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Urease structure
Urease structure

Urease

CAS No.: 9002-13-5
Modify Date.: 2022-02-11 21:44
Introduction: Urease is found in the natural environment (water and soil) and in human body, where its occurrence is connected with protein degradation. It is an enzyme and is capable of urea hydrolysis: one molecule of ammonia and one molecule of carbamate appear in the first step, carbamate spontaneously converts into the second ammonia molecule and carbonic acid in a water solution, and ammonia is protonated. This urea hydrolysis results in pH increase. Urease and ammonia, generated during urea hydrolysis, may be toxic for human tissue and probably have role in long-lasting diseases, like atherosclerosis, urinary tract infections, or rheumatoid arthritis.Urease can be used to analyze urea concentration in blood, urine, alcoholic beverages, natural water and environmental wastewaters; to analyze heavy metal content in natural waters, wastewaters and soil; to determine creatinine, arginine and IgG; to remove urea from artificial kidney dialyzates, alcohol beverages and fertilizer wastewaters; to control or shift pH for multi-enzyme reaction system; to hydrolyze urea as sources of ammonia or carbon dioxide in special cases, and for the wastewater reclamation for life support systems in space. View more+
1. Names and Identifiers
1.1 Name
Urease
1.2 Synonyms

CLEC-urease E.C. 3.5.1.5 jackbeanurease UREA AMIDOHYDROLASE UREA AMIDOLYASE UREA AMYDOLYASE UREASE AMIDOHYDROLASE Urease from Canavalia ensiformis (Jack bean) Urease LF UREASE, SP-OP Urease-CLEC

1.3 CAS No.
9002-13-5
1.4 EINECS(EC#)
232-656-0
1.5 Molecular Formula
N/A (isomer)
2. Properties
3.1 PSA
0.00000
3.1 logP
1.02620
3.1 Appearance
powder
3.2 Chemical Properties
powder
3.3 Color/Form
yellow
3.4 Water Solubility
slight

3.5 StorageTemp
2-8°C
3. Use and Manufacturing
4.1 Usage
Urease from Canavalia ensiformis may be used for urea determination of various samples, such as legumes. It may be useful for the detection of pathogens as well as heavy-metal ions.
4. Safety and Handling
5.1 Hazard Codes
Xn
5.1 Risk Statements
R36/37/38
5.1 Safety Statements
S22;S24;S26;S36/37;S45;S36;S23
5.1 WGK Germany
1
5.1 RTECS
YU1700000
5.1 Report

Reported in EPA TSCA Inventory.

5.2 Safety

A poison by intraperitoneal, subcutaneous, and intravenous routes. When heated to decomposition it emits acrid smoke and irritating vapors.
Safety information of Urease (9002-13-5):
Hazard Codes  Xn
Risk Statements 
36/37/38  Irritating to eyes, respiratory system and skin
42  May cause sensitization by inhalation
Safety Statements
22  Do not breathe dust
24  Avoid contact with skin
26  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37  Wear suitable protective clothing and gloves
45  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
36  Wear suitable protective clothing
23  Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer)
WGK Germany  1
RTECS  YU1700000
F  10-21

5.3 Specification

powder
Safety Statements:22-24-26-36/37-45-36-23
22:Do not breathe dust
24:Avoid contact with skin
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37:Wear suitable protective clothing and gloves
45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
36:Wear suitable protective clothing
23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer)
5.4 Toxicity
1.    

ipr-rat LD50:48 mg/kg

    AJPHAP    American Journal of Physiology. 206 (1964),731.
2.    

ivn-rat LD50:20 mg/kg

    AJPHAP    American Journal of Physiology. 206 (1964),731.
3.    

ipr-mus LD50:50 mg/kg

    AJPHAP    American Journal of Physiology. 206 (1964),731.
4.    

scu-mus LD50:58 mg/kg

    AJPHAP    American Journal of Physiology. 206 (1964),731.
5.    

ipr-rbt LD50:25 mg/kg

    AJPHAP    American Journal of Physiology. 206 (1964),731.
6. Realated Product Infomation