Vitamin D3

Iupac Name：(1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol

CAS No.: 67-97-0

Molecular Weight：384.63800

Modify Date.: 2022-11-08 17:29

Introduction:

The vitamin that mediates intestinal calcium absorbtion, bone calcium metabolism and probably, muscle activity. Occurs in and is isolated from fish liver oils. Vitamin D acts through a receptor that is a member of the ligand-dependent transcription

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1. Names and Identifiers

1.1 Name: Vitamin D3
1.2 Synonyms: (1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(1R)-1,5-dimethylhexyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylenecyclohexanol (1S,3Z)-3-[(2E)-2-{(1R,3aS,7aR)-1-[(1R)-1,5-Dimethylhexyl]-7a-methyloctahydro-4H-inden-4-yliden}ethyliden]-4-methylidencyclohexanol (1S,3Z)-3-[(2E)-2-{(1R,3aS,7aR)-1-[(1R)-1,5-dimethylhexyl]-7a-methyloctahydro-4H-inden-4-ylidene}ethylidene]-4-methylidenecyclohexanol (1S,3Z)-4-Methylene-3-[(2E)-2-{(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methyl-2-heptanyl]octahydro-4H-inden-4-ylidene}ethylidene]cyclohexanol (3b,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol (3S,5Z,7E)-9,10-Secocholesta-5,7,10-trien-3-ol (3Β,Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol (5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-trien-3-ol (5Z,7E,3S)-9,10-Secocholesta-5,7,10(19)-trien-3-ol [3H]-Vitamin D3 10-Secocholesta-5,7,10(19)-trien- 3Z-[2E-[(1R,3aS,7aR)-1S-[1R,5-dimethylhexyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-cyclohexanol 9,10-Secocholesta-5,7,10(19)-trien-3b-ol 9,10-Secocholesta-5,7,10(19)-trien-3-ol, (3Β,5Z,7E)- 9,10-secocholesta-5,7,10-trien-3-ol, (3S,5Z,7E)- calciol cholecalciferol Cholecalciferol d6 Cholecalciferolum colecalciferol cyclohexanol, 3-[(2E)-2-[(1R,3aS,7aR)-1-(1,5-dimethylhexyl)octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1S,3Z)- Cyclohexanol, 3-[(2E)-2-[(1R,3aS,7aR)-1-[(1R)-1,5-dimethylhexyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1S,3Z)- D3-Vicotrat Deparal Devaron Ebivit EINECS 200-673-2 FeraCol Granuvit D3 MC 1275 MFCD00078131 Micro-Dee NEO Dohyfral D3 Oxarol Prezios Provitina rampage UNII-1C6V77QF41 Vi-De3 Videkhol Vigantol VITAMIN D vitamin D3 powder Vitamin D3 solution Vitamin D3-d3 Cholecalciferol (6,19,19-d3) Vitamin D3-d6

1.3 CAS No.: 67-97-0

1.4 CID: 5280795

1.5 EINECS(EC#): 200-673-2

1.6 Molecular Formula: C27H44O (isomer)

1.7 Inchi: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1

1.8 InChkey: QYSXJUFSXHHAJI-YRZJJWOYSA-N

1.9 Canonical Smiles: CC(C)CCCC(C)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C

1.10 Isomers Smiles: C[C@H](CCCC(C)C)[C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C/3\C[C@H](CCC3=C)O)C

2. Properties

2.1 Density: 0.96 g/cm3

2.1 Melting point: 83-86°C(lit.)

2.1 Boiling point: 496.4ºC at 760 mmHg

2.1 Refractive index: 1.507 (15ºC)

2.1 Flash Point: 214.2ºC

2.1 Precise Quality: 384.33900

2.1 PSA: 20.23000

2.1 logP: 7.61900

2.1 Solubility: <0.1G/L(20oC)

2.2 Appearance: Crystalline

2.3 Storage: Keep Cold. Air Sensitive. Light Sensitive.

2.4 Chemical Properties: White or colorless crystalline solid. Odorless;

2.5 Color/Form: White powder

2.6 Odor: ODORLESS

2.7 pKa: 14.74±0.20(Predicted)

2.8 Water Solubility: Insoluble (NTP, 1992)

2.9 Spectral Properties: Specific optical rotation (1.6% in acetone): +84.8 deg at 20 deg C/D; (1.6% in chloroform): +51.9 deg at 20 deg C/D
Max absorption (in alcohol or hexane): 264.5 nm (epsilon= 450-490, 1%, 1 cm)
IR: 14472 (Sadtler Research Laboratories Prism Collection)
UV: 373 (Absorption Spectra in the UV and visible Regions, Academic Press, New York)
MASS: 16657 (NIST/EPA/MSDC Mass Spectral Database, 1990 version)

2.10 Stability: Oxidized and inactivated by moist air within few days.

2.11 StorageTemp: -20°C

3. Use and Manufacturing

3.1 Agricultural Uses: Rodenticide: Used in bait for vermin control. Vitamin D is a steroid hormone that has an important role in regulating bodylevels of calcium and phosphorus, and in mineralization ofbone. Not approved for use in EU countries. Registeredfor use in the U.S. and other countries.

3.2 Definition: A free vitamin D3, isolated in crystalline state fromthe 3,5-dinitrobenzoate, produced by irradiation,and equivalent in activity to vitamin D3 of tunaliver oil.

3.3 General Description: Fine colorless crystals. Water insoluble.

3.4 Potential Exposure: Sterol rodenticide used in bait for vermin control. Vitamin D is a steroid hormone that has an important role in regulating body levels of calcium and phosphorus, and in mineralization of bone. Not approved for use in EU countries

3.5 Purification Methods: It is converted into its 3,5-dinitrobenzoyl ester and crystallised repeatedly from acetone. The ester is then saponified and the free vitamin is isolated. [Laughland & Phillips Anal Chem 28 817 1956, Beilstein 6 III 2811, 6 IV 4149.]

3.6 Shipping: UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required

3.7 Usage: The vitamin that mediates intestinal calcium absorbtion, bone calcium metabolism and probably, muscle activity. Occurs in and is isolated from fish liver oils. Vitamin D acts through a receptor that is a member of the ligand-dependent transcription

4. Safety and Handling

4.1 Symbol: GHS06, GHS08

4.1 Hazard Codes: T+

4.1 Signal Word: Danger

4.1 Risk Statements: R24/25; R26; R48/25

4.1 Safety Statements: S28-S36/37-S45-S28A

4.1 Exposure Standards and Regulations: The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed prescription drug products, incl cholecalciferol, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act.
Cholecalciferol is a food additive permitted for direct addition to food for human consumption, as long as 1) the quantity of the substance added to food does not exceed the amount reasonably required to accomplish its intended physical, nutritive, or other technical effect in food, and 2) any substance intended for use in or on food is of appropriate food grade and is prepared and handled as a food ingredient.
Substance added directly to human food affirmed as generally recognized as safe (GRAS).
Drug products containing certain active ingredients offered over-the-counter (OTC) for certain uses. A number of active ingredients have been present in OTC drug products for various uses, as described below. However, based on evidence currently available, there are inadequate data to establish general recognition of the safety and effectiveness of these ingredients for the specified uses: Cholecalciferol is included in wound healing drug products.

4.2 Packing Group: II

4.2 Octanol/Water Partition Coefficient: log Kow = 10.2 (est)

4.3 Fire Hazard: Flash point data for Vitamin D3 are not available. Vitamin D3 is probably combustible.

4.4 Hazard Class: 6.1

4.4 Hazard Declaration: H301 + H311-H330-H372

4.4 DisposalMethods: SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

4.5 RIDADR: UN 2811 6.1/PG 2

4.5 Safety Profile: Poison by ingestion. An experimental teratogen. When heated to decomposition it emits acrid smoke and irritating fumes.

4.6 Caution Statement: P260-P280-P284-P301 + P310-P310

4.6 Formulations/Preparations: ...May be obtained as crystals, standardized oil solutions, emulsions or beadlets. ...usually stabilized with antioxidants.
Grade: USP, FCC
Trade Names. Sorexa-CD (ergocalciferol with difenacoum), Sorexa-CR (ergocalciferol with warfarin), both Sorex. Quintox (cholecalciferol), Bell Laboratories.

4.7 Incompatibilities: Sensitive to air, light, and moisture. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

4.8 WGK Germany: 2

4.8 RTECS: VS2900000

4.8 Safety: Hazard Codes of?Vitamin D3 (CAS NO.67-97-0):?T+,T
Risk Statements: 26-48-23/24/25?
R26: Very toxic by inhalation.?
R48: Danger of serious damage to health by prolonged exposure.?
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed.
Safety Statements: 28-45-36/37/39?
S28: After contact with skin, wash immediately with plenty of soap-suds.?
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 2
RTECS: VS2900000
F: 8-10-23
HazardClass: 6.1
PackingGroup: II
HS Code: 29130000
HS Code: 29362990

4.9 Sensitive: Air & Light Sensitive

4.10 Specification: Crystalline
usageEng:The vitamin that mediates intestinal calcium absorbtion, bone calcium metabolism and probably, muscle activity. Occurs in and is isolated from fish liver oils. Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor
Safety Statements:28-36/37-45-28A-36/37/39
28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
36/37:Wear suitable protective clothing and gloves
45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
36/37/39:Wear suitable protective clothing, gloves and eye/face protection

4.11 Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	80mg/kg (80mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) GASTROINTESTINAL: OTHER CHANGES	Journal of the American Veterinary Medical Association. Vol. 193, Pg. 211, 1988.
duck	LD50	oral	> 2gm/kg (2000mg/kg)	?	Veterinary and Human Toxicology. Vol. 41, Pg. 344, 1999.
infant	TDLo	oral	39mg/kg/34W-I (39mg/kg)	BEHAVIORAL: ANOREXIA (HUMAN BEHAVIORAL: IRRITABILITY GASTROINTESTINAL: DECREASED MOTILITY OR CONSTIPATION	British Medical Journal. Vol. 295, Pg. 1173, 1987.
mouse	LD50	intraperitoneal	136mg/kg (136mg/kg)	?	Veterinary and Human Toxicology. Vol. 31, Pg. 105, 1989.
mouse	LD50	oral	42500ug/kg (42.5mg/kg)	?	Defense des Vegetaux. Vol. 43(255-256), Pg. 14, 1989.
rat	LD50	oral	42mg/kg (42mg/kg)	?	Toxicology and Applied Pharmacology. Vol. 43, Pg. 125, 1978.

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5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 3

Acute toxicity - Dermal, Category 3

Acute toxicity - Inhalation, Category 2

Specific target organ toxicity \u2013 repeated exposure, Category 1

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H311 Toxic in contact with skin H330 Fatal if inhaled H372 Causes damage to organs through prolonged or repeated exposure
Precautionary statement(s)
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P284 [In case of inadequate ventilation] wear respiratory protection.
Response	P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/\u2026 P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P312 Call a POISON CENTER/doctor/\u2026if you feel unwell. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P310 Immediately call a POISON CENTER/doctor/\u2026 P320 Specific treatment is urgent (see ... on this label). P314 Get medical advice/attention if you feel unwell.
Storage	P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

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6. NMR Spectrum

Predict 1H proton NMR

IR : KBr disc

Mass spectrum (electron ionization)

7. Synthesis Route

67-97-0Total: 50 Synthesis Route

67-97-0 463 Suppliers

Literatures:
Chemische Berichte, , vol. 90, p. 2544,2552
Yield: null

434-16-2 94 Suppliers

67-97-0 463 Suppliers

Literatures:
Justus Liebigs Annalen der Chemie, , vol. 533, p. 118,126 Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, , vol. 241, p. 100,103 Naturwissenschaften, , vol. 25, p. 159 US2099550 , ; Naturwissenschaften, , vol. 43, p. 396 Recueil des Travaux Chimiques des Pays-Bas, , vol. 67, p. 246,255 DE661686 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 25, p. 403 Helvetica Chimica Acta, , vol. 33, p. 2101,2107 Experientia, , vol. 5, p. 321
Yield: null

434-16-2 94 Suppliers

1173-13-3 4 Suppliers

67-97-0 463 Suppliers

17592-07-3 1 Suppliers

5226-01-7 1 Suppliers

Literatures:
Journal of the American Chemical Society, , vol. 103, # 22 p. 6781 - 6783
Yield: ~4%

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8. Precursor and Product

precursor:

93601-52-6

93601-57-1

68323-44-4

26048-46-4

87649-56-7

96685-53-9

88908-86-5

434-16-2

66251-18-1

88908-87-6

67337-15-9

66251-16-9

96685-54-0

67-97-0

96843-44-6

96685-52-8

93489-97-5

96843-45-7

1173-13-3

93490-19-8

93490-17-6

96862-14-5

96688-64-1

93490-16-5

View all

product :

67-97-0

100858-27-3

19356-17-3

138313-18-5

9. Other Information

9.0 Merck: 14,10019

9.1 BRN: 2339331

9.2 毒性: LD50 oral in rat: 42mg/kg

9.3 Vitamin D: Vitamin D is steroid derivatives. It is the general term for the compounds that have similar structures and have the effect of normal skeletal growth and maintenance. At present, there are at least more than ten kinds of sterols that have vitamin D activity. But there are only two important matters, which are known as pro-vitamin D. One is ergosterol that exists in vegetable oil or yeast, which can generate vitamin D2 when irradiated by sunlight or ultraviolet radiation. It is also known as cholecalciferol or ergocalciferol. Another is 7-dehydrochlesterol that exists in the skin. It will become vitamin D3 after irradiated by the light. It is also called cholecalciferol. D2 and D3 have similar structures. They are B ring derivatives of precursors of the sterol. The difference is that the side chain of vitamin D2 has a methyl group and one double bond.
Vitamin D2 and D3 are all colorless crystals. The melting point of D2 and D3 respectively are 115~118℃ and 84~85℃. They are insoluble in water, and soluble in ethanol and other organic solvents. Their solubility in vegetable oil are small. Crystalline vitamin D should be stored in dark to light and oxygen at low temperature. Vitamin D3 is more stable than D2. It is not easy to be oxidized. Vitamin D has heat stability in the near neutral solution. It will be rapidly destroyed in the acidic solution, and the rate of destruction depends on strength and temperature of the acid. However, it is stable in alkaline solution. It can tolerate alkali treatment even under high temperature conditions.
In the industrial synthesis products, vitamin D3 is more. Vitamin D3 is sensitive to light and can be damaged by minerals and oxidation. But vitamin D3 has good stability after esterification and coated by gelatin, sugar and starch. The activity of vitamin D3 is also represented by International Units (IU). The amount of IU crystals vitamin D3 is 0.025μg. The active ingredient content of the industrial synthesis of vitamin D3 additive is more of 500,000 IU/g or 200 000 IU/g. For vitamin additives products, there are also additives that contain vitamin A and vitamin D3. The activity is usually 1g additive containing 500,000 IU of vitamin A and 100,000 IU of vitamin D3. The two has no antagonistic effect. And their production and use are very convenient. Vitamin D can increase the absorption and metabolism of calcium and phosphorus, prevent swine rickets, and promote the development of teeth and bones. Vitamin D dosage of pig feed is 125~200IU/kg. The amount for piglets is higher than growing pig. The amount of boar and growing pig are similar.

9.4 Physiological function: Under UV irradiation vegetative ergosterol and animal 7-dehydrogenation are absorbed and convert into vitamin D2 and vitamin D3. The two vitamin D must produc further chemical changes before used by the body. 7-dehydrocholesterol first form into 25-hydroxy derivative in the liver, then generate active ingredient 1,25-dihydroxyvitamin cholecalciferol [1,25 (OH) 2D5] by hydroxylation. The main function of vitamin D is to promote intestinal absorption of calcium and phosphorus, and regulate metabolism of calcium and phosphorus in order to maintain the body's calcium and phosphorus balance. Calcium absorbed from intestinal canal can be transported through the blood circulation from the liver and kidneys to the bone and other calcified tissues, and excret from the bone to the kidneys. This transport mechanism is controlled by vitamin D. When the concentration of calcium, phosphorus in the body decreases, vitamin D can dissociate calcium from the bone. In addition, vitamin D can also control kidney tubules to reabsorb calcium and phosphorus.
Vitamin D2 and vitamin D3 has the same function on ammals cows and pigs. But vitamin D3 for poultry (birds) is ten times stronger activity than vitamin D2.
Vitamin D deficiency can reduce the intestinal absorption of calcium, and cause the decomposition of bone calcium and phosphorus. Young livestock will appear osteomalacia. Adult animals are easy to appear osteoporosis. Vitamin D deficiency can also lead to animal sternum and spine deformation and layers laying soft-shell eggs. Because vitamin D controls the absorption of calcium and phosphorus, too much vitamin D in dietary can cause hypercalcemia, make excess calcium deposit in the heart, blood vessels, joints, pericardium or intestinal wall, and finally lead to heart failure, joint stiffness or bowel Road disorders.
Sunbathing is the most economical source of vitamin D. ergosterol or 7-dehydrogenation cholesterol in the feed will turn into vitamin D by ultraviolet radiation inside an animal for the utilization of carcass. Hay, corn leaves yeast, barley, oats, wheat after insolation and yeast after ultraviolet treatment are better sources of vitamin D. Animal products can be directly provide vitamin D to livestock, such as eggs, milk. The content of vitamin D in cod liver oil is very high. Diets need to be added vitamin D for reared animals and insufficient sunlight animal.

9.5 Content analysis: Same with “vitamin D2 (01043)”. But all ergocalciferol is replaced by cholecalciferol.

9.6 Maximum level: GB 14880-94: same with “01043, vitamin D2”
FDA, §18. 1950(2000): same with “01043, vitamin D2”

9.7 Chemical property: White columnar crystals or crystalline powder, odorless and tasteless. Melting point 84~88℃, specific rotation αD20 =+105°~+112°. Easily soluble in chloroform, soluble in alcohol, ether, cyclohexane and acetone, slightly soluble in vegetable oil, insoluble in water. Good heat resistance, but unstable for light. Easily oxidized in air. Rats by oral LD1042mg/kg.

9.8 Uses: 1. Vitamin D3 can maintain normal metabolism of calcium and phosphorus, promote the body's absorption of calcium and phosphorus. When it is lacked, children are easy to get rickets. Regulations in China provides it can be used to strengthening margarine. The dosage is 125~156μg/kg. The dosage in fortified dairy products is 63~125μg/kg. The dosage in strengthening infant food is 50~100μg/kg. And the dosage in strengthening milk and milk drink is 10~40μg/kg. The largest dosage in the strengthening solid drinks and ice cream is 10~20μg/kg.
2. Vitamin D3 can maintain normal metabolism of calcium and phosphorus and promote the body's absorption of calcium and phosphorus. The utilization of 1. vitamin D2 and D3 for pigs are the same, but the utilization of vitamin D2 for poultry is only 1/40-1/30 of vitamin D3. When lack of Vitamin D3, eggshell will become thin, the rate of laying will decrease, and rickets will appear. The amount can be 1000-1500IU/kg.
3. Vitamin D is a fat-soluble vitamin. There are a dozen compounds that are known to have the effect of vitamin D. Vitamin D2 and vitamin D3 have the important practical significance in no lines steroid derivative. D3 is given priority to with in the world, "International Standards" of vitamin D is pure crystalline D3. The main function of vitamin D are metabolism of calcium, phosphorus. It is difficult to promote the absorption of calcium and phosphorus and the calcification of bone. When the body is lack of vitamin D, the ability to absorb calcium and phosphorus will decrease, and the content of calcium and phosphorus in the blood will reduce. Then calcium and phosphorus cannot be deposited in bone tissue, even bone salt will dissolve and hinder the bone calcification. Children lack of vitamin D will get rickets. Adult lack of vitamin D will get osteomalacia. Japanese like to produce and use D2. In a variety of demand, the amount of pharmaceutical is 30%, feed additives is 65%, and food additives is 5%. According to the "food fortifier use of health standards (1993)" issued by Ministry of Health, D2 and D3, as nutritional supplements, can be used for liquid milk, margarine, dairy products and baby food.
4. Vitamin medicines. It mainly can promote intestinal absorption and deposition of calcium and phosphorus for the treatment of rickets and osteomalacia.
5. It is mainly used in food, health products and other related products.

9.9 Production method: 1. 7-dehydrocholesterol is dissolved in ethanol, and then treated with ultraviolet light to open the ring. The reaction mixture is concentrated, frozen and filtered. The filtrate is concentrated under reduced pressure nitrogen to dryness to give a crude liquid vitamin D3. Then it is refined to get vitamin D3.
2. Vitamin D3 naturally exists in the liver, egg yolk and milk. The production method in the industry starts from vegetable oil or yeast to extract 7-dehydrocholesterol that is not absorbed by the human body. Then it is dissolved in chloroform or cyclohexane. And then it converts to vitamin D3 by the ultraviolet radiation in the quartz glass flask.
3. Vitamin D3 naturally exists in the liver, egg yolk and milk. The production method in the industry starts from vegetable oil or yeast to extract 7-dehydrocholesterol that is not absorbed by the human body. Then it is dissolved in chloroform or cyclohexane. And then it converts to vitamin D3 by the ultraviolet radiation in the quartz glass flask.

9.10 Chemical Properties: White or colorless crystalline solid. Odorless;

9.11 Originator: Vitamin D, Country Life

9.12 Uses: Vitamin D3 analogue.

9.13 Uses: carnitine replenisher in peripheral arterial disease

9.14 Uses: The vitamin that mediates intestinal calcium absorbtion, bone calcium metabolism and probably, muscle activity. Occurs in and is isolated from fish liver oils. Vitamin D acts through a receptor that i s a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects o n breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.

9.15 Uses: selective phosphodiesterase-4 inhibitor (PDE-4 inhibitor) under investigation for treating respiratory diseases involving chronic inflammation such as asthma or COPD (smoker’s lung)

9.16 Uses: Cholecalciferol and ergocalciferol are used for the control of rats and mice.

9.17 Definition: A free vitamin D 3, isolated in crystalline state from the 3,5-dinitrobenzoate, produced by irradiation, and equivalent in activity to vitamin D3 of tunaliver oil.

9.18 Indications: Vitamin D is the collective term for a group of compounds formed by the action of ultraviolet irradiation on sterols. Cholecalciferol (vitamin D₃) and calciferol (vitamin D₂) are formed by irradiation of the provitamins 7- dehydrocholesterol and ergosterol, respectively. The conversion to vitamin D3 occurs in the skin. The liver is the principal storage site for vitamin D, and it is here that the vitamin is hydroxylated to form 25-hydroxyvitamin D. Additional hydroxylation to form 1,25-dihydroxyvitamin D occurs in the kidney in response to the need for calcium and phosphate

9.19 Indications: Vitamin D₃, through its active metabolite, 1,25- (OH)₂D₃, also plays an important role in maintaining calcium homeostasis by enhancing intestinal calcium absorption, PTH-induced mobilization of calcium from bone, and calcium reabsorption in the kidney.

9.20 Manufacturing Process: 5 g of 7-dehydrocholesteryl acetate (prepared by W.R. Ness, R. S. Kostic and Mosetting, J. Am. Chem. Soc. 78, 436, 1956) were dissolved in 500 ml of nhexane. This solution was irradiated with ultraviolet ray by recyclicly passing it through a quartz apparatus surrounding 450 w high pressure mercury vapor lamps for 80 minutes. After irradiation and then the distillating off of nhexane the solution was added with 50 ml of ethanol and the ethanolic solution was left to stand overnight at the temperature of -20°C. The formed crystals were filtered off from ethanolic solution and filtrate was heated at the temperature 78°C for 4 hours. After cooling of filtrate, the cooled filtrate was added with 4 ml of ethanolic solution containing 0.7 g of potassium hydroxide to effect a reaction at the temperature of 20°C and under nitrogen for 60 minutes. The reaction product was added with 0.7 ml glacial acetic acid and then ethanol was distilled off under reduced pressure from the reaction product. The obtained residue was extracted with 50 ml of n-hexane and extract was washed with water and n-hexane was distilled off from extract to obtain 2.5 g of yellow oily matter containing vitamin D3. The content of vitamin D3 in yellow oily matter was 40.2% by weight.

9.21 Therapeutic Function: Vitamin, Antirachitic

9.22 Biosynthesis: The primary supply of vitamin D₃ in humans is not obtained from the diet but rather is derived from the ultraviolet photoconversion of 7-dehydrocholesterol to vitamin D₃ in skin. Thus, vitamin D₃ synthesis varies with the seasons. D₃ is a prohormone and requires further metabolic conversion to exert biological activity in its target organs. The liver and the kidney are the major sites of metabolic activation of this endogenous sterol hormone. The initial transformation of D3 occurs in the liver and is catalyzed by the enzyme 25-OH-D₃-hydroxylase to form 25-(OH)D₃; this is the primary circulating form of D₃. Circulating 25-(OH)D₃ is then converted by the kidney to the most active form of D₃, 1,25-(OH)₂D₃, by the 1-(OH)-D₃-hydroxylase enzyme. Blood concentrations of 1,25-(OH)₂D₃ are approximately one fivehundredth of those of 25-(OH)D₃. 1, 25-(OH)₂D₃ is converted to the metabolite 24R,25-(OH)₂D₃, which is capable of suppressing parathyroid secretion.
In addition to the endogenous metabolites, some exogenous sterols possess biological activity similar to that of D₃. Ergocalciferol (vitamin D₂) is derived from the plant sterol ergosterol and may act as a substrate for both the 25-hydroxylase and the 1-hydroxylase enzyme systems of the liver and kidney to form 25-(OH)D₂ and 1,25-(OH)₂ D₂, respectively. Ergocalciferol (vitamin D₂) is the form used in commercial vitamins and supplemented dairy products. Dihydrotachysterol, another sterol that is used as a therapeutic agent, also functions as a substrate for the hydroxylase enzymes in the liver and kidney.

9.23 General Description: Fine colorless crystals. Water insoluble.

9.24 Air & Water Reactions: Sensitive to moisture, air and light. . Water insoluble.

9.25 Reactivity Profile: Vitamin D3 may react vigorously with strong oxidizing agents. May react exothermically with reducing agents to release hydrogen gas.

9.26 Health Hazard: SYMPTOMS: Symptoms of exposure to Vitamin D3 may include weakness, fatigue, lassitude headache, nausea, vomiting, diarrhea, polyuria, polydipsia, nocturia, decrease urinary concentrating ability, proteinuria, tissue calcification, hypertension and osteoporosis.

9.27 Fire Hazard: Flash point data for Vitamin D3 are not available. Vitamin D3 is probably combustible.

9.28 Agricultural Uses: Rodenticide: Used in bait for vermin control. Vitamin D is a steroid hormone that has an important role in regulating body levels of calcium and phosphorus, and in mineralization of bone. Not approved for use in EU countries. Registered for use in the U.S. and other countries.

9.29 Trade name: DELSTEROL?; DEPARAL?; D3- VIGANTOL?; QUINTOX?; RAMPAGE?; RICKETON?; TRIVITAN?; VIGORSAN?; VITINC DAN-DEE-3?

9.30 Biochem/physiol Actions: Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.

9.31 Mechanism of action: 1, 25-(OH)₂D₃ exerts its influence within target tissues through high-affinity sterol-specific intracellular receptor proteins.The D₃ receptor, similar to steroid receptor systems, translocates the hormone from the cell cytoplasm to the nucleus, where biological response is initiated via transcription and translation.

9.32 Clinical Use: The principal disorder associated with inadequate vitamin D intake is rickets. The low blood calcium and phosphate levels that occur during vitamin D deficiency stimulate parathyroid hormone secretion to restore calcium levels. In children, this deficiency leads to the formation of soft bones that become deformed easily; in adults, osteomalacia results from the removal of calcium from the bone.Vitamin D deficiency may occur in patients with metabolic disorders, such as hypoparathyroidism and renal osteodystrophy. The requirement for vitamin D is slightly higher in members of darker-pigmented races, since melanin interferes with the irradiation that produces vitamin D₃ in the skin. People with limited exposure to the sun may need to supplement vitamin D intake.

9.33 Side effects: The hypercalcemia resulting from hypervitaminosis D is responsible for toxic symptoms such as muscle weakness, bone pain, anorexia, ectopic calcification, hypertension, and cardiac arrhythmias. Toxicity in infants can result in mental and physical retardation, renal failure, and death.

9.34 Safety Profile: Poison by ingestion. An experimental teratogen. When heated to decomposition it emits acrid smoke and irritating fumes.

9.35 Potential Exposure: Sterol rodenticide used in bait for vermin control. Vitamin D is a steroid hormone that has an important role in regulating body levels of calcium and phosphorus, and in mineralization of bone. Not approved for use in EU countries

9.36 Metabolic pathway: Cholecalciferol (vitamin D3) is the mammalian form of vitamin D. It is normally produced in the skin by the action of UV light on its precursor, 7- dehydrocholesterol. Essential amounts of the vitamin are obtained thus or from dietary sources such as fish oils. The active form of the vitamin is 1,25-dihydroxy-cholecalciferol. Its formation occurs in two stages: 25- hydroxylation in the liver, followed by 1-hydroxylation in the kidney (see Engstrom and Koszewski, 1989 and references cited therein).

9.37 Shipping: UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required

9.38 Purification Methods: It is converted into its 3,5-dinitrobenzoyl ester and crystallised repeatedly from acetone. The ester is then saponified and the free vitamin is isolated. [Laughland & Phillips Anal Chem 28 817 1956, Beilstein 6 III 2811, 6 IV 4149.]

9.39 Degradation: It is unstable in light and air and in acidic media. It is inactivated within a few days under normal exposure conditions. This is due to oxidation and fragmentation of the triene functionality.

9.40 Toxicity evaluation: Another steroidal rodenticide is cholecalciferol, which is in fact the naturally occurring vitamin D3. This compound is an essential factor for vertebrates but in large doses causes hypercalcemia, resulting in calcification and degeneration of various soft tissues, ultimately leading to death. In baits, cholecalciferol may be combined with other, usually anticoagulant, rodenticides. The main natural source of cholecalciferol is fish liver oil, but it is manufactured from ergosterol.

9.41 Incompatibilities: Sensitive to air, light, and moisture. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

9.42 Waste Disposal: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material’s impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

9.43 Usage: Vitamin D3 is used as an essential mediator of intestinal calcium absorption and bone calcium metabolism. It is also used as a therapeutic vitamin. Further, it is used as a nutritional supplement and to fortify foods. In addition to this, it is used as pharmaceutical drug and used in the treatment of respiratory diseases involving chronic inflammation such as asthma.

10. Computational chemical data

Molecular Weight: 384.63800g/mol
Molecular Formula: C₂₇H₄₄O
Compound Is Canonicalized: True
XLogP3-AA: 7.9
Exact Mass: 384.339216023
Monoisotopic Mass: 384.339216023
Complexity: 610
Rotatable Bond Count: 6
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 1
Topological Polar Surface Area: 20.2
Heavy Atom Count: 28
Defined Atom Stereocenter Count: 5
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 2
Undefined Bond Stereocenter Count: 0
Isotope Atom Count: 0
Covalently-Bonded Unit Count: 1
CACTVS Substructure Key Fingerprint: AAADcfB4IAAAAAAAAAAAAAAAAAAAAYAAAAAwYAAAAAAAAGAAAAAAGgAACAAADxSggAICAAAAAgCAAiBCAAAAAAAgAAAACAAAAAgIEAIAAQAAQAAEwAAIgAOAwMAPgAAAAAAAAAAAAAAAACAAAQAACAAAAA==

11. Question & Answer

Vitamin D study sheds light on immune system effects Apr 24 2021
Scientists have uncovered fresh insights into how vitamin D affects the immune system and might influence susceptibility to diseases such as multiple sclerosis. Vitamin D is produced by the body in response to sunlight and is often lauded for its health benefits. Researchers found it also affects k...

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