.0 °C(Predicted)
2.1 Refractive index
2.1 Flash Point
478.1±34.3 °C
2.1 Precise Quality
2.1 PSA
2.1 logP
2.1 Appearance
2.2 Chemical Properties
Light Yellow-Orange Solid
2.3 pKa
2.4 Water Solubility
0.2451 mg/L @ 25 °C (est)
2.5 StorageTemp
Amber Vial, -20°C Freezer, Under Inert Atmosphere
3. Use and Manufacturing
3.1 Usage
Reduced coenzyme Q for improving nervous system cell functions UBIQUINOLSupplier
4. Safety and Handling
NONH for all modes of transport
4.1 Specification

 Coenzyme Q10-hydroquinone , its cas register number 992-78-9. It also can be called 1,4-Benzenediol,2-(3,7,11,15,19,23,27,31,35,39-decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaenyl)-5,6-dimethoxy-3-methyl-,(all-E)- ; Coenzyme Q10, dihydro- ; 1,4-Benzenediol,2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaen-1-yl]-5,6-dimethoxy-3-methyl- ; Ubiquinol 50 ; and Kaneka QH .


2.Hazard identification

2.1 Classification of the substance or mixture

no data available

2.2 GHS label elements, including precautionary statements

Pictogram(s) no data available
Signal word

no data available

Hazard statement(s)

no data available

Precautionary statement(s)

no data available


no data available


no data available


no data available

2.3 Other hazards which do not result in classification

no data available

6. Other Information
6.0 体外研究

The lipophilic environment encircles the lipophilic low-molecular-weight antioxidants (α-tocopherol, β-carotene, and Ubiquinol) and prevents them from reacting as skin protectors.
Oxidative stress is defined as a disturbance in the prooxidant-antioxidant balance in favor of the former and has been suggested to be a relevant factor in aging as well as in different pathological conditions, such as heart attack, diabetes, and cancer. Ubiquinol is very sensitive against oxygen radicals and gives ubiquinone as an oxidation product. Therefore, the ratio of ubiquinol to ubiquinone should be a good marker of oxidative stress because of its definition.

6.1 体内研究

The oxidized (UQox) and reduced (Ubiquinol) forms of ubiquinone (UQ) homologues in rat tissues and subcellular fractionsare analyzed. The levels of these homologues are highest in heart with lesser amounts occurring in kidney, liver and other organs. In liver and blood plasma, the UQred homologue amounted to 70-80% of the total UQ (UQox + Ubiquinol = t-UQ). Ubiquinol is less than 30% of t-UQ in other tissues and blood cells. t-UQ is much higher in leukocytes and platelets in blood than in erythrocytes. In erythrocytes, t-UQ is exclusively located in the cell membranes.Ubiquinol is also found in all subcellular fractions isolated from liver and kidney in about the same ratio as Ubiquinol/t-UQ is present in the whole organ. The levels of Ubiquinol per mg protein in subcellular fractions from liver is highest in mitochondria, with lesser amounts present in plasma membranes, lysosomes, Golgi complex, nuclei, microsomes and cytosol. In the mitochondria, the outer membranes are richer in t-UQ than the inner membranes.

6.2 Description
Ubiquinol is a reduced form of coenzyme Q10 (CoQ10; Item No. 11506), which exists in three redox states: fully oxidized (CoQ10/ubiquinone), partially reduced (semiquinone/ubisemiquinone), and fully reduced (ubiquinol). CoQ10 acts as an electron shuttle in the electron transport chain via its reduction to ubiquinol between mitochondrial complexes I and II, also known as NADH dehydrogenase and succinate dehydrogenase, respectively, and mitochondrial complex III, also known as cytochrome bc1 complex. CoQ10 is also reduced to ubiquinol by ferroptosis suppressor protein 1 (FSP1) with NADPH as a cofactor, and ubiquinol traps lipid peroxyl radicals and inhibits lipid peroxidation helping to prevent ferroptosis.
6.3 Chemical Properties
Light Yellow-Orange Solid
6.4 Uses
Reduced coenzyme Q for improving nervous system cell functions.
6.5 Use Classification
Human drugs -> Rare disease (orphan)
7. Computational chemical data
  • Molecular Weight: 865.4g/mol
  • Molecular Formula: C59H92O4
  • Compound Is Canonicalized: True
  • XLogP3-AA: 20.2
  • Exact Mass: 864.69956141
  • Monoisotopic Mass: 864.69956141
  • Complexity: 1600
  • Rotatable Bond Count: 31
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 4
  • Topological Polar Surface Area: 58.9
  • Heavy Atom Count: 63
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count: 0
  • Defined Bond Stereocenter Count: 9
  • Undefined Bond Stereocenter Count: 0
  • Isotope Atom Count: 0
  • Covalently-Bonded Unit Count: 1
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