![]() |
![]() |
éthoxy-6-méthyl-3a,4,5,5a,6,11,12,13a-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate de méthyle sulfate (salt) (+)-vinblastine (2'Β)-Vincaleukoblastine sulfate (1:1) (2ξ,2'β,3α,4α,5β,19β)-Vincaleukoblastine sulfate (1:1) (3aR,4R,5S,5aR,10bR,13aR)-4-(acétyloxy)-3a-éthyl-9-[(13S,15S,17S)-17-éthyl-17-hydroxy-13-(méthoxycarbonyl)-1,11-diazatétracyclo[13.3.1.0.0]nonadéca-4(12),5,7,9-tétraén-13-yl]-5-hydroxy-8-m (3aR,4R,5S,5aR,10bR,13aR)-4-(acétyloxy)-3a-éthyl-9-[(13S,15S,17S)-17-éthyl-17-hydroxy-13-(méthoxycarbonyl)-1,11-diazatétracyclo[13.3.1.0.0]nonadéca-4(12),5,7,9-tétraén-13-yl]-5-hydroxy-8-méthoxy-6-méthyl-3a,4,5,5a,6,11,12,13a-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate de méthyle sulfate (salt) 29060le EINECS 205-606-0 exal methyl (3aR,4R,5S,5aR,10bR,13aR)-4-(acetyloxy)-3a-ethyl-9-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0.0]nonadeca-4(12),5,7,9-tetraen-13-yl]-5-hydr methyl (3aR,4R,5S,5aR,10bR,13aR)-4-(acetyloxy)-3a-ethyl-9-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0.0]nonadeca-4(12),5,7,9-tetraen-13-yl]-5-hydroxy-8-methoxy-6-methyl-3a,4,5,5a,6,11,12,13a-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate sulfate (salt) Methyl-(3aR,4R,5S,5aR,10bR,13aR)-4-(acetyloxy)-3a-ethyl-9-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0.0]nonadeca-4(12),5,7,9-tetraen-13-yl]-5-hydr Methyl-(3aR,4R,5S,5aR,10bR,13aR)-4-(acetyloxy)-3a-ethyl-9-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0.0]nonadeca-4(12),5,7,9-tetraen-13-yl]-5-hydroxy-8-methoxy-6-methyl-3a,4,5,5a,6,11,12,13a-octahydro-1H-indolizino[8,1-cd]carbazol-5-carboxylatsulfat(salt) MFCD00082457 nsc49842 oxy-8-methoxy-6-methyl-3a,4,5,5a,6,11,12,13a-octahydro-1H-indolizino[8,1-cd]carbazol-5-carboxylatsulfat(salt) oxy-8-methoxy-6-methyl-3a,4,5,5a,6,11,12,13a-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate sulfate (salt) Periblastine rozevinsulfate velban velbe Velsar vinbalastine Vinblastine (sulfate) Vinblastine, sulphate salt Vinblastine-d3 Vincaleukoblastine sulfate salt Vincaleukoblastine, (2'Β)-, sulfate (1:1) Vincaleukoblastine, (2ξ,2'β,3α,4α,5β,19β)-, sulfate (1:1) vincaleukoblastine, (3Β,4'Β)-, sulfate (1:1) vincaleukoblastine,sulfate(1:1)(salt) VLB VLB Vincaleukoblastine sulfate salt
IARC Cancer Review: Group 3 IMEMDT?? IARC Monographs on the Evaluation of Carcinogenic Risk of?chemicals to Man . 7 ,1987,p. 371.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.:?) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT ?? IARC Monographs on the Evaluation of Carcinogenic Risk of?chemicals to Man . 26 ,1981,p. 349.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.:?) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Inadequate Evidence IMEMDT ?? IARC Monographs on the Evaluation of Carcinogenic Risk of?chemicals to Man . 26 ,1981,p. 349.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.:?) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.
Poison by ingestion, intraperitoneal, and intravenous routes. An experimental teratogen. Human systemic effects by intravenous route: blood leukopenia and hair changes. Experimental reproductive effects. Questionable carcinogen. Human mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also?vincaleukoblastine and?sulfates.
Hazard Codes:?Xn,
T
Risk Statements: 22-37/38-41-61-36/37/38-63-23/24/25
R22:Harmful if swallowed.?
R37/38:Irritating to respiratory system and skin.?
R41:Risk of serious damage to the eyes.?
R61:May cause harm to the unborn child.?
R36/37/38:Irritating to eyes, respiratory system and skin.?
R63:Possible risk of harm to the unborn child.?
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-36/39-53-45-37/39-36/37/39?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S53:Avoid exposure - obtain special instructions before use.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S37/39:Wear suitable gloves and eye/face protection.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: 1544
WGK Germany: 3
RTECS: YY8400000
F: 8-10
HazardClass: 6.1(a)
PackingGroup: II
?Vinblastine sulfate , with CAS number of 143-67-9, can be called Vincaleukoblastine derivative ; vincaleukoblastine, (2'beta)- ; Vincaleukoblastine derivative ; Vincaleukoblastine sulfate (1:1) (salt) ; Vinblastine 5 ; Rozevin sulfate .?It is an antineoplastic agents for the treatment of Hodgkin's disease, choriocarcinoma and lymphosarcoma, it also has some effect on acute leukemia, breast cancer.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LDLo | intravenous | 500ug/kg (0.5mg/kg) | BEHAVIORAL: FOOD INTAKE (ANIMAL) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" |
Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii Vol. #3713-83, |
hamster | LD50 | intraperitoneal | 4300ug/kg (4.3mg/kg) | ? | Cancer Letters Vol. 2, Pg. 267, 1977. |
human | TDLo | intravenous | 557ug/kg (0.557mg/kg) | BLOOD: LEUKOPENIA SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
Cancer Chemotherapy Reports. Vol. 29, Pg. 111, 1963. |
mouse | LD50 | intraperitoneal | 2700ug/kg (2.7mg/kg) | ? | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 359, 1979. |
mouse | LD50 | intravenous | 9500ug/kg (9.5mg/kg) | ? | Cancer Research. Vol. 39, Pg. 3575, 1979. |
mouse | LD50 | oral | 423mg/kg (423mg/kg) | ? | Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 68, 1969. |
mouse | LD50 | subcutaneous | 324mg/kg (324mg/kg) | ? | Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 68, 1969. |
rat | LD50 | intraperitoneal | 1mg/kg (1mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" |
Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii Vol. #3713-83, |
rat | LD50 | intravenous | 37mg/kg (37mg/kg) | ? | Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 68, 1969. |
rat | LD50 | oral | 305mg/kg (305mg/kg) | ? | Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 68, 1969. |
rat | LD50 | subcutaneous | 355mg/kg (355mg/kg) | ? | Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 68, 1969. |
Acute toxicity - Oral, Category 4
Skin irritation, Category 2
Serious eye damage, Category 1
Specific target organ toxicity \u2013 single exposure, Category 3
Pictogram(s) | ![]() ![]() |
---|---|
Signal word | Danger |
Hazard statement(s) | H302 Harmful if swallowed H315 Causes skin irritation H318 Causes serious eye damage H335 May cause respiratory irritation |
Precautionary statement(s) | |
Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. |
Response | P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/\u2026if you feel unwell. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P313 If skin irritation occurs: Get medical advice/attention. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310 Immediately call a POISON CENTER/doctor/\u2026 P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P312 Call a POISON CENTER/doctor/\u2026if you feel unwell. |
Storage | P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. |
Disposal | P501 Dispose of contents/container to ... |
none