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Home> Encyclopedia >Pharmaceutical Intermediates>Pharmaceutical>Organic Intermediate
Unii-4bmh7izt98 structure
Unii-4bmh7izt98 structure


Iupac Name:2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate;2-hydroxyethyl(trimethyl)azanium
CAS No.: 856676-23-8
Molecular Weight:421.9182
Modify Date.: 2022-11-27 08:37
Introduction: Choline fenofibrate, a salt formulation of fenofibric acid, is a lipidregulating agent available as delayed release capsules for oral administration. It is indicated in combination with a statin to reduce TG andincrease high-density lipoprotein cholesterol (HDL-C) in patients withmixed dyslipidemia and coronary heart disease (CHD) or a CHD-riskequivalent who are optimal for statin therapy to achieve their lowdensity lipoprotein cholesterol (LDL-C) goal. In addition, cholinefenofibrate is indicated as monotherapy in patients with severehypertriglyceridemia to reduce TG, and in patients with primaryhyperlipidemia or mixed dyslipidemia to reduce elevated LDL-C, totalcholesterol, TG, apolipoprotein B, and to increase HDL-C. Fenofibric acidis also the active metabolite of fenofibrate (Tricor), which has beenpreviously marketed for the treatment of hypercholesterolemia andhypertriglyceridemia. The primary mode of action of fenofibric acidis through the activation of the nuclear transcription factor PPARa,predominantly expressed in tissues that metabolize fatty acids, such asthe liver, kidney, heart, and muscle.On activation by binding of the fibrate, PPARa binds as heterodimers with retinoid X receptor (RXR), which subsequently recognizes and binds to specific PPARa-response elements leading to modulation of expression of the target genes. In particular, the activity of lipoprotein lipase is increased and synthesis of apoprotein C-III is decreased, which together enhance the clearance of circulating TG-rich lipoproteins. The resulting fall in TG produces an alteration in the size and composition of LDL from small dense particles to large buoyant particles. These larger particles have a greater affinity for cholesterol receptors and are catabolized rapidly. Choline fenofibriate acid is contraindicated in patients with severe renal impairment. View more+
1. Names and Identifiers
1.1 Name
1.2 Synonyms

2-hydroxy-N,N,N-trimethyl, 2-{4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate 2-Hydroxy-N,N,N-triMethylethanaMiniuM 2-[4-(4-chlorobenzoyl)phenoxy]-2-Methylpropanoate Abt 335 Choline Fenofibrate Fenofibrate de choline Fenofibrate Impurity 8(Choline Fenofibrate) Trilipix Unii-4bmh7izt98

1.3 CAS No.
1.4 CID
1.5 Molecular Formula
C22H28ClNO5 (isomer)
1.6 Inchi
1.7 InChkey
1.8 Canonical Smiles
1.9 Isomers Smiles
2. Properties
2.1 Melting point
2.1 Boiling point
486.5°C at 760 mmHg
2.1 Flash Point
2.1 Precise Quality
2.1 PSA
2.1 logP
2.1 Chemical Properties
White Solid
3. Use and Manufacturing
3.1 Usage
A new formulation of fenofibric acid, ABT-335,

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 4

Serious eye damage, Category 1

Specific target organ toxicity \u2013 repeated exposure, Category 2

2.2 GHS label elements, including precautionary statements

Signal word


Hazard statement(s)

H302 Harmful if swallowed

H318 Causes serious eye damage

H373 May cause damage to organs through prolonged or repeated exposure

Precautionary statement(s)

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.


P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/\u2026if you feel unwell.

P330 Rinse mouth.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P310 Immediately call a POISON CENTER/doctor/\u2026

P314 Get medical advice/attention if you feel unwell.




P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification


8. Other Information
8.0 Mesh Entry Terms
2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoic acid
8.1 Use Classification
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
9. Computational chemical data
  • Molecular Weight: 421.9182g/mol
  • Molecular Formula: C22H28ClNO5
  • Compound Is Canonicalized: True
  • XLogP3-AA: null
  • Exact Mass: 421.1656007
  • Monoisotopic Mass: 421.1656007
  • Complexity: 446
  • Rotatable Bond Count: 6
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 5
  • Topological Polar Surface Area: 86.7
  • Heavy Atom Count: 29
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count: 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Isotope Atom Count: 0
  • Covalently-Bonded Unit Count: 2
10. Recommended Suppliers
Global37SuppliersView all >>
  • Products:Manufacture & Supply Biopharm Chemical, Specialty Chemical, PetroChemical.
  • Tel:86-592-8883942
Factory Supply Choline Fenofibrate
  • Purity:99%Packing: 200kg/bag FOB
  • Price: 0.1 USD/kilogram
  • Time: 2023/03/01
  • Products:Chemical products
  • Tel:86-571-88938639
Choline fenofibrate
  • Purity:99%Packing: 200kg/bag FOB
  • Price: 1 USD/kilogram
  • Time: 2023/04/23
  • Products:Our company is an internationally oriented research based pharmaceutical company with headquarters located in Hangzhou,China.
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  • Time: 2023/05/22
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Choline fenofibrate
  • Purity:99%Packing: 200kg/bag FOB
  • Price:  
  • Time: 2023/05/11
  • Products:Pharmaceutical, pharmaceutical intermediat,hormone powders
  • Tel:86-27-59335372
Factory supply Choline fenofibrate
  • Purity:99%Packing: 200kg/bag FOB
  • Price: 1 USD/kilogram
  • Time: 2016/09/29
11. Realated Product Infomation